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The advancements in human-centered artificial intelligence (HCAI) systems for Industry 5.0 is a new phase of industrialization that places the worker at the center of the production process and uses new technologies to increase prosperity beyond jobs and growth. HCAI presents new objectives that were unreachable by either humans or machines alone, but this also comes with a new set of challenges. Our proposed method accomplishes this through the knowlEdge architecture, which enables human operators to implement AI solutions using a zero-touch framework. It relies on containerized AI model training and execution, supported by a robust data pipeline and rounded off with human feedback and evaluation interfaces. The result is a platform built from a number of components, spanning all major areas of the AI lifecycle. We outline both the architectural concepts and implementation guidelines and explain how they advance HCAI systems and Industry 5.0. In this article, we address the problems we encountered while implementing the ideas within the edge-to-cloud continuum. Further improvements to our approach may enhance the use of AI in Industry 5.0 and strengthen trust in AI systems. [ABSTRACT FROM AUTHOR]

We study the physics of water switching at 4 to 5 MV as part of Sandia's Z-Refurbishment program. We present time histories of the light emitted by two sets of water switches and correlate the light emission to the accelerator power pulse. Framing camera images demonstrate how the initial 'bushy' streamers collapse to narrow current channels at late time. Spectroscopy of the water switches indicates that the early-time streamers are already hot-dense blackbodies with temperatures between 7000 K and 9000 K. Late time hydrogen emission lines allow estimates of electron densities at that time ranging from 0.2 to 2 x [10.sup.18]/[cm.sup.3]. Index Terms--Optical diagnostics, pulsed power, spectroscopy, water switches.

Ultraviolet (UV) laser-triggered gas switching using laser beams at 266 nm has greatly improved the simultaneity of many large multimodule accelerators. This UV beam however cannot be transmitted significant distances through water or oil. Since the switches in these accelerators are typically submerged in water or oil, the laser beams are often conveyed to the switches through gas-filled 'laser crossover tubes.' These crossover tubes are difficult to field grade properly and are subject to frequent mechanical and electrical failures in the pulse-power environment. We have demonstrated that a 4.6-MV multistage gas switch insulated with S[F.sub.6] can be triggered with a jitter of less than 10 ns using 110-mJ pulses of a green (532-nm) laser beam that has been transported through 67 cm of 1-M[OMEGA]-cm water on its way to the switch. These results may allow elimination of the laser crossover tubes in future accelerators. Index Terms--Gas breakdown, laser-triggered gas switches (LTGSs), refurbished Z-machine (ZR), S[F.sub.6], Z-machine, z -pinches.

Background: Cysticercosis and hydatidosis seriously affect human health and are responsible for considerable economic loss in animal husbandry in non-developed and developed countries. S3Pvac and EG95 are the only field trial-tested vaccine candidates against cysticercosis and hydatidosis, respectively. S3Pvac is composed of three peptides (KETc1, GK1 and KETc12), originally identified in a Taenia crassiceps cDNA library. S3Pvac synthetically and recombinantly expressed is effective against experimentally and naturally acquired cysticercosis. Methodology/Principal Findings: In this study, the homologous sequences of two of the S3Pvac peptides, GK1 and KETc1, were identified and further characterized in Taenia crassiceps WFU, Taenia solium, Taenia saginata, Echinococcus granulosus and Echinococcus multilocularis. Comparisons of the nucleotide and amino acid sequences coding for KETc1 and GK1 revealed significant homologies in these species. The predicted secondary structure of GK1 is almost identical between the species, while some differences were observed in the C terminal region of KETc1 according to 3D modeling. A KETc1 variant with a deletion of three C-terminal amino acids protected to the same extent against experimental murine cysticercosis as the entire peptide. On the contrary, immunization with the truncated GK1 failed to induce protection. Immunolocalization studies revealed the non stage-specificity of the two S3Pvac epitopes and their persistence in the larval tegument of all species and in Taenia adult tapeworms. Conclusions/Significance: These results indicate that GK1 and KETc1 may be considered candidates to be included in the formulation of a multivalent and multistage vaccine against these cestodiases because of their enhancing effects on other available vaccine candidates. [ABSTRACT FROM AUTHOR]

We report here genome sequences and comparative analyses of three closely related parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. longicornis. Parasitoids are important regulators of arthropod populations, including major agricultural pests and disease vectors, and Nasonia is an emerging genetic model, particularly for evolutionary and developmental genetics. Key findings include the identification of a functional DNA methylation tool kit; hymenopteran-specific genes including diverse venoms; lateral gene transfers among Pox viruses, Wolbachia, and Nasonia; and the rapid evolution of genes involved in nuclear-mitochondrial interactions that are implicated in speciation. Newly developed genome resources advance Nasonia for genetic research, accelerate mapping and cloning of quantitative trait loci, and will ultimately provide tools and knowledge for further increasing the utility of parasitoids as pest insect-control agents.