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Qualitat de vida relacionada amb la salut; Olaparib; Càncer de pàncrees Calidad de vida relacionada con la salud; Olaparib, Cáncer de páncreas Health-related quality of life; Olaparib; Pancreatic cancer Background Patients with metastatic pancreatic cancer often have a detriment in health-related quality of life (HRQoL). In the randomized, double-blind, phase III POLO trial progression-free survival was significantly longer with maintenance olaparib, a poly(ADP-ribose) polymerase inhibitor, than placebo in patients with a germline BRCA1 and/or BRCA2 mutation (gBRCAm) and metastatic pancreatic cancer whose disease had not progressed during first-line platinum-based chemotherapy. The prespecified HRQoL evaluation is reported here. Patients and methods Patients were randomized to receive maintenance olaparib (300 mg b.i.d.; tablets) or placebo. HRQoL was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30-item module at baseline, every 4 weeks until disease progression, at discontinuation, and 30 days after last dose. Scores ranged from 0 to 100; a ≥10-point change or difference between arms was considered clinically meaningful. Adjusted mean change from baseline was analysed using a mixed model for repeated measures. Time to sustained clinically meaningful deterioration (TSCMD) was analysed using a log-rank test. Results Of 154 randomized patients, 89 of 92 olaparib-arm and 58 of 62 placebo-arm patients were included in HRQoL analyses. The adjusted mean change in Global Health Status (GHS) score from baseline was

Electroless nickel-based depositions have been considered as one of the industrially effective methods because of their deposition uniformity, good corrosion properties, high wear resistance and good electrical properties. In this study, Ni-P-W-CNF composite depositions were performed by electroless method on an aluminum substrate from an acidic hypophosphite at different sodium tungstate and CNFs contents. The main aim of this study was to deposit Ni-P-W-CNF composites and characterization of their morphology, tribological and corrosion behaviors. The Ni-P-W-CNF composite depositions were characterized using Scanning Electron Microscopy, X-Ray Diffraction analysis and Raman spectroscopy. The tribological behaviors of the Ni-P-W-CNF composite depositions were evaluated with reciprocating ball-on-disk test in dry conditions. The corrosion resistance behavior of the Ni-P-W-CNF composite depositions carried out by means of Tafel Polarization methods in 3.5% NaCl solution. The effects of CNFs and tungsten on the tribological and corrosion behaviors of the composite depositions were discussed. It was found that the best wear and corrosion resistance has been obtained Ni-P-W-CNF electroless co-deposition containing 100 g/L Na2WO4 and 0.2 g/L CNFs in the deposition bath.

An ether based electrolyte containing TEGDME/LiPF6 was optimized, which possessed low viscosity and high ionic conductivity, under dry argon atmosphere in a glove box. In order to prevent air breathing cathode clogging by lithium oxide and provide stability of Li metal anode, different types in varying quantities of polymeric additives such as PEO and PVDF were added into TEGDME/LiPF6. These additives are thought to promote the dissolution of lithium peroxide precipitates formed in course of discharge process and protect the anode. Graphene/alpha-MnO2 nanocomposite air breathing structure coated on nickel mesh was used as cathode. A lithium disk was used as anode while glass fiber was used as the separator in ECC-Air test cells. The cells were cyclically tested using 0.1 mA/cm(2) current density over a voltage range of 2.15-4.25 V. Electrochemical impedance spectroscopy (EIS) measurements was applied to investigate the effect of the polymeric additives on the resistivity of the electrolyte. Results revealed that polymer contained electrolyte structures with PVDF addition provided not only good discharge capacity but also excellent stability. After the electrochemical cycling test, the morphologies of the cathodes were analyzed using scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis, and Raman spectroscopy to determine the reaction products. Copyright (C) 2015, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.

The main objective of this work has been the deposition of hybrid silver/WC/Graphene nanocomposites and characterization of their tribological behaviors. Graphene as a conductive solid lubricant additive was introduced into Ag matrix from the electrolytes in which submicron WC particles and Graphene nanosheets were suspended. The main purpose for two different reinforcements is to improve both wear and friction properties. The friction and wear behaviors of Ag/WC/Graphene coatings on the metal substrates against M50 steel ball were tested under dry sliding wear conditions. Comprehensive characterizations were performed using Scanning Electron Microscopy, X-Ray Diffraction analysis, Raman spectroscopy and 3D profilometry facilities. Tribological test results have revealed that even small amounts of Graphene addition are able to drastically improve the antifriction and antiwear properties of hybrid nano Ag matrix composites. A possible explanation for these results is that the co-deposition of Graphene not only provides an enhanced effect for nanocomposites to produce better wear resistance, but also forms a local protective layer on the contact surfaces to reduce the friction. The investigation shown that hybrid reinforcements of sub-micron WC and Graphene hold great potential applications as effective load bearing and solid lubrication for Ag matrix composites and possibly for similar alloys. (C) 2015 Elsevier B.V. All rights reserved.

Three-dimensional Sn rich Cu6Sn5 electrodes were fabricated by the pulse electrodeposition process on a porous nickel foam substrate to improve discharge capacity and cycle ability of the Sn-Cu alloy negative electrodes for Li-ion batteries. It was aimed to investigate the effect of peak current density on the structure and electrochemical performance of the Sn rich Cu6Sn5 electrodes. The morphology and the structures of the Sn-Cu alloy electrodes were characterized by scanning electron microscopy (SEM). X-ray diffraction (XRD) analyses was also performed to investigate the structure of electro-deposited Sn-Cu based electrodes. The electrochemical features of the electrodes were investigated by charge/discharge tests, cyclic voltammetry experiments and the ac impedance technique. Results showed that morphology of the electrodes exhibited a strong effect on the electrochemical performances and the best electrochemical performances were achieved in the alloy electrodes, which has dendritic like structure obtained using high peak current density. (C) 2016 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.

In spite of its excellent discharge capacity, low conductivity and poor cycling stability prevent to commercialize silicon negative electrodes for the Lithium ion batteries (LIBs). Since graphene has large surface area, high electrical conductivity and discharge capacity, silicon/graphene nanocomposite anodes in proper architectures alleviate difficulties to improve electrochemical performances of the LIBs. This article demonstrates the nanocomposite synthesizing with 10 wt.%, 30 wt.% and 50 wt.% graphene oxide (GO) dispersion in the silicon matrix following reduction of GO (rGO) result in remarkable improvements in the discharge capacity, cycle stability and rate capability. Mechanical milling after GO reduction provides decoration of silicon nanoparticles between the rGO sheets and improves interfacial bonding between silicon and rGO which alleviates huge volume increase during cycling. Among the nanocomposite negative electrodes, 50 wt.% rGO exhibits highest reversible capacity of about 2000 mAh g(-1) after 100 cycles and good coulombic efficiency approximately 99%. This study proves that dispersion of silicon with rGO and the increase content of rGO lead to improve ionic conductivity, cycling stability, reversibility and rate capability of the Lithium ion cell. Because of the easy scaling-up possibility of the method Si/rGO hybrid nanocomposites can be new electrodes for electrochemical energy storage. (C) 2016 Elsevier Ltd. All rights reserved.

Aluminum–nickel/multiwall carbon nanotubes (Al–Ni/MWCNTs) composites have been prepared and tested as a new type of anode material. First, core–shell aluminum–nickel composite particles were fabricated using an electroless deposition of nickel onto the aluminum. Then, Al–Ni/MWCNTs composites were prepared by combining different amounts of MWCNTs (10, 20, 40 wt%) using a planetary ball milling method. The morphologies and structures of the produced Al–Ni/MWCNTs composite powders were characterized using scanning electron microscopy, and energy dispersive spectroscopy was used to understand the elemental surface composition of composites. X-ray diffraction analysis was performed to investigate the structure of the Al–Ni/MWCNTs composite powders. To investigate the electrochemical performance of Al–Ni/MWCNTs composite electrodes, charge/discharge tests and cyclic voltammetry were performed using the produced cells. The amount of MWCNTs was shown to be critical to improving the Al–Ni/MWCNTs composite anodes with respect to cyclability and stability.

Since the EMITFSI/LiTFSI electrolyte possess low viscosity, high ionic conductivity and thermal stability properties, in this study, 1M 1-ethyl-3-methyl-imidazoliumbis (trifluoromethanesulfonyl) imide (EMITFSI)/Lithium bis (trifluoromethanesulfonyl) imide (LiTFSI) based electrolytes were studied for Li-air battery cells. A series of electrolytes was studied with organic compound additions of Poly(ethylene oxide) (PEO) and polyvinylidene fluoride (PVDF). Nano Al2O3 particles with 50 nm in size were also used in 1.0 wt% as inorganic additive to provide stability of the polymer added electrolytes. The nanocomposite electrolytes were prepared in a glove box under dry argon atmosphere. Porous electrode, Gas Diffusion Layer (GDL), was used as cathode, a lithium disk was used as anode while glass fiber was used as the separator in ECC-air test cell. The cells were cyclically tested using 0.1 mA/cm2 current density over a voltage range of 1.5---4.5 V. Electrochemical impedance spectroscopy measurements was applied to investigate the effect of the PVDF/Al2O3 and PEO/Al2O3 nano additives on the resistivity of the electrolyte. After the electrochemical cycling test, the morphologies of the cathodes (GDL) were analyzed using scanning electron microscopy, X-ray diffraction analysis to determine reaction products and lithium compounds during cycling test.

In this study, Sn was electrodeposited onto the porous nickel foam substrate under pulse electrodeposition conditions. Pulse electrodeposition was carried out at three different peak current densities of 10, 20 and 40 mA/cm(2) for 5 min in a pyrophosphate bath containing 40 g/L SnCl2 center dot 2H(2)O,164 g/L K4P2O7 and 19 g/L Glycin. Surface morphology of Sn-Ni foam electrodes were characterized by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) to understand the elemental surface composition of composites. X-ray diffraction (XRD) analysis was carried out to investigate the crystal structure of Sn-Ni foam electrode. The electrochemical performances of electrodes were investigated by charge/discharge tests, cyclic voltammetry experiments and the ac impedance technique. The results yielded encouraging discharge capacities since Ni foam behaves as a stress buffering layer as well as an electronic conductivity component. (C) 2016 Elsevier B.V. All rights reserved.

Several reported problems of commercial LiCoO2 electrode materials such as high cost, toxicity, limited rate capability and safety concerns are still remain to be problematic to develop the lithium ion consumer electronics such as mobile phones, tablets and notebook computers. In this study, an alternative nanocomposite electrode material based on LiCr0.2V0.2Mn0.6O2 and copper coated one were produced via a facile sol-gel method and electroless Cu deposition techniques. The resulting samples were characterized by X-ray diffraction (Rigaku DMax 2200 diffractometer) using a monochromatized Cu-Ka source (lambda =1.5406 angstrom) and 2 theta scan range from 10 degrees to 80 degrees with a speed of 1 degrees min(-1). The scanning electron microscope (SEM) was used in order to characterize the morphology of the active materials. The as-synthesized Cu/LiCr0.2V0.2Mn0.6O2 composite cathode exhibits a stable capacity on cycling and good rate capability after 50 cycles and total capacity retention of 93% is obtained. The unique 2D structure of the composite cathode material, its good electrochemical performances and its relatively low cost comparing to LiCoO2, make this material very promising for applications.

The effects of two different reinforcements of WC and graphene on the structural and tribological properties of copper matrix were investigated. Cu/WC, Cu/graphene and hybrid Cu/WC/graphene nanocomposites were co-deposited by electrophoretic deposition to improve both electrical and tribological behaviors. The friction and wear behaviors of WC and graphene reinforced nanocomposites were investigated against Al2O3 ball under dry sliding wear conditions. Comprehensive characterizations were performed using scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), Raman spectroscopy and 3D profilometry facilities. Tribological test results revealed that small amount of graphene addition was able to drastically improve the antifriction and antiwear properties of hybrid Cu matrix nanocomposites because of its excellent solid lubrication effect. Tribological analysis was shown that hybrid nanocomposite with sub-micrometer WC and graphene reinforcements provided good load-bearing and tribological properties for possible future MEM applications. Wear mechanism investigation has shown that co-deposition of WC and graphene resulted in altering wear mechanisms of the Cu matrix. (C) 2015 Elsevier B.V. All rights reserved.

ALGUL, Hasan/0000-0002-4348-8865 WOS: 000348448400010 Nickel-TiO2 composite coatings were prepared under pulse current conditions by co-deposition of TiO2 particles and nickel from a Watts type bath. The effect of TiO2 particle concentration was studied on microhardness, friction coefficient and wear resistance. The morphological features and the structures were studied by scanning electron microscope, X-ray diffraction analysis and 3D profilometry facilities. A wide particle size range (between 95 and 140 nm) was chosen to provide a high dispersion and load bearing ability for the co-deposited layers. It was determined that increasing the particle concentration in the electrolyte dramatically increased the co-deposited TiO2 particles in the coating. The results showed that the high concentration of TiO2 particles in the electrolyte yielded the highest amount of particles co-deposited in the plating layer. The influence of the co-deposited TiO2 volume on microstructure and tribological properties in the coating were investigated. The wear tests were carried out using a constant load by a reciprocating ball-on disk configuration. Wear loss and friction coefficients of Ni/TiO2 composites were decreased by increasing TiO2 content in the electrolyte because of the increasing content of TiO2 in the deposited layer. The change in wear mechanisms by changing TiO2 content was also determined.