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6. Author Correction: Location and function of TDP-43 in platelets, alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols

Author

Luthi-Carter, Ruth, Cappelli, Sara, Le Roux-Bourdieu, Morgan, Tentillier, Noemie, Quinn, James P., Petrozziello, Tiziana, Gopalakrishnan, Lathika, Sethi, Purva, Choudhary, Himanshi, Bartolini, Giorgia, Gebara, Elias, Stuani, Cristiana, Font, Laure, An, Jiyan, Ortega, Vanessa, Sage, Jessica, Kosa, Edina, Trombetta, Bianca A., Simeone, Roberto, Seredenina, Tamara, Afroz, Tariq, Berry, James D., Arnold, Steven E., Carlyle, Becky C., Adolfsson, Oskar, Sadri-Vakili, Ghazaleh, Buratti, Emanuele, Bowser, Robert, and Agbas, Abdulbaki

Published
2024
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8. Location and function of TDP-43 in platelets, alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols

Author

Luthi-Carter, Ruth, Cappelli, Sara, Le Roux-Bourdieu, Morgan, Tentillier, Noemie, Quinn, James P., Petrozziello, Tiziana, Gopalakrishnan, Lathika, Sethi, Purva, Choudhary, Himanshi, Bartolini, Giorgia, Gebara, Elias, Stuani, Cristiana, Font, Laure, An, Jiyan, Ortega, Vanessa, Sage, Jessica, Kosa, Edina, Trombetta, Bianca A., Simeone, Roberto, Seredenina, Tamara, Afroz, Tariq, Berry, James D., Arnold, Steven E., Carlyle, Becky C., Adolfsson, Oskar, Sadri-Vakili, Ghazaleh, Buratti, Emanuele, Bowser, Robert, and Agbas, Abdulbaki

Published
2024
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24. Research and Development of Medical Countermeasures for Emerging Infectious Diseases, China, 1990–2022

Author

Jiyan Ma, Yang Yang, and Yangmu Huang

Subjects
medical countermeasures, vaccines, infectious diseases, communicable diseases, emerging diseases, research and development, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

Since the severe acute respiratory syndrome outbreak in 2003, China has invested substantial efforts in promoting scientific and technological advances for medical countermeasures against high-threat pathogens. The examination of China’s landscape identifies progress and gaps in research and development (R&D) and also highlights management and regulatory issues that should be of concern to other countries. Our study examined the current state of R&D of medical countermeasures in China during 1990–2022. The findings showed a robust and diversified pipeline responding quickly to disease outbreaks and policy changes. However, proactive and highly innovative candidates are limited, and a large proportion of vaccines and drugs stagnate at the early development stage. A paradigm shift involving a preemptive R&D agenda and persistent investment, innovative technology development, and accelerated research translation is urgently needed to prepare for the next pandemic.

Published
2025
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25. Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance

Author

Zhikai Mai, Liwu Fu, Jiyan Su, Kenneth K.W. To, Chuansheng Yang, and Chenglai Xia

Subjects
Breast cance, Sphingobacterium multivorum, Immune escape, Treg cell, Propionylcarnitine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Intratumor-resident bacteria represent an integral component of the tumor microenvironment (TME). Microbial dysbiosis, which refers to an imbalance in the bacterial composition and bacterial metabolic activities, plays an important role in regulating breast cancer development and progression. However, the impact of specific intratumor-resident bacteria on tumor progression and their underlying mechanisms remain elusive. Methods 16S rDNA gene sequencing was used to analyze the cancerous and paracancerous tissues from breast cancer patients. The mouse models of bearing 4T1 cell tumors were employed to assess the influence of bacterial colonization on tumor growth. Tissue infiltration of regulatory T (Treg) cells and CD8+ T cells was evaluated through immunohistochemistry and flow cytometric analysis. Comparative metabolite profiling in mice tumors was conducted using targeted metabolomics. Differential genes of tumor cells stimulated by bacteria were analyzed by transcriptomics and validated by qPCR assay. Results We found that Sphingobacterium displayed high abundance in cancerous tissues. Intra-tumoral colonization of Sphingobacterium multivorum (S. multivorum) promoted tumor progression in 4T1 tumor-bearing mice. Moreover, S. multivorum diminished the therapeutic efficacy of αPD-1 mAb, which was associated with the increase of regulatory T cell (Treg) infiltration, and decrese of the CD8+ T cell infiltration. Targeted metabolomics revealed a conspicuous reduction of propionylcarnitine in tumors colonized by S. multivorum Furthermore, the combination of metabolite propionylcarnitine and S. multivorum shown to suppress tumor growth compared that in S. multivorum alone in vivo. Mechanistically, S. multivorum promoted the secretion of chemokines CCL20 and CXCL8 from tumor cells. CCL20 secreted into the TME facilitated the recruitment of Treg cells and reduced CD8+ T cell infiltration, thus promoting tumor immune escape. Conclusions This study reveals S. multivorum suppresses immune surveillance within the TME, thereby promoting breast cancer progression.

Published
2025
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26. Supportive care needs of the family caregivers of urostomy patients: a qualitative study

Author

Kaixia Gao, Shaoguo Zhang, Jie Liu, Fang Zhang, Na Liu, Jiyan Dong, Tingting Zhang, Junping Gao, Sufang Qin, Junhong An, and Xiaojuan Han

Subjects
Bladder cancer, Urostomy, Family caregivers, Supportive care, Need, Medicine, Science
Abstract

Abstract Family caregivers play a vital role during the home care of urostomy patients by providing direct care and support. The role of family caregivers may extend to several years, even over ten years, in certain cases. In this process, the caregivers are impacted in various ways due to the patient’s conditions and may not be able to identify and address their own needs, which often get ignored and remain unfulfilled. The present study aimed to explore the supportive care needs of such family caregivers of urostomy patients. The method of qualitative research with the aid of purposive sampling was adopted in the present study. A semi-structured interview was conducted with 22 family caregivers of urostomy patients. Each interview lasted 60 min. Data analysis was conducted by employing the NVivo software for qualitative research and using a thematic approach. Four themes were identified: (i) Strong psychological and physical needs; (ii) Eagerness for information regarding the patient’s diseases; (iii) Need for social support; (iv) Necessity of spiritual support. Further, within these four themes, eight sub-themes were constructed using coders. The respondents reported that they felt equally under pressure as the urostomy patients they were caring for, although the medical staff appeared to be paying little attention to them. The medical staff paid greater attention to the patients, while the caregivers also required their help and support. The need for supportive care is quite common among the family caregivers of patients with urostomy. Medical staff should comprehensively understand the needs of the family caregivers of urostomy patients and then actively provide targeted psychological/physical/information/social/spiritual support to these caregivers. This would result in enhanced caregiving skills and reduced burden among these caregivers.

Published
2025
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27. In situ study on the orientation and strain-rate correlation mechanism of hydrogen embrittlement behavior of ferrite under shear stress

Author

Lingxiao Li, Lunsu Liang, Yuhao Wang, Jiyan Liu, Minghan Sun, Pei Zhao, Junhua Hu, Guangtao Xu, Gang Wang, and Kai Xu

Subjects
Hydrogen embrittlement, Orientation correlation, Strain-rate correlation, Shear deformation, Molecular dynamics, Mining engineering. Metallurgy, TN1-997
Abstract

This study investigates the effects of orientation and strain rate on the hydrogen-enhanced localized plasticity mechanism during shear deformation of interstitial free steel. The stress-orientation correlation of hydrogen embrittlement is related to atomic-scale mechanisms, as evidenced through in situ electron backscatter diffraction, slow-strain-rate shear testing, electron microscopic characterization, and molecular dynamics simulations. The dislocation density increment after hydrogen charging was 59.25% higher along the [100] crystallographic zone axis than along the [11‾1‾] crystallographic zone axis, which is mainly attributed to the combined effect of strain-induced transport and interstitial diffusion of hydrogen atoms. The strain rate correlation of hydrogen embrittlement is also affected by the interstitial diffusion during the strain-induced transport of H. Interstitial diffused hydrogen induce dislocation forest emissions that promote local plasticity, which ultimately leads to the orientation and strain rate correlation of hydrogen embrittlement.

Published
2024
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31. Assessment of the sperm DNA Fragmentation using SCSA by fluorescence microscopy and flow cytometry in males from an andrology clinic

Author

Jiyan Li, Yi Zhou, Bingxin Liu, and Shun Bai

Subjects
sperm dna fragmentation, dfi, scsa, fluorescence microscopy, flow cytometry, Medicine (General), R5-920
Abstract

The assessment of male fertility has traditionally depended on the evaluation of conventional semen parameters. Recent advances have identified sperm DNA fragmentation as a valuable biomarker for the assessment of male infertility. This study recruited 121 men from an andrology clinic to evaluate the diagnostic efficiency of the sperm DNA fragmentation index (DFI), utilizing the sperm chromatin structure assay (SCSA) through both flow cytometry and fluorescence microscopy. The study also explored the relationship between sperm DFI and standard semen parameters such as concentration, motility and morphology. The results showed that men with abnormal semen parameters were found to have significantly reduced sperm progressive motility (p < 0.001), total motility (p < 0.001) and normal morphology (p < 0.001), as well as higher sperm DFI, as determined by both fluorescence microscopy and flow cytometry (both p < 0.001), compared to those with normal semen parameters. A negative correlation was observed between sperm progressive motility, total motility, sperm normal morphology and sperm DFI, regardless of whether the DFI evaluation was conducted using fluorescence microscopy or flow cytometry (all p < 0.001). In conclusion, the application of the SCSA assay via both fluorescence microscopy and flow cytometry reveals that sperm DFI is closely associated with seminal parameters, reinforcing its utility in the clinical evaluation of male fertility.

Published
2024
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32. Long‐term cost‐effectiveness of transcatheter mitral valve repair in HF patients with secondary mitral regurgitation

Author

Younan Yao, Ziyou Zhou, Tian Geng, Anping Cai, Tian Li, Junqing Yang, Jiyan Chen, and Liwen Li

Subjects
Heart failure, Mitral regurgitation, MitraClip, Quality‐adjusted life‐year, Cost‐effectiveness, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Aims The long‐term cost‐effectiveness of MitraClip in heart failure patients with secondary mitral regurgitation is still unclear. This study aimed to evaluate the long‐term cost‐effectiveness of MitraClip added to guideline‐directed medical therapy vs. guideline‐directed medical therapy alone in heart failure patients with secondary mitral regurgitation from the perspective of the healthcare systems of mainland China, the United Kingdom, Germany, and the United States. Methods and results A two‐stage (decision + Markov) model was built. Health utilities were defined by the New York Heart Association class, heart failure re‐hospitalization, and death and were calculated based on the 5 year follow‐up results of the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation trial. Direct healthcare costs were derived from the nationally representative data. Future utilities and costs were discounted at country‐specific rates. The primary outcome was the lifetime incremental cost‐effectiveness ratio. The mean age of the base case in our model was 72.2 years. Over a lifetime horizon, treatment with MitraClip was associated with 829 fewer heart failure re‐hospitalizations per 1000 treated patients. The MitraClip treatment was associated with incremental quality‐adjusted life‐year gains of 0.71, 0.76, 0.78, and 0.78, as well as incremental cost‐effectiveness ratios of ¥468 462, £28 910, €26 045, and $71 199 per quality‐adjusted life‐year for a lifetime horizon in mainland China, the United Kingdom, Germany, and the United States, respectively. In probabilistic sensitivity analysis, 0.2%, 59.4%, 99.6%, and 84.7% of patients were cost‐effective in mainland China, the United Kingdom, Germany, and the United States at the country‐specific willingness‐to‐pay thresholds. Conclusions MitraClip + guideline‐directed medical therapy was cost‐effective in heart failure patients with secondary mitral regurgitation in the United Kingdom, Germany, and the United States, but not in mainland China from the perspective of the national healthcare system.

Published
2024
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34. Bibliometric study on the utilization of sorafenib in hepatocellular carcinoma

Author

Wenjun Meng, Yihang Luo, Lu Zhao, Yaoyu Zhang, Jiyan Liu, Shadan Li, Yang Du, and Hongshuai Li

Subjects
sorafenib, hepatocellular carcinoma, liver cancer, apoptosis, bibliometric analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

BackgroundAlthough the number of studies on sorafenib for hepatocellular carcinoma (HCC) is increasing during the past two decades, no detailed scientometric examination of its knowledge framework has been undertaken. Therefore, we performed a bibliometric analysis on this topic.MethodsVOSviewer and CiteSpace were utilized to analyze the articles regarding sorafenib for HCC from 2005 to 2024, which were retrieved from the Web of Science Core Collection (WoSCC) database.ResultsThere were 7,667 articles related to sorafenib in HCC were retrieved from the WoSCC database, and they covered 99 countries/regions, 5,640 institutions, and 30,450 authors. The most published literature of countries and institutions were China and Sun Yat-sen University, respectively. Cancers is the journal with the most papers published in this field, and the journal with the most co-citations is N Engl J Med. Among authors, Masatoshi Kudo has published the most research papers, and the most co-citations go to JM Llovet. The keywords “survival”, “apoptosis”, “efficacy”, “transarterial chemoembolization”, “lenvatinib”, etc. represent the current hotspots in this field.ConclusionsWe identified current hotspots and trends by bibliometric analysis in sorafenib-HCC field, which might provide valuable guidance for future researches. Further explorations are supposed to conduct the continued study of HCC apoptosis, large-scaled clinical trials with international cooperations, and comprehensive treatments including multiple systemic or locoregional approaches in patients with HCC.

Published
2024
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35. Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity

Author

Ping Cheng, Shichuan Hu, Zhongbing Qi, Xianglin Xu, Xiangyu Long, Anliang Huang, and Jiyan Liu

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background Although immunotherapy can reinvigorate immune cells to clear tumors, the response rates are poor in some patients. Here, CD47 antibody-engineered oncolytic viruses (oAd-αCD47) were employed to lyse tumors and activate immunity. The oAd-αCD47 induced comprehensive remodeling of the tumor microenvironment (TME). However, whether the acidic TME affects the antitumor immunotherapeutic effects of oncolytic viruses-αCD47 has not been clarified.Methods To assess the impact of oAd-αCD47 treatment on the TME, we employed multicolor flow cytometry. Glucose uptake was quantified using 2NBDG, while mitochondrial content was evaluated with MitoTracker FM dye. pH imaging of tumors was performed using the pH-sensitive fluorophore SNARF-4F. Moreover, changes in the calmodulin-dependent protein kinase II (CaMKII)/cyclic AMP activates-responsive element-binding proteins (CREB) and peroxisome proliferator-activated receptor gamma coactivator-1α (PGC1α) signaling pathway were confirmed through western blotting and flow cytometry.Results Here, we identified sodium bicarbonate (NaBi) as the potent metabolic reprogramming agent that enhanced antitumor responses in the acidic TME. The combination of NaBi and oAd-αCD47 therapy significantly inhibited tumor growth and produced complete immune control in various tumor-bearing mouse models. Mechanistically, combination therapy mainly reduced the number of regulatory T cells and enriched the ratio of M1-type macrophages TAMs (M1.TAMs) to M2-type macrophages TAMs (M2.TAMs), while decreasing the abundance of PD-1+TIM3+ expression and increasing the expression of CD107a in the CD8+ T cells. Furthermore, the combination therapy enhanced the metabolic function of T cells and macrophages by upregulating PGC1α, a key regulator of mitochondrial biogenesis. This metabolic improvement contributed to a robust antitumor response. Notably, the combination therapy also promoted the generation of memory T cells, suggesting its potential as an effective neoadjuvant treatment for preventing postoperative tumor recurrence and metastasis.Conclusions Tumor acidic microenvironment impairs mitochondrial energy metabolism in macrophages and T cells inducing oAd-αCD47 immunotherapeutic resistance. NaBi improves the acidity of the TME and activates the CaMKII/CREB/PGC1α mitochondrial biosynthesis signaling pathway, which reprograms the energy metabolism of macrophages and T cells in the TME, and oral NaBi enhances the antitumor effect of oAd-αCD47.

Published
2024
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36. Inflammasomes and idiopathic inflammatory myopathies

Author

Rui Sun, Jiyan Chu, and Ping Li

Subjects
idiopathic inflammatory myopathy, inflammasome, pyroptosis, NLR family pyrin domain containing 3 (NLRP3), absent in melanoma 2 (AIM2), caspase, Immunologic diseases. Allergy, RC581-607
Abstract

Idiopathic inflammatory myopathies (IIM) are a group of systemic autoimmune diseases characterized by muscle weakness and elevated serum creatine kinase levels. Recent research has highlighted the role of the innate immune system, particularly inflammasomes, in the pathogenesis of IIM. This review focuses on the role of inflammasomes, specifically NLRP3 and AIM2, and their associated proteins in the development of IIM. We discuss the molecular mechanisms of pyroptosis, a programmed cell death pathway that triggers inflammation, and its association with IIM. The NLRP3 inflammasome, in particular, has been implicated in muscle fiber necrosis and the subsequent release of damage-associated molecular patterns (DAMPs), leading to inflammation. We also explore the potential therapeutic implications of targeting the NLRP3 inflammasome with inhibitors such as glyburide and MCC950, which have shown promise in reducing inflammation and improving muscle function in preclinical models. Additionally, we discuss the role of caspases, particularly caspase-1, in the canonical pyroptotic pathway associated with IIM. The understanding of these mechanisms offers new avenues for therapeutic intervention and a better comprehension of IIM pathophysiology.

Published
2024
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37. External nutrients fattening promotes hepatopancreases development, metabolism, nutrient deposition and flavor yield during the maturation stage in female Chinese mitten crab (Eriocheir sinensis)

Author

Changyou Song, Jianxiang Chen, Jiyan He, Miaomiao Xue, Pao Xu, Huiming Ding, Ningyuan Wu, Ruicheng Zhao, Gangchun Xu, and Hongxia Li

Subjects
Eriocheir sinensis, Fatten, Hepatopancreases, Nutrient deposition, Flavor yield, Aquaculture. Fisheries. Angling, SH1-691
Abstract

The nutritive value and maturity status of hepatopancreases dominates the quality of Chinese mitten crab, Eriocheir sinensis. However, the underlying function and regulatory mechanism, as well as the external nutrient factors on the development of hepatopancreases in different growth stages of E. sinensis remains unclear. In this study, we first revealed the function of hepatopancreases feeding with iced trash fish (ITF) during the whole culture period; and further investigated the underlying mechanism on nutrient deposition and flavor yield feeding with formulated feed (FEED) in replacement of ITF in female E. sinensis. From the results, growth performance and metabolism indicate E. sinensis was robustly developed, and ITF promotes growth and hepatopancreases development during the maturation period. Meanwhile, activation of fatty acid and amino acid metabolism in hepatopancreases resulted in depletion of monounsaturated fatty acids (MUFAs) but promoted protein deposition during the maturation stage. Integrated analysis of transcriptome and metabolome reveal metabolism, biosynthesis, and flavor presentation were intensively active during maturation, evidenced by the expression of key genes of ALDH, TBXAs, HADHA, UPB1, CYP2, GST, and γ-GT-X1; as well as the key metabolites of GMP and IMP. Additionally, substitution of ITF with FEED further confirm full price artificial feed could meet the nutrient requirements during the maturation period, evidenced by the growth performance, fatty acid and amino acid derived nutrient and flavor yield in hepatopancreases. In conclusion, nutrient and flavor deposition was associated with the fast development of hepatopancreases, and fatten with full price compound feed contributes to the nutrient requirement and flavor yield during the maturation stage.

Published
2024
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38. Multi-omics profiling reveals the lipid metabolism during gonadal maturation in male Chinese mitten crab (Eriocheir sinensis)

Author

Jianxiang Chen, Pao Xu, Gangchun Xu, Miaomiao Xue, Qingyong Wang, Jiyan He, Changchang He, Changxin Kong, Xiaowei Li, Hang Wang, Huaishun Shen, Hongxia Li, and Changyou Song

Subjects
Male Eriocheir sinensis, Gonadal Maturation, Lipid Orchestration, Hepatopancreas, Aquaculture. Fisheries. Angling, SH1-691
Abstract

Well-developed gonads determine the edible quality and progeny quality of the Chinese mitten crabs (Eriocheir sinensis). However, there are fewer studies on gonad development in male crabs. To investigate the physiological changes during gonadal maturation in male crabs, we combined multi-omics to dissect metabolic modifications during gonadal development using immature male crabs (191.67 ± 7.97 g) as a control and males that had undergone fattening as a treatment group. The result reveal PE(18:1(9Z)/0:0), L-a-Lysophosphatidylserine, PC(16:1(9Z)/18:2(9Z,12Z)), pregnanetriol and Alpinumisoflavone were selected as key markers during gonadal development. Additionally, lipid transport was considered the dominant metabolic difference. Specifically, mature gonads were characterized by higher phosphatidylcholines (PCs) and fewer triglycerides (TGs). Correlation analysis on differential lipids (DLMs) uncovered lipid regulation engaged in gonadal maturation in the male crab. A comparison of differential metabolites from the hepatopancreas in the same cohort demonstrated that hepatopancreas-mediated PCs were involved in the lipid orchestration of gonadal development. Based on transcriptome analysis, we identified that gonadal development enhanced meiosis (spdya-a, aurka-a, espl1, cdk1 and smc1ad), stimulated the endocrine system (atp1a1, pfk, ppp2r3a, and cox7a), and decreased energy metabolism (AMPK signaling). Combined with correlation analysis between transcriptome and lipidome revealed lipids modulated physiological changes in the gonads. These findings contribute to the precise nutritional management of gonadal maturation in E. sinensis to improve quality of the gonads of male crab.

Published
2024
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39. Study on lateral stability control of carrier-based aircraft towbarless tractor system

Author

Jiyan Qi, Haoyang Xu, and Ming Su

Subjects
Carrier-based aircraft towbarless tractor system, lateral stability, sliding mode control, traction system, Control engineering systems. Automatic machinery (General), TJ212-225, Systems engineering, TA168
Abstract

The lateral stability and control of carrier-based aircraft towbarless tractor system are analysed. Considering the coupled motion effects of carrier roll, pitch and heave, a four degree of freedom time-varying nonlinear dynamic model of the carrier-based aircraft towbarless tractor system is established. The lateral stability of the traction system is analysed, and the discrimination method of the system instability form is proposed. The yaw rate of the tractor and the lateral speed of the carrier-based aircraft are selected as variables, the lateral stability controller is designed using sliding mode control (SMC) theory and the compensation torque and lateral force required for the lateral stability control of the traction system are obtained, thereby achieving tracking of the ideal values. The simulation results show that the designed control scheme can effectively controls the yaw rate of the target tractor and the lateral speed of the carrier-based aircraft, ensuring the lateral stability of the carrier-based aircraft towbarless tractor system.

Published
2024
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40. Prevotella copri exhausts intrinsic indole-3-pyruvic acid in the host to promote breast cancer progression: inactivation of AMPK via UHRF1-mediated negative regulation

Author

Jiyan Su, Xiaojie Lin, Dan Li, Chunmin Yang, Shumei Lv, Xiaohong Chen, Xiujuan Yang, Botao Pan, Rui Xu, Liping Ren, Yanfang Zhang, Yizhen Xie, Qianjun Chen, and Chenglai Xia

Subjects
Breast cancer, Prevotella copri, indole-3-pyruvic acid, UHRF1, AMPK, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

ABSTRACTEmerging evidence has revealed the novel role of gut microbiota in the development of cancer. The characteristics of function and composition in the gut microbiota of patients with breast cancer patients has been reported, however the detailed causation between gut microbiota and breast cancer remains uncertain. In the present study, 16S rRNA sequencing revealed that Prevotella, particularly the dominant species Prevotella copri, is significantly enriched and prevalent in gut microbiota of breast cancer patients. Prior-oral administration of P. copri could promote breast cancer growth in specific pathogen-free mice and germ-free mice, accompanied with sharp reduction of indole-3-pyruvic acid (IPyA). Mechanistically, the present of excessive P. copri consumed a large amount of tryptophan (Trp), thus hampering the physiological accumulation of IPyA in the host. Our results revealed that IPyA is an intrinsic anti-cancer reagent in the host at physiological level. Briefly, IPyA directly suppressed the transcription of UHRF1, following by the declined UHRF1 and PP2A C in nucleus, thus inhibiting the phosphorylation of AMPK, which is just opposite to the cancer promoting effect of P. copri. Therefore, the exhaustion of IPyA by excessive P. copri strengthens the UHRF1-mediated negative control to inactivated the energy-controlling AMPK signaling pathway to promote tumor growth, which was indicated by the alternation in pattern of protein expression and DNA methylation. Our findings, for the first time, highlighted P. copri as a risk factor for the progression of breast cancer.

Published
2024
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41. The roles of cancer stem cells and therapeutic implications in melanoma

Author

Xiaoli Mu, Yixin Zhou, Yongxin Yu, Mingyi Zhang, and Jiyan Liu

Subjects
melanoma stem cells, surface marker, signaling pathway, tumor microenvironment, therapeutic advances, Immunologic diseases. Allergy, RC581-607
Abstract

Melanoma is a highly malignant skin tumor characterized by high metastasis and poor prognosis. Recent studies have highlighted the pivotal role of melanoma stem cells (MSCs)—a subpopulation of cancer stem cells (CSCs)—in driving tumor growth, metastasis, therapeutic resistance, and recurrence. Similar to CSCs in other cancers, MSCs possess unique characteristics, including specific surface markers, dysregulated signaling pathways, and the ability to thrive within complex tumor microenvironment (TME). This review explored the current landscape of MSC research, discussing the identification of MSC-specific surface markers, the role of key signaling pathways such as Wnt/β-catenin, Notch, and Hedgehog (Hh), and how interactions within the TME, including hypoxia and immune cells, contribute to MSC-mediated drug resistance and metastatic behavior. Furthermore, we also investigated the latest therapeutic strategies targeting MSCs, such as small-molecule inhibitors, immune-based approaches, and novel vaccine developments, with an emphasis on their potential to overcome melanoma progression and improve clinical outcomes. This review aims to provide valuable insights into the complex roles of MSCs in melanoma biology and offers perspectives for future research and therapeutic advances against this challenging disease.

Published
2024
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44. Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial

Author

Reynolds, Harmony R., Page, Courtney B., Shaw, Leslee J., Berman, Daniel S., Chaitman, Bernard R., Picard, Michael H., Kwong, Raymond Y., Min, James K., Leipsic, Jonathon, Mancini, G.B. John, Budoff, Matthew J., Hague, Cameron J., Senior, Roxy, Szwed, Hanna, Bhargava, Balram, Celutkiene, Jelena, Gadkari, Milind, Bainey, Kevin R., Doerr, Rolf, Ramos, Ruben B., Ong, Peter, Naik, Sudhir R., Steg, Philippe Gabriel, Goetschalckx, Kaatje, Chow, Benjamin J.W., Scherrer-Crosbie, Marielle, Phillips, Lawrence, Mark, Daniel B., Spertus, John A., Alexander, Karen P., O’Brien, Sean M., Boden, William E., Bangalore, Sripal, Stone, Gregg W., Maron, David J., Hochman, Judith S., Mavromatis, Kreton, Linefsky, Jason, Miller, Todd, Banerjee, Subhash, Newman, Jonathan D., Donnino, Robert M., Saric, Muhamed, Abdul-Nour, Khaled, Stone, Peter H., Jang, James J., Yee, Gennie, Weitz, Steven, Arnold, Suzanne, James Henry, O’Keefe, Jr, Shapiro, Michael D., Fein, Steven A., Torosoff, Mikhail T., Lyubarova, Radmila, Mookherjee, Sulagna, Drzymalski, Krzysztof, McFalls, Edward O., Garcia, Santiago A., Bertog, Stefan C., Siddiqui, Rizwan A., Ishani, Areef, Hansen, Ronnell A., Georges Khouri, Michel, Goldberg, Jonathan L., Goldweit, Richard, Cohen, Ronny A., Mirrer, Brooks, Navarro, Victor, Winchester, David E., Kronenberg, Marvin, McFarren, Christopher, Heitner, John F., Dauber, Ira M., Cannan, Charles, Sudarshan, Sriram, Mehta, Puja K., McDaniel, Michael, Lerakis, Stamatios, Quyyumi, Arshed, Wenger, Nanette K., Hedgepeth, Chester M., Hurlburt, Heather, Rosen, Alan, Sahul, Zakir, Leung, Steve, Reda, Hassan, Ziada, Khaled, Setty, Sampoornima, Barua, Rajat S., Hage, Fadi, Davies, James E., Leesar, Massoud, Heo, Jaekyeong, Iskandrian, Amy, Al Solaiman, Firas, Singh, Satinder, Dajani, Khaled, El-Hajjar, Mohammad, Der Mesropian, Paul, Sacco, Joseph, McCandless, Brian, Orgera, Marisa, Sidhu, Mandeep S., Arif, Imran, Kerr, Hanan, Trejo (Gutierrez), Jorge F., Fletcher, Gerald, Lane, Gary E., Neeson, Lynn M., Parikh, Pragnesh P., Pollak, Peter M., Shapiro, Brian P., Landolfo, Kevin, Gemignani, Anthony, OʼRourke, Daniel, Meadows, Judith L., Call, Jason T., Hannan, Joseph, Bojar, Robert, Kumar, Deepti, Mukai, John, Martin, Edward T., Vorobiof, Gabriel, Moorman, Alec, Kinlay, Scott, Hamburger, Robert J., Rocco, Thomas P., Bhatt, Deepak L., Croce, Kevin, Quin, Jacquelyn A., Anumpa, Jati, Zenati, Marco, Faxon, David P., Rayos, Glenn, Seedhom, Ashraf, Sullenberger, Lance, Kumkumian, Gregory, Sedlis, Steven P., Donnino, Robert M., Lorin, Jeffrey, Tamis-Holland, Jacqueline E., Kornberg, Robert, Leber, Robert, Saba, Souheil, Lee, Michael W., Small, Delano R., Nona, Wassim, Alexander, Patrick B., Rehman, Iram, Badami, Umesh, Marzo, Kevin, Robbins, Inga H., Levite, Howard A., Shetty, Sanjay, Patel, Mayuri, Hamroff, Glenn S., Little, Raymond W., Zimbelman, Brandi D., Lui, Charles Y., Smith, Brigham R., Vezina, Daniel P., Khor, Lillian L., Abraham, Josephine D., Bull, David A., McKellar, Stephen H., Booth, David, Kotter, John, Abdel-Latif, Ahmed, Hu, Bob, Labovitz, Arthur J., Berlowitz, Michael, Rogal, Philip, Matar, Fadi, Caldeira, Christiano, Rodriguez, Fatima, Schnittger, Ingela, Fearon, William F., Deedwania, Prakash, Reddy, Kiran, Sweeny, Joseph, Spizzieri, Christopher, Hochberg, Claudia P., Salerno, William D., Wyman, Ray, Zarka, Amer, Shah, Anil V., Haldis, Thomas, Kohn, Jeffrey A., Girotra, Saket, Almousalli, Omar, Krishnam, Mayil S., Milliken, Jeffrey C., Patel, Pranav M., Seto, Arnold H., Harley, Kevin T., Gibson, Michael A., Allen, Byron J., Coram, Rita, Thomas, Sabu, Schwartz, Ronald G., Chen, Wei, El Shahawy, Mahfouz, Stafford, James, Abernethy, William B., Zurick, Andrew, Meyer, Thomas M., Morford, Ronald G., Rutkin, Bruce, Bokhari, Sabahat, Sokol, Seth I., Meisner, Jay, Hamzeh, Ihab, Misra, Arunima, Matthew, Wall, Jr, De Rosen, Veronica Lenges, Alam, Mahboob, Turner, Michael C., Mulhearn, Thomas J., Good, Arnold P., Shammas, Nicolas W., Chilton, Robert, Nguyen, Patricia K., Jezior, Matthew, Gordon, Paul C., Crain, Thomas, Stenberg, Robert, Pedalino, Ronald P., Wiesel, Joseph, Juang, George J., Al-Amoodi, Mohammed, Wohns, David, Lader, Ellis W., Mumma, Michael, Dharmarajan, Lekshmi, Joseph F.X., McGarvey, Jr, Downes, Thomas R., Luckasen, Gary J., Cheong, Benjamin, Potluri, Srinivasa, Mastouri, Ronald A., Breall, Jeffery A., Revtyak, George E., Bazeley, Jonathan W., Li, Dayuan, Giedd, Kenneth, Old, Wayne, Burt, Francis, Sokhon, Kozhaya, Gopal, Deepika, Valeti, Uma S., Kobashigawa, Jon, Chakanalil Govindan, Sajeev, Gopalan Nair, Rajesh, Nanjappa Manjunath, Cholenahally, Moorthy, Nagaraja, Cholenahally Manjunath, Satvic, Narayanappa, Suryaprakash, Pandit, Neeraj, Kumar Nath, Ranjit, Dwivedi, S.K., Narain, V.S., Chandra, Sharad, Wander, Gurpreet S., Tandon, Rohit, Ralhan, Sarju, Aslam, Naved, Goyal, Abhishek, Karthikeyan, G., Ramakrishnan, S., Seth, Sandeep, Yadav, Rakesh, Singh, Sandeep, Roy, Ambuj, Parakh, Neeraj, Kumar Verma, Sunil, Narang, Rajiv, Mishra, Sundeep, Naik, Nitish, Sharma, Gautam, Kumar Choudhary, Shiv, Patel, Chetan, Gulati, Gurpreet, Sharma, Sanjeev, Bahl, V.K., Mathew, Anoop, Punnoose, Eapen, Gadage, Siddharth, Umesh Pillay, Tapan, Satheesh, Santhosh, Mathur, Atul, Christopher, Johann, Menon, Rajeev, Kumar, Nirmal, Oomman, Abraham, Mao, Robert, Solomon, Hilda, Parveen Khan, Sajeeda, Grant, Purvez, Kachru, Ranjan, VK, Ajit Kumar, Ganapathi, Sanjay, K., Jayakumar, Sivadasanpillai, Harikrishnan, Sasidharan, Bijulal, T.R., Kapilamoorthy, Polamuri, Praneeth, Kaul, Upendra, Fox, Keith A.A., Carruthers, Kathryn, Elghamaz, Ahmed, Gurunathan, Sothinathan, Karogiannis, Nikolaos, Shah, Benoy N., Trimlett, Richard H.J., Rubens, Michael B., Nicol, Edward D., Mittal, Tarun K., Hampson, Reinette, Andreas Gamma, Reto, de Belder, Mark A., Thambyrajah, Jeet, Nageh, Thuraia, Davies, John R., Lindsay, Steven J., Kurian, John, Jamil, Haqeel, Raheem, Osama, Hoye, Angela, Donnelly, Patrick, Valec ka, Bernardas, Chauhan, Anoop, Barr, Craig, Alfakih, Khaled, Byrne, Jonathan, Webb, Ian, Henriksen, Peter, O. Kane, Peter, de Silva, Ramesh, Conway, Dwayne S.G., Sirker, Alexander A., Hoole, Stephen P., Witherow, Fraser N., Johnston, Nicola, Harbinson, Mark, Walsh, Simon, Douglas, Hanna, Luckie, Matthew, Sobolewska, Jolanta, Jeetley, Paramjit, Patel, Niket, Kotecha, Tushar, Travill, Christopher, Karimullah, Iqbal, Al-Bustami, Mahmud, Braganza, Denise, Henderson, Robert, Pointon, Kate, Naik, Surendra, Mathew, Thomas, Berry, Colin, Collison, Damien, Roditi, Giles, Moriarty, Andrew J., Glover, Jason D., Pradhan, Jiwan, Ghada, Mikhail, Francis, Darrel P., Dzavik, Vladimir, Diaz, Ariel, Rheault, Philippe, Barrero, Miguel, Gagné, Carl-Éric, Pépin-Dubois, Yanek, Costa, Ricardo, Tung Sia, Ying, Lemay, Catherine, Gisbert, Alejandro, Gervais, Pierre, Rheault, Alain, Carl Phaneuf, Denis, Gosselin, Gilbert, Garg, Pallav, Hessian, Renee C., Beanlands, Rob S., Davies, Richard F., Cheema, Asim N., Bagai, Akshay, Wald, Ron, Goodman, Shaun, Graham, John Joseph, Peterson, Mark, Chow, Chi-Ming, Abramson, Beth, Nazir Cheema, Asim, Tariq Vakani, Mohammad, Cha, James, Howarth, Andrew G., Wong, Graham, Uxa, Amar, Galiwango, Paul, Kassam, Saleem, Mukherjee, Ashok, Joseph Ricci, A., Lam, Andy, Me, Shamir, Udell, Jacob, Généreux, Philippe, Hameed, Adnan, Daba, Ledjalem, Hueb, Whady, Cury Rezende, Paulo, Ciappina Hueb, Alexandre, Emanuela, Paola, Smanio, Poggio, Schaan de Quadros, Alexandre, Abdala, Renato, Kalil, Karam, da Costa Vieira, José Luiz, Grossmann, Gabriel, Píccaro de Oliveira, Pedro, Bridi, Leonardo, Savaris, Simone, Vitola, João V., Cerci, Rodrigo J., Farias, Fabio R., Fernandes, Miguel M., Antonio Marin-Neto, José, Schmidt, André, de Oliveira Lima Filho, Moysés, Mendes Oliveira, Ricardo, Reynaldo, João, Chierice, Abbud, Polanczyk, Carísi A., Furtado, Mariana V., Smidt, Luis F., Carlos Carvalho, Antonio, Pucci, Gustavo, Lyra, Flavio, Rabelo, Alvaro, Junior, Alves, Dracoulakis, Marianna D.A., Lima, Rodolfo G.S.D., Figueiredo, Estevao, Ricardo Caramori, Paulo, Tumelero, Rogerio, Dall’Orto, Frederico, Mesquita, Claudio T., Colafranseschi, Alexandre S., Amarino C., Oliveira, Jr, Carvalho, Luiz A., Palazzo, Isabella C., Sousa, Andre S., da Silva, Expedito Eustáquio Ribeiro, Gabriel, Pedro, de Barros e Silva, Melo, de Pádua Silva Baptista, Luciana, Jamus Rodrigues, Marcelo, de Resende, Marcos Valério Coimbra, Francisco Saraiva, Jose, Costantini, Costantino, Ruzyllo, Witold, Demkow, Marcin, Pracon, Radoslaw, Kepka, Cezary, Teresinska, Anna, Kryczka, Karolina, Henzel, Jan, Solecki, Mateusz, Kaczmarska, Edyta, Mazurek, Tomasz, Drozdz, Jaroslaw, Czarniak, Bartosz, Frach, Malgorzata, Szymczyk, Konrad, Niedzwiecka, Iwona, Sobczak, Sebastian, Ciurus, Tomasz, Jakubowski, Piotr, Misztal-Teodorczyk, Magdalena, Teodorczyk, Dawid, Fratczak, Aleksandra, Szkopiak, Marcin, Lebioda, Patrycja, Wlodarczyk, Michal, Plachcinska, Anna, Kusmierek, Jacek, Miller, Magdalena, Marciniak, Halina, Wojtczak-Soska, Karolina, Łuczak, Katarzyna, Tarchalski, Tomasz, Cichocka-Radwan, Anna, Anna Szulczyk, Grazyna, Witkowski, Adam, Kukuła, Krzysztof, Celińska-Spodar, Małgorzta, Zalewska, Joanna, Gajos, Grzegorz, Bury, Krzysztof, Pruszczyk, Piotr, Roik, Marek, Łoboz-Grudzień, Krystyna, Sokalski, Leszek, Brzezińska, Barbara, Lesiak, Maciej, Łanocha, Magdalena, Reczuch, Krzysztof W., Kalarus, Zbigniew, Swiatkowski, Andrzej, Szulik, Mariola, Musial, Wlodzimierz J., Bockeria, Leo, Petrosyan, Karen, Trifonova, Tatiana, Chernyavskiy, Alexander M., Kretov, Evgeniy I., Grazhdankin, Igor O., Bershtein, Leonid L., Sayganov, Sergey A., Kuzmina-Krutetskaya, Anastasia M., Zbyshevskaya, Elizaveta V., Katamadze, Nana O., Demchenko, Elena A., Kozlov, Pavel S., Kozulin, Vikentiy Y., Lubinskaya, Ekaterina I., Lopez-Sendon, Jose, Castro, Almudena, Refoyo Salicio, Elena, Guzman, Gabriela, Galeote, Gabriel, Valbuena, Silvia, Peteiro, Jesús, Dolores Martínez-Ruíz, María, Pérez-Fernández, Ruth, Cuenca-Castillo, José J., Flores-Ríos, Xacobe, Prada-Delgado, Óscar, Barge-Caballero, Gonzalo, Ramon Gonzalez Juanatey, Jose, Souto Bayarri, Miguel, Pubull Nuñez, Virginia, Ocaranza Sanchez, Raymundo, Cid Alvarez, Belen, Peña Gil, Carlos, Martinez Monzonis, Amparo, Sionis, Alessandro, Vila Perales, Montserrat, Maria Padró, Josep, Serra Peñaranda, Antonio, García Picart, Joan, Ginel Iglesias, Antonino, Garcia-Moll Marimon, Xavier, Pons Lladó, Guillem, Carreras Costa, Francesc, Miro, Vicente, Diez, Jose L., Calvillo, Pilar, Marin Ortuño, F., Valdés Chávarri, M., Tello Montolliu, A., Pinar Bermudez, E., De La Morena, G., Gracida Blancas, Montserrat, Enrique Castillo Luena, Jose, Fernandez-Aviles, Francisco, Chen, Jiyan, Wu, Yongjian, Ma, Yitong, Yang, Yining, Ji, Zheng, Yang, Xinchun, Lin, Wenhua, Zeng, Hesong, Fu, Xin, Wang, Songtao, Cheng, Gong, Zhao, Yulan, Fang, Xuehua, Zeng, Qiutang, Su, Xi, Li, Qingxian, Nie, Shao-Ping, Yu, Qin, Wang, Jianʼan, Zhang, Shuyang, Liu, Zhenyu, Maggioni, Aldo P., Piero Perna, Gian, Marini, Marco, Gabrielli, Gabriele, Provasoli, Stefano, Verna, Edoardo, Monti, Lorenzo, Nardi, Barbara, Di Chiara, Antonio, Mortara, Andrea, Galvani, Marcello, Ottani, Filippo, Sicuro, Marco, Calabro, Paolo, Formisano, Tiziana, Tarantini, Giuseppe, Cucchini, Umberto, Luigi Andres, Anto, Racca, Emanuela, Briguori, Carlo, Amati, Roberto, Vergoni, William, Russo, Aldo, Fanelli, Raffaele, Poh, Kian-Keong, Chai, Ping, Lau, Titus, Loh, Joshua P., Tay, Edgar L., Teoh, Kristine, Teo, Lynette L., Ong, Ching-Ching, Wong, Raymond C., Loh, Poay-Huan, Kofidis, Theodoros, Xian Chan, Wan, Hui Chan, Koo, Foo, David, Loh Kwok Kong, Jason, Ching, Min, Er, Haider Jafary, Fahim, Chua, Terrance, Stumpf, Juergen, Matschke, Klaus, Simonis, Gregor, Kadalie, Clemens T., Sechtem, Udo, Christian Schulze, P., Goebel, Bjoern, Lenk, Karsten, Nickenig, Georg, Schuchlenz, Herwig, Weikl, Stefan, Marthe Lang, Kurt Huber, Irene, Jakl-Kotauschek, Gabriele, Vertes, Matyas Keltai Andras, Varga, Albert, Fontos, Geza, Merkely, Bela, Kerecsen, Gabor, Hinic, Sasa, Zdravkovic, Marija, Mudrenovic, Vladan, Crnokrak, Bogdan, Beleslin, Branko D., Boskovic, Nikola N., Petrovic, Marija T., Dobric, Milan R., Markovic, Zeljko Z., Mladenovic, Ana S., Cemerlic-Adjic, Nada, Davidović, Goran, Vučić, Rada, Nikola Dekleva, Milica, Stankovic, Goran, Apostolovic, Svetlana, Escobedo, Jorge, Baleón-Espinosa, Rubén, Campos-Santaolalla, Arturo S., Durán-Cortés, Elihú, Flores-Palacios, José M., García-Rincón, Andrés, Jiménez-Santos, Moisés, Peñafiel, Joaquín V., Ortega-Ramírez, José A., Valdespino-Estrada, Aquiles, Alexánderson Rosas, Erick, Murphy, Deirdre, Selvanayagam, Joseph B., Joseph, Majo X., Thambar, Suku T., Rankin, Jamie, Beltrame, John F., Hillis, Graham S., Thuaire, Christophe, Dutoiu, Téodora, Juliard, Jean-Michel, Slama, Michel S., El Mahmoud, Rami, Nicollet, Eric, Goube, Pascal, Barone-Rochette, Gilles, Furber, Alain, Bière, Loïc, Laucevicius, Elvin Kedhi, Aleksandras, Timmer, MD Jorik, Hermanides, Rik, Kaplan, Eliza, Riezebos, Robert K., Samadi, Pouneh, van Dongen, Elise, Niehe, Sander R., Suryapranata, Harry, van Vugt, Stijn, Cacela, Duarte, Santana, Ana, Fiarresga, Antonio, Sousa, Lidia, Marques, Hugo, Patricio, Lino, Bernanrdes, Luis, Rio, Pedro, Carvalho, Ramiro, Ferreira, Rui, Silva, Tiago, Rodrigues, Ines, Modas, Pedro, Portugal, Guilherme, Fragata, Jose, Pinto, Fausto J., Nobre Menezes, Miguel, Cantinho Lopes, Guilhermina, Gomes Almeida, Ana, Canas Silva, Pedro, Nobre, Angelo, Rita Francisco, Ana, Ferreira, Nuno, Lopes, Ricardo L., Diaz, Rafael, Guzman, Luis, César Figal, Julio, Méndiz, Oscar, Cortés, Claudia, René Favaloro, Roberto, Alvarez, Carlos, Courtis, Javier, Zeballos, Gabriela, Schiavi, Lilia, Rubio, Mariano, Alsweiler, Caroline, Patrick Devlin, Gerard, Fisher, Raewyn, Alan Huston Stewart, Ralph, Douglas White, Harvey, Benatar, Jocelyne, Kedev, Sasko, Peovska Mitevska, Irena, Srbinovska Kostovska, Elizabeta, Pejkov, Hristo, Held, Claes, Eggers, Kai, Frostfelt, Gunnar, Johnston, Nina, Olsowka, Maciej, Åkerblom, Axel, Soveri, Inga, Aspberg, Johannes, Beyar, Rafael, Nikolsky, Eugenia, Sharir, Tali, Elian, Dan, Kerner, Arthur, Massalha, Samia, Fukuda, Keiichi, Kohsaka, Shun, Yasuda, Satoshi, Nishimura, Shigeyuki, Van de Werf, Frans, Claes, Kathleen, Hung, Chung-Lieh, Yun, Chun-Ho, Jia-Yin Hou, Charles, Kuo, Jen-Yuan, Yeh, Hung-I, Hung, Ta-Chuan, Li, Jiun-Yi, Chien, Chen-Yen, Tsai, Cheng-Ting, Liu, Chun-Chieh, Yu, Fa-Chang, Lin, Yueh-Hung, Lan, Wei-Ren, Yen, Chih-Hsuan, Tsai, Jui-Peng, Sung, Kuo-Tzu, Ntsekhe, Mpiko, Pandie, Shaheen, Viljoen, Charle A., De Andrade, Marianne, Moccetti, Tiziano, Grazia Rossi, M., Abdelhamid, Magdy, Adel, Ahmed, Kamal, Ahmed, Mahrous, Hossam, El Kaffas, Sameh, El Fishawy, Hussien, Pop, Calin, Claudia, Matei, Popescu, Bogdan A., Ginghina, Carmen, Deleanu, Dan, Iliescu, Vlad A., Al-Mallah, Mouaz H., Aljzeeri, Ahmed, Najm, Hani, Alghamdi, Ali, Ramos, Walter Enrique Mogrovejo, Kuanprasert, Srun, Prommintikul, Arintaya, Nawarawong, Weerachai, Woragidpoonpol, Surin, Tepsuwan, Thitipong, Taksaudom, Noppon, Rimsukcharoenchai, Chataroon, Euathrongchit, Juntima, Wannasopha, Yutthaphan, Yamwong, Sukit, Sritara, Piyamitr, Aramcharoen, Suthara, Meemuk, Krissada, Khairuddin, Ahmad, Abd Hadi, Hafidz, Azmi Yahaya, Shaiful, Doan, John, Lee, Raven, Patel, Risha, Yang Cho, So, Milbrandt, Susan, Shelstad, Dawn, Kamath, Preeti, Tejani, Ishita, Quiles, Kirsten J., Schley, Allison, Golden, Heather, Osseni, Hermine, Wiyarand, Charlene, Douglass, Peter, Pomeroy, Hayley, Craft, Alexandra, Harvey, Bethany, Anaya, Olivia, Goold, Phoebe, Giovannone, Steven, Pritchard, Lori, Gans Paul Kennedy, Rosann, Ganesan, Shobana, Schlichting, David, Naher, Aynun, Stewart, Wendy L., Salmi, Kristin M., Johnson, Debra K., Herrmann, Rebekah R., Arges, Kristine, LeFevre, Melissa, Tomfohr, Jennifer, Ann Byrne, Kimberly, Zappernick, Taissa, Canada, Sallie, Kakade, Meghana, Mieses, Patricia, Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Rantinella, Magdalena, Rodriguez, Jessica, Mancilla, Olivia, Stinson, Susan, Weyand, Terry, Crook, Sherron C., Ho, Jean, Khan, Saadat, Mohamed, Mahmoud, Soltau, Mary R., Rose, Delsa K., Wimmer, Rebecca J., Desire, Sukie, Rashid, Fauzia, Asier, Senait, Patel, Keyur, Gillis, Jennifer, Manocchia, Megan, Moore, Susan, Congdon, Elizabeth, Brandt, Gail, Marchelletta, Nora, Wippler, Kristina, Halverson, Kimberly E., Roraff, Christine, Thorsen, Jonean, Ojajuni, Amarachi, Olurinde, Oni, Surineni, Kamalakar, Valaiyapathi, Badhma, Kartje, Carol M., Rawlins, Michele, Thomson, Jennifer, Colleen Rogge, Mary, Bunke, Julie, Unterbrink, Kendra, Fannon, Jacqueline, Burman, Cynthia, Dubin, Marcia F., Beaudry, Sarah, Tirado, Stephanie A., Halliday, Janet, Julian, Stephanie, Pamela, Stanford M. Lane, Jennifer L., Arsenault, Patricia, Sigel, Pamela, Brooks, Miriam, Douangvila, Ladda, Gevorgyan, Rubine, Ranjbaran, Fatima, Smith, Bryn, Ohmart, Carly, Ly, Samantha, Quinn, Margot C., Temiyasathit, Sara, Do, Jacquelyn, Tobin, Desiree, Langdon, Jennifer, Werner Bayer, Marcia, OʼMalley, Amanda, Orvis, Erin, Murphy, Mandy, Greenberg, Ann, Iraola, Margaret, Maranan, Leandro C., Malinay, Ammy, Edillo, Candice P., Ostrander, Ann, Wasmiller, Stephanie, Drewes, Wendy, Patel, Dipti, White, Jackie M., Hallam, Alison, Spooner, Benjamin J., Hollenweger, Linda M., Little, Holly, Little, Tiffany, Eskelson, Nona A., Taul, Yvonne, Rodgers, Caroline, Isaacs, Jennifer, Bulkley, Viktoria, Kaneshiro, Renee, Kirby, Bonnie J., Tran, Nhi N., Jahrsdorfer, Catherine, Yunis, Reem, Patro, Jhina, Vega, Antonia, Bloise-Adames, Hugo, Jimenez, Santa, Saint Vrestil, Nicole, Bhandari, Reyna, Schade, Danielle, Yost, Roxanne, Beardsley, Paula, Fine, Denise, Tancredi, Jana, Arakelian, Patricia, Mathus, Susan, OʼNeill, Deborah, Burkhardt, Joy, Hosino, Suellen, Lubyanaya, Oksana A., Salas, Jose D., Aguirre, Maria, Dhawan, Manu, Parra, Diana, Tran, Tri, Fowler-Lehman, Katie, Spitzer, Natalie, Riedberger, Casey, Weick, Catherine, Quiles, Kirsten J., Drum, Carrie, Miller-Cox, Kimberly, Ollinger, Amy, Capasso-Gulve, Elizabeth, Melanie Loehr, Alaine, Mosley, Marlowe, Heydari, Shirin, Lundeen, Andrea M., Karanjah, Edgar, Marfori, Wanda C., Hernandez-Rangel, Eduardo, Singh, Pam, Marie Webb, Anne, Fridell, Ellie, Wilson, Heidi, Kim, Angela, Wilmot, Patrick, Stevens, Ramona, Black, Loriane, Hull, Amber B., Lim, Olivia J., Tucker, Helen C., Putnam, Natasha C., Hall, Linda L., Cauthren, Tia, Tucker, Trish, Horton, Hollie, Orga, Jan, White, Joyce R., Baumann, Cynthia, Seeratan, Vidya, Jimenez, Magnolia, Schultz, Cidney, Russo, Jeanne, Huda, Zohra, Boan, Araceli, Hinton, Christine R., Archer, Beth A., Dionne, Julia S., Allardyce, Cheryl A., Sikora, Lindsey N., Czerniak, Jennifer H., Mull, Jennifer A., Ferguson, Elizabeth, Laube, Frances, Shammas, Gail A., Christensen, Lori, Park, Holly, Hecht, Joan, Vo, Davis, Hirsch, James, Bindeman, Jody, Salkind, Sara, Desimone, Lori-Ann, Felix-Stern, Lina, Gomes, Jassira, Gordon, Catherine, Mann, Aimee, McCreary, Theresa, Quiles, Kirsten J., Gopaul, Candace, Hultberg, Karen, Huk, Tauqir, Hussain, Afshan, Zambrano, Yesenia, Medina Rodriguez, Sarah, Milner, Trudie, Mulder, Abbey, Van Oosterhout, Stacie, Meyer, Martha, Clapp, Nancy L., Barrentine, Heather, Jose, Jenne M., Manchery, Jenne, McKinney, Vera, Schwarz, Linda, Kaczkowski, Scott M., Jaskowiak, Adam J., Klitch, Joel, Dees, Debra, Vasquez, Precilia, Hannemann, Elise L., Mae Foltz, Judy, DeRosa, Emily, Jorgenson, Beth, Riestenberg-Smith, Joyce, Bariciano, Rebecca, Waldron, Jessica, Mayon, Michelle, Ann Peichel, Gretchen, Starks, Brandy, Garcia, Lucilla, Thottam, Maria, Anand, Anjali, Raj, Janitha, Ravindran, Reshma, Rajalekshmi, VS, Nataraj, Nandita, Bajaj, Sheromani, Yadav, Vandana, Mishra, Girish, Tewari, Roma, Mishra, Meenakshi, Patel, Shivali, Singh, Suman, Kaur, Baljeet, Gupta, Sonika, Suvarna, Chandini, Mannekkattukudy Kurian, Binoy, Rupesh Karwa, Sheetal, Kolhe, Suvarna, Vindhya, R.J., Jain, Peeyush, Seth, Ashok, Singh Meharwal, Zile, Verma, Atul, Bhatia, Mona, Sachdeva, Ankush, Indira Devi, Thounaojam, Jungla, Nungshi, Manjula Rani, K., Sowjanya Reddy, M., Preethi, K., Sidh, Rinu R., Priya, Vamshi, Preethi, Kotiboinna, Hande, Shweta, Dubey, Abhishek, Rawat, Vineeth, Kavita, Chacko, CP Manas, Babu, Suresh, Reddy, Sowjanya, Rani, Manjula, Arambam, Priyadarshani, Singh, Bebek, Young, Grace M., Kinsey, Christopher, Kavalakkat, Raisa, Evans, Jo, Hassan, Ikraam, Williams, Sarah, Holland, Kim, Swan, Karen, Atkinson, Bev, Kunhunny, Swapna, Atkinson, Craig, Krannila, Carita, Vinod, Manitha, Chaytor, Lisa, Cox, Leanne, Morrow, Julie, Rowe, Kay, Kelly, Stephanie, Regan, Susan, Turnbull, Dawn, Fleming, Catherine, Ghosh, Arijit, Gratrix, Karen, Preston, Stephen, Cartwright, Anne, Knightonc, Abigail, Martin, Katherine, Flint, Laura, Harrison, James, Lakeman, Nicki, Ljubez, Anja, Wright, Judith, Exley, Donna, Andiapen, Mervyn, Richards, Amy J., Wong, Lisa, Munro, Melanie J., McEvoy, Michelle, Brown, Caroline, Charles, Thabitha, Kolakaluri, Laurel, Phillips, Hannah, Morby, Louise, Hallett, Karen, Corbett, Carolyn, Winstanley, Lynne, Smit, Angelique, Gent, Susan, Hussain, Nafisa, Haines, Fiona, Taaffe, Joanne, Burton, Jane, Colton, Maria, King, Rachel, Brown, Ammani, Docherty, Andrew, McCloy, Lisa, Robb, Kate, Paterson, Craig, Crawford, Wenda, Kelly, Joanne, McGregor, Lorraine, Mackin, Anne, Knight, Janet P., Bose, Tuhina, Proietti, Anna, Brousseau, Myriam, Corfias, Magalie, Blaise, Patricia, Harvey, Luc, Alarie, Patricia, Arcand, Linda, Roy, Isabelle, Montpetit, Estelle, Drouin, Katia, Bergeron, Christine, Shelley, Christine, Masson, Christine, Carr, Sandy, Bone, Catherine, Moga, Ermina, Kourzenkova, Janetta, Walter, Olga, Hogg, Norma, Welsh, Suzanne, Hussain, Mohammed, Bello, Olugbenga, Syed, Ishba, Kushniriuk, Khrystyna, Otis, Judy, Otis, Rebecca, Seib, Michelle M., Rivest, Sandra M., Sandonato, Rosa, Chow, Jackie, Starovoytov, Andrew, Uchida, Naomi, Meadows, Ngaire, Asif, Nadia, Tavares, Suzana, Bozek, Bev, Shier, Maria, Larmand, Lori-Ann, Janmohamed, Amir, Hart, Brenda, Marucci, Jane, Tai, Sharon, Brons, Sonya, Beck, Chris, Wong, Glenda, Etherington, Krystal, Arumairajah, Thippeekaa, Aprile, Maria, Karlsson, Sara, Webber, Susan, Mercure, Chantale, Aedy, Nancy, Farquharson, Fran, Siddiqui, Anam, Emy Takiuti, Myrthes, Pizzol Caetano, Leonardo, Peixoto Deiro, Aline, Manica Muller, Alice, de Moraes, Maria Antonieta Pereira, Maria Ascoli, Bruna, Zottis Poletti, Sílvia, Zier, Sandra S., Veiga, Vilmar, Franca da Cunha, Diego, Rucatti, Guilherme G., Igansi, Fernanda, Haeffner, Mauren P., Almeida, Viviane, Sanchez de Souza, Gabriela, Almeida, Mayana, dos Santos, Viviane, Oliveira, Natalia S., Edilena Paulino Azevedo, Bruna, Bizzaro Santos, Marco, Germann, Amanda, Gomes, Vitor, Homem, Rosa, Magedanz, Ellen, Laimer, Rosane, Tognon, Alexandre, Santos, Roberta P., Yumi Okada, Mariana, Paula Batista, Ana, Nogueira Rabaça, Aline, Miranda Trama, Larissa, Silva, Talita, de Souza Ormundo, Camila Thais, Vicente, Carla, Pinheiro, Caroline, Komar, Daniele, Walesiak, Olga, Malinowska, Katarzyna, Maksym, Jakub, Wojtera, Karolina, Fojt, Anna, Szczerba, Ewa, Swiderek, Marta, Wojtala, Ewelina, Karwowski, Jaroslaw, Łabyk, Andrzej, Szramowska, Agnieszka, Zdończyk, Olga, Jaroch, Joanna, Kolodziej, Adam, Marcinkiewicz-Siemion, Marta, Bockeria, Olga, Kudzoeva, Zalina, Aripova, Nodira, Naryshkin, Ivan A., Kuleshova, Alena, Malaev, Dastan, Subbotina, Irina, Gumerova, Victoria, Nikolaeva, Olga B., Fernández-Figares, Pharm, Virginia, Alonso-Álvarez, Moisés Blanco-Calvo Encarnación, García-González, Paula, Seijas Amigo, Jose, Fernández Martínez, Begoña Igual, Ana, Romero Aniorte, M. Quintana Giner A.I., Rivera Caravaca, J.M., Cañavate, Olga, Guerrero, Sonia, Riera, Silvia, Lasala, Maria, Lorenzo, Maria, Sobrino, Olga, Vazquez, Alexandra, Dong, Haojian, He, Peiyu, Xia, Chunli, Yang, Junqing, Zhong, Qi, Tian, Yanmeng, Li, Dongze, Li, Xiaomei, Ma, Xiang, Yu, Zixiang, Zhao, Qian, Li, Chunguang, Zhang, Lei, Zhao, Yu, Zhu, Bolin, Chen, Mulei, Chi, Hongjie, Wang, Yang, Zhang, Jing, Jing, Rui, Liu, Jingjing, Zhou, Qiang, Xu, Chang, Li, Zhuxi, Li, Junhua, Xiong, Luyang, Gao, Dan, Jiang, Dengke, Leng, Ran, Wang, Xutong, Yuan, Qianqian, Zhang, Lili, Bai, Ziliang, Li, Jianhua, Qi, Jie, Wang, Fei, Wang, Haitao, Yang, Bin, Yue, Zhou, Zhang, Zhulin, Dong, Yumei, Mao, Jiajia, Zhang, Bin, Li, Xiuhong, Yao, Xiaowei, Zhong, Nier, Zhou, Ning, Huang, Yaping, Zhou, Wei, Panpan, Peng, Yu Kunwu Yudong, Su, Xin, Wang, Chen, Zhao, Yunhai, Geng, Yaming, Wang, Yanfu, Fan, Jing-Yao, Feng, Si-Ting, Wang, Xiao, Yan, Yan, Zhang, Hui-Min, Chi, Lingping, Liu, Fang, Chen, Han, Jiang, Jun, Li, Huajun, Han, Yechen, Xu, Lihong, Chen, Gang, Hu, Rongrong, Pietrucci, Francesca, Di Donato, Anna, Pezzetta, Francesca, Casali, Valentina, Attanasio, Chiara, Leone, Gianpiero, Pisano, Francesco, Bare, Cristina, Fimiani, Fabio, Barioli, Alberto, Ramani, Federica, Rolfo, Fabrizio, Goletto, Cecilia, De Micco, Francesca, Di Marco, Stefano, Tricoli, Martina, Villella, Massimo, Tan, Sik-Yin V., Sia, Winnie C., Leong, Audrey W., Hai Yan, Li, Ismail, Nasrul, Tun Kyaw, Min, Yip, Deborah, Grahl, Dorit, Guenther, Franziska, Bonin, Kerstin, Wenzelburger, Ina, Gruensfelder, Susanne, Sinning, Jan-Malte, Weber, Marcel, Werner, Nikos, Steinmaurer, Gudrun, Winter, Tijana, Andric, Max-Paul, Tscharre, Claudia, Maximilian, Bernhard, Jäger, Wegmayrc, Egger, Floria, Davidovits, Judit Sebo Zoltan, Matics, Laszlone, Ágoston, Gergely, Dekany, Gabor, Bartykowszki, Andrea, Jakal, Agnes, Djokic, Jelena, Djordjevic-Dikic, Ana D., Giga, Vojislav L., Stepanovic, Jelena J., Velicki, Lazar, Pupic, Ljiljana, Simović, Stefan M., Stevo Martinovic, Miroslav, Stevanovic, Gordana, Dobric, Milan, Salinger Martinovic, Sonja, Stanojevic, Dragana, de Jesús-Pérez, Ramon, Brassetti, María Fernanda Canales, Adrián Vences Anaya, Diego, Pérez García, María, Estela Carvajal Juarez, Isabel, Madero Rovalo, Magdalena, Lee, Sau, Thomas, Prince, Chaplin, Melissa D., Stansborough, Jeanette K., Black, Marilyn, Bonner, Michelle M., Ireland, Kim F., Venn-Edmonds, Clare, Thobois, Corine, Tachot, Emilie, Laure, Christophe, Vassaliere, Christel, Abergel, Helene, Fuentes, Axelle, Eliahou, Ludivine, Dubourg, Olivier, Michaud, Pierre, Hadjih, Sarah, Brito, Patricia, Cornet, Charles, Rautureau, Jeremy, Juceviciene, Agne, Kalibataite-Rutkauskiene, Irma, Keinaite, Laura, Laukyte, Monika, Mikolaitiene, Gelmina, Smigelskaite, Akvile, Tamasauskiene, Ilona, Urboniene, Agne, Bouwhuis, Ilse, Nijmeijer, Jeannette, Lia, Elisabeth, J.M. Schoep, Ahoud, M. Janzen Sandra, Selas, Mafalda, Silva, Filipa, Freixo, Cláudia, Zimbarra Cabrita, Inês, Rocha, Andreia, Patuleia Figueiras, Francisca, Coelho, Andreia, Capinha, Marta, Inês Caetano, Maria, Silva, Susana, Tinnirello, Veronica, Nicolás Mungo, Matías, Garcia, Marina, Godoy, Valeria, Victoria Actis, Maria, Scaro, Graciela, Low, Liz, Scales, Jayne, Abercrombie, Kirsty, Howell, Leah, Patten, Cathrine, Björklund, Christina, Andreasson, Maria, Essermark, Marie, Persson, Liselotte, Harel, Or, Bentzvi, Margalit, Helmer, Ludmila, Ueda, Ikuko, Fujita, Jun, Furukawa, Akemi, Hirase, Kanae, Nagai, Toshiyuki, Otsuka, Fumiyuki, Nakano, Shintaro, Robesyn, Valerie, Yang, Yi-Hsuan, Mtana, Noloyiso, Anesini, Adriana, Maspoli, Simona, Mombelli, Manuela, Talaat, Ahmed, Rosca, Monica, Beladan, Carmen C., Zahrani, Sarah, Antonio Monsalve Davila, Marco, Khwakhong, Supatchara, Chaiyasri, Anong, Mekara, Warangkana, Kulthawong, Supap, Amaritakomol, Anong, Panpunuan, Pachara, Syamira Mokhtar, Noor, Asiah Basri, Nor, Yusnida, Irni, Hashim, Humayrah, Berger, Jeffrey, Williams, David, Harrington, Robert, Jiang, Lixin, Lopes, Renato D., Noel Bairey Merz, C., Weintraub, William, Donato Morales Rodríguez, Erick, Maurovich-Horvat, Pal, Sonawane, Poonam, Francis, Ramakrishnan, Rajesh, Nayak, T. Soundarya, Boer, Stephanie C., Rosenberg, Yves, Hamm, Christian, Helm, Malte, Peterson, Eric, Ballantyne, Christie, Calfas, Karen, Ann Champagne, Mary, Fleg, Jerome, McCullough, Peter A., Menasche, Philippe, Davidson, Michael, Fremes, Stephen, Guyton, Robert, Mack, Michael, Mohr, Fred, Rao, Anupama, Sabik, Joe, Shapira, Oz, Taggart, David, Tatoulis, James, Blankenship, Jim, Brener, Sorin, Buller, Chris, Colombo, Antonio, de Bruyne, Bernard, Kereiakes, Dean, Lefevre, Thierry, Moses, Jeffrey, Mahaffey, Ken, Cruz-Flores, Salvador, Danchin, Nicholas, Feen, Eli, Garcia, Mario J., Hauptman, Paul, Laddu, Abhay A., Passamani, Eugene, Pina, Ileana L., Simoons, Maarten, Skali, Hicham, Thygesen, Kristian, Waters, David, Endsley, Patricia, Esposito, Gerard, Kanters, Jeffrey, Pownall, John, Stournaras, Dimitrios, Friedrich, Matthias, Hachamovitch, Rory, Oliver, Dana, Harrel, Frank, Blume, Jeffrey, Lee, Kerry, Kullo, Iftikhar, McManus, Bruce, Newby, Kristin, Cohen, David, Bugiardini, Raffaele, Mattina, Deirdre, Ali, Ziad, Mathew, Roy, Friedman, Lawrence, Anderson, Jeffrey, Berg, Jessica, DeMets, David, Michael Gibson, C., Lamas, Gervasio, Deming, Nicole, Himmelfarb, Jonathan, Ouyang, Pamela, Woodard, Pamela, Nwosu, Samuel, Kirby, Ruth, Jeffries, Neal, Denaro, Jean E., Boumakis, Stephanie, Chan, Kevin, Cobb, Gia, Contreras, Aira, Cukali, Diana, Ferket, Stephanie, Gabriel, Andre, Hansen, Antonietta, Roberts, Arline, Chang, Michelle, Islam, Sharder, Wayser, Graceanne, Yakubov, Solomon, Yee, Michelle, Callison, Caroline, Hogan, Isabelle, Qelaj, Albertina, Pirro, Charlotte, Van Loo, Kerrie, Wisniewski, Brianna, Gilsenan, Margaret, Lang, Bevin, Mohamed, Samaa, Esquenazi-Karonika, Shari, Mathews, Patenne D., Naumova, Anna, Lyo, Jihyun, Setang, Vincent, Xavier, Mark, Anstrom, Kevin, Baloch, Khaula, Blount, Janet, Cowper, Patricia, Davidson-Ray, Linda, Drew, Laura, Harding, Tina, David Knight, J., Minshall Liu, Diane, O’Neal, Betsy, Redick, Thomas, Jones, Philip, Nugent, Karen, Jingyan Wang, Grace, Goyal, Abhinav, Hetrick, Holly, Hayes, Sean W., Friedman, John D., Mark Hyun, R. James Gerlach, Miranda-Peats, Romalisa, Slomka, Piotr, Thomson, Louise, Pierre Mongeon, Francois, Michael, Steven, Hung, Judy, Zeng, Xin, Eckstein, Jane, Guruge, Bandula, Streif, Mary, Alfonso, Maria A., Corral, Maria P., Garcia, Javier J., Horst, Jennifer, Jankovic, Ivana, Konigstein, Maayan, Lustre, Mitchel B., Peralta, Yolayfi, Sanchez, Raquel, Arsanjani, Reza, Elmor, Kimberly, Gomez, Millie, Hindoyan, Niree, Nakanishi, Rine, Barbara Srichai-Parsia, M., Yeoh, Eunice, Youn, Tricia, Bianchini, Francesca, Ceseri, Martina, Lorimer, Andrea, Magnoni, Marco, Orso, Francesco, Sarti, Laura, Mazza Barbosa, Lilian, Bello Duarte, Tauane, Colaiácovo Soares, Tamara, de Aveiro Morata, Julia, Carvalho, Pedro, de Carvalho Maffei, Natalia, Egydio, Flávia, Kawak, Anelise, Oliveira, Janaina, Restelli Piloto, Elissa, Pozzibon, Jaqueline, Camara, Diane, Mowafy, Neamat, Spindler, Caroline, Dai, Hao, Feng, Fang, Li, Jia, Li, Li, Liu, Jiamin, Xie, Qiulan, Zhang, Haibo, Zhang, Jianxin, Zhang, Lihua, Zhang, Liping, Zhang, Ning, Zhong, Hui, Escobar, Claudia, Eugenia Martin, Maria, Pascual, Andrea, Moraga, Paloma, Hernandez, Victoria, Posada, Maria, Fernandez, Sara, Luis Narro Villanueva, José, Selgas, Rafael, Luyten, Ann, Garcevic, Nevena, Stojkovic, Jelena, Ahmed, Asker, Bhatt, Richa, Chadha, Nitika, Kumar, Vijay, Lubna, Sadath, Naik, Pushpa, Pandey, Shruti, Ramasamy, Karthik, Saleem, Mohammed, Sharma, Pratiksha, and Siddaram, Hemalata

Published
2024
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45. Effect of Adding Electroacupuncture to Standard Triple Antiemetic Therapy on Chemotherapy-Induced Nausea and Vomiting: A Randomized Controlled Clinical Trial

Author

Shen, Guoshuang, Ren, Dengfeng, Zhao, Fuxing, Wang, Miaozhou, Liu, Zhen, Feng, Xiumei, He, Yingjian, Liu, Xinlan, Ling, Xiaoling, Zhao, Yi, Song, Feixue, Ma, Jiyan, Li, Enxi, She, Tong, Liu, Zhilin, Li, Zitao, Huang, Shifen, Chen, Yongzhi, Yang, Jingru, Li, Xuan, Duan, Li, Da, Mengting, Zheng, Yonghui, Li, Yongxin, and Zhao, Jiuda

Published
2024
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47. Analysis of Genetic Diversity of 24 Morinda officinalis How. Based on Phenotypic and Molecular Markers

Author

Lei HE, Fengmin LIU, Yueyan FENG, Zijian WANG, Jiyan CHEN, and Weili ZHANG

Subjects
morinda officinalis how., principal component analysis, srap molecular marker, cddp molecular marker, genetic diversity, Agriculture
Abstract

【Objective】Deqing County, Guangdong Province is a native habitat of Morinda officinalis How., a genuine medicinal herb in China. In the study, the genetic diversity of germplasm resources of 24 varieties of Morinda officinalis How. were analyzed.【Method】A total of 24 Morinda officinalis How. resources collected from Deqing County as research objects, and principal component analysis and molecular marker methods (SRAP and CDD) were used to analyze the genetic diversity of 24 Morinda officinalis How. materials.【Result】Phenotypic analysis showed that, in the cluster map based on principal component analysis, Guanwei Town, Gaoliang Town, Fengcun Town and Gaoliang Town were clustered in four groups. In addition, 100 and 98 total bands were obtained in 18 pairs of SRAP primer combinations and 16 CDDP primers, among them, there were 50 SRAP polymorphic bands, resulting in a polymorphism ratio of 50%. The average genetic similarity coefficient (GS) was 0.87, and the GS ranged from 0.71 to 0.97. There were 80 polymorphic bands in CDDP, with a polymorphism ratio of 79.0%. The GS among germplasm resources ranged from 0.71 to 0.96, with an average (GS) of 0.86. When the coefficient was 0.82, both SRAP and CDDP molecular markers showed certain similarities among the germplasm resources of Gaoliang Town, Guanxu Town and Fengcun Town.【Conclusion】Combined with the clustering results of phenotypic and molecular marker, the genetic relationship is closest between Gaoliang Town and Guanwei Town as well as Gaoliang Town and Fengcun Town. The results of SRAP and CDDP molecular marker methods have certain differences in the genetic diversity of Morinda officinalis How., and the combined analysis can better reflect the genetic diversity of Morinda officinalis How. and the phylogenetic relationship of Morinda officinalis How. resources.

Published
2024
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48. Progress on HIV and other sexually transmitted infections elimination among youth and adults across BRICS-plus countries: Results from the Global Burden of Disease Study 2021

Author

Rizhen Wang, Yinuo Sun, Huan Wang, Xiaoran Yu, JiYan Ma, Zuokun Liu, Jing Li, Zhiyong Zou, and Yangmu Huang

Subjects
HIV, Sexually transmitted diseases, Incidence, Age-period-cohort analysis, Health disparities, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
Abstract

Background: Global strategies aim to eradicate HIV and other sexually transmitted infections (STIs) by 2030. We aim to assess HIV and other STIs morbidity trends from 1992 to 2021 across BRICS-plus (Brazil, Russia, India, China, South Africa, Egypt, Ethiopia, Iran, Saudi Arabia, and the United Arab Emirates), which accounts for nearly half of the world population. Methods: HIV and other STIs morbidity estimates were derived from the Global Burden of Disease Study 2021. We derived percentage changes to evaluate the progress towards HIV 2020 milestones and annualised rate of change to determine the progress needed to achieve 2030 targets. We used age-period-cohort (APC) model to estimate period (cohort) relative risks for both disease areas. Results: Around 46 % of global incident cases attributed to HIV and other STIs were found in BRICS-plus countries, exceeding the combined totals of North American countries. The HIV new cases in BRICS-plus declined by 8.2 % between 2010 and 2020. No countries within BRICS-plus achieved a target of a 75 % decrease in HIV new cases in 2020 or 2021, but India (-41.7 %), Ethiopia (-34.4 %), China (-29.7 %), and South Africa (-11.7 %) showed reductions. Individuals aged 15–24 years (-32·9 %) had a decline for HIV new cases, while individuals aged ≥ 25 years plateaued. There were evident period risks of morbidity for HIV in Russia and Iran since 2012 and for syphilis and gonorrhea in Brazil since 2012. Younger generations had a higher risk of contracting HIV in Brazil, China, Egypt, Iran, and Russia, and other STIs in Brazil, India, Iran, and South Africa, particularly genital herpes. Conclusion: BRICS-plus was still far from reaching the global 2030 targets for both disease areas. Adults aged ≥ 25 years have little progress in HIV new cases, and youth and adults in other STIs.

Published
2025
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