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763 results on '"Almansour, Abdulrahman I."'

35. Unveiling the correlation between the structure and property of the amorphous state of hydrated nickel sulfate (NiSO4·6H2O) induced by acoustic shock waves – An X-ray diffraction, thermal calorimetric and dielectric spectroscopic approach

Author

Aswathappa, Sivakumar, Dai, Lidong, Jude Dhas Sathiyadhas, Sahaya, Britto Dhas Sathiyadhas Amalapushpam, Martin, Thangavel, Vasanthi, Nalagounder Vijayakumar, Vellapalayam, Suresh Kumar, Raju, and Almansour, Abdulrahman I.

Published
2024
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38. Nanoscale molecular reactions in microbiological medicines in modern medical applications

Author

Shesayar Radjarejesri, Agarwal Amit, Taqui Syed Noeman, Natarajan Yuvaraj, Rustagi Sarvesh, Bharti Sweety, Trehan Anchal, Sivasubramanian Kanagasabapathy, Muruganandham Moorthy, Velmurugan Palanivel, Arumugam Natarajan, Almansour Abdulrahman I., Kumar Raju Suresh, and Sivakumar Subpiramaniyam

Subjects
atom, molecular size, nanoscale, quantum atoms, Chemistry, QD1-999
Abstract

Everything around us is made up of atoms and molecules. The properties of quantum atoms are sought to understand the behavior of a particular object. But with the advent of research, it was discovered that there is a quantity smaller than the molecular size. The nanoscale measures a fraction of a billionth of a meter. The atom of an object measures 0.1 nm. Since atoms are the building blocks of matter, at the nanoscale one can combine these atoms to create new materials. The proposed model displays the properties of these nano-scale elements in modern medical applications. The nano-scale research of matter is fascinating because it is the basic phase in which atoms are held together. Therefore, by manipulating material at this level, one can create many different types of objects. This proposed model calculates the operation requirements and expects the results. Based on the operational requirements, the proposed model provides the suggestions. This will be helpful for the medical researchers to identify the proper medical treatments based on the microbiological requirements.

Published
2023
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39. A one-pot, multicomponent tandem synthesis of fused polycyclic pyrrolo[3,2-c]quinolinone/pyrrolizino[2,3-c]quinolinone hybrid heterocycles via environmentally benign solid state melt reaction

Author

Mani Suresh, Raju Rajesh, Arumugam Natarajan, Almansour Abdulrahman I., Suresh Kumar Raju, and Perumal Karthikeyan

Subjects
tandem multicomponent reaction, eco-friendly protocol, solid state melt reaction, pyrrolo[3,2-c]quinolinone/pyrrolizino[2,3-c]quinolinone, Chemistry, QD1-999
Abstract

Structurally diverse fused polycyclic pyrrolo[3,2-c]quinolinone/pyrrolizino[2,3-c]quinolinone hybrids were synthesized to get excellent yields via a tandem multi-component reaction sequence employing an environmentally benign solid state melt reaction involving [3+2]-cycloaddition process followed by two consecutive annulation steps. Baylis–Hillman products, used as dipolarophiles, were synthesized from various substituted aryl/heteroaryl aldehydes in the presence of DABCO and methyl acrylate, while the 1,3-dipole component was derived in situ from indoline-2,3-dione and acyclic/cyclic amino acid viz N-methylgylcine/l-proline. The structure of the unusual tandem products was unambiguously assigned by spectroscopic and XRD analysis. The products arose through the formation of three new rings, five new bonds, and three adjoining stereocenters with complete diastereomeric control.

Published
2023
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40. Environmentally friendly synthesis and computational studies of novel class of acridinedione integrated spirothiopyrrolizidines/indolizidines

Author

Raju Rajesh, Raghunathan Raghavachary, Arumugam Natarajan, Almansour Abdulrahman I., Kumar Raju Suresh, Vivekanand P. A., Ebenezer Cheriyan, Solomon Rajadurai Vijay, and Perumal Karthikeyan

Subjects
spirooxindolo/acenathenothiopyrrolidines, spirooxindolo/acenathenoindolizidines, acridinedione, ecofriendly green protocol, 1,3-dipolar cycloaddition, Chemistry, QD1-999
Abstract

An efficient and environmentally benign synthesis of a new class of acridinedione embedded spirooxindolo/acenaphthenothiopyrrolizidines and spirooxindolo/acenathenoindolizidines has been synthesized in good to excellent yields employing ionic liquid accelerated one-pot [3 + 2]-cycloaddition strategy. The pre-requisite starting substrates, O-acryloyl acridinediones were prepared from dimedone in three good yielding steps, while the 1,3-dipole was derived in situ from isatin/acenaphthenequinone and thiazolidine-4-carboxylc acid/l-pipecolinic acid via decarboxylative condensation. The cycloadduct possesses three stereogenic carbons, one of which is a spiro carbon through the formation of two C–C and one C–N bonds in one-pot synthetic transformation. Geometrical parameters of the synthesized compounds were calculated using the B3LYP/6-311g(d,p) level of theory. The activity of these molecules was evaluated against main protease of COVID-19 to screen them for their inhibitor efficiency. In order to get a broad understanding of the interactions of these synthesized ligands, a detailed molecular docking analysis was performed. Molecular docking analysis shows that compound 8b has the highest binding affinity toward the protein. The compound can be a potential candidate for the treatment of COVID-19.

Published
2023
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