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1. Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation

2. Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs

3. Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA

4. Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

5. Asymmetric trichotomous partitioning overcomes dataset limitations in building machine learning models for predicting siRNA efficacy

6. Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

7. Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors

8. Multispecies-targeting siRNAs for the modulation of JAK1 in the skin

9. Awake intracerebroventricular delivery and safety assessment of oligonucleotides in a large animal model

10. Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity

11. Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models

12. PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

13. Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

14. A era dos medicamentos de ARN interferência: o panorama clínico dos fármacos para silenciamento génico

15. Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy

16. 2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

17. Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference

18. Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

19. Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition

20. Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the httQ140/Q140 mouse model of Huntington's disease

21. Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing

22. High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

23. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

24. Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin

25. A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics

26. Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System

27. Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

28. Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

29. Delivering siRNA Compounds During HOPE to Modulate Organ Function

30. Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

31. Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo

32. Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo

33. 2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

34. Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference

35. Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo

36. Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition

37. An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis

38. Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin

39. Functional features defining the efficacy of cholesterol-conjugated, self-deliverable, chemically modified siRNAs

40. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

41. High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

42. RNAi Modulation of Placental sFLT1 for the Treatment of Preeclampsia

43. Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

44. Experimental validation of the importance of seed complement frequency to siRNA specificity

45. Defining the optimal parameters for hairpin-based knockdown constructs

46. Position-specific chemical modification of siRNAs reduces 'off-target' transcript silencing

47. Off-target effects by siRNA can induce toxic phenotype

48. The contributions of dsRNA structure to Dicer specificity and efficiency

49. RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

50. The Chromosomal Location of the Bacillus subtilis Sporulation Gene spoIIR Is Important for Its Function

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