145 results on '"Abdulghani, M."'
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2. Effect of cigarette smoke extract and hypoxia on vasoactive gene expression and mediator release in human pulmonary artery smooth muscle and endothelial cells
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Alqarni, Abdullah Abdulghani M.
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WG Cardiocascular system - Abstract
Background: Pulmonary hypertension is a common and serious complication of COPD. Studies suggest that hypoxia and cigarette smoke (CS) can cause vascular remodelling in COPD as a result of cell proliferation; however, the underlying cause is not fully understood. In addition, it is suggested that the use of e-cig may lead to vascular diseases, but no data are available on what effect e-cig may have on dysfunction of pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells (PAECs). Thus, we hypothesise that cigarette smoke extract (CSE) and hypoxia can induce imbalanced vasoactive gene expression and mediator release, and then contribute to cell proliferation and apoptosis. Furthermore, e-cig vapour extract with and without nicotine (ECVE-/+n) may have similar effects as CSE. Methods: Western blotting and real-time RT-PCR were used to assess the protein and mRNA expression of vasoactive genes, respectively. ELISA was used to assess the prostanoids and endothelin production. Nitric oxide levels were assessed by nitrate/nitrite assay. WST-1 and CCK-8 assays were used to assess cell proliferation. Results: We found that CSE induced cyclooxygenase-2 (COX-2) and thromboxane synthase (TXAS) and reduced prostaglandin (PG) I synthase at mRNA levels in PASMCs and PAECs. CSE treatment reduced PGI synthase protein expression and PGI2 production in PASMCs (but not in PAECs). Interestingly, CSE had the ability to reduce and increase microsomal prostaglandin E synthase-1 (mPGES-1) protein expression/PGE2 production in PASMCs and PAECs, respectively. Despite the undetected TXAS protein expression, CSE increased thromboxane A2 (TXA2) production in both cell types, likely as a result of the increased COX-2 protein expression. Although hypoxia induced COX-2 mRNA expression in PASMCs (but in PAECs), it had no effect on the mRNA levels of PGIS and TXAS in both cell types. We also demonstrated that hypoxia induced TXA2, PGE2, and PGI2 production as a result of the upregulated TXAS and COX-2 and unchanged PGIS protein expression in PASMCs. Interestingly, hypoxia had no effect on the protein expression of TXAS and COX-2 and the production of PGI2 and PGE2 in PAECs, but it induced the production of TXA2. Both CSE and hypoxia had no effect on endothelial nitric oxide synthase (eNOS) mRNA expression, but reduced eNOS protein expression/nitric oxide production in PAECs. Although hypoxia failed to affect mRNA endothelin-1 levels and endothelin production in both cell types, CSE increased mRNA endothelin-1 levels and reduced endothelin production in PAECs (but not in PASMCs). Intriguingly, hypoxia did not enhance CSE-induced effects and ECVE+/-n had no similar effects as CSE. The results also showed CSE-induced proliferation of both cell types and hypoxia-induced proliferation of PASMCs were inhibited by the stable PGI2 analogue, selective COX-2 inhibitor and TXA2 receptor antagonist and nitric oxide donor (but not by mPGES-1 inhibitor and ET-A and ET-B receptor antagonist), whereas hypoxia-induced PAEC proliferation was only reduced by nitric oxide donor. Although hypoxia failed to cause apoptosis, CSE induced apoptosis only in PAECs and this was unlikely mediated by altered release of vasoactive mediators. Conclusion: Our results suggest that CSE (but not ECVE+/-n) and hypoxia to a lesser extent can induce imbalanced vasoactive gene expression and mediator release; however, it is unlikely that hypoxia can further amplify CSE-induced effects. The CSE- and hypoxia-induced imbalanced release of vasoactive mediators (particularly prostanoids (e.g. TXA2) and nitric oxide) may be critically involved in the contribution to vascular remodelling via the induction of cell proliferation. These data provide new insights into our understanding of CS- and hypoxia-induced vascular remodelling and may represent a potential therapeutic target for pulmonary hypertension in COPD.
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- 2020
3. A note of thanks
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Abdulghani, M. Ossama, Shehab, Mohammad S., Aref, Hany, Nassef, Ayman, Abdelalim, Ahmed M., Abdulghani, Khaled O., Badry, Reda, Kamel, Mona S., and Elsamman, Amr
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- 2022
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4. Examining obstacles to Saudi women's right to work in the Kingdom of Saudi Arabia
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Alharbi, Hani Abdulghani M., Sseyonjo, M., and Chigara, B.
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346.01 ,Saudi domestic law ,Religion and culture barriers ,Limited access to higher education ,Obligations to respect, protect and fulfil - Abstract
This thesis determines and examines the obstacles to Saudi women's right to work in terms of religious and cultural barriers and limited access to higher education through an analysis of Sharia sources, Saudi domestic law and international human rights treaties pertaining to Saudi women's right to work in the Kingdom of Saudi Arabia. It also delineates the provisions for women's right to work in Sharia and Saudi domestic law in the public and private sectors. The thesis also examines the reservations that the Kingdom of Saudi Arabia has entered into, and some of the international human rights treaties it has ratified, with a particular focus on the application of the Convention on the Elimination of All Forms of Discrimination against Women (CEDAW). It also examines Saudi Arabia's obligations under International Labour Organization (ILO) Conventions. In the context of Saudi domestic law, it identifies obstacles that underlie Saudi Arabia's decision not to ratify the International Covenant on Economic, Social and Cultural Rights (ICESCR); it examines the arguments for the Kingdom of Saudi Arabia signing up to the ICESCR; and it examines Saudi Arabia's obligations to respect, protect and fulfil women's right to work under CEDAW. The protection of women's right to work under customary international law, by its sources will be explored. This section will look through customary international law elements; whether or not women's right to work is protected. Finally, the thesis provides recommendations for action which can be taken by the Kingdom of Saudi Arabia to provide Saudi women with equal rights to work. It also makes recommendations concerning ratified and pending international human rights treaties which have the capacity to protect Saudi women's right to work.
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- 2018
5. Mitigating interference and reducing detection complexity in asynchronous cooperative relay network utilising new distributed space time block coding
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Abdulghani M. Elazreg and Ahmad H. Kharaz
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Telecommunication ,TK5101-6720 - Abstract
Abstract The synchronisation in wireless cooperative relay networks is impossible to achieve in real environment utilising orthogonal space time block coding. There have been several approaches proposed to mitigate the effect of synchronisation among the relay nodes at the receiver. All have managed to reduce the inter‐symbol interference at the expense of low data rate with high detection complexity. Others achieved full data rate and high cooperative diversity using high decoding complexity that requires a feedback link. In this paper, a new approach is presented that reduces inter‐symbol interference, achieves full data rate and full cooperative diversity with low complexity. This uses a new efficient distributed orthogonal space time block coding design with a sub‐optimum detection scheme utilising dual relay nodes. This reduces the number of timing misalignments among the relay nodes and minimises the detection complexity. Furthermore, the new proposed method uses linear decoding process to achieve full data rate and full cooperative diversity without the need for any a feedback link. The analytical analysis and simulation results confirmed that sub‐optimum approach with the new efficient design are very effective at reducing the lack of synchronisation among the relay nodes at the destination node with low encoding and decoding complexities.
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- 2021
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6. Frequency of peri-ictal apnea and cardiac arrhythmias in epileptic seizures
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Yousif, Rady, Abdulghani, M. Ossama, Gaber, A., El Khayat, Naglaa, Abo Elnaga, Y. A., and Wahid El Din, Mona Mokhtar
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- 2021
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7. Quantification of maxillary dental midline deviation in 2D photographs: Methodology trial
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Alarabi, Abdulghani M., Revie, Gavin F., and Bearn, David R.
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- 2019
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8. Performance Evaluation of Multi-Agent Reinforcement Learning Algorithms.
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Abdulghani, Abdulghani M., Abdulghani, Mokhles M., Walters, Wilbur L., and Abed, Khalid H.
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MACHINE learning ,MARL ,REINFORCEMENT learning ,DISTRIBUTED algorithms ,MULTIAGENT systems ,AUGMENTED reality ,ALGORITHMS - Abstract
Multi-Agent Reinforcement Learning (MARL) has proven to be successful in cooperative assignments. MARL is used to investigate how autonomous agents with the same interests can connect and act in one team. MARL cooperation scenarios are explored in recreational cooperative augmented reality environments, as well as realworld scenarios in robotics. In this paper, we explore the realm of MARL and its potential applications in cooperative assignments. Our focus is on developing a multi-agent system that can collaborate to attack or defend against enemies and achieve victory withminimal damage. To accomplish this, we utilize the StarCraftMulti-Agent Challenge (SMAC) environment and train four MARL algorithms: Q-learning with Mixtures of Experts (QMIX), Value-DecompositionNetwork (VDN), Multi-agent Proximal PolicyOptimizer (MAPPO), andMulti-Agent Actor Attention Critic (MAA2C). These algorithms allow multiple agents to cooperate in a specific scenario to achieve the targeted mission. Our results show that the QMIX algorithm outperforms the other three algorithms in the attacking scenario, while the VDN algorithm achieves the best results in the defending scenario. Specifically, the VDNalgorithmreaches the highest value of battlewonmean and the lowest value of dead alliesmean. Our research demonstrates the potential forMARL algorithms to be used in real-world applications, such as controllingmultiple robots to provide helpful services or coordinating teams of agents to accomplish tasks that would be impossible for a human to do. The SMACenvironment provides a unique opportunity to test and evaluateMARL algorithms in a challenging and dynamic environment, and our results show that these algorithms can be used to achieve victory with minimal damage. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Review on Solar Ponds in Libya (PAST EFFORTS, CURRENT CHALLENGES AND FUTURE PROSPECTS)
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Abdulghani M. Ramadan and Khairy R. Agha
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Evaporation Pond ,Salt Diffsion ,Solar Pond ,Thrmal Storage ,Renewable energy sources ,TJ807-830 - Abstract
Solar and renewable energies applications got a great interest and attention in the last few decades. Problems related to CO2 emissions, air pollution, Ozone layer depletion, global warming and environment issues raise the necessity for getting a clean and safe energy. For this purpose, the Center for Solar Energy Studies (CSERS) in Libya conducted a huge research work in different applications for solar and renewable energies. One of these important activities is the Solar Gradient Solar Pond technology. It is an effective solar energy collection and storage system which presents a relatively simple and economic method of providing low grade energy with the advantage of annual storage cycle. This paper presents a general review on researches and studies on solar ponds that were conducted by CSERS research team. Tajoura’s Experimental Solar Pond (TESP) is designed as an experimental facility enabling the investigation of various aspects of pond performance. It is constructed by the Center for Solar Energy Studies, in joint cooperation with a Swiss company, with a surface area of about 830 m2, and a depth of 2.5 m, coupled with an evaporative pond of 105 m2 area and 1.5 m deep, equipped with all necessary equipments and measuring control system. The paper also shows the experience of operating MSF desalination unit coupled with TESP solar pond. Finally, other factors affecting the solar pond’s thermal stability were also discussed.
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- 2018
10. Theoretical Study for a Solar Powered Desalination Unit using Humidification –Dehumidification Technique
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Abdulghani M. Ramadan and Mabrouk Algamil
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desalination ,humidification ,dehumidification ,GOR ,solar air heater ,fresh water ,HDH ,Renewable energy sources ,TJ807-830 - Abstract
A solar powered desalination unit which is working on a humidification –dehumidification technique (HDH) is one of the most important techniques used in seawater desalination in remote and rural areas. It is easy to design, operate and maintain. In this paper, a theoretical study based on a design methodology for a solar assisted desalination unit working on a HDH principle under the prevailing conditions of Tajoura-Libya is carried out. The main target is to study the effect of different design and operating parameters that influence the performance of the unit and its productivity under different design scenarios; (spring, summer, autumn and winter). Results show that the productivity of the unit is increased with a corresponding increase in the inlet air mass flow rate to the solar air heater, inlet water mass flow rate to the humidifier and cooling water mass flow rate to the dehumidifier. A significant increase in the productivity of the unit is achieved when the initial water temperature and the initial mass of water inside the storage tank were increased. Moreover, Gained Output Ratio, GOR, values vary between (0.27 and 0.79) for winter and spring designs and (1.94 and 2.75) for autumn and summer designs respectively. In general, the productivity of the unit is estimated to be within a range from a minimum of (2 ~ 4) kg/m2.day, in winter to a maximum of (10 ~ 12) kg/m2.day, in summer, which makes it very convenient for using in rural and remote areas.
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- 2017
11. Sleep pattern in epilepsy patients: a polysomnographic study
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Tork, Mohamed A., Rashed, Hebatallah R., Elnabil, Lobna, Salah-Eldin, Nahed, Elkhayat, Naglaa, Abdelhady, Ayman A., Abdulghani, M. Ossama, and Abdulghani, Khaled O.
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- 2020
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12. Burnout Syndrome among Emergency Physicians and Nurses in Abha and Khamis Mushait Cities, Aseer Region, Southwestern Saudi Arabia
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Abdulghani M. Alqahtani, Nabil J. Awadalla, Safar A. Alsaleem, Awad S. Alsamghan, and Mohammed Abadi Alsaleem
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Technology ,Medicine ,Science - Abstract
Objectives. To explore the magnitude and determinants of burnout among emergency physicians and nurses working at emergency departments of hospitals in Abha and Khamis Mushait cities. Subjects and Methods. A cross-sectional hospital-based study was conducted in emergency departments of hospitals in Abha and Khamis Mushait cities belonging to Ministry of Health. All physicians (n=95) and nurses (n=187) currently working at these sites were invited to participate in the study by filling a validated self-administered questionnaire including two main sections: personal and professional characteristics of physicians and nurses as well as Maslach burnout inventory (MBI) to assess the three components of the burnout syndrome: emotional exhaustion, depersonalization, and reduced personal accomplishment. Results. The study included 282 physicians and nurses. The age of more than half of them (54.3%) ranged between 31 and 35 years. Most of them (70.9%) were females. About two-thirds of the respondents (66.3%) were nurses while the remaining 33.7% were physicians. Majority of the emergency healthcare professionals (88.7%) had high emotional exhaustion. The prevalence of high depersonalization (cynicism) was 20.6% whereas that of low personal accomplishment was 41.1% among emergency healthcare professionals. The overall prevalence of burnout among healthcare professionals was 16.3%. Multivariate logistic regression analysis revealed that male healthcare professionals were at almost higher three-folded risk for developing burnout compared to females (aOR=2.76; 95% confidence interval (CI): 1.21-6.28, p=0.017)). Smokers were at higher significant risk for burnout compared to nonsmokers (aOR=15.37; 95% CI: 7.06-33.45, p
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- 2019
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13. Refractory epilepsy and obstructive sleep apnea: is there an association?
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Rashed, Hebatallah R., Tork, Mohamad A., El-Nabil, Lobna M., El-Khayat, Naglaa M., Ahmed, Nahed S., Abdelhady, Salem T., Abdulghani, Khaled O., and Abdulghani, M. Ossama
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- 2019
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14. Simulation Study of the Thermal Performance of MSF Desalination Unit Operating by Solar Vacuum Tube Collectors
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Mohammad .J.R. Abdunnabi and Abdulghani .M. Ramadan
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MSF desalination plant ,fresh water ,configuration optimisation ,simulation ,TRNSYS ,Renewable energy sources ,TJ807-830 - Abstract
The Center for Solar Energy Research and Studies (CSERS) has a good experience in operating and evaluating the thermal performance of small scale 5 m3/day Multi-Stage Flushing (MSF) desalination plant connected to solar pond according to the local weather conditions of Tajoura area. However, a new project has been suggested to run the desalination plant with vacuum tubes solar thermal collectors utilizing available technology and experience. In this study an attempt was made to make the best use of readily available components to operate the MSF desalination unit with field of solar thermal collectors. Several configurations of collectors and tank arrangements were designed and examined through the use of simulation software, TRNSYS. The study has shown that the layout-3 (two 500 litre storage tanks each of them connected to 9x5 vacuum tube collectors) gives the best performance with an annual solar fraction over 77% at load temperature of 70 °C with flow rate of 2500 lit/hr, and over 68% at load temperature of 80 °C for working condition of 8 hours daily. The study has also shown that running the desalination plant for 24 hours a day reduces the solar fraction of the solar collector field to 25%
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- 2015
15. Skin healing effects of an innovative polymer-based oil Nigella sativa: a rabbit model experimental study.
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BEN SALAH, G., JEBAHI, S., BESSALEH, S., AHMAD, M. A., KHIREDDINE, H., ABDULGHANI, M., and MEJRI, N.
- Abstract
OBJECTIVE: Natural wound dressings composed of gelatin (GEL) and chitosan (CH) impregnated with bioactive compounds (Nigella sativa oil) were prepared and characterized to evaluate their potential application. MATERIALS AND METHODS: The formulated composite was subjected to γ-irradiation. In vitro, the ferric-reducing antioxidant power (FRAP) assay and antibiofilm activities were evaluated. In vivo, the tissue wound-healing process was studied by applying GEL-CH-Nigella in dorsal skin rabbit tissue. On days 7 and 14, the biochemical biomarker and histological analysis were determined. RESULTS: At 10 kGy, FRAP assays exhibited the highest antioxidant activity (380 mmol/ kg). A significant inhibition of anti-biofilm activity was observed against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) (p<0.01). Fourteen days post-surgery, a significant reduction in thiobarbituric acid-reactive compounds (TBARs) was observed compared to the GELCH group. Concerning oxidative stress status, GEL-CH-Nigella significantly improved superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities. A histological analysis revealed that GEL-CH-Nigella accelerated wound closure and improved collagenisation and enhanced epidermal tissue thickness. CONCLUSIONS: These results indicate that GEL-CH-Nigella wound dressing is a promising biomaterial for engineered tissue. [ABSTRACT FROM AUTHOR]
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- 2023
16. Announcing the new launch of The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
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Abdulghani, M. Ossama, Abdelalim, Ahmed M., and Abdulghani, Khaled O.
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- 2018
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17. The Malaysia DREEM: perceptions of medical students about the learning environment in a medical school in Malaysia
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Al-Naggar RA, Abdulghani M, Osman MT, Al-Kubaisy W, Daher AM, Nor Aripin KN, Assabri A, Al-Hidabi DA, Ibrahim MIBM, Al-Rofaai A, Ibrahim HS, Al-Talib H, Al-Khateeb A, Othman GQ, Abdulaziz QA, Chinna K, and Bobryshev YV
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Special aspects of education ,LC8-6691 ,Medicine (General) ,R5-920 - Abstract
Redhwan A Al-Naggar,1 Mahfoudh Abdulghani,2,14 Muhamed T Osman,3 Waqar Al-Kubaisy,1 Aqil Mohammad Daher,15 Khairun Nain Bin Nor Aripin,4 Ali Assabri,5 Dawood A Al-Hidabi,6 Mohamed Izham B Mohamed Ibrahim,7 Ahmed Al-Rofaai,8 Hisham S Ibrahim,9 Hassanain Al-Talib,10 Alyaa Al-Khateeb,11 Gamil Qasem Othman,6 Qaid Ali Abdulaziz,6 Karuthan Chinna,12 Yuri V Bobryshev131Population Health and Preventive Medicine Department, Faculty of Medicine, Universiti Teknologi MARA, 2Pharmacology Department, International Medical School, Management and Science University, 3Department of Pathology, Faculty of Medicine & Defence Health, National Defence University of Malaysia, Kuala Lumpur, Malaysia, 4Faculty of Medicine and Health Sciences, Islamic Science University of Malaysia, Kuala Lumpur, Malaysia; 5Community Medicine Department, Faculty of Medicine and Health Science, Sana'a University, 6University of Science and Technology, Sana'a, Yemen; 7College of Pharmacy, Qatar University, Doha, Qatar; 8School of Biological Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia, 9Physiology Discipline-Faculty Of Medicine and Health Sciences-Universiti Sultan Zainal Abidin, Terengganu, Malaysia, 10Laboratory Medical Science Cluster, Drug Discovery & Health Community of Research, Faculty of Medicine, Universiti Teknologi MARA, 11Biochemistry and Molecular Medicine Discipline, Drug Discovery & Health Community of Research, Faculty of Medicine, Universiti Teknologi MARA, 12Social and Preventive Medicine, University Malaya, Kuala Lumpur, Malaysia; 13Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia; 14Pharmacology Department, Unaizah College of Pharmacy (UCP), Qassim University, Al Qassim, Saudi Arabia; 15Department of Community medicine, Faculty of Medicine & Defence Health, National Defence University of Malaysia, Kuala Lumpur, MalaysiaBackground: Students’ perceptions of their learning environment, by defining its strengths and weaknesses, are important for continuous improvement of the educational environments and curriculum. Therefore, the aim of this study was to explore students' perceptions of their learning environment, among medical students in Malaysia. Various aspects of the education environment were compared between year levels and sex.Methods: This cross-sectional study was conducted at the Management and Science University, Shah Alam, Malaysia in 2012. A total number of 438 medical students participated in this study, and the response rate was 87.6%. Data were analyzed using SPSS. Comparisons of the mean scores of Dundee Ready Education Environment Measure (DREEM) subscales were calculated. The t-test was used to determine statistically significant differences.Results: The majority of the study participants were female, Malay, and from year 3 (68.7%, 65.3%, and 55.7%; respectively). Analysis of each of the 50 items of the DREEM inventory showed that 47 items scored ranged between 2.00 and 3.00, and three items scored below 2.00. These were identified as problem areas in this medical school that are required to be critically addressed. The overall score showed that the medical students’ perceptions were positive. The students' perception toward educational environment was positive for all five DREEM subscales.Conclusion: The study found that, in general, the perceptions of the participants about the learning environment were positive. Nevertheless, the study also found there is a need for curriculum improvement in this school and identified priority areas for such improvement.Keywords: students’ perceptions, DREEM, Malaysia, learning environment, medical education
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- 2014
18. A Comparison between Evaporation Ponds and Evaporation Surfaces as a Source of the Concentrated Salt Brine for Salt Gradient Maintenance at Tajoura’s Solar Pond
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Abdulghani M. Ramadan, Khairy R. Agha, and Saleh M. Abughres
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Solar pond ,Evaporation ,Evaporation pond ,Evaporation surface ,Salinity profile ,Area ratio ,Concentration. ,Renewable energy sources ,TJ807-830 - Abstract
One of the main problems that negatively affect the operation of salt gradient solar ponds and influence its thermal stability is the maintenance of salt gradient profile. Evaporation pond (EP) is designed to generate the salt which is lost by upward salt diffusion from the lower convective zone (LCZ) of the solar pond. Another attractive method is the Evaporation Surface facility (ES). Regions with moderate to high precipitation favor Evaporation Surfaces over Evaporation Ponds. Dry climates will generally favor Evaporation Ponds for the brine re-concentration. This paper investigates the differences between (EP) and (ES) both as a source for salt brine generation by evaporation. The effect of (EP) depth on the area ratio and daily variations of salt concentrations for three years of operation is shown. Results show that evaporation can be a reasonable method for salt brine generation. Reducing the depth of (EP) improves the capability of (EP) for brine re-concentration. It also increases the (EP) surface area for the same quantity of saline water used. Therefore, ESs are more powerful than Eps in salt re-concentration.
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- 2013
19. Multiple Data Augmentation Strategy for Enhancing the Performance of YOLOv7 Object Detection Algorithm.
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Abdulghani, Abdulghani M., Abdulghani, Mokhles M., Walters, Wilbur L., and Abed, Khalid H.
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DATA augmentation ,COMPUTER software ,ARTIFICIAL intelligence ,AUTONOMOUS robots ,MEDICAL care - Abstract
The object detection technique depends on various methods for duplicating the dataset without adding more images. Data augmentation is a popular method that assists deep neural networks in achieving better generalization performance and can be seen as a type of implicit regularization. This method is recommended in the case where the amount of high-quality data is limited, and gaining new examples is costly and time-consuming. In this paper, we trained YOLOv7 with a dataset that is part of the Open Images dataset that has 8,600 images with four classes (Car, Bus, Motorcycle, and Person). We used five different data augmentations techniques for duplicates and improvement of our dataset. The performance of the object detection algorithm was compared when using the proposed augmented dataset with a combination of two and three types of data augmentation with the result of the original data. The evaluation result for the augmented data gives a promising result for every object, and every kind of data augmentation gives a different improvement. The mAP@.5 of all classes was 76%, and F1-score was 74%. The proposed method increased the mAP@.5 value by +13% and F1-score by +10% for all objects. [ABSTRACT FROM AUTHOR]
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- 2023
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20. AI Safety Approach for Minimizing Collisions in Autonomous Navigation.
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Abdulghani, Abdulghani M., Abdulghani, Mokhles M., Walters, Wilbur L., and Abed, Khalid H.
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COLLISIONS (Physics) ,COMPUTER software ,ARTIFICIAL intelligence ,MEDICAL care ,AUTONOMOUS robots - Abstract
Autonomous agents can explore the environment around them when equipped with advanced hardware and software systems that help intelligent agents minimize collisions. These systems are developed under the term Artificial Intelligence (AI) safety. AI safety is essential to provide reliable service to consumers in various fields such as military, education, healthcare, and automotive. This paper presents the design of an AI safety algorithm for safe autonomous navigation using Reinforcement Learning (RL). Machine Learning Agents Toolkit (ML-Agents) was used to train the agent with a proximal policy optimizer algorithm with an intrinsic curiosity module (PPO+ ICM). This training aims to improve AI safety and minimize or prevent any mistakes that can cause dangerous collisions by the intelligent agent. Four experiments have been executed to validate the results of our research. The designed algorithm was tested in a virtual environment with four different models. A comparison was presented in four cases to identify the best-performing model for improving AI safety. The designed algorithm enabled the intelligent agent to perform the required task safely using RL. A goal collision ratio of 64% was achieved, and the collision incidents were minimized from 134 to 52 in the virtual environment within 30 min. [ABSTRACT FROM AUTHOR]
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- 2023
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21. Elevated serum Bcl-2 in children with temporal lobe epilepsy
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Kilany, Ayman, Raouf, Ehab R. Abdel, Gaber, Ahmed A., Aloush, Taha Kamel, Aref, Hany A., Anwar, Mona, Henshall, David C., and Abdulghani, M. Osama
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- 2012
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22. Evaluation of Different Combined Regimens in the Treatment of Cholinergic Urticaria
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Alsamarai, Abdulghani M., Hasan, Ali A., and Alobaidi, Amina H.
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- 2012
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23. Evaluation of Different Combined Regimens in the Treatment of Cholinergic Urticaria
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Abdulghani M. Alsamarai, MD, PhD, Ali A. Hasan, MBChB, HDIA, and Amina H. Alobaidi, BSc, MSc, PhD, DHPE
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Immunologic diseases. Allergy ,RC581-607 - Abstract
Background Cholinergic urticaria is uncommon and accounts for 10% of all young adults. To date, there is no effective therapy for cholinergic urticaria.Objective To determine the therapeutic efficacy of different drug combinations in the treatment of cholinergic urticaria.Patients and Methods The participants included in the study are in the age range of 16 to 29 years, with cholinergic urticaria of any duration as diagnosed by physicians. Patients were recruited from Asthma and Allergy Centers in Baghdad and Tikrit. The selected patients were divided randomly into 3 groups according to the treatment protocol. All patients completed screening before treatment.Results The study indicated that cholinergic urticaria was completely controlled in 30.4% of patients (group A) receiving 4 mg of chlorpheniramine maleate, half hour before the exercise, plus chlordiazopoxide (5 mg) and clindium bromide (2.5 mg) tablets, 3 times daily. However, cure rate was higher (83.1%) in patients (group B) receiving 4 mg of chlorpheniramine maleate (histadine), 3 times daily, plus 25 mg of maprotiline HCl (ludiomil), once daily at night. Furthermore, the complete cure rate was 85.4% in patients (group C) receiving 4 mg of chlorpheniramine maleate (histadine)3 times daily, plus 200 mg of cimetidine (tagadine), 3 times daily. The frequency of relapse was higher in group A (89%) as compared with group B (68.4%) and group C (23.5%) (P
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- 2012
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24. Implementation of Strangely Behaving Intelligent Agents to Determine Human Intervention During Reinforcement Learning.
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Rosser, Christopher C., Walters, Wilbur L., Abdulghani, Abdulghani M., Abdulghani, Mokhles M., and Abed, Khalid H.
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INTELLIGENT agents ,REINFORCEMENT learning ,INTRINSIC motivation ,MACHINE learning ,HUMAN-machine systems - Abstract
Intrinsic motivation helps autonomous exploring agents traverse a larger portion of their environments. However, simulations of different learning environments in previous research show that after millions of timesteps of successful training, an intrinsically motivated agent may learn to act in ways unintended by the designer. This potential for unintended actions of autonomous exploring agents poses threats to the environment and humans if operated in the real world. We investigated this topic by using Unity's MachineLearningAgent Toolkit (ML-Agents) implementation of the Proximal Policy Optimization (PPO) algorithm with the Intrinsic Curiosity Module (ICM) to train autonomous exploring agents in three learning environments. We demonstrate that ICM, although designed to assist agent navigation in environments with sparse reward generation, increasing gradually as a tool for purposely training misbehaving agent in significantly less than 1 million timesteps.We present the following achievements: 1) experiments designed to cause agents to act undesirably, 2) a metric for gauging how well an agent achieves its goal without collisions, and 3) validation of PPO best practices. Then, we used optimized methods to improve the agent's performance and reduce collisions within the same environments. These achievements help further our understanding of the significance of monitoring training statistics during reinforcement learning for determining how humans can intervene to improve agent safety and performance. [ABSTRACT FROM AUTHOR]
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- 2022
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25. The microvascular effects of insulin resistance and diabetes on cardiac structure, function, and perfusion: a cardiovascular magnetic resonance study
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Larghat, Abdulghani M., Swoboda, Peter P., Biglands, John D., Kearney, Mark T., Greenwood, John P., and Plein, Sven
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- 2014
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26. Epicardial left ventricular myocardial rotation correlates with resting myocardial blood flow in type 2 diabetes mellitus patients with angiographically normal coronary arteries
- Author
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Larghat Abdulghani M, Biglands John D, Kidambi Ananth, Greenwood John P, and Plein Sven
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2013
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- View/download PDF
27. Myocardial microvascular function at rest and stress measured with dynamic contrast-enhanced MRI
- Author
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Broadbent David A, Biglands John D, Larghat Abdulghani M, Sourbron Steven, Plein Sven, and Buckley David L
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2012
- Full Text
- View/download PDF
28. Numbers needed to detect a significant change in myocardial strain and left ventricular twist measured by complementary spatial modulation of magnetization (CSPAMM)
- Author
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Swoboda Peter, Larghat Abdulghani M, Fairbairn Timothy, Motwani Manish, Greenwood John P, and Plein Sven
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2012
- Full Text
- View/download PDF
29. Systolic versus diastolic myocardial blood flow in patients with suspected coronary artery disease - a cardiovascular magnetic resonance study
- Author
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Motwani Manish, Fairbairn Timothy, Larghat Abdulghani M, Mather Adam N, Biglands John D, Radjenovic Aleksandra, Greenwood John P, and Plein Sven
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2012
- Full Text
- View/download PDF
30. 'TDMGDSA' A Two Dimensional Multigroup Diffusion Synthetic Accelerated Transport Code
- Author
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Tareq G. Aboalfaraj and Abdulghani M. Melaibari
- Subjects
Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Neutron transport codes are essential tools in nuclear reactor and shielding design. Transport codes implement an iterative technique that suffers from slow convergence while solving highly scattering problems. This necessitated the development of acceleration methods, among which, the diffusion synthetic acceleration (DSA) is the fastest and the only stable method.In this paper we present the development of “TDMGDSA”, a two dimensional multi-group diffusion synthetic accelerated neutron transport computer code. TDMGDSA implements DSA to solve the discrete ordinate equations in X–Y geometry for three spatial differencing schemes; the diamond, weighted diamond, and linear discontinuous differencing. TDMGDSA is the first to implement a linear form of DSA for the diamond differencing, and is one of the first to implement DSA for the weighted diamond and linear discontinuous differencing schemes. TDMGDSA has been tested and is shown to be working reliably.
- Published
- 1994
- Full Text
- View/download PDF
31. Myocardial blood flow in patients withType 2 Diabetes Mellitus and normal coronary angiography
- Author
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Radjenovic Aleksandra, Maredia Neil, Fairbairn Tim A, Greenwood John P, Biglands John, Larghat Abdulghani M, Ball Stephen, and Plein Sven
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2011
- Full Text
- View/download PDF
32. Effect of improving spatial or temporal resolution with k-t SENSE acceleration in first pass CMR myocardial perfusion imaging
- Author
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Greenwood John P, Kozerke Sebastian, Larghat Abdulghani M, Radjenovic Aleksandra, Maredia Neil, and Plein Sven
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2010
- Full Text
- View/download PDF
33. Subendocardial to subepicardial absolute myocardial blood flow at rest and hyperaemia determined by first pass-cmr and fermi deconvolution modelling
- Author
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Greenwood John P, Biglands John, Maredia Neil, Radjenovic Aleksandra, Larghat Abdulghani M, Herold Jerosch, and Plein Sven
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2010
- Full Text
- View/download PDF
34. Reproducibility of First Pass Perfusion CMR at rest and during hyperaemia for estimation of myocardial perfusion
- Author
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Biglands John, Maredia Neil, Radjenovic Aleksandra, Larghat Abdulghani M, Greenwood John, and Plein Sven
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2010
- Full Text
- View/download PDF
35. Endocardial to epicardial perfusion ratios at rest and stress determined by perfusion-CMR
- Author
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Greenwood John P, Maredia Neil, Radjenovic Aleksandra, Larghat Abdulghani M, Kozerke Sebastian, and Plein Sven
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2009
- Full Text
- View/download PDF
36. Reproducibility of first-pass cardiovascular magnetic resonance myocardial perfusion
- Author
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Larghat, Abdulghani M., Maredia, Neil, Biglands, John, Greenwood, John P., Ball, Stephen G., Jerosch-Herold, Michael, Radjenovic, Aleksandra, and Plein, Sven
- Published
- 2013
- Full Text
- View/download PDF
37. Burnout Syndrome among Emergency Physicians and Nurses in Abha and Khamis Mushait Cities, Aseer Region, Southwestern Saudi Arabia
- Author
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Awad S. Alsamghan, Safar A. Alsaleem, Nabil J. Awadalla, Abdulghani M. Alqahtani, and Mohammed Abadi Alsaleem
- Subjects
Adult ,Male ,Sleep Wake Disorders ,medicine.medical_specialty ,Multivariate analysis ,Article Subject ,Burnout syndrome ,education ,Saudi Arabia ,Nurses ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Burnout ,Burnout, Psychological ,Logistic regression ,lcsh:Technology ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Physicians ,Depersonalization ,medicine ,Prevalence ,Humans ,030212 general & internal medicine ,Emotional exhaustion ,lcsh:Science ,General Environmental Science ,Sleep disorder ,business.industry ,lcsh:T ,Smoking ,lcsh:R ,General Medicine ,medicine.disease ,Confidence interval ,Logistic Models ,Family medicine ,Multivariate Analysis ,Emergency Medicine ,Female ,lcsh:Q ,medicine.symptom ,business ,Research Article - Abstract
Objectives. To explore the magnitude and determinants of burnout among emergency physicians and nurses working at emergency departments of hospitals in Abha and Khamis Mushait cities.Subjects and Methods. A cross-sectional hospital-based study was conducted in emergency departments of hospitals in Abha and Khamis Mushait cities belonging to Ministry of Health. All physicians (n=95) and nurses (n=187) currently working at these sites were invited to participate in the study by filling a validated self-administered questionnaire including two main sections: personal and professional characteristics of physicians and nurses as well as Maslach burnout inventory (MBI) to assess the three components of the burnout syndrome: emotional exhaustion, depersonalization, and reduced personal accomplishment.Results. The study included 282 physicians and nurses. The age of more than half of them (54.3%) ranged between 31 and 35 years. Most of them (70.9%) were females. About two-thirds of the respondents (66.3%) were nurses while the remaining 33.7% were physicians. Majority of the emergency healthcare professionals (88.7%) had high emotional exhaustion. The prevalence of high depersonalization (cynicism) was 20.6% whereas that of low personal accomplishment was 41.1% among emergency healthcare professionals. The overall prevalence of burnout among healthcare professionals was 16.3%. Multivariate logistic regression analysis revealed that male healthcare professionals were at almost higher three-folded risk for developing burnout compared to females (aOR=2.76; 95% confidence interval (CI): 1.21-6.28, p=0.017)). Smokers were at higher significant risk for burnout compared to nonsmokers (aOR=15.37; 95% CI: 7.06-33.45, pConclusion. A considerable proportion of physicians and nurses working at emergency departments of hospitals in Abha and Khamis Mushait cities had burnout syndrome, particularly high emotional exhaustion and low personal accomplishment.
- Published
- 2019
38. Examining obstacles to Saudi women's right to work in the Kingdom of Saudi Arabia
- Author
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Alharbi, Hani Abdulghani M, Sseyonjo, M, and Chigara, B
- Subjects
Obligations to respect, protect and fulfil ,CEDAW ,Saudi domestic law ,Limited access to higher education ,Religion and culture barriers - Abstract
This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University London This thesis determines and examines the obstacles to Saudi women’s right to work in terms of religious and cultural barriers and limited access to higher education through an analysis of Sharia sources, Saudi domestic law and international human rights treaties pertaining to Saudi women’s right to work in the Kingdom of Saudi Arabia. It also delineates the provisions for women’s right to work in Sharia and Saudi domestic law in the public and private sectors. The thesis also examines the reservations that the Kingdom of Saudi Arabia has entered into, and some of the international human rights treaties it has ratified, with a particular focus on the application of the Convention on the Elimination of All Forms of Discrimination against Women (CEDAW). It also examines Saudi Arabia’s obligations under International Labour Organization (ILO) Conventions. In the context of Saudi domestic law, it identifies obstacles that underlie Saudi Arabia’s decision not to ratify the International Covenant on Economic, Social and Cultural Rights (ICESCR); it examines the arguments for the Kingdom of Saudi Arabia signing up to the ICESCR; and it examines Saudi Arabia’s obligations to respect, protect and fulfil women’s right to work under CEDAW. The protection of women’s right to work under customary international law, by its sources will be explored. This section will look through customary international law elements; whether or not women's right to work is protected. Finally, the thesis provides recommendations for action which can be taken by the Kingdom of Saudi Arabia to provide Saudi women with equal rights to work. It also makes recommendations concerning ratified and pending international human rights treaties which have the capacity to protect Saudi women’s right to work. AL-Baha University
- Published
- 2018
39. Mitigating interference and reducing detection complexity in asynchronous cooperative relay network utilising new distributed space time block coding.
- Author
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Elazreg, Abdulghani M. and Kharaz, Ahmad H.
- Abstract
The synchronisation in wireless cooperative relay networks is impossible to achieve in real environment utilising orthogonal space time block coding. There have been several approaches proposed to mitigate the effect of synchronisation among the relay nodes at the receiver. All have managed to reduce the inter‐symbol interference at the expense of low data rate with high detection complexity. Others achieved full data rate and high cooperative diversity using high decoding complexity that requires a feedback link. In this paper, a new approach is presented that reduces inter‐symbol interference, achieves full data rate and full cooperative diversity with low complexity. This uses a new efficient distributed orthogonal space time block coding design with a sub‐optimum detection scheme utilising dual relay nodes. This reduces the number of timing misalignments among the relay nodes and minimises the detection complexity. Furthermore, the new proposed method uses linear decoding process to achieve full data rate and full cooperative diversity without the need for any a feedback link. The analytical analysis and simulation results confirmed that sub‐optimum approach with the new efficient design are very effective at reducing the lack of synchronisation among the relay nodes at the destination node with low encoding and decoding complexities. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
40. Effects of kiwi's pectin methylesterase inhibitor, nanomilling and pasteurization on orange juice quality.
- Author
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Bazaraa, Wael A., Ammar, Abdalla S., and Aqlan, Abdulghani M.
- Subjects
PECTINESTERASE ,FOOD pasteurization ,ORANGE juice ,FREEZE-drying ,VITAMIN C ,PHASE separation ,LOW temperatures - Abstract
Endogenous pectin methylesterase (PME) is the enzyme responsible for phase separation and cloud loss in orange juice (OJ) manufacturing. The effect of kiwi's PME inhibitor (PMEI), nanomilling, and pasteurization on OJ quality was evaluated. The microbial quality, PME activity, OJ separation, pH, ascorbic acid content and the sensory characteristics of the juice were followed during 5 weeks storage (4°C). PMEI as freeze‐dried kiwi powder (0.3%, w/w) succeeded in inhibiting 89.3% of the OJ PME without affecting the microbial and the sensory quality. Nanomilling of OJ pulp, to prepare nano‐particles OJ (NPOJ), reduced the initial microbial load by 1.65 and 1.83 log for psychrotrophs and yeasts and molds, respectively; significantly (p <.05) inactivated 40.9% of the residual PME activity and the juice separation was significantly reduced by 48.3% (after 14 days of storage). Nanomilling exhibited no effect on OJ pH, but slight (p <.05) decrease in ascorbic acid content was noted. The combination of PMEI with NPOJ resulted in improved OJ stability with reduced separation to 36.4% of that of control. Such combination also allowed to use a lower pasteurization temperature at lower exposure time (60°C/5 min) needed to obtain new NPOJ with comparable high quality as fresh OJ and which has a shelf life of 3 weeks (4°C). [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
41. Risk Factors for Allergy in Secondary School Girls
- Author
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Alobaidi, Ramla Hamed Ahmed and Alsamarai, Amina Hamed Ahmed Alobaidi and Abdulghani M.
- Published
- 2015
42. Epicardial left ventricular myocardial rotation correlates with resting myocardial blood flow in type 2 diabetes mellitus patients with angiographically normal coronary arteries
- Author
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John D Biglands, John P Greenwood, Abdulghani M Larghat, Ananth Kidambi, and Sven Plein
- Subjects
Medicine(all) ,medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,endocrine system diseases ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,nutritional and metabolic diseases ,Blood flow ,medicine.disease ,Coronary artery disease ,lcsh:RC666-701 ,Heart failure ,Diabetic cardiomyopathy ,Internal medicine ,Angiography ,Poster Presentation ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,Prediabetes ,Cardiology and Cardiovascular Medicine ,business ,Perfusion ,Angiology - Abstract
Background Type 2 Diabetes Mellitus (T2DM) and prediabetes are associated with an increased cardiovascular risk and heart failure independent of the presence of obstructive coronary artery disease, caused in part by myocardial microvascular dysfunction. Recent studies have reported contractile dysfunction and increased rotation with the onset of diabetic cardiomyopathy in uncomplicated T2DM patients. Independently, higher resting myocardial blood flow (MBF) has been reported in T2DM. The objective of this study was to determine whether there is a correlation between LV Epicardial Rotation (LV ER) and resting MBF in T2DM patients with angiographically normal coronaries, measured by tissue tagging and perfusion cardiovascular Magnetic Resonance (CMR). Methods Sixty five patients with no coronary stenosis >30% on invasive angiography were recruited and categorized into T2DM, prediabetes and normal controls groups according to American Diabetes Association guidelines. All patients underwent rest and adenosine stress myocardial perfusion CMR at a single mid-LV location, cine imaging covering the entire heart and myocardial tissue tagging in three LV short axis locations (apical, mid LV and basal). LV volumes and mass were calculated from cine images. LV rotation in three myocardial layers (endocardial, midmyocardial and epicardial) was calculated from CSPAMM tissue images using Tag Track (Gyrotools, Zurich). For this study, only rest MBF was calculated using Fermi-constrained deconvolution for the entire myocardium. Results Patient characteristics and results are shown in Table 1. Patients with T2DM had significantly higher resting MBF than the two other groups. Corresponding mid LV ER was higher in T2DM patients compared to patients with prediabetes and normal controls (Figure 1) (not statistically significant). Univariate analysis showed a significant positive correlation between MBF and LV ER in the entire study population (Pearson coefficient (r) of 0.25, p = 0.05). In the individual groups, the linear determination coefficient (R2) showed that LV ER in T2DM patients had stronger positive correlation (R2 = 0.31) with resting MBF than in patients with prediabetes (R2 = 0.16) and controls (R2 = 0.29), Figure 1. Conclusions T2DM patients when compared to age-matched patients with prediabetes and normal controls have higher peak LV ER. Resting MBF correlates with LV ER. These results suggest that LV ER analysis in uncomplicated T2DM patients may be useful for non-invasive screening of early subtle contractile dysfunction associated with microvascular dysfunction in diabetes patients.
- Published
- 2013
43. Systolic versus diastolic myocardial blood flow in patients with suspected coronary artery disease - a cardiovascular magnetic resonance study
- Author
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John D Biglands, Abdulghani M Larghat, Manish Motwani, Adam N Mather, Timothy A. Fairbairn, Aleksandra Radjenovic, Sven Plein, and John P Greenwood
- Subjects
Medicine(all) ,medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Radiological and Ultrasound Technology ,business.industry ,Diastole ,Blood flow ,medicine.disease ,Coronary artery disease ,lcsh:RC666-701 ,Internal medicine ,Poster Presentation ,medicine ,Magnetic resonance study ,Cardiology ,Radiology, Nuclear Medicine and imaging ,In patient ,cardiovascular diseases ,Systole ,Cardiology and Cardiovascular Medicine ,business ,Angiology ,circulatory and respiratory physiology - Abstract
This study has shown that in patients with suspected and confirmed CAD, estimates of MBF by perfusion-CMR are significantly higher in diastole than systole during maximal hyperemic stress.
- Published
- 2012
44. Numbers needed to detect a significant change in myocardial strain and left ventricular twist measured by complementary spatial modulation of magnetization (CSPAMM)
- Author
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Abdulghani M Larghat, Sven Plein, Timothy A. Fairbairn, John P Greenwood, Manish Motwani, and Peter P Swoboda
- Subjects
Medicine(all) ,Reproducibility ,medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Radiological and Ultrasound Technology ,business.industry ,Spatial modulation ,Magnetization ,Nuclear magnetic resonance ,lcsh:RC666-701 ,Poster Presentation ,Myocardial strain ,Medicine ,Radiology, Nuclear Medicine and imaging ,sense organs ,Twist ,skin and connective tissue diseases ,Cardiology and Cardiovascular Medicine ,business ,Angiology - Abstract
We have calculated the inter-study reproducibility of myocardial strain and twist measured by CSPAMM and calculated the number of subjects required to detect a significant change in these parameters.
- Published
- 2012
45. Effect of improving spatial or temporal resolution on image quality and quantitative perfusion assessment with k-t SENSE acceleration in first-pass CMR myocardial perfusion imaging
- Author
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Neil Maredia, Sebastian Kozerke, Abdulghani M Larghat, John P Greenwood, Aleksandra Radjenovic, Sven Plein, University of Zurich, and Plein, S
- Subjects
Adult ,Male ,Image quality ,Image processing ,610 Medicine & health ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,170 Ethics ,03 medical and health sciences ,Acceleration ,Myocardial perfusion imaging ,0302 clinical medicine ,k-t SENSE ,Coronary Circulation ,Image Processing, Computer-Assisted ,medicine ,adenosine stress myocardial perfusion imaging ,Humans ,2741 Radiology, Nuclear Medicine and Imaging ,Radiology, Nuclear Medicine and imaging ,10237 Institute of Biomedical Engineering ,Image resolution ,Physics ,Artifact (error) ,medicine.diagnostic_test ,business.industry ,Preclinical and Clinical Imaging-Full Papers ,Reproducibility of Results ,Middle Aged ,Image Enhancement ,Magnetic Resonance Imaging ,Radiology Nuclear Medicine and imaging ,myocardial perfusion reserve index ,Temporal resolution ,Female ,Artifacts ,Nuclear medicine ,business ,Perfusion ,Fermi deconvolution ,Biomedical engineering - Abstract
k-t Sensitivity-encoded (k-t SENSE) acceleration has been used to improve spatial resolution, temporal resolution, and slice coverage in first-pass cardiac magnetic resonance myocardial perfusion imaging. This study compares the effect of investing the speed-up afforded by k-t SENSE acceleration in spatial or temporal resolution. Ten healthy volunteers underwent adenosine stress myocardial perfusion imaging using four saturation-recovery gradient echo perfusion sequences: a reference sequence accelerated by sensitivity encoding (SENSE), and three k-t SENSE–accelerated sequences with higher spatial resolution (“k-t High”), shorter acquisition window (“k-t Fast”), or a shared increase in both parameters (“k-t Hybrid”) relative to the reference. Dark-rim artifacts and image quality were analyzed. Semiquantitative myocardial perfusion reserve index (MPRI) and Fermi-derived quantitative MPR were also calculated. The k-t Hybrid sequence produced highest image quality scores at rest (P = 0.015). Rim artifact thickness and extent were lowest using k-t High and k-t Hybrid sequences (P < 0.001). There were no significant differences in MPRI and MPR values derived by each sequence. Maximizing spatial resolution by k-t SENSE acceleration produces the greatest reduction in dark rim artifact. There is good agreement between k-t SENSE and standard acquisition methods for semiquantitative and fully quantitative myocardial perfusion analysis. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc.
- Published
- 2010
46. Endocardial to epicardial perfusion ratios at rest and stress determined by perfusion-CMR
- Author
-
John P Greenwood, Abdulghani M Larghat, Aleksandra Radjenovic, Sven Plein, Sebastian Kozerke, and Neil Maredia
- Subjects
Medicine(all) ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,Radiological and Ultrasound Technology ,business.industry ,Blood flow ,Perfusion reserve ,Stress (mechanics) ,lcsh:RC666-701 ,Internal medicine ,Poster Presentation ,cardiovascular system ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,business ,human activities ,Perfusion ,Physiological Phenomenon ,Rest (music) ,Endocardium ,Angiology - Abstract
Animal experiments using labelled microspheres have shown that at rest, blood flow to the subendocardial layer is higher than to the subepicardium. With increasing levels of stress this transmural gradient of myocardial blood flow is reduced, so that the endocardium has a lower perfusion reserve than the epicardium [1]. The causes for this observation include higher compressive forces and higher resting metabolic activity in the endocardium. If microvascular function is impaired, endocardial perfusion reserve is reduced further [2]. Myocardial perfusion-CMR is usually performed with coverage of several myocardial sections to allow detection of ischemic perfusion defects. Consequently, compromises regarding image quality and motion artefact are made. For the study of global physiological phenomena and diffuse myocardial disease, optimised acquisition of a single section may be more useful.
- Published
- 2009
47. Solar energy potential for hot water in the hotel sector in Libya.
- Author
-
Abdunnabi, Mohammad J. R., Idweib, Abdulfatah A., and Ramadan, Abdulghani M.
- Published
- 2015
- Full Text
- View/download PDF
48. Myocardial blood flow in patients withType 2 Diabetes Mellitus and normal coronary angiography
- Author
-
John D Biglands, Abdulghani M Larghat, Neil Maredia, Aleksandra Radjenovic, T A Fairbairn, Sven Plein, Stephen G. Ball, and John P Greenwood
- Subjects
Medicine(all) ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,endocrine system diseases ,Radiological and Ultrasound Technology ,business.industry ,nutritional and metabolic diseases ,Type 2 Diabetes Mellitus ,Blood flow ,medicine.disease ,Coronary artery disease ,lcsh:RC666-701 ,Internal medicine ,Diabetes mellitus ,Heart failure ,Poster Presentation ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,In patient ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,circulatory and respiratory physiology ,Angiology - Abstract
Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk of heart failure independently of underlying coronary artery disease (CAD) [1]. Myocardial blood flow (MBF) and MBF reserve can be abnormal in patients with T2DM due to myocardial microvascular dysfunction, contributing to the development of heart failure [2]. The myocardial layers may be affected differently by this disease process.
- Published
- 2011
49. Reproducibility of strain and twist measurements calculated using CSPAMM tagging
- Author
-
Peter P Swoboda, Abdulghani M Larghat, John P Greenwood, and Sven Plein
- Subjects
Medicine(all) ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Reproducibility ,Radiological and Ultrasound Technology ,Strain (chemistry) ,business.industry ,Coefficient of variation ,Pulse sequence ,Rotation ,Standard deviation ,Nuclear magnetic resonance ,Flip angle ,lcsh:RC666-701 ,Poster Presentation ,cardiovascular system ,Medicine ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Twist ,Cardiology and Cardiovascular Medicine ,business - Abstract
Methods 12 healthy volunteers (6 males, mean age 33±7 years) underwent CMR studies on a 1.5T system (Intera CV, Philips Healthcare, The Netherlands). Tagged CMR images were acquired at the apex, mid-ventricle and base with a CSPAMM pulse sequence (field of view: 300mm, matrix 128 x 128, slice thickness 10mm, tag separation 8mm, 18 phases, typical TR/TE 30ms/6ms, flip angle 25 degrees). In 6 volunteers repeat data sets were acquired after a mean interval of 8±3 days. Data were analysed by two independent observers using Tagtrack software (Gyrotools, CH). Circumferential Langranian strain, radial Langranian strain and rotation were calculated for the three short axis slices. Endocardial and epicardial borders were drawn, and a midline calculated automatically. Left ventricular twist was calculated by subtracting the basal rotation from the apical rotation. The mean difference between paired measurements, the standard deviation (SD) of the differences and the coefficient of variability (Co-V) were calculated.
- Published
- 2011
50. Detection of triple vessel coronary artery disease by visual and quantitative first pass CMR myocardial perfusion imaging in the CE-MARC study
- Author
-
Aleksandra Radjenovic, Stephen G. Ball, Catherine J Dickinson, Jane Nixon, Sven Plein, John F. Younger, Neil Maredia, John P. Ridgway, Julia Brown, John P Greenwood, John D Biglands, Colin C Everett, and Abdulghani M Larghat
- Subjects
Medicine(all) ,Coronary angiography ,First pass ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Pathology ,medicine.medical_specialty ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Gated SPECT ,Perfusion scanning ,Myocardial perfusion imaging ,lcsh:RC666-701 ,Triple vessel coronary artery disease ,Internal medicine ,cardiovascular system ,Cardiology ,Medicine ,Oral Presentation ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,business ,Gradient echo ,Angiology - Abstract
Methods Thirty-nine patients with 3VD at X-ray coronary angiography and 39 matched patients with no significant coronary disease were identified from the CE-MARC study population [1]. Patients were matched by age, gender, hypertension and diabetes. CMR adenosine stress perfusion imaging was undertaken using a saturation-recovery gradient echo pulse sequence producing three image slices per R-R interval. Visual and Fermi deconvolutionderived CMR myocardial perfusion reserve (MPR) analyses were performed. Gated SPECT imaging was performed and interpreted by an experienced observer blinded to other test results.
- Published
- 2011
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