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Society 5.0 aims to promote quality of life and well-being of citizens, reducing inequalities and promoting sustainability with the support of technologies 4.0. Therefore, redesigning value chains to bring social, economic, and environmental gains becomes of particular interest in alignment with a new model of a people-centric super-smart society. This paper aimed to outline a conceptual design of urban agriculture (UA) 5.0 by applying a three-phase methodology supported by data triangulation. A relationship between Industry 4.0, food system, and sustainable society was identified, encompassing many points of convergence between UA and Industry 4.0 (35) as well as Society 5.0 (43). As a result, this paper proposed UA 5.0 as a multifaceted concept that brings a new paradigm for systemic agriculture integrated in cities, considering six key dimensions for its development (spatial, social, technological, economic, sustainability, and systems integration). This exploratory study contributes to in-depth discussions, and new strategies among policy makers for building a more resilient urban food system as an embedded solution in smart cities. The results discussed also outline a basis for developing super smart food system industries by exploring each of the dimensions proposed in this paper.

Due to the highly dynamic and competitive environment, organizations are led to rethink their processes and strategies. In the industrial field, Lean Manufacturing (LM) is widely recognized as a traditional approach to eliminate waste in the value stream and ensure the efficiency of production processes. On the other hand, Industry 4.0 has recently emerged, incurring disruptive changes in manufacturing processes based on a technology-driven approach. The integration of these two philosophies to achieve organizational goals is interesting in order to guarantee competitiveness, especially for manu-facturing companies. This paper proposed an integration of LM tools and technologies 4.0, considering the perspectives of the industrial field in the digital era. Based on a three-step methodology, which included technological and industrial mapping, it was identified 25 synergy points. From interactions of LM tools mainly with Big Data Analytics, The Cloud, Virtual Simulation and Augmented Reality, multi-level circular diagrams pointed out the main contributions of Just in Time 4.0 (JIT 4.0), Kaizen 4.0, Kanban 4.0, Poka-Yoke 4.0, Value Stream Mapping 4.0 (VSM 4.0) and Total Productive Maintenance 4.0 (TPM 4.0). Also, five attributes of Lean 4.0 were identified, highlighting the integration between pro-cesses, devices and stakeholders; waste minimization; and autonomous, pointing to gains for the organization from this holistic integration approach.

In this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and PL 188, were studied with regard to the physicochemical aspects of sol-gel transition and pharmaceutical formulation issues such as dissolution-release profiles. In particular, we evaluated the cytotoxicity, genotoxicity, and in vivo pharmacological performance of PL 407 and PL 407-PL 188 hydrogels containing tramadol (TR) to analyze its potential treatment of acute pain. Drug-micelle interaction studies showed the formation of PL 407-PL 188 binary systems and the drug partitioning into the micelles. Characterization of the sol-gel transition phase showed an increase on enthalpy variation values that were induced by the presence of TR hydrochloride within the PL 407 or PL 407-PL 188 systems. Hydrogel dissolution occurred rapidly, with approximately 30%-45% of the gel dissolved, reaching ~80%-90% up to 24 hours. For in vitro release assays, formulations followed the diffusion Higuchi model and lower K(rel) values were observed for PL 407 (20%, K(rel) = 112.9 ± 10.6 μg · h(-1/2)) and its binary systems PL 407-PL 188 (25%-5% and 25%-10%, K(rel) =80.8 ± 6.1 and 103.4 ± 8.3 μg · h(-1/2), respectively) in relation to TR solution (K(rel) =417.9 ± 47.5 μg · h(-1/2), P<0.001). In addition, the reduced cytotoxicity (V79 fibroblasts and hepatocytes) and genotoxicity (V79 fibroblasts), as well as the prolonged analgesic effects (>72 hours) pointed to PL-based hydrogels as a potential treatment, by subcutaneous injection, for acute pain.