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Your search keyword '"Abdel-Wahhab, Mosaad A."' showing total 314 results
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314 results on '"Abdel-Wahhab, Mosaad A."'

27. Dietary aflatoxins exposure, environmental enteropathy, and their relation with childhood stunting.

Author

Urugo, Markos Makiso, Teka, Tilahun A., Lema, Tefera Belachew, Lusweti, Janerose Nasimiyu, Djedjibegovíc, Jasmina, Lachat, Carl, Tesfamariam, Kokeb, Mesfin, Addisalem, Astatkie, Tess, and Abdel-Wahhab, Mosaad A.

Subjects
SANITATION, AFLATOXINS, INTESTINAL diseases, STUNTED growth, FOOD contamination, NUTRIENT uptake, GUT microbiome
Abstract

Childhood stunting is a global phenomenon affecting more than 149 million children under the age of 5 worldwide. Exposure to aflatoxins (AFs) in utero, during breastfeeding, and consumption of contaminated food affect the gut microbiome, resulting in intestinal dysfunction and potentially contributing to stunting. This review explores the potential relationship between AF exposure, environmental enteropathy and childhood stunting. AFs bind to DNA, disrupt protein synthesis and elicit environmental enteropathy (EE). An EE alters the structure of intestinal epithelial cells, impairs nutrient uptake and leads to malabsorption. This article proposes possible intervention strategies for researchers and policymakers to reduce AF exposure, EE and childhood stunting, such as exposure reduction, the implementation of good agricultural practices, dietary diversification and improving environmental water sanitation and hygiene. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Cold Plasma Technology Impact on Microorganisms Inactivation in Foods: A Systematic Review.

Author

Marvdashti, Leila Monjazeb, Arabameri, Majid, Yousefi, Bahman, Eslami, Majid, Emadi, Alireza, Ebrahimi, Arezoo, Abdolshahi, Anna, and Abdel-Wahhab, Mosaad A.

Subjects
LOW temperature plasmas, MICROBIAL inactivation, FOOD contamination, HIERARCHICAL clustering (Cluster analysis), FOOD contamination prevention, FOOD pathogens, PLASMA gases, PLASMA materials processing
Abstract

Cold plasma is a high-end technology that offers favorable opportunities for microorganism inactivation in contaminated food. This review aimed to evaluate the efficacy of cold plasma treatment to reduce different pathogen and spoilage microorganisms in various foods. In addition, the effect of influential factors related to plasma processing, including microorganism type, gas type, treatment time, and treatment voltage, on the reduction rate of microorganisms was assessed using principal component analysis and hierarchical cluster analysis. The extracted data showed that most researcher investigated plasma efficiency on the inactivation of Escherichia coli in different food samples. Also in most studies the plasma was generated using air as plasma gas. The microorganism inactivation rate obtained by cold plasma treatments was raging from -0.90 to 8.00 log CFU. The plasma voltage (0.7) and plasma gas (0.66) had a significant correlation with principal component 1 and had a negative correlation coefficient with treatment time (-0.76). The reduction rate (0.68) and microorganism (0.7) were positively correlated with principal components 2. The findings indicated that cold plasma has an excellent potential to decontaminate hazardous organisms in different food. Besides, plasma treatment conditions should be considered to optimize the effective inactivation rates. The reduction rate of microorganisms in different foods is strongly influenced by microbial factors and technical plasma performance factors. Regarding the crucial damage to microorganism cell components using plasma, this novel technology could efficiently apply for preservation and also promote the shelf life of food products. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Zinc citrate‐coated whey protein nanoparticles alleviate kidney damage and the disturbances in inflammatory gene expression in rats.

Author

El‐Nekeety, Aziza A., Hassan, Mona A., Abdel‐Aziem, Sekena H., Hassan, Nabila S., and Abdel‐Wahhab, Mosaad A.

Subjects
WHEY proteins, GENE expression, NITRIC-oxide synthases, KIDNEYS, ZINC
Abstract

This work was conducted to synthesize whey protein nanoparticles (WPNPs) for the coating of zinc citrate (Zn CITR) at three levels and to study their protective role against CCl4‐induced kidney damage and inflammatory gene expression disorder in rats. Seventy male Sprague‐Dawley rats were divided into seven groups and treated orally for 4 weeks as follows; the control group, the group treated twice a week with CCl4 (5 mL/kg b.w), the groups received CCl4 plus WPNPs (300 mg/kg b.w); the group received 50 mg/kg b.w of Zn CITR or the three formulas of Zn CITR‐WPNPs at low, medium and high doses (LD, MD, and HD). Blood and kidney samples were collected for different assays and histological analyses. The fabricated particles were semispherical, with an average size of 160 ± 2.7, 180 ± 3.1, and 200 ± 2.6 nm and ζ potential of −126, −93, and −84 mV for ZN CITR‐WPNPs (LD), Zn CITR‐WPNPs (MD), and ZN CITR‐WPNPs (HD), respectively. CCl4 significantly increased (p ≤ 0.05) kidney function indices, oxidative stress markers, messenger RNA expression of transforming growth factor‐β1, interleukin (IL)‐1β, IL‐10, IL‐6, inducible nitric oxide synthase, and tumor necrosis factor‐α and significantly decreased (p ≤ 0.05) renal superoxide dismutase, catalase, and glutathione peroxidase along with the histological changes in the kidney tissues. WPNPs, Zn CITR, and Zn CITR loaded WPNPS showed a protective effect against these complications and Zn CITR‐WPNPs (LD) was more effective. WPNPs can be used effectively for coating Zn CITR at a level of 7 mg/g WPNPs to be used as a supplement for the protection of the kidney against different toxicants to enhance immunity and avoid harm of excess Zn. [ABSTRACT FROM AUTHOR]

Published
2023
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