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Artificial intelligence (AI) is increasingly being used in the medical field, specifically for brain cancer imaging. In this review, we explore how AI-powered medical imaging can impact the diagnosis, prognosis, and treatment of brain cancer. We discuss various AI techniques, including deep learning and causality learning, and their relevance. Additionally, we examine current applications that provide practical solutions for detecting, classifying, segmenting, and registering brain tumors. Although challenges such as data quality, availability, interpretability, transparency, and ethics persist, we emphasise the enormous potential of intelligent applications in standardising procedures and enhancing personalised treatment, leading to improved patient outcomes. Innovative AI solutions have the power to revolutionise neuro-oncology by enhancing the quality of routine clinical practice. [ABSTRACT FROM AUTHOR]

This paper presents the potential for fractal analysis of time sequence contrast-enhanced (CE) computed tomography (CT) images to differentiate between aggressive and nonaggressive malignant lung tumors (i.e., high and low metabolic tumors). The aim is to enhance CT tumor staging prediction accuracy through identifying malignant aggressiveness of lung tumors. As branching of blood vessels can be considered a fractal process, the research examines vascularized tumor regions that exhibit strong fractal characteristics. The analysis is performed after injecting 15 patients with a contrast agent and transforming at least 11 time sequence CE CT images from each patient to the fractal dimension and determining corresponding lacunarity. The fractal texture features were averaged over the tumor region and quantitative classification showed up to 83.3 % accuracy in distinction between advanced (aggressive) and early-stage (nonaggressive) malignant tumors. Also, it showed strong correlation with corresponding lung tumor stage and standardized tumor uptake value of fluorodeoxyglucose as determined by positron emission tomography. These results indicate that fractal analysis of time sequence CE CT images of malignant lung tumors could provide additional information about likely tumor aggression that could potentially impact on clinical management decisions in choosing the appropriate treatment procedure. Index Terms--Fractal dimension (FD), lacunarity, texture analysis, tumor aggression.

An important aspect for an improved cardiac functional analysis is the accurate segmentation of the left ventricle (LV). A novel approach for fully-automated segmentation of the LV endocardium and epicardium contours is presented. This is mainly based on the natural physical characteristics of the LV shape structure. Both sides of the LV boundaries exhibit natural elliptical curvatures by having details on various scales, i.e. exhibiting fractal-like characteristics. The fractional Brownian motion (fBm), which is a non-stationary stochastic process, integrates well with the stochastic nature of ultrasound echoes. It has the advantage of representing a wide range of non-stationary signals and can quantify statistical local self-similarity throughout the time-sequence ultrasound images. The locally characterized boundaries of the fBm segmented LV were further iteratively refined using global information by means of second-order moments. The method is benchmarked using synthetic 3D+time echocardiographic sequences for normal and different ischemic cardiomyopathy, and results compared with state-of-the-art LV segmentation. Furthermore, the framework was validated against real data from canine cases with expert-defined segmentations and demonstrated improved accuracy. The fBm-based segmentation algorithm is fully automatic and has the potential to be used clinically together with 3D echocardiography for improved cardiovascular disease diagnosis. [ABSTRACT FROM AUTHOR]

The structural complexity of brain tumor tissue represents a major challenge for effective histopathological diagnosis. Tumor vasculature is known to be heterogeneous, and mixtures of patterns are usually present. Therefore, extracting key descriptive features for accurate quantification is not a straightforward task. Several steps are involved in the texture analysis process where tissue heterogeneity contributes to the variability of the results. One of the interesting aspects of the brain lies in its fractal nature. Many regions within the brain tissue yield similar statistical properties at different scales of magnification. Fractal-based analysis of the histological features of brain tumors can reveal the underlying complexity of tissue structure and angiostructure, also providing an indication of tissue abnormality development. It can further be used to quantify the chaotic signature of disease to distinguish between different temporal tumor stages and histopathological grades.Brain meningioma subtype classifications' improvement from histopathological images is the main focus of this chapter. Meningioma tissue texture exhibits a wide range of histological patterns whereby a single slide may show a combination of multiple patterns. Distinctive fractal patterns quantified in a multiresolution manner would be for better spatial relationship representation. Fractal features extracted from textural tissue patterns can be useful in characterizing meningioma tumors in terms of subtype classification, a challenging problem compared to histological grading, and furthermore can provide an objective measure for quantifying subtle features within subtypes that are hard to discriminate., (© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.)

Brain parenchyma microvasculature is set in disarray in the presence of tumors, and malignant brain tumors are among the most vascularized neoplasms in humans. As microvessels can be easily identified in histologic specimens, quantification of microvascularity can be used alone or in combination with other histological features to increase the understanding of the dynamic behavior, diagnosis, and prognosis of brain tumors. Different brain tumors, and even subtypes of the same tumor, show specific microvascular patterns, as a kind of "microvascular fingerprint," which is particular to each histotype. Reliable morphometric parameters are required for the qualitative and quantitative characterization of the neoplastic angioarchitecture, although the lack of standardization of a technique able to quantify the microvascular patterns in an objective way has limited the "morphometric approach" in neuro-oncology.In this chapter, we focus on the importance of computational-based morphometrics, for the objective description of tumoral microvascular fingerprinting. By also introducing the concept of "angio-space," which is the tumoral space occupied by the microvessels, we here present fractal analysis as the most reliable computational tool able to offer objective parameters for the description of the microvascular networks.The spectrum of different angioarchitectural configurations can be quantified by means of Euclidean and fractal-based parameters in a multiparametric analysis, aimed to offer surrogate biomarkers of cancer. Such parameters are here described from the methodological point of view (i.e., feature extraction) as well as from the clinical perspective (i.e., relation to underlying physiology), in order to offer new computational parameters to the clinicians with the final goal of improving diagnostic and prognostic power of patients affected by brain tumors., (© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.)

The data presented in this article deals with the problem of brain tumor image translation across different modalities. The provided dataset represents unpaired brain magnetic resonance (MR) and computed tomography (CT) image data volumes of 20 patients. This includes 179 two-dimensional (2D) axial MR and CT images. The MR cases are acquired using Siemens Verio scanner, while the CT images with a Siemens Somatom scanner. The MR and CT tumor volumes were collected, diagnosed and annotated by experienced radiologists specialized in oncology and radiotherapy. The collected image volumes can be useful for researchers working in the field of artificial intelligence (AI) applications for brain tumor detection, classification and segmentation in MR and CT modalities. The provided tumor masks per each tumor volume can assist data scientists with limited background in cancer imaging. Moreover, clinical interpretation is given per each tumor volume, which can assist in deep learning model training with multiple source data (non-imaging or textual data) as well. The provided dataset can facilitate for annotation-efficient lesion segmentation using bidirectional MR-CT cross-modality image translation., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships which have, or could be perceived to have, influenced the work reported in this article., (© 2022 The Author(s).)