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1. Evaluation of phytochemical composition, toxicity in Drosophila melanogaster and effects on antibiotics modulation of Plathymenia reticulata Benth extract

Author

E.M. Luna, T.S. Freitas, F.F. Campina, M.S. Costa, J.E. Rocha, R.P. Cruz, D.L. Sena Júnior, Z.S. Silveira, N.S. Macedo, J.C.A. Pinheiro, F.N. Pereira-Júnior, M.A.N. Lisboa, G.V. Cruz, J.T. Calixto Júnior, A.M.R. Teixeira, and H.D.M. Coutinho

Subjects
Plant extract, Plathymenia reticulata, Antimicrobian activity, Toxicity, Toxicology. Poisons, RA1190-1270
Abstract

Bacterial resistance is interfering with the action of antibiotics for clinical use in treating pathologies. The search for new substances capable of combating this resistance is necessary. An alternative to the search for these substances is in the extract of medicinal plants. Plathymenia reticulata, plant of the Fabaceae family, is a common tree species from the Brazilian cerrado, and is commonly used in areas of environmental degradation. This species is rich in phenolic compounds, such as flavonoids and tannins, compounds that are associated with various biological effects. A hydroethanolic extract from the bark of Plathymenia reticulata (HEPrB) was produced and then tests were carried out to verify the direct antibacterial activity, the modulatory effect of antibiotics for clinical use and their toxicity in Drosophila melanogaster flies. Through the analysis with UPLC, a wide variety of flavonoids contained in the HEPrB was observed. Direct antibacterial activity was observed for the standard strain of Staphylococcus aureus, however, the extract showed antagonistic activity or no significance in relation to the antibiotics tested in this study. As for toxicity, the HEPrB did not show significant damage in the proposed model. The results emphasize care when associating the consumption of teas with treatments with antibiotics for clinical use.

Published
2021
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2. Vibrational spectra of pilocarpine hydrochloride crystals

Author

Paulo Freire, Nirla Rodrigues Romero, Ricardo Ferreira Bento, José H. C. Monteiro da Silva, F. M. Pontes, Manoel Andrade-Neto, M. C. F. de Oliveira, A.M.R. Teixeira, José Albérsio de Araújo Lima, Universidade Federal do Mato Grosso, Universidade Federal do Ceará (UFC), Universidade Regional do Cariri, and Universidade Estadual Paulista (Unesp)

Subjects
Physics, Raman scattering, Analytical chemistry, General Physics and Astronomy, Infrared spectroscopy, normal modes, Fourier transform spectroscopy, pilocarpine hydrochloride, symbols.namesake, Nuclear magnetic resonance, Fourier transform, Normal mode, symbols, Wave vector, Density functional theory, Fourier transform infrared spectroscopy, infrared spectroscopy, Basis set
Abstract

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:01:27Z No. of bitstreams: 1 S0103-97332009000100012.pdf: 249754 bytes, checksum: 9915c64ac233ca4a4b457907a79841a8 (MD5) Made available in DSpace on 2013-08-22T19:01:27Z (GMT). No. of bitstreams: 1 S0103-97332009000100012.pdf: 249754 bytes, checksum: 9915c64ac233ca4a4b457907a79841a8 (MD5) Previous issue date: 2009-03-01 Made available in DSpace on 2013-09-30T20:01:28Z (GMT). No. of bitstreams: 2 S0103-97332009000100012.pdf: 249754 bytes, checksum: 9915c64ac233ca4a4b457907a79841a8 (MD5) S0103-97332009000100012.pdf.txt: 27844 bytes, checksum: 42a96ad199aac25818f3619e382b2c39 (MD5) Previous issue date: 2009-03-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:15:44Z No. of bitstreams: 2 S0103-97332009000100012.pdf: 249754 bytes, checksum: 9915c64ac233ca4a4b457907a79841a8 (MD5) S0103-97332009000100012.pdf.txt: 27844 bytes, checksum: 42a96ad199aac25818f3619e382b2c39 (MD5) Made available in DSpace on 2014-05-20T15:15:44Z (GMT). No. of bitstreams: 2 S0103-97332009000100012.pdf: 249754 bytes, checksum: 9915c64ac233ca4a4b457907a79841a8 (MD5) S0103-97332009000100012.pdf.txt: 27844 bytes, checksum: 42a96ad199aac25818f3619e382b2c39 (MD5) Previous issue date: 2009-03-01 Pilocarpine is a natural substance with potential application in the treatment of several diseases. In this work Fourier Transform (FT)-Raman spectrum and the Fourier Transform infra red (FT-IR) spectrum of pilocarpine hydrochloride C11H17N2O2+.Cl- were investigated at 300 K. Vibrational wavenumber and wave vector have been predicted using density functional theory (B3LYP) calculations with the 6-31 G(d,p) basis set. A comparison with experiment allowed us to assign most of the normal modes of the crystal. Universidade Federal do Mato Grosso Instituto de Física Universidade Federal do Ceará (UFC) Departamento de Física Universidade Regional do Cariri Dep. Ciências Físicas e Biológicas Universidade Estadual do Ceará Universidade Federal do Ceará (UFC) Dep. Química Orgânica e Inorgânica Universidade Federal do Ceará (UFC) Departamento de Farmácia Universidade Estadual de São Paulo Faculdade de Ciências

Published
2009

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