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1. Profile of volatile compounds released by Waitea circinata against Magnaporthe oryzae under different periods and temperatures

Author

Luiza Vieira da Cruz, Marcos Henrique Faleiros Santos, Bryna Tamilla Alves Falcão Gama, Leila Garcês de Araújo, Ana Paula Terezan, Jerônimo Raimundo de Oliveira Neto, Luiz Carlos da Cunha, Anselmo Elcana de Oliveira, Márcia Matos da Silva, Carla Thaís Pereira Coelho, and Vanessa Gisele Pasqualotto Severino

Subjects
rice blast, mycorrhizal fungus, biofungicide, Agriculture (General), S1-972
Abstract

Rice blast caused by the Magnaporthe oryzae pathogen is a major disease in this crop, and may cause devastating losses. This study aimed to investigate the profile of Waitea circinata mycorrhiza volatile compounds in antagonism to M. oryzae, under different growth periods and temperatures, using a completely randomized design. Volatile organic compounds were extracted by headspace solid phase microextraction and analyzed by gas chromatography mass spectrometry, while multidimensional scaling was used to compare the produced volatile organic compounds. The main compounds responsible by the antagonism to M. oryzae were longifolene, trans-β-farnesene, (Z)-α-bisabolene and δ-amorphene, which can be used as biofungicides and incorporated into rice blast management strategies.

Published
2023
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2. Energy and lipid contents, and polyphenols composition of pequi pulp according to the fruit native area

Author

Nara Rúbia Rodrigues do Nascimento-Silva, Aline Medeiros Alves-Santos, Cecília Maria Alves de Oliveira, Ana Paula Terezan, Aline Priscilla Gomes da Silva, and Maria Margareth Veloso Naves

Subjects
native fruit, functional food, nutrients, bioactive compounds, phenolic compounds, Agriculture, Agriculture (General), S1-972
Abstract

ABSTRACT: Pequi (Caryocar spp.) is a fruit native to the Brazilian Savannah (Cerrado), and Caryocar brasilienseCamb. is one of the most prevalent species in this biome. The consumption of the pequi pulp has been associated with health benefits, such as antioxidant, anti-inflammatory, hypolipidemic, hepatoprotective, and anticarcinogenic effects. These benefits have been attributed to its high density in nutrients and bioactive compounds. However, there is evidence about considerable variation in the nutritional profile among pequi pulps of different species, and among pulps of the same species, but from different areas of the Cerrado. In addition, there is no information in literature regarding the polyphenols profile of C. brasiliense pulp, neither about the influence of the native area of the fruit on the composition of these phytochemicals. So, this study analyzed the nutrient composition and identified the phenolic compounds in the pulp of C. brasiliense fruits native to four different areas of the Cerrado. There was a remarkable variation in the contents of energy (176.3-387.2 kcal/100 g) and lipids (13.0-37.5 g/100 g) among samples. In contrast, no difference was observed in the polyphenols composition, since gallic acid, protocatechuic acid, catechin, epicatechin, p-coumaric acid, and ellagic acid were identified in all pequi pulps. C. brasiliense pulp shows potential to be used as a functional ingredient rich in bioactive compounds, but with different contents of energy and lipids according to the fruit’s native area to attempt distinct health allegations of the product.

Published
2022
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3. Cytotoxicity and genotoxicity of Agaricus blazei methanolic extract fractions assessed using gene and chromosomal mutation assays

Author

Marilanda Ferreira Bellini, Leonardo Neves Cabrioti, Ana Paula Terezan, Berenice Quinzani Jordão, Lúcia Regina Ribeiro, and Mário Sérgio Mantovani

Subjects
Agaricus blazei, hgprt locus, micronucleus, Genetics, QH426-470
Abstract

Functional food investigations have demonstrated the presence of substances that could be beneficial to human health when consumed. However, the toxic effects of some substances contained in foods have been determined. Reported medicinal and nutritive properties have led to the extensive commercialization of the basidiomycete fungi Agaricus blazei Murrill (sensu Heinemann), also known as Agaricus brasiliensis Wasser et al., Agaricus subrufescens Peck or the Brazilian medical mushroom (BMM). Different methanolic extract fractions (ME) of this mushroom were submitted to the cytokinesis-block micronucleus (CBMN) clastogenic assay and the hypoxanthine-guanine phosphoribosyl transferase locus (HGPRT) assay for gene mutation, both using Chinese hamster ovary cells clone K1 (CHO-K1). The results suggest that all the fractions tested possess cytotoxic and mutagenic potential but no clastogenic effects. Further information is needed on the biochemical components of the A. blazei methanol fractions to identify any substances with cytotoxic and/or mutagenicity potential. These findings indicate that A. blazei methanolic extract should not be used due to their genotoxicity and care should be taken in the use of A. blazei by the general population until further biochemical characterization of this fungi is completed.

Published
2008
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4. Constituintes químicos e atividade antimicrobiana dos extratos de Dilodendron bipinnatum (sapindaceae) Chemical constituents and antimicrobial activity of extracts from Dilodendron bipinnatum (sapindaceae)

Author

Josiane Cristina dos Santos, Carlos Alberto Nastally de Oliveira, Larissa Varella, Andréia Pereira Matos, Ana Paula Terezan, Ana Cristina Leite, João Batista Fernandes, Paulo Cezar Vieira, Maria Fátima das Graças Fernandes da Silva, and José Rubens Pirani

Subjects
Sapindaceae, Dilodendron bipinnatum, antimicrobial activities, Chemistry, QD1-999
Abstract

The phytochemical investigation of ethanolic extracts from leaves, branches and stems of D. bipinnatum afforded the steroids β-sitosterol, stigmasterol, campesterol, sitostenone and sitosterol-3-O-β-D-glycopyranoside, along with two cycloartane triterpenes: cycloeucalenol and 24-methylenecycloartenol. The antimicrobial activity of the extracts was evaluated against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6623), Pseudomonas aeruginosa (ATCC 15442), Micrococcus luteus (ATCC 9341) and Candida albicans (ATCC 10231). The extracts of the leaves and branches showed moderate activity against Candida albicans. The extract of the branches was active against Micrococcus luteus. This is the first report on the phytochemical study of D. bipinnatum.

Published
2010
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5. Evaluation of the Toxicity of Virola sebifera Crude Extracts, Fractions and Isolated Compounds on the Nest of Leaf-Cutting Ants

Author

Keylla Utherdyany Bicalho, Ana Paula Terezan, Denise Cristina Martins, Taís Garcia Freitas, João Batista Fernandes, Maria Fátima das Graças Fernandes da Silva, Paulo Cezar Vieira, Fernando Carlos Pagnocca, and Odair Côrrea Bueno

Subjects
Zoology, QL1-991
Abstract

The phytochemical study of Virola sebifera leaves led to the isolation of three lignans: (+)-sesamin, (−)-hinokinin, and (−)-kusunokinin and three flavonoids: quercetin-3-O-α-L-rhamnoside, quercetin-3-O-β-D-glucoside, and quercetin-3-methoxy-7-O-β-D-glucoside by using techniques as high-speed counter-current chromatography and high-performance liquid chromatography. The crude extracts, fractions, and isolated compounds were evaluated for their insecticidal and fungicidal potential against Atta sexdens rubropilosa and its symbiotic fungus Leucoagaricus gongylophorus. The bioassay results showed a high insecticidal activity for the methanol crude extract of the leaves of V. sebifera and its n-hexane, dichloromethane and ethyl acetate fractions. The fungicidal bioassay revealed high toxicity of the lignans against L. gongylophorus.

Published
2012
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6. Tapirira guianensis Aubl. Extracts inhibits proliferation and migration of oral cancer cells lines

Author

Richele P. Severino, Ana Maciel Ribeiro, Hélio Batista dos Santos, Ralph Gruppi Thomé, Ana Paula Terezan, Rosy Iara Maciel de Azambuja Ribeiro, Luiz Fernando de Camargos, Vanessa Gisele Pasqualotto Severino, Fábio Vieira dos Santos, Renato José Silva-Oliveira, Rui Manuel Reis, Gabriela Francine Martins Lopes, [et. al.], and Universidade do Minho

Subjects
Salmonella typhimurium, 0301 basic medicine, Apoptosis, HNSCC, lcsh:Chemistry, 0302 clinical medicine, Cell Movement, Cytotoxic T cell, Tapirira guianensis, Cytotoxicity, lcsh:QH301-705.5, Spectroscopy, biology, Caspase 3, General Medicine, 3. Good health, Computer Science Applications, Gene Expression Regulation, Neoplastic, Drug Combinations, 030220 oncology & carcinogenesis, Matrix Metalloproteinase 2, Proteoglycans, Collagen, Poly(ADP-ribose) Polymerases, Cell Survival, Anacardiaceae, cytotoxic activity, alkaloids, apoptosis markers, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Alkaloids, Cell Line, Tumor, medicine, Humans, fas Receptor, Physical and Theoretical Chemistry, Molecular Biology, Cell Proliferation, Science & Technology, Cytotoxic activity, Mutagenicity Tests, Plant Extracts, Cell growth, Organic Chemistry, Epithelial Cells, medicine.disease, biology.organism_classification, Antineoplastic Agents, Phytogenic, Head and neck squamous-cell carcinoma, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Cell culture, Apoptosis markers, Cancer cell, Immunology, Cancer research, Laminin
Abstract

Cancer of the head and neck is a group of upper aerodigestive tract neoplasms in which aggressive treatments may cause harmful side effects to the patient. In the last decade, investigations on natural compounds have been particularly successful in the field of anticancer drug research. Our aim is to evaluate the antitumor effect of Tapirira guianensis Aubl. extracts on a panel of head and neck squamous cell carcinoma (HNSCC) cell lines. Analysis of secondary metabolites classes in fractions of T. guianensis was performed using Nuclear Magnetic Resonance (NMR). Mutagenicity effect was evaluated by Ames mutagenicity assay. The cytotoxic effect, and migration and invasion inhibition were measured. Additionally, the expression level of apoptosis-related molecules (PARP, Caspases 3, and Fas) and MMP-2 was detected using Western blot. Heterogeneous cytotoxicity response was observed for all fractions, which showed migration inhibition, reduced matrix degradation, and decreased cell invasion ability. Expression levels of MMP-2 decreased in all fractions, and particularly in the hexane fraction. Furthermore, overexpression of FAS and caspase-3, and increase of cleaved PARP indicates possible apoptosis extrinsic pathway activation. Antiproliferative activity of T. guianensis extract in HNSCC cells lines suggests the possibility of developing an anticancer agent or an additive with synergic activities associated with conventional anticancer therapy., The authors acknowledge CNPq, FAPEMIG (APQ-00953-12), Ministerio da Ciencia, Tecnologia e Inovacao-MCTI, and Fundo Nacional de Saude-FNS (1302/13), FINEP (MCTI/FINEP/MS/ SCTIE/DECIT-01/2013-FPXII-BIOPLAT) and CAPES (Brazilian agencies) for the financial support of this study. We thank Arali Aparecida Costa Araujo for her support in collecting of T. guianensis and Joao Maximo De Siqueira (UFSJ) and Paulo Cezar Vieira (UFSCar) for their support in the phytochemical analysis., info:eu-repo/semantics/publishedVersion

Published
2016

7. Activities of Extracts and Compounds from Spiranthera odoratissima St. Hil. (Rutaceae) in Leaf-cutting Ants and their Symbiotic Fungus

Author

Ana Paula Terezan, Paulo C. Vieira, Odair Correa Bueno, João B. Fernandes, Fernando Carlos Pagnocca, Tais Garcia Freitas, Raquel Andrade Rossi, José Rubens Pirani, Roberta N. A. Almeida, M. Fátima das G. F. da Silva, Universidade Federal de São Carlos (UFSCar), Universidade Estadual Paulista (Unesp), and Universidade de São Paulo (USP)

Subjects
Leucoagaricus gongylophorus, Atta sexdens rubropilosa, biology, Traditional medicine, Limonin, Plant composition, General Chemistry, Fungus, biology.organism_classification, limonoids, chemistry.chemical_compound, Spiranthera odoratissima, Rutaceae, chemistry, Atta sexdens, furoquinoline alkaloids, Medicinal plants, Limonexic acid
Abstract

Made available in DSpace on 2013-08-12T19:08:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01 Made available in DSpace on 2013-09-30T18:47:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:56:28Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T13:56:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) The study of the Spiranthera odoratissima St. Hil (Rutaceae) branches extracts led to the isolation of the furoquinoline (dictamine, gamma-fagarine and skimmianine) and 2-arylquinoli-4-one (1-methyl-2-phenylquinolin-4-one) alkaloids and limonoids (limonexic acid and limonin). The compounds 1-methyl-2-phenylquinolin-4-one and limonexic acid were isolated for the first time from the Spiranthera. These furoquinoline and 2-arylquinoli-4-one alkaloids and limonoids showed insecticidal and/or fungicidal activity in the nest of the Atta sexdens rubropilosa. Universidade Federal de São Carlos (UFSCar), Dept Quim, BR-13565905 São Carlos, SP, Brazil Univ Estadual Paulista, Ctr Estudos Insetos Sociais, BR-13506900 Rio Claro, SP, Brazil Univ São Paulo, Dept Bot, Inst Biociencias, BR-05508900 São Paulo, Brazil Univ Estadual Paulista, Ctr Estudos Insetos Sociais, BR-13506900 Rio Claro, SP, Brazil

Published
2010

8. Cytotoxicity and genotoxicity of Agaricus blazei methanolic extract fractions assessed using gene and chromosomal mutation assays

Author

Berenice Quinzani Jordão, Mário Sérgio Mantovani, Leonardo Neves Cabrioti, Lúcia Regina Ribeiro, Marilanda Ferreira Bellini, Ana Paula Terezan, Universidade Estadual de Londrina (UEL), Universidade Federal de São Carlos (UFSCar), and Universidade Estadual Paulista (Unesp)

Subjects
Mushroom, education.field_of_study, lcsh:QH426-470, Traditional medicine, Population, Agaricus blazei, Biology, Gene mutation, medicine.disease_cause, biology.organism_classification, lcsh:Genetics, Clastogen, Botany, Genetics, medicine, micronucleus, Agaricus subrufescens, education, Micronucleus, Cytotoxicity, Molecular Biology, hgprt locus, Genotoxicity
Abstract

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:05:00Z No. of bitstreams: 1 S1415-47572008000100021.pdf: 78956 bytes, checksum: 47e6639a24371f4c6004a2abbcc0173f (MD5) Made available in DSpace on 2013-08-22T19:05:00Z (GMT). No. of bitstreams: 1 S1415-47572008000100021.pdf: 78956 bytes, checksum: 47e6639a24371f4c6004a2abbcc0173f (MD5) Previous issue date: 2008-01-01 Made available in DSpace on 2013-09-30T20:08:37Z (GMT). No. of bitstreams: 2 S1415-47572008000100021.pdf: 78956 bytes, checksum: 47e6639a24371f4c6004a2abbcc0173f (MD5) S1415-47572008000100021.pdf.txt: 32471 bytes, checksum: 4b76650d16eda360ce4bb8dfe66a14e6 (MD5) Previous issue date: 2008-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:17:31Z No. of bitstreams: 2 S1415-47572008000100021.pdf: 78956 bytes, checksum: 47e6639a24371f4c6004a2abbcc0173f (MD5) S1415-47572008000100021.pdf.txt: 32471 bytes, checksum: 4b76650d16eda360ce4bb8dfe66a14e6 (MD5) Made available in DSpace on 2014-05-20T15:17:31Z (GMT). No. of bitstreams: 2 S1415-47572008000100021.pdf: 78956 bytes, checksum: 47e6639a24371f4c6004a2abbcc0173f (MD5) S1415-47572008000100021.pdf.txt: 32471 bytes, checksum: 4b76650d16eda360ce4bb8dfe66a14e6 (MD5) Previous issue date: 2008-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Functional food investigations have demonstrated the presence of substances that could be beneficial to human health when consumed. However, the toxic effects of some substances contained in foods have been determined. Reported medicinal and nutritive properties have led to the extensive commercialization of the basidiomycete fungi Agaricus blazei Murrill (sensu Heinemann), also known as Agaricus brasiliensis Wasser et al., Agaricus subrufescens Peck or the Brazilian medical mushroom (BMM). Different methanolic extract fractions (ME) of this mushroom were submitted to the cytokinesis-block micronucleus (CBMN) clastogenic assay and the hypoxanthine-guanine phosphoribosyl transferase locus (HGPRT) assay for gene mutation, both using Chinese hamster ovary cells clone K1 (CHO-K1). The results suggest that all the fractions tested possess cytotoxic and mutagenic potential but no clastogenic effects. Further information is needed on the biochemical components of the A. blazei methanol fractions to identify any substances with cytotoxic and/or mutagenicity potential. These findings indicate that A. blazei methanolic extract should not be used due to their genotoxicity and care should be taken in the use of A. blazei by the general population until further biochemical characterization of this fungi is completed. Universidade Estadual de Londrina (UEL) Departamento de Biologia Geral Universidade Federal de São Carlos (UFSCar) Departamento de Química Universidade Estadual Paulista Universidade Estadual Paulista

Published
2008

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