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Non-small cell lung cancer (NSCLC) is a leading cause of morbidity and mortality. Carboplatin and cisplatin based regimens are used in the treatment of NSCLC. The aim of the study was to find out whether there is a difference in white matter (WM) changes between two platinum-based chemotherapy agents using diffusion tensor imaging (DTI).

We aimed to investigate whether there is a difference between intrahepatic cholangiocarcinoma (IHCC) and liver metastases of gastrointestinal system (GIS) adenocarcinoma in terms of apparent diffusion coefficient (ADC) values.

Chaotic meta-Fibonacci sequences which are generated by intriguing examples of nonlinear recurrences still keep their mystery although substantial progress has been made in terms of well-behaved solutions of nested recurrences. In this study, a recent generalization of Hofstadter’s famous Q-sequence is studied beyond the known methods of generational approaches in order to propose a generalized conjecture regarding the existence of infinitely many different solutions for all corresponding recurrences of this generalization.

Aim: In this study, we aimed to evaluate the preoperative and postoperative clinical findings of the patients who underwent surgical treatment due to proximal femoral fracture and demographic characteristics of orthopedically traumatic inpatients in our clinic.Patients and Method: This study includes all the patients who hospitalized in our clinic between the dates of 01 January and 31 December 2014. In our retrospective, cross-sectional and descriptive study; the records of the patients were checked, and demographic and clinical data were evaluated.Results: A total of 3793 patients underwent surgical treatment. Of the patients who underwent surgery, 283 were operated on due to the fracture of the proximal region of the femur. The patients mean age was 55.77 ± 29.98 years. When we investigated by age group, 94 (33.2%) patients were under 40 years old while 36 (12.7%) patients aged 40-60 years and 153 (54.1%) patients aged 60 years and over. 49.8% (141) of the patients were male; 50.2% (142) were female. 36,7% (104) of the patients had various additional diseases. While 91.2% (258) of the patients who were with a clinic fracture were treated and discharged with healing, 1.8% (5) deaths were observed. 7.1% (20) of patients were transferred to intensive care. Compared by age, in older age group ASA it is seen that scores, comorbidities, and hospitalization time increase as well as the necessity of intensive care unit. Conclusion: As preoperative preparations takes longer and due to the higher level of the need for intensive care in postoperative period along with frequent comorbidities for aged patients It will be appropriate to follow these aged patients as multidisciplinary

Abstract Triple negative breast cancer (TNBC) subtype is characterized with higher EMT/stemness properties and immune suppressive tumor microenvironment (TME). Women with advanced TNBC exhibit aggressive disease and have limited treatment options. Although immune suppressive TME is implicated in driving aggressive properties of basal/TNBC subtype and therapy resistance, effectively targeting it remains a challenge. Minnelide, a prodrug of triptolide currently being tested in clinical trials, has shown anti-tumorigenic activity in multiple malignancies via targeting super enhancers, Myc and anti-apoptotic pathways such as HSP70. Distinct super-enhancer landscape drives cancer stem cells (CSC) in TNBC subtype while inducing immune suppressive TME. We show that Minnelide selectively targets CSCs in human and murine TNBC cell lines compared to cell lines of luminal subtype by targeting Myc and HSP70. Minnelide in combination with cyclophosphamide significantly reduces the tumor growth and eliminates metastasis by reprogramming the tumor microenvironment and enhancing cytotoxic T cell infiltration in 4T1 tumor-bearing mice. Resection of residual tumors following the combination treatment leads to complete eradication of disseminated tumor cells as all mice are free of local and distant recurrences. All control mice showed recurrences within 3 weeks of post-resection while single Minnelide treatment delayed recurrence and one mouse was free of tumor. We provide evidence that Minnelide targets tumor intrinsic pathways and reprograms the immune suppressive microenvironment. Our studies also suggest that Minnelide in combination with cyclophosphamide may lead to durable responses in patients with basal/TNBC subtype warranting its clinical investigation.

Estimation is an essential competence with a developmental role in the learning of various mathematical topics. Yet, as previous studies highlight, this competence is either excluded or ambivalently included in intended curricula around the world. The current study investigates the estimation-related opportunities in the primary curricula of three Eastern Mediterranean countries (Cyprus, Greece, and Turkey). Our analyses are framed by four forms of estimation (computational, measurement, quantity, number line). As with previous studies in other contexts, computational estimation and measurement estimation are extensively addressed in the curricula of Cyprus and Turkey, yet without any meaningful justification for their inclusion. All three curricula fail to recognise the importance of number line estimation and quantity estimation, the two forms with the most significant developmental implications for the later learning of other mathematical concepts and areas of mathematics. Among the three curricula under scrutiny, the Greek is the one with the fewest and most superficial references to estimation. In closing, we discuss the implications of this study and suggestions for future research.

Teacher quality has attracted much attention both conceptually and empirically, especially in tackling some global challenges. Initial teacher education (ITE) has historically been one of the key actors in developing teacher quality and one of the foci in research. The article contributes to these debates by comparing two ITE programmes, from Scotland and Turkey, which have been recently reshaped. Both countries have currently declared new reformative steps and introduced internationally cared new conceptions into teacher quality. This study utilized a comparative approach and document analysis to investigate the evolution of views on teacher quality in different countries. The findings provide insights into the changes that have occurred in each country's perspective over time. Drawing from the two contexts, the paper sought evidence in articulated reports for core values and capacities, digital transformation, teacher agency, and innovative and inclusive pedagogies, which are considered important elements of the teaching profession in related literature. Followingly, the study outlines and compares the decisions and intended actions of these two contexts in terms of similarities and discrepancies under the aforementioned four indicators that can be both an example for international ITE programmes and a road map for teacher quality in ITE curricula design. By comparing two examples of ITE programmes with the suggested indicators of teacher quality, we would like to extract insights to reconsider and re-conceptualize teacher quality in much wider literature and future research.

Although the impacts of math anxiety, attitude toward math, and math self-efficacy on math achievement have been well-defined in the relevant literature, the interrelations among these predictors to explain math achievement are understudied. This study examined the structural relationships among math achievement, math anxiety, math self-efficacy, and attitude toward math. Within this scope, a full mediation model involving math anxiety as the mediator in the relationship of math achievement with attitude toward math and math self-efficacy was proposed. Data collected from 470 middle school students were used for the analyses. Structural equation modeling and bootstrapping methods were used to investigate the proposed relationships. Moreover, various alternative models were tested to see whether the proposed model was empirically the best model to explain math achievement. The findings showed that the proposed model fit the data well and was superior to alternative models. Accordingly, attitude toward math and math self-efficacy had significant and positive indirect effects on math achievement as mediated by math anxiety. In conclusion, the study provided a meaningful model based on a strong theoretical and empirical background to explain math achievement.

With this quantitative study we aimed to develop a scale that could be used to assess the attitudes of special education needs (SEN) teachers towards students with multiple disabilities. The scale was tested in 2 stages using 2 different samples. Firstly, the scale was administered to a convenience sample of 215 teachers. For the first study, the participants responded to 39 items related to the scale and 9 demographic questions. This sample was used to perform an exploratory factor analysis (EFA), which showed that the proposed scale had 5 factors and 22 items. A revised scale was applied to 228 participants. The sample was used to complete a confirmatory factor analysis to test the fit of the data to the theoretical structure. The scale's internal consistency was found to have a Cronbach [alpha] of 0.869. With this scale it will be possible to measure special education teachers' attitudes towards students with multiple disabilities.

Abstract Background and Aim Vaccination programs become increasingly crucial during migratory movements driven by conflict and other disruptions. This study aims to determine the prevalence of childhood vaccination hesitancy among Syrian parents under temporary protection and identify areas for targeted interventions. Method A total of 227 Syrian parents attending three Immigrant Health Centers in Sultangazi were assessed using the Arabic version of the Parent Attitude about Childhood Vaccines (PACV) survey, conducted between October and December 2023. Results The prevalence of vaccine hesitancy among these parents was found to be 10.6%. An inverse correlation was observed between maternal education level and vaccine hesitancy, indicating that higher education levels were associated with lower levels of hesitancy. Conclusion The observed rate of vaccine hesitancy among Syrian parents under temporary protection underscores the urgent need for targeted interventions. Tailored vaccination strategies for immigrant populations are essential to improve immunization rates and ensure the health and well-being of these communities.