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669 results on '"Allen, Norrina B"'

3. Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study

Author

Kim, John S., Sun, Yifei, Balte, Pallavi, Cushman, Mary, Boyle, Rebekah, Tracy, Russell P., Styer, Linda M., Bell, Taison D., Anderson, Michaela R., Allen, Norrina B., Schreiner, Pamela J., Bowler, Russell P., Schwartz, David A., Lee, Joyce S., Xanthakis, Vanessa, Doyle, Margaret F., Regan, Elizabeth A., Make, Barry J., Kanaya, Alka M., Wenzel, Sally E., Coresh, Josef, Isasi, Carmen R., Raffield, Laura M., Elkind, Mitchell S. V., Howard, Virginia J., Ortega, Victor E., Woodruff, Prescott, Cole, Shelley A., Henderson, Joel M., Mantis, Nicholas J., Parker, Monica M., Demmer, Ryan T., and Oelsner, Elizabeth C.

Published
2024
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18. A Proposed Pediatric Clinical Cardiovascular Health Reference Standard

Author

Petito, Lucia C., McCabe, Megan E., Pool, Lindsay R., Krefman, Amy E., Perak, Amanda M., Marino, Bradley S., Juonala, Markus, Kähönen, Mika, Lehtimäki, Terho, Bazzano, Lydia A., Liu, Lei, Pahkala, Katja, Laitinen, Tomi T., Raitakari, Olli T., Gooding, Holly C., Daniels, Stephen R., Skinner, Asheley C., Greenland, Philip, Davis, Matthew M., Wakschlag, Lauren S., Van Horn, Linda, Hou, Lifang, Lloyd-Jones, Donald M., Labarthe, Darwin R., and Allen, Norrina B.

Published
2024
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20. Multiple Prior Live Births Are Associated With Cardiac Remodeling and Heart Failure Risk in Women

Author

Sarma, AMY A., PANIAGUA, SAMANTHA M., LAU, EMILY S., WANG, DONGYU, LIU, ELIZABETH E., LARSON, MARTIN G., HAMBURG, NAOMI M., MITCHELL, GARY F., KIZER, JORGE, PSATY, BRUCE M., ALLEN, NORRINA B., LELY, A. TITIA, GANSEVOORT, RONALD T., ROSENBERG, EMILY, MUKAMAL, KENNETH, BENJAMIN, EMELIA J., VASAN, RAMACHANDRAN S., CHENG, SUSAN, LEVY, DANIEL, BOER, RUDOLF A. DE, GOTTDIENER, JOHN S., SHAH, SANJIV J., and HO, JENNIFER E.

Published
2023
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32. Adherence to Pediatric Screening.

Author

Gauen, Abigail M., Yaojie Wang, Perak, Amanda M., Davis, Matthew M., Rosenman, Marc, Lloyd-Jones, Donald M., Zmora, Rachel, Allen, Norrina B., and Petito, Lucia C.

Published
2024
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33. Association of Cardiovascular Health in Young Adulthood With Long-Term Blood Pressure Trajectories.

Author

Guo, James W, Ning, Hongyan, Allen, Norrina B, Reges, Orna, Gabriel, Kelley Pettee, and Lloyd-Jones, Donald M

Subjects
DIASTOLIC blood pressure, SYSTOLIC blood pressure, YOUNG adults, BLOOD pressure, MIDDLE age
Abstract

BACKGROUND Cardiovascular health (CVH) in young adulthood (YA) has been associated with cardiovascular outcomes in older age. However, little is known about the relationship between YA CVH and mid-life blood pressure (BP) trajectories. METHODS Baseline CVH (defined by 7 of the American Heart Association's [AHA] Life's Essential 8 [LE8] metrics, excluding BP) was measured in YA with individual metrics scored and averaged as a composite LE8 score. Categorical CVH status was defined as high, moderate, and low. Latent class analysis was used to identify trajectories of mid-BP (mean of systolic blood pressure [SBP] and diastolic blood pressure [DBP]) from average ages 35 to 55 years. Multinomial logistic regression was used to estimate the association of YA CVH status (continuously and categorically) with mid-life BP trajectory group membership. RESULTS There were 3,688 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study in YA with follow-up data for mid-life BP trajectories. We observed 3 BP trajectory groups, labeled as Persistently-Low, Middle, and High-Increasing. On average, each 10-points higher baseline LE8 score (mean [SD] of 73.5 [13.1]) in YA was associated with adjusted odds ratios of 0.78 (95% CI, 0.72–0.84) for membership in the Middle and 0.65 (0.57–0.73) for membership in the High-Increasing trajectory groups. Compared with categorical low CVH status at baseline, those with high CVH were significantly less likely to be in the Middle and High-Increasing BP trajectory groups. CONCLUSIONS Moderate or low CVH status in YA is associated with elevated mid-life BP trajectory. These data suggest that young adult CVH promotion may be important for the primordial prevention of hypertension. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Indices of Childhood Socioeconomic Status and Dysanapsis among Older Adults: The Multi-Ethnic Study of Atherosclerosis Lung Study.

Author

Lovinsky-Desir, Stephanie, Hirsch, Jana A., Hoffman, Eric A., Allen, Norrina B., Bertoni, Alain G., Guo, Junfeng, Jacobs Jr., David R., Laine, Andrew F., Malinsky, Daniel, Michos, Erin D., Sack, Coralynn, Shen, Wei, Watson, Karol E., Wysoczanski, Artur, Barr, R. Graham, and Smith, Benjamin M.

Subjects
ETHNICITY, OLDER people, SOCIOECONOMIC status, LUNGS, GENETIC risk score, SOCIAL status
Abstract

The article presents a study which hypothesized that lower childhood socioeconomic status (SES), assessed by lower parental educational attainment, would be associated with smaller adult airway tree caliber relative to lung volume. Topics discussed include characteristics of multi-ethnic study of atherosclerosis lung study participants stratified by highest educational degree obtained by both parents, ways lower childhood SES are assessed, and findings of the study.

Published
2024
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47. User Testing with Microinteractions: Enhancing a Next Generation Repository

Author

Gonzales, Sara, Carson, Matthew B., Viger, Guillaume, OKeefe, Lisa, Allen, Norrina B., Ferrie, Joseph P., and Holmes, Kristi

Subjects
United States. National Institutes of Health, University and college libraries -- Research, Medical colleges -- Research, Business, Library and information science
Abstract

Enabling and supporting discoverability of research outputs and datasets are key functions of university and academic health center institutional repositories. Yet adoption rates among potential repository users are hampered by a number of factors, prominent among which are difficulties with basic usability. In their efforts to implement a local instance of InvenioRDM, a turnkey next generation repository, team members at Northwestern University's Galter Health Sciences Library & Learning Center supplemented agile development principles and methods and a user experience design-centered approach with observations of users' microinteractions (interactions with each part of the software's interface that requires human intervention). Microinteractions were observed through user testing sessions conducted in Fall 2019. The result has been a more user-informed development effort incorporating the experiences and viewpoints of a multidisciplinary team of researchers spanning multiple departments of a highly ranked research university., INTRODUCTION Galter Health Sciences Library & Learning Center facilitates and supports the discoverability of knowledge for the faculty, students, and staff of the Feinberg School of Medicine at Northwestern University. [...]

Published
2021
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50. Peripheral Blood Mononuclear Cell Gene Expression Associated with Pulmonary Microvascular Perfusion: The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease.

Author

Buschur, Kristina L., Pottinger, Tess D., Vogel-Claussen, Jens, Powell, Charles A., Aguet, Francois, Allen, Norrina B., Ardlie, Kristin, Bluemke, David A., Durda, Peter, Hermann, Emilia A., Hoffman, Eric A., Lima, João A.C., Liu, Yongmei, Malinsky, Daniel, Manichaikul, Ani, Motahari, Amin, Post, Wendy S., Prince, Martin R., Rich, Stephen S., and Rotter, Jerome I.

Subjects
MONONUCLEAR leukocytes, CHRONIC obstructive pulmonary disease, CONTRAST-enhanced magnetic resonance imaging, GENE expression, PERFUSION, MAGNETIC resonance imaging, CHEMOKINE receptors
Abstract

Rationale: Chronic obstructive pulmonary disease (COPD) and emphysema are associated with endothelial damage and altered pulmonary microvascular perfusion. The molecular mechanisms underlying these changes are poorly understood in patients, in part because of the inaccessibility of the pulmonary vasculature. Peripheral blood mononuclear cells (PBMCs) interact with the pulmonary endothelium. Objectives: To test the association between gene expression in PBMCs and pulmonary microvascular perfusion in COPD. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study recruited two independent samples of COPD cases and controls with ⩾10 pack-years of smoking history. In both samples, pulmonary microvascular blood flow, pulmonary microvascular blood volume, and mean transit time were assessed on contrast-enhanced magnetic resonance imaging, and PBMC gene expression was assessed by microarray. Additional replication was performed in a third sample with pulmonary microvascular blood volume measures on contrast-enhanced dual-energy computed tomography. Differential expression analyses were adjusted for age, gender, race/ethnicity, educational attainment, height, weight, smoking status, and pack-years of smoking. Results: The 79 participants in the discovery sample had a mean age of 69 ± 6 years, 44% were female, 25% were non-White, 34% were current smokers, and 66% had COPD. There were large PBMC gene expression signatures associated with pulmonary microvascular perfusion traits, with several replicated in the replication sets with magnetic resonance imaging (n = 47) or dual-energy contrast-enhanced computed tomography (n = 157) measures. Many of the identified genes are involved in inflammatory processes, including nuclear factor-κB and chemokine signaling pathways. Conclusions: PBMC gene expression in nuclear factor-κB, inflammatory, and chemokine signaling pathways was associated with pulmonary microvascular perfusion in COPD, potentially offering new targetable candidates for novel therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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