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3. Together for the Future – Development of a Digital Website to Support Chronic Obstructive Pulmonary Disease Self-Management: A Qualitative Study

Author

Kjellsdotter A, Andersson S, and Berglund M

Subjects
copd-team, digital tool, self-management, sustainable learning, patient involvement, Medicine (General), R5-920
Abstract

Anna Kjellsdotter,1,2 Susanne Andersson,3,4 Mia Berglund2 1Research and Development Centre, Skaraborg Hospital, Skövde, Sweden; 2School of Health Sciences, Skövde University, Skövde, Sweden; 3Department of Health Sciences, University West, Trollhättan, Sweden; 4Research, Education, Development & Innovation, Primary Health Care, Region Västra Götaland, SwedenCorrespondence: Anna KjellsdotterResearch and Development Centre, Skaraborg Hospital Skövde, Skövde, S-541 85, SwedenTel +46 768051962Email anna.kjellsdotter@vgregion.seBackground: Symptom burden, impaired functional performance and decreased quality of life are not only consequences of the underlying physiological disorder chronic obstructive pulmonary disease (COPD) but also dependent on a patient’s ability to learn to live with and manage their illness. A digital website may be important for empowering patients with COPD to learn about and self-manage their illness. The aim of this study was to describe a developing process of a digital COPD-web as a part of a self-management education program for persons living with COPD.Methods: A qualitative approach with a phenomenological perspective was used. The study was based on group and individual interviews with a multidisciplinary COPD-team and patients who developed the COPD-web.Results: The developing process appears as a person-centred and holistic self-care approach both in content and development. Developing a digital COPD-web requires ongoing multidisciplinary collaboration and spawns a sense of pride that reinforces shared responsibility. The phenomenon consists of four constituents: learning by participating in development, the patient perspective as guiding approach, responsibility and motivation as driving forces and digital technology as a knowledge arena.Conclusion: The results indicate that constructive collaboration between a multidisciplinary COPD-team and patients as co-creators in an ongoing creative and reflective process is a key concept to develop a digital COPD-web with a holistic approach. Digital resources in the future might create time and space for reflective conversations in a COPD-web with virtual chatrooms.Keywords: COPD-team, digital tool, self-management, sustainable learning, patient involvement

Published
2021

5. Prevention of gestational diabetes with a prepregnancy lifestyle intervention – findings from a randomized controlled trial

Author

Rönö K, Stach-Lempinen B, Eriksson JG, Pöyhönen-Alho M, Klemetti MM, Roine RP, Huvinen E, Andersson S, Laivuori H, Valkama A, Meinilä J, Kautiainen H, Tiitinen A, and Koivusalo SB

Subjects
Preconception, pregnancy, obesity, nutrition, physical activity, Gynecology and obstetrics, RG1-991
Abstract

Kristiina Rönö,1 Beata Stach-Lempinen,2 Johan Gunnar Eriksson,3,4 Maritta Pöyhönen-Alho,1 Miira Marjuska Klemetti,1,2,5 Risto Paavo Roine,6,7 Emilia Huvinen,1 Sture Andersson,8 Hannele Laivuori,6,9–11 Anita Valkama,3,4 Jelena Meinilä,3,4 Hannu Kautiainen,3,12 Aila Tiitinen,1 Saila Birgitta Koivusalo1 1Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Women’s Hospital, Helsinki, Finland; 2Department of Obstetrics and Gynecology, South Karelia Central Hospital, Lappeenranta, Finland; 3Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 4Public Health Research Program, Folkhälsan Research Center, Helsinki, Finland; 5Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 6Department of Health and Social Management, Research Centre for Comparative Effectiveness and Patient Safety, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; 7Group Administration, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 8University of Helsinki and Helsinki University Hospital, Children’s Hospital, Pediatric Research Center, Helsinki, Finland; 9Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; 10Department of Obstetrics and Gynecology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; 11Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland; 12Department of General Practice and Primary Health Care, University of Eastern Finland, Kuopio, Finland Purpose: Lifestyle intervention studies performed during pregnancy have shown inconsistent results in relation to prevention of gestational diabetes mellitus (GDM). Therefore, the aim of this study was to assess the effect of an intervention initiated already before pregnancy in prevention of GDM in high-risk women.Patients and methods: A randomized controlled trial was conducted in four Finnish maternity hospitals between the years 2008 and 2014. Altogether 228 high-risk women planning pregnancy were randomized to an intervention (n=116) or a control group (n=112). The risk factors were body mass index ≥30 kg/m2 (n=46), prior GDM (n=120), or both (n=62), without manifest diabetes at study inclusion. Trained study nurses provided individualized lifestyle counseling every 3 months in addition to a group session with a dietician. The control group received standard antenatal care. GDM was defined as one or more pathological glucose values in a 75 g 2-hour oral glucose tolerance test, performed between 12 and 16 weeks of gestation and if normal repeated between 24 and 28 weeks of gestation.Results: Within 12 months, 67% of the women (n=72) in the intervention group and 63% of the women (n=71) in the control group (p=0.84) became pregnant. The cumulative incidence of GDM among the women available for the final analyses was 60% (n=39/65) in the intervention group and 54% (n=34/63) in the control group (p=0.49). GDM was diagnosed already before 20 weeks of gestation in 60% (n=44/73) of the cases.Conclusion: The preconceptional lifestyle intervention applied in the present study did not reduce the incidence of GDM. Keywords: preconception, pregnancy, obesity, nutrition, physical activity

Published
2018

7. Cognitive impairment in cervical cancer survivors—Exploring the discrepancy between subjective and objective assessment.

Author

Areklett, Elisabeth Wang, Andersson, S., Fagereng, E., Bruheim, K., Stubberud, J., and Lindemann, K.

Subjects
*CERVICAL cancer, *COGNITIVE processing speed, *EXECUTIVE function, *CANCER survivors, *COGNITION disorders
Abstract

Objective: Cancer‐related cognitive impairment has severe implications for the quality of life and societal participation of cervical cancer survivors (CCS). However, there is no research on the association between subjective and objective cognitive impairment (CI) in cervical cancer. This cross‐sectional study aimed to examine the frequency and severity of objective CI in CCS reporting significant subjective CI and explore the discrepancy between subjective and objective CI. Methods: Sixty‐five CCS reporting significant subjective CI, defined as 1.5 SD below the normative mean, underwent neuropsychological (NP) assessment covering attention, verbal memory, processing speed, verbal fluency, and executive functions. CCS were compared to healthy age‐matched controls (n = 74). A subjective versus objective discrepancy score was calculated based on the standardized scores within each group. Results: The CCS group performed significantly poorer across all NP tests compared to healthy controls (all p‐values <0.001) and 81.5% had scores below cut‐off as defined by the International Cognition and Cancer Task Force. However, compared to published normative data, most CCS performed within the clinically normal range. Processing speed and verbal memory were the most affected cognitive domains. By calculating a discrepancy score, both groups on average displayed a quite accurate concordance between subjective and objective cognitive functioning. Conclusion: Although CI is evident in CCS, our results confirm that objective and subjective CI represent different constructs and highlight the limitations of normative data. Differentiating subjective and objective CI is important when tailoring effective interventions in the survivorship care of CCS. [ABSTRACT FROM AUTHOR]

Published
2024
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19. The effect of dietary counselling on food intakes in pregnant women at risk for gestational diabetes: a secondary analysis of a randomised controlled trial RADIEL

Author

Valkama, A., Koivusalo, S., Lindstrom, J., Meinila, J., Kautiainen, H., Stach-Lempinen, B., Rono, K., Klemetti, M., Poyhonen-Alho, M., Tiitinen, A., Huvinen, E., Laivuori, H., Andersson, S., Roine, R., and Eriksson, J.G.

Subjects
Gestational diabetes -- Risk factors, Nutrition counseling -- Patient outcomes, Food habits -- Health aspects, Pregnant women -- Health aspects, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVES: The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide. GDM may be prevented by improving the diets of pregnant women. The objective of this study was to evaluate the effect of dietary counselling on the diets of pregnant women at GDM risk. SUBJECTS/METHODS: This study was a secondary analysis of a randomised controlled trial the Finnish gestational diabetes prevention study (RADIEL) in which pre-pregnant and pregnant women with previous GDM or BMI [greater than or equal to] 30 kg/[m.sup.2] were allocated into two groups, namely the control and the intervention groups. The control group received standard antenatal dietary counselling according to the Finnish Nutrition Recommendations. The intervention group participated in one individual dietary counselling session and one group dietary counselling session in addition to the standard counselling. This study included women who were recruited during pregnancy. To assess changes in food intake, food-intake questionnaires were collected during the first and the second trimester of pregnancy. Bootstrap type analysis of covariance was used, and 242 participants were included in the final analysis to study changes in food intake. RESULTS: The intakes of low-fat cheese (baseline adjusted mean 0.09 times/day; 95% confidence interval (CI) 0.07, 0.24; P = 0.040) and fish (baseline adjusted mean 0.28 times per week; 95% CI 0.08, 0.49; P = 0.011) showed a significant increase in the intervention group compared with the control group. CONCLUSIONS: This study showed that dietary counselling in early pregnancy can lead to modest dietary improvements in pregnant women at GDM risk. European Journal of Clinical Nutrition (2016) 70, 912-917; doi:10.1038/ejcn.2015.205; published online 16 December 2015, INTRODUCTION Gestational diabetes mellitus (GDM) is defined as glucose intolerance with its first detection during pregnancy. (1) Factors associated with GDM risk are pre-pregnancy overweight, previous GDM and a family [...]

Published
2016
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20. ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016

Author

Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., Shekerdemian, L. S., Coss-Bu, J. A., Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, J. C., Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, A. M. F., van Ieperen, S. N. M., Der Kinderen, E. P. H. M., Van Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Kyle, U. G., Akcan-Arikan, A., Silva, J. C., Mackey, G., Lusk, J., Goldsworthy, M., Shekerdemian, L. S., Coss-Bu, J. A., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano’, S. M., De Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, I. R., El Adawy, A. S., Mohammed, H. M. E. H., Mohamed, A. N., Parry, S. M., Knight, L. D., Denehy, L., De Morton, N., Baldwin, C. E., Sani, D., Kayambu, G., da Silva, V. Z. M., Phongpagdi, P., Puthucheary, Z. A., Granger, C. L., Rydingsward, J. E., Horkan, C. M., Christopher, K. B., McWilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, L. M., Rattray, J., Kenardy, J., Hull, A. M., Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, J. C., Rocha, L. L., De Freitas, F. F. M., Cavalheiro, A. M., Lucinio, N. M., Lobato, M. S., Ebeling, G., Kraegpoeth, A., Laerkner, E., De Brito-Ashurst, I., White, C., Gregory, S., Forni, L. G., Flowers, E., Curtis, A., Wood, C. A., Siu, K., Venkatesan, K., Muhammad, J. B. H., Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., de Molina, F. J. González, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, R. M., Palencia, E., Jareño, A., Granada, R. M., Ignacio, M. L., Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Riera, J., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Atchade, E., Mignot, T., Houzé, S., Jean-Baptiste, S., Thabut, G., Lortat-Jacob, B., Tanaka, S., Augustin, P., Desmard, M., Montravers, P., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, M. A., Patel, C., Mohankumar, L., Akhtar, N., Noriega, S. K. Pacheco, Aldana, N. Navarrete, León, J. L. Ávila, Baquero, J. Durand, Bernal, F. Fernández, Ahmadnia, E., Hadley, J. S., Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Gimillo, M. Rodriguez, Barinas, O. Diaz, Cortes, M. L. Blasco, Franco, J. Ferreres, Roca, J. M. Segura, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, P. J., Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Romero, J. C. García, Herrera, A. N. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Hualde, J. Barado, Hernández, A. Ansotegui, Irazabal, J. M. Guergué, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, E. Heusch, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, J. M., Arias-Verdu, M. D., Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., De La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Pertuz, E. D. Díaz, Hernández, A. Ansotegui, Romero, J. C. García, Sánchez, M. J. Gómez, Herrera, A. N. García, Ramírez, J. Roldán, Sanz, E. Regidor, Hualde, J. Barado, León, J. P. Tirapu, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, J. L., Pérez, H., Calpe, P., Alcala, M. A., Robaglia, D., Perez, C., Lan, S. K., Cunha, M. M., Moreira, T., Santos, F., Lafuente, E., Fernandes, M. J., Silva, J. G., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Herrera, A. N. García, Romero, J. C. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Echeverría, J. G. Armando, Hernández, A. Ansotegui, Hualde, J. Barado, Podlepich, V., Sokolova, E., Alexandrova, E., Lapteva, K., Kurtz, P., Shuinotsuka, C., Rabello, L., Vianna, G., Reis, A., Cairus, C., Salluh, J., Bozza, F., Torres, J. C. Barrios, Araujo, N. J. Fernández, García-Olivares, P., Keough, E., Dalorzo, M., Tang, L. K., De Sousa, I., Díaz, M., Marcos-Zambrano, L. J., Guerrero, J. E., Gomez, S. E. Zamora, Lopez, G. D. Hernandez, Cuellar, A. I. Vazquez, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Bhasin, D., Rai, S., Singh, H., Gupta, O., Bhattal, M. K., Sampley, S., Sekhri, K., Nandha, R., Aliaga, F. A., Olivares, F., Appiani, F., Farias, P., Alberto, F., Hernández, A., Pons, S., Sonneville, R., Bouadma, L., Neuville, M., Mariotte, E., Radjou, A., Lebut, J., Chemam, S., Voiriot, G., Dilly, M. P., Mourvillier, B., Dorent, R., Nataf, P., Wolff, M., Timsit, J. F., Ediboglu, O., Ataman, S., Ozkarakas, H., Kirakli, C., Vakalos, A., Avramidis, V., Obukhova, O., Kurmukov, I. A., Kashiya, S., Golovnya, E., Baikova, V. N., Ageeva, T., Haritydi, T., Kulaga, E. V., Rios-Toro, J. J., Perez-Borrero, L., Aguilar-Alonso, E., Arias-Verdu, M. D., Garcia-Alvarez, J. M., Lopez-Caler, C., De La Fuente-Martos, C., Rodriguez-Fernandez, S., Sanchez-Orézzoli, M. Gomez, Martin-Gallardo, F., Nikhilesh, J., Joshi, V., Villarreal, E., Ruiz, J., Gordon, M., Quinza, A., Gimenez, J., Piñol, M., Castellanos, A., Ramirez, P., Jeon, Y. D., Jeong, W. Y., Kim, M. H., Jeong, I. Y., Ahn, M. Y., Ahn, J. Y., Han, S. H., Choi, J. Y., Song, Y. G., Kim, J. M., Ku, N. S., Shah, H., Kellner, F., Rezai, F., Mistry, N., Yodice, P., Ovnanian, V., Fless, K., Handler, E., Alejos, R. Martínez, Romeu, J. D. Martí, Antón, D. González, Quinart, A., Martí, A. Torres, Llaurado-Serra, M., Lobo-Civico, A., Ventura-Rosado, A., Piñol-Tena, A., Pi-Guerrero, M., Paños-Espinosa, C., Peralvo-Bernat, M., Marine-Vidal, J., Gonzalez-Engroba, R., Montesinos-Cerro, N., Treso-Geira, M., Valeiras-Valero, A., Martinez-Reyes, L., Sandiumenge, A., Jimenez-Herrera, M. F., Helyar, S., Riozzi, P., Noon, A., Hallows, G., Cotton, H., Keep, J., Hopkins, P. A., Taggu, A., Renuka, S., Sampath, S., Rood, P. J. T., Frenzel, T., Verhage, R., Bonn, M., Pickkers, P., van der Hoeven, J. G., van den Boogaard, M., Corradi, F., Melnyk, L., Moggia, F., Pienovi, R., Adriano, G., Brusasco, C., Mariotti, L., Lattuada, M., Bloomer, M. J., Coombs, M., Ranse, K., Endacott, R., Maertens, B., Blot, K., Blot, S., Amerongen, M. P. van Nieuw, van der Heiden, E. S., Twisk, J. W. R., Girbes, A. R. J., Spijkstra, J. J., Riozzi, P., Helyar, S., Cotton, H., Hallows, G., Noon, A., Bell, C., Peters, K., Feehan, A., Keep, J., Hopkins, P. A., Churchill, K., Hawkins, K., Brook, R., Paver, N., Endacott, R., Maistry, N., van Wijk, A., Rouw, N., van Galen, T., Evelein-Brugman, S., Taggu, A., Krishna, B., Sampath, S., Putzu, A., Fang, M., Berto, M. Boscolo, Belletti, A., Cassina, T., Cabrini, L., Mistry, M., Alhamdi, Y., Welters, I., Abrams, S. T., Toh, C. H., Han, H. S., Gil, E. M., Lee, D. S., Park, C. M., Winder-Rhodes, S., Lotay, R., Doyle, J., Ke, M. W., Huang, W. C., Chiang, C. H., Hung, W. T., Cheng, C. C., Lin, K. C., Lin, S. C., Chiou, K. R., Wann, S. R., Shu, C. W., Kang, P. L., Mar, G. Y., Liu, C. P., Dubó, S., Aquevedo, A., Jibaja, M., Berrutti, D., Labra, C., Lagos, R., García, M. F., Ramirez, V., Tobar, M., Picoita, F., Peláez, C., Carpio, D., Alegría, L., Hidalgo, C., Godoy, K., Bakker, J., Hernández, G., Sadamoto, Y., Katabami, K., Wada, T., Ono, Y., Maekawa, K., Hayakawa, M., Sawamura, A., Gando, S., Marin-Mateos, H., Perez-Vela, J. L., Garcia-Gigorro, R., Peiretti, M. A. Corres, Lopez-Gude, M. J., Chacon-Alves, S., Renes-Carreño, E., Montejo-González, J. C., Parlevliet, K. L., Touw, H. R. W., Beerepoot, M., Boer, C., Elbers, P. W. G., Tuinman, P. R., Abdelmonem, S. A., Helmy, T. A., El Sayed, I., Ghazal, S., Akhlagh, S. H., Masjedi, M., Hozhabri, K., Kamali, E., Zýková, I., Paldusová, B., Sedlák, P., Morman, D., Youn, A. M., Ohta, Y., Sakuma, M., Bates, D., Morimoto, T., Su, P. L., Chang, W. Y., Lin, W. C., Chen, C. W., Facchin, F., Zarantonello, F., Panciera, G., De Cassai, A., Venrdramin, A., Ballin, A., Tonetti, T., Persona, P., Ori, C., Del Sorbo, L., Rossi, S., Vergani, G., Cressoni, M., Chiumello, D., Chiurazzi, C., Brioni, M., Algieri, I., Tonetti, T., Guanziroli, M., Colombo, A., Tomic, I., Colombo, A., Crimella, F., Carlesso, E., Gasparovic, V., Gattinoni, L., Neto, A. Serpa, Schmidt, M., Pham, T., Combes, A., de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Katira, B. H., Engelberts, D., Giesinger, R. E., Ackerley, C., Yoshida, T., Zabini, D., Otulakowski, G., Post, M., Kuebler, W. M., McNamara, P. J., Kavanagh, B. P., Pirracchio, R., Rigon, M. Resche, Carone, M., Chevret, S., Annane, D., Eladawy, S., El-Hamamsy, M., Bazan, N., Elgendy, M., De Pascale, G., Vallecoccia, M. S., Cutuli, S. L., Di Gravio, V., Pennisi, M. A., Conti, G., Antonelli, M., Andreis, D. T., Khaliq, W., Singer, M., Hartmann, J., Harm, S., Carmona, S. Alcantara, Almudevar, P. Matia, Abellán, A. Naharro, Ramos, J. Veganzones, Pérez, L. Pérez, Valbuena, B. Lobo, Sanz, N. Martínez, Simón, I. Fernández, Arrigo, M., Feliot, E., Deye, N., Cariou, A., Guidet, B., Jaber, S., Leone, M., Resche-Rigon, M., Baron, A. Vieillard, Legrand, M., Gayat, E., Mebazaa, A., Balik, M., Kolnikova, I., Maly, M., Waldauf, P., Tavazzi, G., Kristof, J., Herpain, A., Su, F., Post, E., Taccone, F., Vincent, J. L., Creteur, J., Lee, C., Hatib, F., Jian, Z., Buddi, S., Cannesson, M., Fileković, S., Turel, M., Knafelj, R., Gorjup, V., Stanić, R., Gradišek, P., Cerović, O., Mirković, T., Noč, M., Tirkkonen, J., Hellevuo, H., Olkkola, K. T., Hoppu, S., Lin, K. C., Hung, W. T., Chiang, C. C., Huang, W. C., Juan, W. C., Lin, S. C., Cheng, C. C., Lin, P. H., Fong, K. Y., Hou, D. S., Kang, P. L., Wann, S. R., Chen, Y. S., Mar, G. Y., Liu, C. P., Paul, M., Bougouin, W., Geri, G., Dumas, F., Champigneulle, B., Legriel, S., Charpentier, J., Mira, J. P., Sandroni, C., Cariou, A., Zimmerman, J., Sullivan, E., Noursadeghi, M., Fox, B., Sampson, D., McHugh, L., Yager, T., Cermelli, S., Seldon, T., Bhide, S., Brandon, R. A., Brandon, R. B., Zwaag, J., Beunders, R., Pickkers, P., Kox, M., Gul, F., Arslantas, M. K., Genc, D., Zibandah, N., Topcu, L., Akkoc, T., Cinel, I., Greco, E., Lauretta, M. P., Andreis, D. T., Singer, M., Garcia, I. Palacios, Cordero, M., Martin, A. Diaz, Pallás, T. Aldabó, Montero, J. 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J., Gonzalez, C. A., Pinto, J. L., Orozco, V., Patiño, J. A., Garcia, P. K., Contreras, K. M., Rodriguez, P., Echeverri, J. E., GETGAG Working Group, JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group, CAPCRI Study, for the ReVA Research Network and the PROVE Network Investigators, from the FROG ICU Investigators, The WIND study group, Plug Working Group, GETGAG/SEMICYUC, AKI Research Group, St George’s University of London, IPREA Study Group, FINNRESUSCI Study Group, PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre, ENVIN-HELICS Study Group, ARIAM registry of adult cardiac surgery, The Rapid Diagnosis of Infections in the Critically Ill Team, Tokyo Womens Medical University, PLUG working group, PLUG Working Group, On behalf of Okayama Research Investigation Organizing Network (ORION)investigators, PS-ICU Group, Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group, Student Research Committee - Shiraz University of Medical Sciences, ARIAM-ANDALUCIA, The WIND study group, PLUG Working Group, The WIND study group, PLUG Working Group, and Plug working group

Published
2016
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23. Coping with Change in ICT-Based Learning Environments: Newly Qualified Rwandan Teachers' Reflections

Author

Mukama, E. and Andersson, S. B.

Abstract

The overarching aim of this study is to investigate how newly qualified Rwandan teachers can contribute to the creation of theoretical and practical knowledge for professional development with information and communication technology (ICT). Questionnaires, focus groups and interviews were used for data collection. The findings show that novice teachers are motivated to acquire ICT and that they succeed in situations where school administrators grant easy access to computers. The novice teachers expressed a strong desire to be trusted and be allowed time to use computers and related skills in their learning and teaching. These views are discussed in terms of learning conditions created in schools so that participants become active, responsible and committed practitioners. We assume that such attitudes can be a model for their future roles in fostering change in social practice. For example, this study shows that gender equity becomes an aspect of change in an ICT-learning environment, which creates new opportunities for continuous education. To achieve this, as revealed by the findings, there is a need to develop school-based curricula, appropriate pedagogy and teacher professional development in the area of ICT literacy, which allows the teachers to develop a critical mind to the new tools.

Published
2008
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29. Hippocampal Sparing Radiotherapy in adults with Primary Brain Tumors: A comparative planning and dosimetric study using IMPT, IMRT and 3DCRT

Author

Aka, P, Taylor, R, Hugtenburg, R, Lambert, J, Powell, J, Bevolo, T, Gao, M, Gondi, V, Hartsell, W.H, Bolsi, A, Beer, J, Belosi, M.F, Siewert, D, Lomax, A.J, Weber, D.C, Huang, Y.J, Huang, C.C, Chao, P.J, Liu, C, Shang, H, Ding, X, Wang, Y, Mammar, H, Froelich, Sébastien, Alapetite, Claire, Bolle, Stéphanie, Calugaru, Valentin, Feuvret, Loic, Helfre, Sylvie, Champion, Laurence, Goudjil, Farid, Dendal, Remi, Engelholm, S.A, Munck Af Rosenschold, P, Kristensen, I, Smulders, B, Muhic, A, Alkner, S, Jacob, E, Engelholm, S, Aljabab, S, Lui, A, Wong, T, Liao, J, Laramore, G, Parvathaneni, U, Kharouta, M, Pidikiti, R, Jesseph, F, Smith, M, Dobbins, D, Mattson, D, Choi, S, Mansur, D, Machtay, M, Bhatt, A, Lütgendorf-Caucig, C, Dunavölgyi, R, Georg, P, Perpar, A, Fussl, C, Konstantinovic, R, Ulrike, M, Piero, F, Eugen, H, Vidal, M, Gerard, A, Barnel, C, Maneval, D, Herault, J, Claren, A, Doyen, J, Dendale, R, Toutee, A, Pasquie, I, Goudjil, F, Lumbroso Lerouic, L, Levy, C, Desjardins, L, 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Laramore, G.E, Yang, P, van der Weide, H, Maduro, J, Heesters, M, Gawryszuk, A, Davila-Fajardo, R, Langendijk, H, Eckhard, M, Maxwell, A, VanNamen, K, Cashin, M, Jacovic, A, Dunn, M, kim, T, Jung, J, Kim, J, Swerdloff, S, Saunders, A, Thomas, J, Kidani, T, Okada, A, Tomida, K, Pennington, H, Xiaoqiang, L, Weigang, H, An, Q, Di, Y, Craig, S, Inga, G, Peyman, K, Xuanfeng, D, Cunningham, C, de Kock, M, Slabbert, J, Panaino, C.M, Phoenix, B, Regan, P.H, Shearman, R, Collins, S.M, Taylor, M.J, Grayson, M, Kato, K, Choi, H, Jang, J.W, Shin, W.G, Min, C.H, McMahon, S, Padilla Cabal, F, Fragoso, J.A, Resch, A.F, Katsis, A, Girdhani, S, Marshall, A, Jackson, I, Bentzen, S, Parry, R, Gantz, S, Schellhammer, S, Hoffmann, A, Delorme, R, Dos Santos, M, Salmon, R, Öden, J, Bullivant, K, Rucksdashal, R, Ferret, E, Covington, F, Rice, S, Decesaris, C, Siddiqui, O, Kowalski, E, Samanta, S, and Rothwell, B

Subjects
Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0642, Physics: Absolute and Relative DosimetryPTC58-0180, Biology: Biology and Clinical InterfacePTC58-0685, Physics: Commissioning New FacilitiesPTC58-0385, Physics: 4D Treatment and DeliveryPTC58-0546, Clinics: EyePTC58-0714, Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0528, Physics: Quality Assurance and VerificationPTC58-0507, Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0661, Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0221, Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0531, Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0653, Biology: Drug and Immunotherapy CombinationsPTC58-0163, Clinics: Sarcoma - LymphomaPTC58-0055, Biology: Drug and Immunotherapy CombinationsPTC58-0166, Clinics: CNS / Skull BasePTC58-0198, Physics: Treatment PlanningPTC58-0421, Clinics: PediatricsPTC58-0560, General: New HorizonsPTC58-0709, Physics: Treatment PlanningPTC58-0664, Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0286, Physics: Treatment PlanningPTC58-0666, Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0346, Physics: Treatment PlanningPTC58-0547, Physics: Treatment PlanningPTC58-0308, Physics: Treatment PlanningPTC58-0549, Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0111, Physics: Absolute and Relative DosimetryPTC58-0050, Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0587, Biology: Biology and Clinical InterfacePTC58-0454, Physics: Absolute and Relative DosimetryPTC58-0052, Physics: Commissioning New FacilitiesPTC58-0395, Physics: 4D Treatment and DeliveryPTC58-0534, Physics: Dose Calculation and OptimisationPTC58-0072, Physics: 4D Treatment and DeliveryPTC58-0533, Physics: 4D Treatment and DeliveryPTC58-0538, Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0113, Physics: Quality Assurance and VerificationPTC58-0633, Physics: Treatment PlanningPTC58-0431, Physics: Beam Delivery and Nozzle DesignPTC58-0230, Biology: Mathematical Modelling SimulationPTC58-0179, Clinics: Head and Neck / EyePTC58-0365, Physics: Treatment PlanningPTC58-0319, Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0697, Biology: Biology and Clinical InterfacePTC58-0663, Physics: Commissioning New FacilitiesPTC58-0240, Physics: Adaptive TherapyPTC58-0177, Physics: Commissioning New FacilitiesPTC58-0363, Physics: Commissioning New FacilitiesPTC58-0487, Physics: 4D Treatment and DeliveryPTC58-0209, Physics: 4D Treatment and DeliveryPTC58-0206, Clinics: CNS / Skull BasePTC58-0294, Physics: Commissioning New FacilitiesPTC58-0127, Biology: Mathematical Modelling SimulationPTC58-0068, Physics: Treatment Planning Poster Discussion SessionsPTC58-0062, Physics: 4D Treatment and DeliveryPTC58-0692, Physics: Quality Assurance and VerificationPTC58-0723, Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0494, Physics: Treatment PlanningPTC58-0643, Physics: Treatment PlanningPTC58-0521, Physics: Treatment PlanningPTC58-0402, Physics: Treatment PlanningPTC58-0405, Clinics: Head and Neck / EyePTC58-0273, Clinics: GIPTC58-0397, Physics: Treatment PlanningPTC58-0648, Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0489, Physics: Quality Assurance and VerificationPTC58-0617, Physics: Quality Assurance and VerificationPTC58-0616, Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0668, Clinics: CNS / Skull BasePTC58-0188, Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0625, Physics: Treatment PlanningPTC58-0654, Physics: Treatment PlanningPTC58-0655, Biology: Drug and Immunotherapy Combinations Poster Discussion SessionsPTC58-0133, Clinics: PediatricsPTC58-0313, Physics: Treatment PlanningPTC58-0659, Poster AbstractsClinics: CNSPTC58-0290, Physics: Commissioning New FacilitiesPTC58-0064, Physics: Adaptive TherapyPTC58-0396, Physics: Dose Calculation and OptimisationPTC58-0281, Physics: Quality Assurance and VerificationPTC58-0427, Physics: Quality Assurance and VerificationPTC58-0669, General: New Horizons SessionPTC58-0191, Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0217, Physics: Quality Assurance and VerificationPTC58-0303, Physics: Quality Assurance and VerificationPTC58-0665, Clinics: Sarcoma - LymphomaPTC58-0495, Physics: Dose Calculation and OptimisationPTC58-0398, Physics: Quality Assurance and VerificationPTC58-0667, Physics: Quality Assurance and VerificationPTC58-0425, Physics: Quality Assurance and VerificationPTC58-0541, Physics: Treatment PlanningPTC58-0584, Physics: Quality Assurance and VerificationPTC58-0540, Biology: Drug and Immunotherapy Combinations Poster Discussion SessionsPTC58-0163, Physics: Treatment PlanningPTC58-0224, Physics: Treatment PlanningPTC58-0229, Clinics: PediatricsPTC58-0249, Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0555, Clinics: PediatricPTC58-0463, Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0556, Physics: Absolute and Relative DosimetryPTC58-0498, Physics: Commissioning New FacilitiesPTC58-0078, Physics: Dose Calculation and OptimisationPTC58-0270, Physics: Dose Calculation and OptimisationPTC58-0032, Physics: Dose Calculation and OptimisationPTC58-0274, Physics: 4D Treatment and DeliveryPTC58-0614, Physics: Dose Calculation and OptimisationPTC58-0026, Clinics: Head and Neck / EyePTC58-0280, Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0091, Physics: Treatment PlanningPTC58-0593, Biology: Drug and Immunotherapy CombinationsPTC58-0012, Physics: Dose Calculation and OptimisationPTC58-0025, Physics: Dose Calculation and OptimisationPTC58-0146, Clinics: Sarcoma - LymphomaPTC58-0261, Physics: Treatment PlanningPTC58-0110, Clinics: Lung / Sarcoma / LymphomaPTC58-0733, Physics: Quality Assurance and VerificationPTC58-0554, Physics: Treatment PlanningPTC58-0597, Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0330, Physics: Treatment PlanningPTC58-0115, Physics: Treatment PlanningPTC58-0598, Physics: Absolute and Relative DosimetryPTC58-0040, Physics: Absolute and Relative DosimetryPTC58-0282, Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0399, Physics: Absolute and Relative DosimetryPTC58-0283, Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0569, Clinics: GUPTC58-0647, Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0506, Physics: Commissioning New FacilitiesPTC58-0047, Physics: Dose Calculation and OptimisationPTC58-0067, Clinics: GUPTC58-0409, Physics: Dose Calculation and OptimisationPTC58-0065, Biology: BNCT Poster Discussion SessionsPTC58-0586, Physics: Absolute and Relative Dosimetry PTC58-0393, Physics: Image GuidancePTC58-0712, Physics: Quality Assurance and VerificationPTC58-0645, Physics: Treatment PlanningPTC58-0683, Biology: BNCT Poster Discussion SessionsPTC58-0107, Physics: Treatment Planning Poster Discussion SessionsPTC58-0266, Physics: Monitoring and Modelling MotionPTC58-0530, Biology: BNCT Poster Discussion SessionsPTC58-0341, Physics: Commissioning New FacilitiesPTC58-0172, Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0456, Physics: Dose Calculation and OptimisationPTC58-0170, Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0458, Physics: Absolute and Relative DosimetryPTC58-0034, Physics: Quality Assurance and VerificationPTC58-0417, Physics: Quality Assurance and VerificationPTC58-0413, Physics: Treatment Planning Poster Discussion SessionsPTC58-0492, Physics: Dose Calculation and OptimisationPTC58-0168, Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0724, Physics: Treatment PlanningPTC58-0694, Physics: Adaptive TherapyPTC58-0005, Physics: Treatment PlanningPTC58-0696, Physics: Treatment PlanningPTC58-0453, Physics: Adaptive TherapyPTC58-0366, Clinics: BreastPTC58-0197, Physics: Beam Delivery and Nozzle DesignPTC58-0652, Physics: Treatment Planning Poster Discussion SessionsPTC58-0017, Physics: Treatment PlanningPTC58-0338, Clinics: Head and Neck / EyePTC58-0539, General: New Horizons SessionPTC58-0390, Physics: Image Guidance Poster Discussion SessionsPTC58-0651, General: New HorizonsPTC58-0660, Physics: Dose Calculation and OptimisationPTC58-0360, Physics: Image GuidancePTC58-0297, Physics: 4D Treatment and DeliveryPTC58-0147, Scientific: RTTPTC58-0388, Physics: Dose Calculation and OptimisationPTC58-0484, General: New HorizonsPTC58-0301, Physics: Dose Calculation and OptimisationPTC58-0485, General: New HorizonsPTC58-0304, Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0532, Clinics: GIPTC58-0575, General: New HorizonsPTC58-0306, Physics: Quality Assurance and VerificationPTC58-0589, Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0344, Physics: Quality Assurance and VerificationPTC58-0225, Physics: Treatment PlanningPTC58-0381, Physics: Quality Assurance and VerificationPTC58-0467, Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0585, Physics: Commissioning New FacilitiesPTC58-0416, Physics: Quality Assurance and VerificationPTC58-0228, Physics: Quality Assurance and VerificationPTC58-0348, Physics: Dose Calculation and OptimisationPTC58-0234, Physics: Quality Assurance and VerificationPTC58-0101, Physics: Treatment PlanningPTC58-0386, Physics: Dose Calculation and OptimisationPTC58-0118, Physics: Treatment PlanningPTC58-0265, Physics: Dose Calculation and OptimisationPTC58-0119, Clinics: GIPTC58-0218, Physics: Treatment PlanningPTC58-0267, Physics: Treatment PlanningPTC58-0387, Clinics: BreastPTC58-0142, Physics: Treatment PlanningPTC58-0269, Physics: Beam Delivery and Nozzle DesignPTC58-0620, Clinics: PediatricsPTC58-0048, Physics: Quality Assurance and VerificationPTC58-0220, Physics: Quality Assurance and VerificationPTC58-0461, Physics: Treatment PlanningPTC58-0029, Physics: Absolute and Relative DosimetryPTC58-0571, Physics: Image GuidancePTC58-0046, Clinics: GUPTC58-0557, Physics: Absolute and Relative DosimetryPTC58-0211, Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0131, Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0373, General: New HorizonsPTC58-0411, Physics: Dose Calculation and OptimisationPTC58-0595, Clinics: CNS / Skull BasePTC58-0361, General: New HorizonsPTC58-0414, General: New HorizonsPTC58-0537, Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0628, Physics: Treatment PlanningPTC58-0271, Physics: Commissioning New FacilitiesPTC58-0307, Physics: Quality Assurance and VerificationPTC58-0359, Physics: Quality Assurance and VerificationPTC58-0354, General: New HorizonsPTC58-0419, Physics: Treatment PlanningPTC58-0035, Biology: BNCTPTC58-0474, Clinics: GIPTC58-0460, Biology: BNCTPTC58-0596, Clinics: GIPTC58-0222, Physics: Image GuidancePTC58-0193, Clinics: PediatricPTC58-0312, Clinics: GUPTC58-0441, Clinics: LungPTC58-0701, Clinics: EyePTC58-0536, Clinics: GUPTC58-0205, Physics: Dose Calculation and OptimisationPTC58-0140, Clinics: GUPTC58-0208, Physics: Dose Calculation and OptimisationPTC58-0020, Physics: Image GuidancePTC58-0195, Poster AbstractsClinics: CNSPTC58-0717, Physics: Quality Assurance and VerificationPTC58-0325, Physics: Dose Calculation and OptimisationPTC58-0015, Physics: Commissioning New FacilitiesPTC58-0634, General: New HorizonsPTC58-0646, Physics: Quality Assurance and VerificationPTC58-0566, Physics: Dose Calculation and OptimisationPTC58-0134, Physics: Dose Calculation and OptimisationPTC58-0376, Biology: Mathematical Modelling SimulationPTC58-0462, Biology: BNCTPTC58-0567, General: New HorizonsPTC58-0527, Physics: Treatment PlanningPTC58-0482, Clinics: GI, GU, BreastPTC58-0693, Physics: Commissioning New FacilitiesPTC58-0518, Physics: Quality Assurance and VerificationPTC58-0686, Physics: Quality Assurance and VerificationPTC58-0202, Physics: Quality Assurance and VerificationPTC58-0322, Physics: Quality Assurance and VerificationPTC58-0564, Physics: Quality Assurance and VerificationPTC58-0680, Physics: Treatment PlanningPTC58-0247, Physics: Quality Assurance and VerificationPTC58-0682, Physics: Quality Assurance and VerificationPTC58-0440, Biology: Translational and BiomarkersPTC58-0514, Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0178, Clinics: EyePTC58-0520, Physics: Absolute and Relative DosimetryPTC58-0231, Clinics: Head and Neck / EyePTC58-0424, Physics: Absolute and Relative DosimetryPTC58-0471, Physics: Absolute and Relative DosimetryPTC58-0356, Physics: Dose Calculation and OptimisationPTC58-0491, Physics: Dose Calculation and OptimisationPTC58-0250, Physics: Commissioning New FacilitiesPTC58-0650, Biology: Biology and Clinical InterfacePTC58-0719, Physics: Absolute and Relative DosimetryPTC58-0232, Physics: Absolute and Relative DosimetryPTC58-0353, General: New HorizonsPTC58-0511, Physics: Quality Assurance and VerificationPTC58-0219, Physics: Absolute and Relative DosimetryPTC58-0238, General: New HorizonsPTC58-0512, Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0401, Clinics: PediatricPTC58-0688, Physics: Quality Assurance and VerificationPTC58-0457, Physics: Quality Assurance and VerificationPTC58-0214, Physics: Quality Assurance and VerificationPTC58-0459, General: New HorizonsPTC58-0516, Physics: Treatment PlanningPTC58-0372, Physics: Treatment PlanningPTC58-0011, Physics: Treatment PlanningPTC58-0254, Physics: Quality Assurance and VerificationPTC58-0332, Clinics: CNS / Skull BasePTC58-0468, Biology: Mathematical Modelling SimulationPTC58-0357, Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0649, Physics: Dose Calculation and OptimisationPTC58-0006, Physics: Quality Assurance and VerificationPTC58-0212, Physics: Image Guidance Poster Discussion SessionsPTC58-0565, Physics: Treatment PlanningPTC58-0018, Physics: Treatment PlanningPTC58-0019, Clinics: BreastPTC58-0576, Clinics: Head and Neck / EyePTC58-0335, Clinics: Head and Neck / EyePTC58-0577, General: New HorizonsPTC58-0621, Physics: Absolute and Relative DosimetryPTC58-0426, Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0268, Physics: Absolute and Relative DosimetryPTC58-0423, Physics: Treatment PlanningPTC58-0184, Physics: Quality Assurance and VerificationPTC58-0149, Clinics: GIPTC58-0378, Clinics: GIPTC58-0257, Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0662, General: New HorizonsPTC58-0627, Physics: Treatment PlanningPTC58-0186, Physics: Treatment PlanningPTC58-0185, Physics: Quality Assurance and VerificationPTC58-0144, Biology: BNCT Poster Discussion SessionsPTC58-0602, Physics: Treatment PlanningPTC58-0189, Physics: Dose Calculation and OptimisationPTC58-0315, Clinics: Head and neckPTC58-0300, General: New Horizons SessionPTC58-0347, Physics: Image GuidancePTC58-0082, Clinics: BreastPTC58-0443, Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0629, Physics: Adaptive Therapy Poster Discussion SessionsPTC58-0007, Physics: Commissioning New FacilitiesPTC58-0472, Clinics: GI, GU, BreastPTC58-0515, Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0606, Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0450, Physics: Absolute and Relative DosimetryPTC58-0657, Physics: Dose Calculation and OptimisationPTC58-0551, Physics: Treatment PlanningPTC58-0192, Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0675, Physics: Treatment PlanningPTC58-0194, Physics: Dose Calculation and OptimisationPTC58-0544, Physics: Treatment PlanningPTC58-0199, Physics: Quality Assurance and VerificationPTC58-0037, Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0207, Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0434, Physics: Quality Assurance and VerificationPTC58-0036, Physics: Quality Assurance and VerificationPTC58-0278, Physics: Quality Assurance and VerificationPTC58-0394, Physics: Quality Assurance and VerificationPTC58-0151, Physics: Quality Assurance and VerificationPTC58-0154, Physics: Dose Calculation and OptimisationPTC58-0428, Clinics: BreastPTC58-0116, Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0435, Physics: Commissioning New FacilitiesPTC58-0681, Physics: Absolute and Relative DosimetryPTC58-0323, Physics: Dose Calculation and OptimisationPTC58-0583, Physics: Absolute and Relative DosimetryPTC58-0448, Clinics: CNS / Skull BasePTC58-0251, General: New HorizonsPTC58-0721, Physics: Absolute and Relative DosimetryPTC58-0203, Physics: Dose Calculation and OptimisationPTC58-0455, Physics: 4D Treatment and DeliveryPTC58-0130, Physics: Commissioning New FacilitiesPTC58-0679, Physics: Absolute and Relative DosimetryPTC58-0329, General: New HorizonsPTC58-0604, Physics: Absolute and Relative DosimetryPTC58-0449, Clinics: CNS / Skull BasePTC58-0132, General: New HorizonsPTC58-0607, Physics: Quality Assurance and VerificationPTC58-0122, Physics: Quality Assurance and VerificationPTC58-0243, Physics: Treatment PlanningPTC58-0165, Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0437, Physics: 4D Treatment and DeliveryPTC58-0377, Physics: Quality Assurance and VerificationPTC58-0125, Physics: Quality Assurance and VerificationPTC58-0245, Physics: Dose Calculation and OptimisationPTC58-0337, Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0334, Physics: Quality Assurance and VerificationPTC58-0121, General: New Horizons SessionPTC58-0563, General: New Horizons SessionPTC58-0321, Clinics: Head and Neck / EyePTC58-0477, Physics: Quality Assurance and VerificationPTC58-0480, Clinics: GUPTC58-0010, Clinics: EyePTC58-0684, Clinics: GUPTC58-0496, Clinics: Head and neckPTC58-0676, Clinics: GUPTC58-0137, Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0256, Physics: 4D Treatment and DeliveryPTC58-0117, Physics: Absolute and Relative DosimetryPTC58-0552, Physics: Absolute and Relative DosimetryPTC58-0310, Physics: Absolute and Relative DosimetryPTC58-0672, Physics: Absolute and Relative DosimetryPTC58-0436, Physics: Dose Calculation and OptimisationPTC58-0452, Physics: Dose Calculation and OptimisationPTC58-0331, Physics: Commissioning New FacilitiesPTC58-0213, Biology: Mathematical Modelling SimulationPTC58-0272, Clinics: EyePTC58-0326, Physics: Commissioning New FacilitiesPTC58-0568, Physics: Dose Calculation and OptimisationPTC58-0444, Physics: Quality Assurance and VerificationPTC58-0379, Physics: Treatment Planning Poster Discussion SessionsPTC58-0095, Physics: Treatment PlanningPTC58-0053, Physics: Absolute and Relative DosimetryPTC58-0438, Physics: Absolute and Relative DosimetryPTC58-0317, Physics: Quality Assurance and VerificationPTC58-0497, Physics: Quality Assurance and VerificationPTC58-0375, Physics: Treatment PlanningPTC58-0056, Physics: 4D Treatment and DeliveryPTC58-0124, Clinics: GIPTC58-0009, Physics: Quality Assurance and VerificationPTC58-0014, Physics: Quality Assurance and VerificationPTC58-0374, Clinics: LungPTC58-0727, General: New Horizons SessionPTC58-0578, Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0470, Clinics: LungPTC58-0204, Clinics: Head and neckPTC58-0227, Clinics: LungPTC58-0446, Physics: Quality Assurance and VerificationPTC58-0190, Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0609, Clinics: LungPTC58-0689, General: New HorizonsPTC58-0021, General: New HorizonsPTC58-0262, Biology: BNCT Poster Discussion SessionsPTC58-0081, Clinics: GIPTC58-0726, General: New HorizonsPTC58-0145, Physics: Image GuidancePTC58-0573, General: New HorizonsPTC58-0027, General: New HorizonsPTC58-0028, Biology: Mathematical Modelling and SimulationPTC58-0148, Physics: Dose Calculation and OptimisationPTC58-0635, Physics: Image GuidancePTC58-0215, Physics: Image GuidancePTC58-0336, Poster AbstractsClinics: CNSPTC58-0535, Physics: Quality Assurance and VerificationPTC58-0187, Biology: BNCT Poster Discussion SessionsPTC58-0084, General: New Investigator SessionPTC58-0339, General: New Horizons SessionPTC58-0420, Physics: Treatment Planning Poster Discussion SessionsPTC58-0523, Biology: BNCT Poster Discussion SessionsPTC58-0088, Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0112, Physics: Quality Assurance and VerificationPTC58-0182, Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0615, Physics: Quality Assurance and VerificationPTC58-0080, Biology: BNCTPTC58-0085, Physics: Adaptive Therapy Poster Discussion SessionsPTC58-0722, General: New HorizonsPTC58-0253, General: New HorizonsPTC58-0255, Clinics: PediatricPTC58-0703, General: New HorizonsPTC58-0499, Physics: Image Guidance Poster Discussion SessionsPTC58-0380, General: New HorizonsPTC58-0259, Clinics: GI, GU, BreastPTC58-0288, Clinics: GI, GU, BreastPTC58-0045, Physics: Absolute and Relative DosimetryPTC58-0619, Clinics: PediatricPTC58-0707, Physics: Quality Assurance and VerificationPTC58-0196, Physics: Quality Assurance and VerificationPTC58-0074, Physics: Quality Assurance and VerificationPTC58-0077, Biology: BNCT Poster Discussion SessionsPTC58-0073, Biology: BNCTPTC58-0075, Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0093, Clinics: GUPTC58-0161, Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0371, Physics: Monitoring and Modelling MotionPTC58-0181, General: New HorizonsPTC58-0120, General: New HorizonsPTC58-0362, General: New HorizonsPTC58-0364, Physics: Image GuidancePTC58-0473, Scientific: RTTPTC58-0641, Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0296, General: New HorizonsPTC58-0004, General: New HorizonsPTC58-0128, Clinics: BreastPTC58-0316, Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0236, General: New HorizonsPTC58-0008, General: New Investigator SessionPTC58-0673, Physics: Quality Assurance and VerificationPTC58-0167, Physics: Quality Assurance and VerificationPTC58-0289, Physics: Quality Assurance and VerificationPTC58-0284, General: New Horizons SessionPTC58-0522, Physics: Quality Assurance and VerificationPTC58-0164, Physics: Quality Assurance and VerificationPTC58-0285, Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0623, Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0502, Clinics: GUPTC58-0293, Biology: Translational and BiomarkersPTC58-0599, Biology: BNCTPTC58-0063, Clinics: LungPTC58-0656, General: New HorizonsPTC58-0592, Biology: BNCT Poster Discussion SessionsPTC58-0092, Poster AbstractsClinics: CNSPTC58-0302, Physics: Image GuidancePTC58-0464, General: New HorizonsPTC58-0352, Physics: Image GuidancePTC58-0465, General: New HorizonsPTC58-0476, Physics: Image GuidancePTC58-0100, General: New HorizonsPTC58-0235, Biology: Mathematical Modelling and SimulationPTC58-0349, Physics: Treatment PlanningPTC58-0094, Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0367, Physics: Dose Calculation and OptimisationPTC58-0400, Biology: Translational and BiomarkersPTC58-0244, Physics: Dose Calculation and OptimisationPTC58-0640, Biology: Mathematical Modelling and SimulationPTC58-0355, General: New Investigator SessionPTC58-0320, Physics: Quality Assurance and VerificationPTC58-0057, Physics: Quality Assurance and VerificationPTC58-0174, Physics: Quality Assurance and VerificationPTC58-0295, Physics: Dose Calculation and OptimisationPTC58-0529, Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0123, Physics: Quality Assurance and VerificationPTC58-0171, Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0049, Clinics: BreastPTC58-0731, General: New HorizonsPTC58-0223, General: New HorizonsPTC58-0102, General: New HorizonsPTC58-0466, Scientific: RTTPTC58-0503, Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0389, General: New HorizonsPTC58-0108, General: New HorizonsPTC58-0109, Physics: Commissioning New FacilitiesPTC58-0736, Biology: Mathematical Modelling and SimulationPTC58-0343, Biology: Mathematical Modelling and SimulationPTC58-0342, Clinics: GI, GU, BreastPTC58-0237, Physics: Dose Calculation and OptimisationPTC58-0711, Biology: Mathematical Modelling and SimulationPTC58-0581, Clinics: GI, GU, BreastPTC58-0114, Clinics: Base of SkullPTC58-0730, Clinics: Head and neckPTC58-0383, Clinics: CNS / Skull BasePTC58-0559, Clinics: Base of SkullPTC58-0613, General: New HorizonsPTC58-0691, Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0054, General: New HorizonsPTC58-0210, Clinics: BreastPTC58-0729, General: New HorizonsPTC58-0574, Clinics: GI, GU, BreastPTC58-0239, Scientific: RTTPTC58-0637, General: New HorizonsPTC58-0579, Clinics: Lung / Sarcoma / LymphomaPTC58-0176, General: New HorizonsPTC58-0699, Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0156, Biology: Mathematical Modelling and SimulationPTC58-0333, Biology: Translational and BiomarkersPTC58-0345, Physics: Image GuidancePTC58-0369, Physics: Commissioning New FacilitiesPTC58-0509, Biology: Mathematical Modelling SimulationPTC58-0658, Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0051, General: New Investigator SessionPTC58-0548, Clinics: GI, GU, BreastPTC58-0241, Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0412, Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0024, Clinics: LungPTC58-0226, Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0069, General: New HorizonsPTC58-0562, General: New HorizonsPTC58-0561, General: New HorizonsPTC58-0201, Biology: Mathematical Modelling and SimulationPTC58-0439, General: New HorizonsPTC58-0445, General: New HorizonsPTC58-0324, Physics: Image GuidancePTC58-0031, Biology: Mathematical Modelling and SimulationPTC58-0558, Physics: Image GuidancePTC58-0392, Biology: Mathematical Modelling and SimulationPTC58-0678, Physics: Beam Delivery and Nozzle DesignPTC58-0090, General: New Investigator SessionPTC58-0630, Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0524, Physics: Commissioning New FacilitiesPTC58-0713, Clinics: GI, GU, BreastPTC58-0139, Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0248, Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0368, Biology: Enhanced Biology in Treatment PlanningPTC58-0519, General: New Horizons SessionPTC58-0720, Physics: Quality Assurance and VerificationPTC58-0083, General: New HorizonsPTC58-0311, General: New HorizonsPTC58-0674, General: New HorizonsPTC58-0553, Physics: Image GuidancePTC58-0023, Scientific: RTTPTC58-0612, General: New HorizonsPTC58-0677, Biology: Mathematical Modelling and SimulationPTC58-0545, Physics: Dose Calculation and OptimisationPTC58-0601, Physics: Dose Calculation and OptimisationPTC58-0725, Physics: Quality Assurance and VerificationPTC58-0098, Physics: Dose Calculation and OptimisationPTC58-0605, Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0517, Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0618, Physics: Monitoring and Modelling MotionPTC58-0481, Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0071, Physics: Adaptive TherapyPTC58-0351, Physics: 4D Treatment and DeliveryPTC58-0702, Physics: Image GuidancePTC58-0734, Physics: Image GuidancePTC58-0611, Physics: Treatment Planning Poster Discussion SessionsPTC58-0486, Physics: Absolute and Relative Dosimetry Poster Discussion SessionsPTC58-0442, Biology: Drug and Immunotherapy CombinationsPTC58-0327, Clinics: Head and Neck / EyePTC58-0096, Clinics: LungPTC58-0159, Physics: Treatment PlanningPTC58-0708, General: New HorizonsPTC58-0097, Physics: Treatment Planning Poster Discussion SessionsPTC58-0350, Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0016, Physics: Adaptive TherapyPTC58-0104, Physics: Absolute and Relative Dosimetry Poster Discussion SessionsPTC58-0433, Physics: Image GuidancePTC58-0608, Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0610, Clinics: Head and neckPTC58-0058, Physics: Treatment PlanningPTC58-0715, Clinics: Head and neckPTC58-0298, Clinics: EyePTC58-0099, General: New HorizonsPTC58-0086, General: New HorizonsPTC58-0089, Clinics: Lung / Sarcoma / LymphomaPTC58-0200, Poster AbstractsClinics: CNSPTC58-0157, Clinics: LungPTC58-0141, Clinics: LungPTC58-0260, Clinics: LungPTC58-0264, Physics: Image GuidancePTC58-0513, Physics: Image GuidancePTC58-0631, Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0469, Biology: BNCT Poster Discussion SessionsPTC58-0384, Physics: Image GuidancePTC58-0639, Clinics: PediatricsPTC58-0700, Clinics: LungPTC58-0136, Clinics: BreastPTC58-0706, General: New HorizonsPTC58-0079, Biology: Drug and Immunotherapy Combinations Poster Discussion SessionsPTC58-0406, Clinics: Base of SkullPTC58-0382, Physics: Image GuidancePTC58-0624, Physics: Beam Delivery and Nozzle DesignPTC58-0173, Biology: Drug and Immunotherapy CombinationsPTC58-0358, Poster AbstractsClinics: CNSPTC58-0690, General: New HorizonsPTC58-0061, Clinics: Lung / Sarcoma / LymphomaPTC58-0580, Physics: Monitoring and Modelling MotionPTC58-0162, Physics: Adaptive TherapyPTC58-0550, Physics: Adaptive TherapyPTC58-0430, Clinics: Lung / Sarcoma / LymphomaPTC58-0103, General: New Investigator SessionPTC58-0252, Physics: Quality Assurance and VerificationPTC58-0704, Physics: Image GuidancePTC58-0418, Clinics: Base of SkullPTC58-0572, Clinics: Lung / Sarcoma / LymphomaPTC58-0106, Physics: Beam Delivery and Nozzle DesignPTC58-0022, Physics: Monitoring and Modelling MotionPTC58-0279, Physics: Treatment Planning Poster Discussion SessionsPTC58-0447, Physics: Treatment PlanningPTC58-0622, Clinics: PediatricsPTC58-0644, Biology: Biology and Clinical InterfacePTC58-0490, Clinics: CNS / Skull BasePTC58-0716, General: New HorizonsPTC58-0292, Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0570, General: New HorizonsPTC58-0059, Physics: Quality Assurance and VerificationPTC58-0710, Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0216, Physics: Image GuidancePTC58-0404, Physics: Image GuidancePTC58-0525, Physics: Image GuidancePTC58-0526, Poster AbstractsClinics: CNSPTC58-0328, Clinics: LungPTC58-0070, Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0135, Biology: BNCT Poster Discussion SessionsPTC58-0391, Physics: Treatment PlanningPTC58-0510, Physics: Treatment PlanningPTC58-0636, Physics: Treatment PlanningPTC58-0638, Physics: Image GuidancePTC58-0408, Physics: Absolute and Relative Dosimetry Poster Discussion SessionsPTC58-0632, Physics: Treatment Planning Poster Discussion SessionsPTC58-0318, Biology: Enhanced Biology in Treatment PlanningPTC58-0246, Clinics: PediatricsPTC58-0504, General: New HorizonsPTC58-0160, Physics: Image Guidance Poster Discussion SessionsPTC58-0076, Physics: Monitoring and Modelling MotionPTC58-0143, Biology: Mathematical Modelling and SimulationPTC58-0718, Physics: Image GuidancePTC58-0671, Clinics: LungPTC58-0183, Physics: Image GuidancePTC58-0670, Report, Physics: Treatment Planning Poster Discussion SessionsPTC58-0422, Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0129, Physics: Adaptive Therapy Poster Discussion SessionsPTC58-0705, Biology: Enhanced Biology in Treatment PlanningPTC58-0258, General: New HorizonsPTC58-0030, General: New HorizonsPTC58-0150, Biology: Biology and Clinical InterfacePTC58-0479, General: New HorizonsPTC58-0153, Clinics: PediatricPTC58-0087, General: New HorizonsPTC58-0152, General: New HorizonsPTC58-0155, General: New HorizonsPTC58-0033, General: New HorizonsPTC58-0158, Physics: Image GuidancePTC58-0429, Biology: Translational and BiomarkersPTC58-0287, Physics: Adaptive TherapyPTC58-0403, Physics: Image GuidancePTC58-0309
Published
2020

30. Collagen X Biomarker (CXM), Linear Growth, and Bone Development in a Vitamin D Intervention Study in Infants

Author

Hauta-Alus, H. H. (Helena H.), Holmlund-Suila, E. M. (Elisa M.), Valkama, S. M. (Saara M.), Enlund-Cerullo, M. (Maria), Rosendahl, J. (Jenni), Coghlan, R. F. (Ryan F.), Andersson, S. (Sture), and Mäkitie, O. (Outi)

Subjects
Linear growth, Early childhood, Collagen X biomarker, Vitamin D, Bone
Abstract

Collagen X biomarker (CXM) is suggested to be a biomarker of linear growth velocity. However, early childhood data are limited. This study examines the relationship of CXM to the linear growth rate and bone development, including the possible modifying effects of vitamin D supplementation. We analyzed a cohort of 276 term-born children participating in the Vitamin D Intervention in Infants (VIDI) study. Infants received 10 μg/d (group-10) or 30 μg/d (group-30) vitamin D3 supplementation for the first 2 years of life. CXM and length were measured at 12 and 24 months of age. Tibial bone mineral content (BMC), volumetric bone mineral density (vBMD), cross-sectional area (CSA), polar moment of inertia (PMI), and periosteal circumference (PsC) were measured using peripheral quantitative computed tomography (pQCT) at 12 and 24 months. We calculated linear growth as length velocity (cm/year) and the growth rate in length (SD unit). The mean (SD) CXM values were 40.2 (17.4) ng/mL at 12 months and 38.1 (12.0) ng/mL at 24 months of age (p = 0.12). CXM associated with linear growth during the 2-year follow-up (p = 0.041) but not with bone (p = 0.53). Infants in group-30 in the highest tertile of CXM exhibited an accelerated mean growth rate in length compared with the intermediate tertile (mean difference [95% CI] −0.50 [−0.98, −0.01] SD unit, p = 0.044) but not in the group-10 (p = 0.062) at 12 months. Linear association of CXM and growth rate until 12 months was weak, but at 24 months CXM associated with both length velocity (B for 1 increment of √CXM [95% CI] 0.32 [0.12, 0.52] cm/yr, p = 0.002) and growth rate in length (0.20 [0.08, 0.32] SD unit, p = 0.002). To conclude, CXM may not reliably reflect linear growth from birth to 12 months of age, but its correlation with growth velocity improves during the second year of life.

Published
2022

31. VEDLIoT: Very Efficient Deep Learning in IoT

Author

Kaiser, Martin, Griessl, René, Kucza, Nils, Haumann, Carola, Tigges, Lennart, Mika, Kevin, Hagemeyer, Jens, Porrmann, Florian, Rückert, Ulrich, vor dem Berge, M., Krupop, S., Porrmann, M., Tassemeier, M., Trancoso, P., Qararyah, F., Zouzoula, S., Casimiro, A., Bessani, A., Cecilio, J., Andersson, S., Brunnegard, O., Eriksson, O., Weiss, R., Mcierhofer, F., Salomonsson, H., Malekzadeh, E., Odman, D., Khurshid, A., Felber, P., Pasin, M., Schiavoni, V., Menetrey, J., Gugala, K., Zierhoffer, P., Knauss, E., Heyn, H., and ARRAY(0xab8ee90)

Subjects
Performance (cs.PF), FOS: Computer and information sciences, Computer Science - Cryptography and Security, Computer Science - Performance, Computer Science - Distributed, Parallel, and Cluster Computing, Hardware Architecture (cs.AR), Distributed, Parallel, and Cluster Computing (cs.DC), Computer Science - Hardware Architecture, Cryptography and Security (cs.CR)
Abstract

The VEDLIoT project targets the development of energy-efficient Deep Learning for distributed AIoT applications. A holistic approach is used to optimize algorithms while also dealing with safety and security challenges. The approach is based on a modular and scalable cognitive IoT hardware platform. Using modular microserver technology enables the user to configure the hardware to satisfy a wide range of applications. VEDLIoT offers a complete design flow for Next-Generation IoT devices required for collaboratively solving complex Deep Learning applications across distributed systems. The methods are tested on various use-cases ranging from Smart Home to Automotive and Industrial IoT appliances. VEDLIoT is an H2020 EU project which started in November 2020. It is currently in an intermediate stage with the first results available., Comment: This publication incorporates results from the VEDLIoT project, which received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 957197

Published
2022
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32. Iron status in early childhood is modified by diet, sex and growth:secondary analysis of a randomized controlled vitamin D trial

Author

Holmlund-Suila, E. M. (Elisa M.), Hauta-alus, H. H. (Helena H.), Enlund-Cerullo, M. (Maria), Rosendahl, J. (Jenni), Valkama, S. M. (Saara M.), Andersson, S. (Sture), and Mäkitie, O. (Outi)

Subjects
Ferritin, Toddler, Iron deficiency, Infant, Anemia, Diet
Abstract

Background and aims: During early childhood the risk of iron deficiency (ID) is high. Serum ferritin serves as a marker of iron status. We explored prevalence of ID and iron deficiency anemia (IDA), and identified determinants of iron status in infants and toddlers. Methods: We performed a secondary analysis of the Vitamin D intervention in infants (VIDI) study in Finnish healthy term infants. According to study protocol, at 12- and 24-months of age iron status, growth and dietary intakes were evaluated. ID was defined as serum ferritin

Published
2022

49. Effect of high-dose vs standard-dose vitamin D supplementation on neurodevelopment of healthy term infants:a randomized clinical trial

Author

Tuovinen, S. (Soile), Räikkönen, K. (Katri), Holmlund-Suila, E. (Elisa), Hauta-alus, H. (Helena), Helve, O. (Otto), Rosendahl, J. (Jenni), Enlund-Cerullo, M. (Maria), Kajantie, E. (Eero), Valkama, S. (Saara), Viljakainen, H. (Heli), Mäkitie, O. (Outi), Andersson, S. (Sture), and Heinonen, K. (Kati)

Abstract

Importance: Vitamin D may be important for neurodevelopment. The optimal daily dose of vitamin D for early brain development is not known. Objectives: To test whether a higher (1200 IU) vs standard (400 IU) dose of vitamin D₃ has beneficial effects on neurodevelopment in the first 2 years of life and whether serum 25-hydroxyvitamin D concentration is associated with neurodevelopment. Design, Setting, and Participants: This double-blind, interventional randomized clinical trial involved healthy infants born full-term between January 1, 2013, and June 30, 2014, at a maternity hospital in Helsinki, Finland, at the 60th northern latitude. Two-year follow-up was conducted by May 30, 2016. Data analysis was by the intention-to-treat principle. Data were analyzed from November 1, 2020, to May 31, 2021. Interventions: Randomization of 404 infants to receive 400 IU of oral vitamin D₃ supplementation daily and 397 infants to receive 1200 IU of oral vitamin D3 supplementation daily from 2 weeks to 24 months of age. Main Outcomes and Measures: Primary outcomes were child total developmental milestone scores at 12 and 24 months of age measured using the Ages and Stages Questionnaire (total score is calculated as a mean of the 5 subscale scores: total score range, 0–60, where 0 indicates delay in all developmental domains and 60 indicates that the child can master all age-specific skills) as well as externalizing, internalizing, and dysregulation problems and competencies scores at 24 months measured using the Infant-Toddler Social and Emotional Assessment (range 0–2, where 0 indicates no problems or no competencies and 2 indicates a high level of problems or a high level of competencies; variables were standardized to the mean [SD] of 0 [1]). Secondary outcomes were specific skills, problems, and competencies derived from these questionnaires. Results: Of the 987 families recruited, 495 children were randomly assigned to receive 400 IU of vitamin D₃, and 492 children were randomly assigned to receive 1200 IU of vitamin D₃. A total of 801 families participated in the follow-up at 12 and/or 24 months, with 404 children (207 girls [51.2%]) in the 400-IU group and 397 children (198 girls [49.9%]) in the 1200-IU group. All children were of Northern European ethnicity. No differences were found between the 400-IU group and the 1200-IU group in the mean (SD) adjusted Ages and Stages Questionnaire total score at 12 months (45.0 [7.1] vs 46.2 [7.9]; mean difference [MD], 1.17 [95% CI, –0.06 to 2.38]) or 24 months (50.9 [5.3] vs 51.5 [5.5]; MD, 0.48 [95% CI, –0.40 to 1.36]). No differences were found between the 400-IU group and the 1200-IU group at 24 months in the mean (SD) adjusted Infant-Toddler Social and Emotional Assessment externalizing domain score (–0.07 [1.00] vs 0.07 [0.98]; MD, 0.15 [95% CI, –0.01 to 0.31]), internalizing domain score (0.04 [1.06] vs –0.02 [0.98]; MD, –0.07 [95% CI, –0.24 to 0.1.0]), dysregulation domain score (–0.00 [1.04] vs 0.02 [0.96]; MD, 0.02 [95% CI, –0.14 to 0.18]), or competencies score (–0.02 [1.02] vs 0.01 [1.02]; MD, 0.03 [95% CI, –0.13 to 0.20]). The 1200-IU group did have a higher risk in the adjusted model of scoring 1.5 SDs or more on the externalizing domain score (odds ratio, 2.33 [95% CI, 1.19–4.56]; P = .01). Levels of serum 25-hydroxyvitamin D were not associated with the primary outcomes. Conclusions and Relevance: Higher-than-standard vitamin D₃ doses provide no systematic benefits for child neurodevelopment up to 2 years of age. However, the potential disadvantageous effects of higher doses could not be fully excluded; even if minimal, the potential nonbeneficial effects of higher-than-standard doses warrant further studies in which both safety and benefits should be evaluated. Trial Registration: ClinicalTrials.gov Identifier: NCT01723852

Published
2021

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