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Indonesia is currently struggling with stunting, wasting, obesity, and micronutrient deficiencies. Nutritional imbalance, which varies by gender, age, and activity level, contributes to these issues. This research developed a food detector with an innovative camera sensor to accurately measure food calories. The study adopted a developmental approach, using a pre-experimental design and “post-test only” research. The study included various food ingredients with calorie counts. Camera sensors were used instead of load cell sensors to weigh food and convert it to calories. Camera sensory testing was done on processed food samples. A number of food image data tests showed high accuracy. With test results close to real data, the device showed promising accuracy. This model system used camera resolution to detect calories, helping people measure and manage their diets in quality and quantity. We hope this technology will continue to improve, making it more accessible and aiding nutritional management.

The EGFR-C797S resistance mutation to third-generation drugs has been overcome by fourth-generation inhibitors, allosteric inhibitors, namely EAI045 and has reached phase 3 clinical trials, so the Allosteric Site is currently an attractive target for development. In this study, researchers are interested in knowing the activity of metabolite compounds from marine natural ingredients Clathria Sp. against the Allosteric Site of EGFR computationally. The methods used include molecular docking using Autodock4 software and Molecular Dynamics simulation performed using GROMACS software. The research began with the preparation of metabolite samples from Clathria Sp. through the KnapSack database site and the preparation of EGFR receptors that have been complexed with allosteric inhibitors, namely proteins with PDB code 5D41. Each compound was docked to the Allosteric Site of the natural ligand and then molecular dynamics simulations were performed on the compound with the best docking energy compared to the natural ligand. From the docking results, the Clathrin_A compound showed the lowest binding energy compared to other metabolites, and the value was close to the natural ligand. Then from the molecular dynamics results, the clathrin_A compound shows good stability and resembles the natural ligand, which is analyzed through RMSD, RMSF, SASA, Rg, and PCA, and shows the binding free energy from MMPBSA analysis which is close to the natural ligand. It can be concluded, Clathrin_A compound has potential as an allosteric inhibitor.

Lifestyle changes have led to an increase in cases of non-communicable diseases in Indonesia, including hypertension and stroke. Unhealthy eating behavior, smoking habits, alcohol consumption, stress, and lack of physical activity are risk factors for degenerative diseases, besides the other risk factors such as age, gender, and heredity. This research aimed to determine the factor of obesity, smoking behavior, physical activity, and hypertension on the incidence of stroke in South Sulawesi Province. The method of research was analytic observational with a case-control approach. The case group was stroke patients as many as 750 cases and the control group was non-stroke patients as many as 750 cases. Data analysis using Path analysis. The results showed that there was a significant relationship between stroke and hypertension with a path coefficient value of 0.33, the relationship between physical activity and the incidence of stroke through hypertension with a path coefficient value of 0.13, obesity and the incidence of stroke through hypertension with a path coefficient value of 0, 21, there is a relationship between smoking and the incidence of stroke through hypertension with a path coefficient value of 0.08. Hypertension is a risk factor that directly affects the incidence of stroke compared to other risk factors. however, all of these risk factors can be reduced, especially by doing routine and regular physical activity every day.

Handling of nutritional problems of children under five can be done through the development of food products in the form of Moringa leaf flour cookies and Moringa seed flour cookies given to toddlers, and then assessed an increase in body weight and nutritional status. The purpose of the study was to look at differences in body weight and nutritional status after intervention from Moringa leaf flour cookies and Moringa seed flour cookies in toddlers. The study design uses a Randomized Controlled Trial Single Blind Pre-post Study. The study was conducted in the working area of the Tampa Padang Public Health Center in August-October 2019 on children aged 3-5 years. The number of samples was 50 people, 25 children have interfered with Moringa leaf flour cookies, and 25 children were intervened by Moringa seed flour. Analysis of nutrient consumption of toddler foods using the Nutri Survey program. Maternal nutrition consumption is expressed in percent of RDA. Statistical analysis using the T-test. The results showed changes in body weight before and after giving Moringa seed cookies and Moringa leaf cookies (p=0,025). There is a difference in the increase in weight of the two groups of samples, but statistically has not been able to improve the nutritional status, both those who were given Moringa seed flour substitute cookies and those who were given Moringa leaf flour substitution cookies (p=0,495). In conclusion, there is a change in toddler's body weight, but it is not yet significant to the nutritional status of toddlers. Penanganan masalah gizi anak balita dapat dilakukan melalui pengembangan produk pangan berupa cookies tepung daun kelor dan cookies tepung biji kelor yang diberikan kepada balita, selanjutnya dinilai peningkatan Berat Badan dan Status gizinya. Tujuan penelitian yaitu melihat perbedaan berat badan dan status gizi setelah diintervensi cookies tepung daun kelor dan cookies tepung biji kelor pada anak balita. Desain penelitian menggunakan Randomized Controlled Trial Single Blind Pre-post Study. Penelitian dilakukan di Wilayah Kerja Puskesmas Tampa Padang Kecamatan Kaluku, Kabupaten Mamuju Sulawesi Barat. Waktu penelitian dimulai pada bulan Agustus – Oktober 2019 terhadap anak balita berumur 3-5 tahun. Jumlah sampel 50 orang, 25 anak diintervensi cookies tepung daun kelor dan 25 anak diintervensi tepung biji kelor. Analisis zat gizi konsumsi pangan anak balita menggunakan program Nutri Survei. Konsumsi gizi ibu dinyatakan dalam persen AKG. Analisis statistik menggunakan uji T. Hasil penelitian menunjukkan perubahan berat badan sebelum dan setelah pemberian cookies biji kelor dan cookies daun kelor dengan nilai p=0,025 (p-value0,05). Kesimpulan, terdapat perubahan berat badan balita namun belum signifikan terhadap status gizi balita yang mendapatkan cookies berbahan daun kelor.