728 results on '"A. Lepape"'
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2. Relationship between SARS-CoV-2 infection and ICU-acquired candidemia in critically ill medical patients: a multicenter prospective cohort study
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Reizine, Florian, Massart, Nicolas, Mansour, Alexandre, Fedun, Yannick, Machut, Anaïs, Vacheron, Charles-Hervé, Savey, Anne, Friggeri, Arnaud, and Lepape, Alain
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- 2024
- Full Text
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3. Central venous catheter insertion site and infection prevention in 2024. Author’s reply
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Massart, Nicolas, Cosme, Vincent, Reizine, Florian, Friggeri, Arnaud, and Lepape, Alain
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- 2024
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4. Reflections of a graduate student team on developing and implementing a transdisciplinary research project: Challenges, recommendations, and lessons learned
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Horne, Lydia, Soucy, Alyssa, DiMatteo-LePape, Asha, Briones, Valeria, and Wolf-Gonzalez, Gabriela
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- 2024
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5. Can cashew nut allergy resolve spontaneously?
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Tamazoust Guiddir, Audrey Siberil, Françoise Lepape, Marion Hacker, and Ariane Nemni
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cashew nut allergy ,children ,natural history ,recombinant Ana o 3 ,recovery ,Immunologic diseases. Allergy ,RC581-607 - Published
- 2024
- Full Text
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6. Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050
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Naghavi, Mohsen, Vollset, Stein Emil, Ikuta, Kevin S, Swetschinski, Lucien R, Gray, Authia P, Wool, Eve E, Robles Aguilar, Gisela, Mestrovic, Tomislav, Smith, Georgia, Han, Chieh, Hsu, Rebecca L, Chalek, Julian, Araki, Daniel T, Chung, Erin, Raggi, Catalina, Gershberg Hayoon, Anna, Davis Weaver, Nicole, Lindstedt, Paulina A, Smith, Amanda E, Altay, Umut, Bhattacharjee, Natalia V, Giannakis, Konstantinos, Fell, Frederick, McManigal, Barney, Ekapirat, Nattwut, Mendes, Jessica Andretta, Runghien, Tilleye, Srimokla, Oraya, Abdelkader, Atef, Abd-Elsalam, Sherief, Aboagye, Richard Gyan, Abolhassani, Hassan, Abualruz, Hasan, Abubakar, Usman, Abukhadijah, Hana J, Aburuz, Salahdein, Abu-Zaid, Ahmed, Achalapong, Sureerak, Addo, Isaac Yeboah, Adekanmbi, Victor, Adeyeoluwa, Temitayo Esther, Adnani, Qorinah Estiningtyas Sakilah, Adzigbli, Leticia Akua, Afzal, Muhammad Sohail, Afzal, Saira, Agodi, Antonella, Ahlstrom, Austin J, Ahmad, Aqeel, Ahmad, Sajjad, Ahmad, Tauseef, Ahmadi, Ali, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Ibrar, Ahmed, Mohammed, Ahmed, Saeed, Ahmed, Syed Anees, Akkaif, Mohammed Ahmed, Al Awaidy, Salah, Al Thaher, Yazan, Alalalmeh, Samer O, AlBataineh, Mohammad T, Aldhaleei, Wafa A, Al-Gheethi, Adel Ali Saeed, Alhaji, Nma Bida, Ali, Abid, Ali, Liaqat, Ali, Syed Shujait, Ali, Waad, Allel, Kasim, Al-Marwani, Sabah, Alrawashdeh, Ahmad, Altaf, Awais, Al-Tammemi, Alaa B., Al-Tawfiq, Jaffar A, Alzoubi, Karem H, Al-Zyoud, Walid Adnan, Amos, Ben, Amuasi, John H, Ancuceanu, Robert, Andrews, Jason R, Anil, Abhishek, Anuoluwa, Iyadunni Adesola, Anvari, Saeid, Anyasodor, Anayochukwu Edward, Apostol, Geminn Louis Carace, Arabloo, Jalal, Arafat, Mosab, Aravkin, Aleksandr Y, Areda, Demelash, Aremu, Abdulfatai, Artamonov, Anton A, Ashley, Elizabeth A, Asika, Marvellous O, Athari, Seyyed Shamsadin, Atout, Maha Moh'd Wahbi, Awoke, Tewachew, Azadnajafabad, Sina, Azam, James Mba, Aziz, Shahkaar, Azzam, Ahmed Y., Babaei, Mahsa, Babin, Francois-Xavier, Badar, Muhammad, Baig, Atif Amin, Bajcetic, Milica, Baker, Stephen, Bardhan, Mainak, Barqawi, Hiba Jawdat, Basharat, Zarrin, Basiru, Afisu, Bastard, Mathieu, Basu, Saurav, Bayleyegn, Nebiyou Simegnew, Belete, Melaku Ashagrie, Bello, Olorunjuwon Omolaja, Beloukas, Apostolos, Berkley, James A, Bhagavathula, Akshaya Srikanth, Bhaskar, Sonu, Bhuyan, Soumitra S, Bielicki, Julia A, Briko, Nikolay Ivanovich, Brown, Colin Stewart, Browne, Annie J, Buonsenso, Danilo, Bustanji, Yasser, Carvalheiro, Cristina G, Castañeda-Orjuela, Carlos A, Cenderadewi, Muthia, Chadwick, Joshua, Chakraborty, Sandip, Chandika, Rama Mohan, Chandy, Sara, Chansamouth, Vilada, Chattu, Vijay Kumar, Chaudhary, Anis Ahmad, Ching, Patrick R, Chopra, Hitesh, Chowdhury, Fazle Rabbi, Chu, Dinh-Toi, Chutiyami, Muhammad, Cruz-Martins, Natalia, da Silva, Alanna Gomes, Dadras, Omid, Dai, Xiaochen, Darcho, Samuel D, Das, Saswati, De la Hoz, Fernando Pio, Dekker, Denise Myriam, Dhama, Kuldeep, Diaz, Daniel, Dickson, Benjamin Felix Rothschild, Djorie, Serge Ghislain, Dodangeh, Milad, Dohare, Sushil, Dokova, Klara Georgieva, Doshi, Ojas Prakashbhai, Dowou, Robert Kokou, Dsouza, Haneil Larson, Dunachie, Susanna J, Dziedzic, Arkadiusz Marian, Eckmanns, Tim, Ed-Dra, Abdelaziz, Eftekharimehrabad, Aziz, Ekundayo, Temitope Cyrus, El Sayed, Iman, Elhadi, Muhammed, El-Huneidi, Waseem, Elias, Christelle, Ellis, Sally J, Elsheikh, Randa, Elsohaby, Ibrahim, Eltaha, Chadi, Eshrati, Babak, Eslami, Majid, Eyre, David William, Fadaka, Adewale Oluwaseun, Fagbamigbe, Adeniyi Francis, Fahim, Ayesha, Fakhri-Demeshghieh, Aliasghar, Fasina, Folorunso Oludayo, Fasina, Modupe Margaret, Fatehizadeh, Ali, Feasey, Nicholas A, Feizkhah, Alireza, Fekadu, Ginenus, Fischer, Florian, Fitriana, Ida, Forrest, Karen M, Fortuna Rodrigues, Celia, Fuller, John E, Gadanya, Muktar A, Gajdács, Márió, Gandhi, Aravind P, Garcia-Gallo, Esteban E, Garrett, Denise O, Gautam, Rupesh K, Gebregergis, Miglas Welay, Gebrehiwot, Mesfin, Gebremeskel, Teferi Gebru, Geffers, Christine, Georgalis, Leonidas, Ghazy, Ramy Mohamed, Golechha, Mahaveer, Golinelli, Davide, Gordon, Melita, Gulati, Snigdha, Gupta, Rajat Das, Gupta, Sapna, Gupta, Vijai Kumar, Habteyohannes, Awoke Derbie, Haller, Sebastian, Harapan, Harapan, Harrison, Michelle L, Hasaballah, Ahmed I, Hasan, Ikramul, Hasan, Rumina Syeda, Hasani, Hamidreza, Haselbeck, Andrea Haekyung, Hasnain, Md Saquib, Hassan, Ikrama Ibrahim, Hassan, Shoaib, Hassan Zadeh Tabatabaei, Mahgol Sadat, Hayat, Khezar, He, Jiawei, Hegazi, Omar E, Heidari, Mohammad, Hezam, Kamal, Holla, Ramesh, Holm, Marianne, Hopkins, Heidi, Hossain, Md Mahbub, Hosseinzadeh, Mehdi, Hostiuc, Sorin, Hussein, Nawfal R, Huy, Le Duc, Ibáñez-Prada, Elsa D, Ikiroma, Adalia, Ilic, Irena M, Islam, Sheikh Mohammed Shariful, Ismail, Faisal, Ismail, Nahlah Elkudssiah, Iwu, Chidozie Declan, Iwu-Jaja, Chinwe Juliana, Jafarzadeh, Abdollah, Jaiteh, Fatoumatta, Jalilzadeh Yengejeh, Reza, Jamora, Roland Dominic G, Javidnia, Javad, Jawaid, Talha, Jenney, Adam W J, Jeon, Hyon Jin, Jokar, Mohammad, Jomehzadeh, Nabi, Joo, Tamas, Joseph, Nitin, Kamal, Zul, Kanmodi, Kehinde Kazeem, Kantar, Rami S, Kapisi, James Apollo, Karaye, Ibraheem M, Khader, Yousef Saleh, Khajuria, Himanshu, Khalid, Nauman, Khamesipour, Faham, Khan, Ajmal, Khan, Mohammad Jobair, Khan, Muhammad Tariq, Khanal, Vishnu, Khidri, Feriha Fatima, Khubchandani, Jagdish, Khusuwan, Suwimon, Kim, Min Seo, Kisa, Adnan, Korshunov, Vladimir Andreevich, Krapp, Fiorella, Krumkamp, Ralf, Kuddus, Mohammed, Kulimbet, Mukhtar, Kumar, Dewesh, Kumaran, Emmanuelle A P, Kuttikkattu, Ambily, Kyu, Hmwe Hmwe, Landires, Iván, Lawal, Basira Kankia, Le, Thao Thi Thu, Lederer, Ingeborg Maria, Lee, Munjae, Lee, Seung Won, Lepape, Alain, Lerango, Temesgen Leka, Ligade, Virendra S, Lim, Cherry, Lim, Stephen S, Limenh, Liknaw Workie, Liu, Chaojie, Liu, Xiaofeng, Liu, Xuefeng, Loftus, Michael J, M Amin, Hawraz Ibrahim, Maass, Kelsey Lynn, Maharaj, Sandeep B, Mahmoud, Mansour Adam, Maikanti-Charalampous, Panagiota, Makram, Omar M, Malhotra, Kashish, Malik, Ahmad Azam, Mandilara, Georgia D, Marks, Florian, Martinez-Guerra, Bernardo Alfonso, Martorell, Miquel, Masoumi-Asl, Hossein, Mathioudakis, Alexander G, May, Juergen, McHugh, Theresa A, Meiring, James, Meles, Hadush Negash, Melese, Addisu, Melese, Endalkachew Belayneh, Minervini, Giuseppe, Mohamed, Nouh Saad, Mohammed, Shafiu, Mohan, Syam, Mokdad, Ali H, Monasta, Lorenzo, Moodi Ghalibaf, AmirAli, Moore, Catrin E, Moradi, Yousef, Mossialos, Elias, Mougin, Vincent, Mukoro, George Duke, Mulita, Francesk, Muller-Pebody, Berit, Murillo-Zamora, Efren, Musa, Sani, Musicha, Patrick, Musila, Lillian A, Muthupandian, Saravanan, Nagarajan, Ahamarshan Jayaraman, Naghavi, Pirouz, Nainu, Firzan, Nair, Tapas Sadasivan, Najmuldeen, Hastyar Hama Rashid, Natto, Zuhair S, Nauman, Javaid, Nayak, Biswa Prakash, Nchanji, G Takop, Ndishimye, Pacifique, Negoi, Ionut, Negoi, Ruxandra Irina, Nejadghaderi, Seyed Aria, Nguyen, QuynhAnh P, Noman, Efaq Ali, Nwakanma, Davis C, O'Brien, Seamus, Ochoa, Theresa J, Odetokun, Ismail A, Ogundijo, Oluwaseun Adeolu, Ojo-Akosile, Tolulope R, Okeke, Sylvester Reuben, Okonji, Osaretin Christabel, Olagunju, Andrew T, Olivas-Martinez, Antonio, Olorukooba, Abdulhakeem Abayomi, Olwoch, Peter, Onyedibe, Kenneth Ikenna, Ortiz-Brizuela, Edgar, Osuolale, Olayinka, Ounchanum, Pradthana, Oyeyemi, Oyetunde T, P A, Mahesh Padukudru, Paredes, Jose L, Parikh, Romil R, Patel, Jay, Patil, Shankargouda, Pawar, Shrikant, Peleg, Anton Y, Peprah, Prince, Perdigão, João, Perrone, Carlo, Petcu, Ionela-Roxana, Phommasone, Koukeo, Piracha, Zahra Zahid, Poddighe, Dimitri, Pollard, Andrew J, Poluru, Ramesh, Ponce-De-Leon, Alfredo, Puvvula, Jagadeesh, Qamar, Farah Naz, Qasim, Nameer Hashim, Rafai, Clotaire Donatien, Raghav, Pankaja, Rahbarnia, Leila, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Mosiur, Rahman, Muhammad Aziz, Ramadan, Hazem, Ramasamy, Shakthi Kumaran, Ramesh, Pushkal Sinduvadi, Ramteke, Pramod W, Rana, Rishabh Kumar, Rani, Usha, Rashidi, Mohammad-Mahdi, Rathish, Devarajan, Rattanavong, Sayaphet, Rawaf, Salman, Redwan, Elrashdy Moustafa Mohamed, Reyes, Luis Felipe, Roberts, Tamalee, Robotham, Julie V, Rosenthal, Victor Daniel, Ross, Allen Guy, Roy, Nitai, Rudd, Kristina E, Sabet, Cameron John, Saddik, Basema Ahmad, Saeb, Mohammad Reza, Saeed, Umar, Saeedi Moghaddam, Sahar, Saengchan, Weeravoot, Safaei, Mohsen, Saghazadeh, Amene, Saheb Sharif-Askari, Narjes, Sahebkar, Amirhossein, Sahoo, Soumya Swaroop, Sahu, Maitreyi, Saki, Morteza, Salam, Nasir, Saleem, Zikria, Saleh, Mohamed A, Samodra, Yoseph Leonardo, Samy, Abdallah M, Saravanan, Aswini, Satpathy, Maheswar, Schumacher, Austin E, Sedighi, Mansour, Seekaew, Samroeng, Shafie, Mahan, Shah, Pritik A, Shahid, Samiah, Shahwan, Moyad Jamal, Shakoor, Sadia, Shalev, Noga, Shamim, Muhammad Aaqib, Shamshirgaran, Mohammad Ali, Shamsi, Anas, Sharifan, Amin, Shastry, Rajesh P, Shetty, Mahabalesh, Shittu, Aminu, Shrestha, Sunil, Siddig, Emmanuel Edwar, Sideroglou, Theologia, Sifuentes-Osornio, Jose, Silva, Luís Manuel Lopes Rodrigues, Simões, Eric A F, Simpson, Andrew J H, Singh, Amit, Singh, Surjit, Sinto, Robert, Soliman, Sameh S M, Soraneh, Soroush, Stoesser, Nicole, Stoeva, Temenuga Zhekova, Swain, Chandan Kumar, Szarpak, Lukasz, T Y, Sree Sudha, Tabatabai, Shima, Tabche, Celine, Taha, Zanan Mohammed-Ameen, Tan, Ker-Kan, Tasak, Nidanuch, Tat, Nathan Y, Thaiprakong, Areerat, Thangaraju, Pugazhenthan, Tigoi, Caroline Chepngeno, Tiwari, Krishna, Tovani-Palone, Marcos Roberto, Tran, Thang Huu, Tumurkhuu, Munkhtuya, Turner, Paul, Udoakang, Aniefiok John, Udoh, Arit, Ullah, Noor, Ullah, Saeed, Vaithinathan, Asokan Govindaraj, Valenti, Mario, Vos, Theo, Vu, Huong T L, Waheed, Yasir, Walker, Ann Sarah, Walson, Judd L, Wangrangsimakul, Tri, Weerakoon, Kosala Gayan, Wertheim, Heiman F L, Williams, Phoebe C M, Wolde, Asrat Arja, Wozniak, Teresa M, Wu, Felicia, Wu, Zenghong, Yadav, Mukesh Kumar Kumar, Yaghoubi, Sajad, Yahaya, Zwanden Sule, Yarahmadi, Amir, Yezli, Saber, Yismaw, Yazachew Engida, Yon, Dong Keon, Yuan, Chun-Wei, Yusuf, Hadiza, Zakham, Fathiah, Zamagni, Giulia, Zhang, Haijun, Zhang, Zhi-Jiang, Zielińska, Magdalena, Zumla, Alimuddin, Zyoud, Sa'ed H. H, Zyoud, Samer H, Hay, Simon I, Stergachis, Andy, Sartorius, Benn, Cooper, Ben S, Dolecek, Christiane, and Murray, Christopher J L
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- 2024
- Full Text
- View/download PDF
7. Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021
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Bender, Rose Grace, Sirota, Sarah Brooke, Swetschinski, Lucien R, Dominguez, Regina-Mae Villanueva, Novotney, Amanda, Wool, Eve E, Ikuta, Kevin S, Vongpradith, Avina, Rogowski, Emma Lynn Best, Doxey, Matthew, Troeger, Christopher E, Albertson, Samuel B, Ma, Jianing, He, Jiawei, Maass, Kelsey Lynn, A.F.Simões, Eric, Abdoun, Meriem, Abdul Aziz, Jeza Muhamad, Abdulah, Deldar Morad, Abu Rumeileh, Samir, Abualruz, Hasan, Aburuz, Salahdein, Adepoju, Abiola Victor, Adha, Rishan, Adikusuma, Wirawan, Adra, Saryia, Afraz, Ali, Aghamiri, Shahin, Agodi, Antonella, Ahmadzade, Amir Mahmoud, Ahmed, Haroon, Ahmed, Ayman, Akinosoglou, Karolina, AL-Ahdal, Tareq Mohammed Ali, Al-amer, Rasmieh Mustafa, Albashtawy, Mohammed, AlBataineh, Mohammad T., Alemi, Hediyeh, Al-Gheethi, Adel Ali Saeed, Ali, Abid, Ali, Syed Shujait Shujait, Alqahtani, Jaber S, AlQudah, Mohammad, Al-Tawfiq, Jaffar A., Al-Worafi, Yaser Mohammed, Alzoubi, Karem H, Amani, Reza, Amegbor, Prince M, Ameyaw, Edward Kwabena, Amuasi, John H, Anil, Abhishek, Anyanwu, Philip Emeka, Arafat, Mosab, Areda, Damelash, Arefnezhad, Reza, Atalell, Kendalem Asmare, Ayele, Firayad, Azzam, Ahmed Y, Babamohamadi, Hassan, Babin, François-Xavier, Bahurupi, Yogesh, Baker, Stephen, Banik, Biswajit, Barchitta, Martina, Barqawi, Hiba Jawdat, Basharat, Zarrin, Baskaran, Pritish, Batra, Kavita, Batra, Ravi, Bayileyegn, Nebiyou Simegnew, Beloukas, Apostolos, Berkley, James A, Beyene, Kebede A, Bhargava, Ashish, Bhattacharjee, Priyadarshini, Bielicki, Julia A, Bilalaga, Mariah Malak, Bitra, Veera R, Brown, Colin Stewart, Burkart, Katrin, Bustanji, Yasser, Carr, Sinclair, Chahine, Yaacoub, Chattu, Vijay Kumar, Chichagi, Fatemeh, Chopra, Hitesh, Chukwu, Isaac Sunday, Chung, Eunice, Dadana, Sriharsha, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Darban, Isaac, Dash, Nihar Ranjan, Dashti, Mohsen, Dashtkoohi, Mohadese, Dekker, Denise Myriam, Delgado-Enciso, Ivan, Devanbu, Vinoth Gnana Chellaiyan, Dhama, Kuldeep, Diao, Nancy, Do, Thao Huynh Phuong, Dokova, Klara Georgieva, Dolecek, Christiane, Dziedzic, Arkadiusz Marian, Eckmanns, Tim, Ed-Dra, Abdelaziz, Efendi, Ferry, Eftekharimehrabad, Aziz, Eyre, David William, Fahim, Ayesha, Feizkhah, Alireza, Felton, Timothy William, Ferreira, Nuno, Flor, Luisa S, Gaihre, Santosh, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Geffers, Christine, Gerema, Urge, Ghaffari, Kazem, Goldust, Mohamad, Goleij, Pouya, Guan, Shi-Yang, Gudeta, Mesay Dechasa, Guo, Cui, Gupta, Veer Bala, Gupta, Ishita, Habibzadeh, Farrokh, Hadi, Najah R, Haeuser, Emily, Hailu, Wase Benti, Hajibeygi, Ramtin, Haj-Mirzaian, Arvin, Haller, Sebastian, Hamiduzzaman, Mohammad, Hanifi, Nasrin, Hansel, Jan, Hasnain, Md Saquib, Haubold, Johannes, Hoan, Nguyen Quoc, Huynh, Hong-Han, Iregbu, Kenneth Chukwuemeka, Islam, Md. Rabiul, Jafarzadeh, Abdollah, Jairoun, Ammar Abdulrahman, Jalili, Mahsa, Jomehzadeh, Nabi, Joshua, Charity Ehimwenma, Kabir, Md. Awal, Kamal, Zul, Kanmodi, Kehinde Kazeem, Kantar, Rami S., Karimi Behnagh, Arman, Kaur, Navjot, Kaur, Harkiran, Khamesipour, Faham, Khan, M Nuruzzaman, Khan suheb, Mahammed Ziauddin, Khanal, Vishnu, Khatab, Khaled, Khatib, Mahalaqua Nazli, Kim, Grace, Kim, Kwanghyun, Kitila, Aiggan Tamene Tamene, Komaki, Somayeh, Krishan, Kewal, Krumkamp, Ralf, Kuddus, Md Abdul, Kurniasari, Maria Dyah, Lahariya, Chandrakant, Latifinaibin, Kaveh, Le, Nhi Huu Hanh, Le, Thao Thi Thu, Le, Trang Diep Thanh, Lee, Seung Won, LEPAPE, Alain, Lerango, Temesgen L., Li, Ming-Chieh, Mahboobipour, Amir Ali, Malhotra, Kashish, Mallhi, Tauqeer Hussain, Manoharan, Anand, Martinez-Guerra, Bernardo Alfonso, Mathioudakis, Alexander G., Mattiello, Rita, May, Jürgen, McManigal, Barney, McPhail, Steven M, Mekene Meto, Tesfahun, Mendez-Lopez, Max Alberto Mendez, Meo, Sultan Ayoub, Merati, Mohsen, Mestrovic, Tomislav, Mhlanga, Laurette, Minh, Le Huu Nhat, Misganaw, Awoke, Mishra, Vinaytosh, Misra, Arup Kumar, Mohamed, Nouh Saad, Mohammadi, Esmaeil, Mohammed, Mesud, Mohammed, Mustapha, Mokdad, Ali H, Monasta, Lorenzo, Moore, Catrin E, Motappa, Rohith, Mougin, Vincent, Mousavi, Parsa, Mulita, Francesk, Mulu, Atsedemariam Andualem, Naghavi, Pirouz, Naik, Ganesh R, Nainu, Firzan, Nair, Tapas Sadasivan, Nargus, Shumaila, Negaresh, Mohammad, Nguyen, Hau Thi Hien, Nguyen, Dang H, Nguyen, Van Thanh, Nikolouzakis, Taxiarchis Konstantinos, Noman, Efaq Ali, Nri-Ezedi, Chisom Adaobi, Odetokun, Ismail A., Okwute, Patrick Godwin, Olana, Matifan Dereje, Olanipekun, Titilope O, Olasupo, Omotola O., Olivas-Martinez, Antonio, Ordak, Michal, Ortiz-Brizuela, Edgar, Ouyahia, Amel, Padubidri, Jagadish Rao, Pak, Anton, Pandey, Anamika, Pantazopoulos, Ioannis, Parija, Pragyan Paramita, Parikh, Romil R, Park, Seoyeon, Parthasarathi, Ashwaghosha, Pashaei, Ava, Peprah, Prince, Pham, Hoang Tran, Poddighe, Dimitri, Pollard, Andrew, Ponce-De-Leon, Alfredo, Prakash, Peralam Yegneswaran, Prates, Elton Junio Sady, Quan, Nguyen Khoi, Raee, Pourya, Rahim, Fakher, Rahman, Mosiur, Rahmati, Masoud, Ramasamy, Shakthi Kumaran, Ranjan, Shubham, Rao, Indu Ramachandra, Rashid, Ahmed Mustafa, Rattanavong, Sayaphet, Ravikumar, Nakul, Reddy, Murali Mohan Rama Krishna, Redwan, Elrashdy Moustafa Mohamed, Reiner, Robert C, Jr., Reyes, Luis Felipe, Roberts, Tamalee, Rodrigues, Mónica, Rosenthal, Victor Daniel, Roy, Priyanka, Runghien, Tilleye, Saeed, Umar, Saghazadeh, Amene, Saheb Sharif-Askari, Narjes, Saheb Sharif-Askari, Fatemeh, Sahoo, Soumya Swaroop, Sahu, Monalisha, Sakshaug, Joseph W, Salami, Afeez Abolarinwa, Saleh, Mohamed A., Salehi omran, Hossein, Sallam, Malik, Samadzadeh, Sara, Samodra, Yoseph Leonardo, Sanjeev, Rama Krishna, Sarasmita, Made Ary, Saravanan, Aswini, Sartorius, Benn, Saulam, Jennifer, Schumacher, Austin E, Seyedi, Seyed Arsalan, Shafie, Mahan, Shahid, Samiah, Sham, Sunder, Shamim, Muhammad Aaqib, Shamshirgaran, Mohammad Ali, Shastry, Rajesh P., Sherchan, Samendra P, Shiferaw, Desalegn, Shittu, Aminu, Siddig, Emmanuel Edwar, Sinto, Robert, Sood, Aayushi, Sorensen, Reed J D, Stergachis, Andy, Stoeva, Temenuga Zhekova, Swain, Chandan Kumar, Szarpak, Lukasz, Tamuzi, Jacques Lukenze, Temsah, Mohamad-Hani, Tessema, Melkamu B Tessema, Thangaraju, Pugazhenthan, Tran, Nghia Minh, Tran, Ngoc-Ha, Tumurkhuu, Munkhtuya, Ty, Sree Sudha, Udoakang, Aniefiok John, Ulhaq, Inam, Umar, Tungki Pratama, Umer, Abdurezak Adem, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Van den Eynde, Jef, Walson, Judd L, Waqas, Muhammad, Xing, Yuhan, Yadav, Mukesh Kumar, Yahya, Galal, Yon, Dong Keon, Zahedi Bialvaei, Abed, Zakham, Fathiah, Zeleke, Abyalew Mamuye, Zhai, Chunxia, Zhang, Zhaofeng, Zhang, Haijun, Zielińska, Magdalena, Zheng, Peng, Aravkin, Aleksandr Y, Vos, Theo, Hay, Simon I, Mosser, Jonathan F., Lim, Stephen S, Naghavi, Mohsen, Murray, Christopher J L, and Kyu, Hmwe Hmwe
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- 2024
- Full Text
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8. Current knowledge and practice of Candida auris screening in France: A nationwide survey from the French Society of Medical Mycology (SFMM)
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Guitard, J., Bellanger, A.P., Dorin, J., Cassaing, S., Capitaine, A., Gabriel, F., Nicolas, M., Coron, N., Penn, P., Moniot, M., Quinio, D., Ranque, S., Sasso, M., Lepape, P., Dannaoui, E., Brun, S., Lacroix, C., Cornu, M., Debourgogne, A., Durieux, M.F., Laurent, G., Bru, V., Bourgeois, N., Brunet, K., Chouaki, T., Huguenin, A., Hasseine, L., Maubon, D., Gangneux, J.P., Desbois-Nogard, N., Houze, S., Dalle, F., Bougnoux, M.E., Alanio, A., Costa, D., Botterel, F., and Hennequin, C.
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- 2024
- Full Text
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9. Impact of Pseudomonas aeruginosa carriage on intensive care unit-acquired pneumonia: a European multicentre prospective cohort study
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Paling, F., Recanatini, C., Timbermont, L., Ewout van der Schalk, T., Sifakis, F., Wolkewitz, M., Hazard, D., Bonten, M., Goossens, H., Malhotra-Kumar, S., Kluytmans, J., Weber, S., Ali, O., Ruzin, A., Jafri, H., Lammens, C., Vlaeminck, J., Hullegie, S., Troeman, D., van Hout, D., Prins, D., Kalyani, R., Shoemaker, K., Vilken, T., Coppens, J., Xavier, B.B., Coenjaerts, F., Temelkov, A., Odisseeva, E., Vatcheva, R., Drab, M., Vajter, J., Tamme, K., Fartoukh, M., LePape, A., Landais, M., Plantefève, G., Tacconelli, E., Kaasch, A., Jurkinya, R., Zsolt, I., van Rijen, M., Cremer, O., Carevic, B., Jevdjić, J., Escudero, D., Garcia, M.S., Prat-Aymerich, C., Suberviola-Cañas, B., Arenzana-Seisdedos, A., Bodur, H., Kirakli, C., Bozkurt, I., Long, S., van Werkhoven, C.H., van der Schalk, T.E., Torrens, G., DiGiandomenico, A., Esser, M.T., and Oliver, A.
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- 2024
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10. Association between selective digestive decontamination and decreased rate of acquired candidemia in mechanically ventilated ICU patients: a multicenter nationwide study
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Reizine, Florian, Massart, Nicolas, Joussellin, Vincent, Machut, Anaïs, Vacheron, Charles-Hervé, Savey, Anne, Friggeri, Arnaud, and Lepape, Alain
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- 2023
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11. Granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients presenting sepsis-induced immunosuppression: The GRID randomized controlled trial
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Vacheron, Charles-Hervé, Lepape, Alain, Venet, Fabienne, Monneret, Guillaume, Gueyffier, Francois, Boutitie, Florent, Vallin, Helene, Schwebel, Carole, Maucort-Boulch, Delphine, and Friggeri, Arnaud
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- 2023
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12. Effect of SARS-CoV-2 infection and pandemic period on healthcare-associated infections acquired in intensive care units
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Lepape, Alain, Machut, Anaïs, Bretonnière, Cedric, Friggeri, Arnaud, Vacheron, Charles-Hervé, and Savey, Anne
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- 2023
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13. WINTER HABITAT SELECTION OF MOOSE IN MAINE AND RUMINATIONS ON THE IMPACT OF CHANGING WEATHER CONDITIONS
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DiMatteo-LePape, Asha, Morano, Sabrina, De Urioste-Stone, Sandra, and Kantar, Lee E.
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Cold weather -- Analysis ,Moose -- Analysis ,Climatic changes -- Analysis ,Forests and forestry -- Analysis ,White-tailed deer -- Analysis ,General interest ,News, opinion and commentary ,University of Maine - Abstract
Winter habitat use by moose (Alces alces) in response to climate change may reflect shifts in biotic and abiotic stressors that pose both environmental challenges and opportunities. Snow depth, temperature, winter length, and forest composition influence moose mobility, habitat use, and access to forage and cover resources. We analyzed habitat selection in winter home ranges of adult female moose (n = 96) over the course of six winters (2014-2019) to explore the influence of winter weather and forest composition on landscape and habitat use. Second order (home range) resource selection functions were estimated using generalized linear mixed models. Moose selected most strongly for forest habitat, specifically evergreen and mixed forests, which had similar strength of selection and represented ~50% of home ranges. The models identified a slight positive association with regenerating forest, although high levels of variance indicated a weak relationship. Contrary to our prediction, we did not detect any influence of weather conditions on winter habitat selection. Maine's mosaic of forest types and commercial forestry seemingly provide adequate food and cover resources for moose regardless of winter conditions, with the three habitat types selected for representing ~70% of home ranges. Due to the coarse resolution of the data we analyzed, more specific data on forest structure such as stand age, canopy, and forage species may be required to identify finer relationships in habitat use and specific resource requirements during winter. It is possible that other factors associated with climate change, such as increases in deer (Odocoileus virginianus) populations, parasites, and disease will have greater influence on moose than habitat per se. However, because these potential influences are indirectly related to habitat use by moose, further research is warranted to best understand the multiple factors and relationships affecting winter habitat use. Key words: Alces alces, seasonal resources, home range, landscape use, New England, weather conditions, winter., INTRODUCTION Moose (Alces alces) population dynamics are largely influenced by forage and cover resources in forest habitats; within Maine's boreal forest moose landscape use is likely driven by access to [...]
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- 2023
14. Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial
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Jean Chastre, Bruno François, Marc Bourgeois, Apostolos Komnos, Ricard Ferrer, Galia Rahav, Nicolas De Schryver, Alain Lepape, Iftihar Koksal, Charles-Edouard Luyt, Miguel Sánchez-García, Antoni Torres, Philippe Eggimann, Despoina Koulenti, Thomas L. Holland, Omar Ali, Kathryn Shoemaker, Pin Ren, Julien Sauser, Alexey Ruzin, David E. Tabor, Ahmad Akhgar, Yuling Wu, Yu Jiang, Antonio DiGiandomenico, Susan Colbert, Drieke Vandamme, Frank Coenjaerts, Surbhi Malhotra-Kumar, Leen Timbermont, Antonio Oliver, Olivier Barraud, Terramika Bellamy, Marc Bonten, Herman Goossens, Colin Reisner, Mark T. Esser, Hasan S. Jafri, and The COMBACTE-MAGNET EVADE Study Group
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Monoclonal antibody ,Prevention ,Pharmacokinetics ,Pseudomonas aeruginosa ventilator-associated pneumonia ,Safety ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) was a phase 2, randomised, parallel-group, double-blind, placebo-controlled study in Europe, Turkey, Israel, and the USA. Subjects ≥ 18 years old, mechanically ventilated, tracheally colonised with PA, and without new-onset pneumonia, were randomised (1:1:1) to MEDI3902 500, 1500 mg (single intravenous dose), or placebo. The primary efficacy endpoint was the incidence of nosocomial PA pneumonia through 21 days post-dose in MEDI3902 1500 mg versus placebo, determined by an independent adjudication committee. Results Even if the initial sample size was not reached because of low recruitment, 188 subjects were randomised (MEDI3902 500/1500 mg: n = 16/87; placebo: n = 85) between 13 April 2016 and 17 October 2019. Out of these, 184 were dosed (MEDI3902 500/1500 mg: n = 16/85; placebo: n = 83), comprising the modified intent-to-treat set. Enrolment in the 500 mg arm was discontinued due to pharmacokinetic data demonstrating low MEDI3902 serum concentrations. Subsequently, enrolled subjects were randomised (1:1) to MEDI3902 1500 mg or placebo. PA pneumonia was confirmed in 22.4% (n = 19/85) of MEDI3902 1500 mg recipients and in 18.1% (n = 15/83) of placebo recipients (relative risk reduction [RRR]: − 23.7%; 80% confidence interval [CI] − 83.8%, 16.8%; p = 0.49). At 21 days post-1500 mg dose, the mean (standard deviation) serum MEDI3902 concentration was 9.46 (7.91) μg/mL, with 80.6% (n = 58/72) subjects achieving concentrations > 1.7 μg/mL, a level associated with improved outcome in animal models. Treatment-emergent adverse event incidence was similar between groups. Conclusions The bivalent, bispecific monoclonal antibody MEDI3902 (gremubamab) did not reduce PA nosocomial pneumonia incidence in PA-colonised mechanically ventilated subjects. Trial registration Registered on Clinicaltrials.gov ( NCT02696902 ) on 11th February 2016 and on EudraCT ( 2015-001706-34 ) on 7th March 2016.
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- 2022
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15. Prognosis of Old Intensive Care COVID-19 Patients at a Glance: The Senior COVID Study
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Charles-Hervé Vacheron, Laurent Bitker, Fabrice Thiolliére, Fabien Subtil, Paul Abraham, Vincent Collange, Baptiste Balança, Max Haïne, Céline Guichon, Christophe Leroy, Marie Simon, Amélie Malapert, Mélanie Roche, Jean-Baptiste Pialat, Laurent Jallades, Alain Lepape, Arnaud Friggeri, and Claire Falandry
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Anesthesiology ,RD78.3-87.3 - Published
- 2022
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16. Immune Profiling Panel Gene Set Identifies Critically Ill Patients With Low Monocyte Human Leukocyte Antigen-DR Expression: Preliminary Results From the REAnimation Low Immune Status Marker (REALISM) Study
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Peronnet, Estelle, Blein, Sophie, Venet, Fabienne, Cerrato, Elisabeth, Fleurie, Aurore, Llitjos, Jean-François, Kreitmann, Louis, Terraz, Gabriel, Conti, Filippo, Gossez, Morgane, Rimmelé, Thomas, Textoris, Julien, Lukaszewicz, Anne-Claire, Brengel-Pesce, Karen, Monneret, Guillaume, Arnal, Sophie, Augris-Mathieu, Caroline, Bayle, Frederique, Caruso, Liana, Ber, Charles-Eric, Ben-Amor, Asma, Bellocq, Anne-Sophie, Benatir, Farida, Bertin-Maghit, Anne, Bertin-Maghit, Marc, Boibieux, Andre, Bouffard, Yves, Cejka, Jean-Christophe, Cerro, Valerie, Crozon-Clauzel, Jullien, Davidson, Julien, Debord-Peguet, Sophie, Delwarde, Benjamin, Deleat-Besson, Robert, Delsuc, Claire, Devigne, Bertrand, Fayolle-Pivot, Laure, Faure, Alexandre, Floccard, Bernard, Gatel, Julie, Genin, Charline, Girardot, Thibaut, Gregoire, Arnaud, Hengy, Baptiste, Huriaux, Laetitia, Jadaud, Catherine, Lepape, Alain, Leray, Veronique, Lukaszewicz, Anne-Claire, Marcotte, Guillaume, Martin, Olivier, Matray, Marie, Maucort-Boulch, Delphine, Meuret, Pascal, Monard, Celine, Moriceau, Florent, Monneret, Guillaume, Panel, Nathalie, Rahali, Najia, Rimmele, Thomas, Truc, Cyrille, Uberti, Thomas, Vallin, Helene, Venet, Fabienne, Tissot, Sylvie, Zadam, Abbes, Blein, Sophie, Brengel-Pesce, Karen, Cerrato, Elisabeth, Cheynet, Valerie, Gallet-Gorius, Emmanuelle, Guichard, Audrey, Jourdan, Camille, Koenig, Natacha, Mallet, Francois, Meunier, Boris, Moucade, Virginie, Mommert, Marine, Oriol, Guy, Pachot, Alexandre, Peronnet, Estelle, Schrevel, Claire, Tabone, Olivier, Textoris, Julien, Marcos, Javier Yugueros, Becker, Jeremie, Bequet, Frederic, Bounab, Yacine, Brajon, Florian, Canard, Bertrand, Collus, Muriel, Garcon, Nathalie, Gorse, Irene, Guyard, Cyril, Lavocat, Fabien, Leissner, Philippe, Louis, Karen, Mistretta, Maxime, Moriniere, Jeanne, Mouscaz, Yoann, Noailles, Laura, Perret, Magali, Reynier, Frederic, Riffaud, Cindy, Rol, Mary-Luz, Sapay, Nicolas, Tran, Trang, Vedrine, Christophe, Carre, Christophe, Cortez, Pierre, de Monfort, Aymeric, Florin, Karine, Fraisse, Laurent, Fugier, Isabelle, Payrard, Sandrine, Peleraux, Annick, Quemeneur, Laurence, Griffiths, Andrew, Toetsch, Stephanie, Ashton, Teri, Gough, Peter J., Berger, Scott B., Gardiner, David, Gillespie, Iain, Macnamara, Aidan, Raychaudhuri, Aparna, Smylie, Rob, Tan, Lionel, and Tipple, Craig
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- 2023
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17. Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial
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Chastre, Jean, François, Bruno, Bourgeois, Marc, Komnos, Apostolos, Ferrer, Ricard, Rahav, Galia, De Schryver, Nicolas, Lepape, Alain, Koksal, Iftihar, Luyt, Charles-Edouard, Sánchez-García, Miguel, Torres, Antoni, Eggimann, Philippe, Koulenti, Despoina, Holland, Thomas L., Ali, Omar, Shoemaker, Kathryn, Ren, Pin, Sauser, Julien, Ruzin, Alexey, Tabor, David E., Akhgar, Ahmad, Wu, Yuling, Jiang, Yu, DiGiandomenico, Antonio, Colbert, Susan, Vandamme, Drieke, Coenjaerts, Frank, Malhotra-Kumar, Surbhi, Timbermont, Leen, Oliver, Antonio, Barraud, Olivier, Bellamy, Terramika, Bonten, Marc, Goossens, Herman, Reisner, Colin, Esser, Mark T., and Jafri, Hasan S.
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- 2022
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18. Performance of 30 commercial SARS-CoV-2 serology assays in testing symptomatic COVID-19 patients
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Vauloup-Fellous, Christelle, Maylin, Sarah, Périllaud-Dubois, Claire, Brichler, Ségolène, Alloui, Chakib, Gordien, Emmanuel, Rameix-Welti, Marie-Anne, Gault, Elyanne, Moreau, Frédérique, Fourati, Slim, Challine, Dominique, Pawlotsky, Jean-Michel, Houhou-Fidouh, Nadhira, Damond, Florence, Mackiewicz, Vincent, Charpentier, Charlotte, Méritet, Jean-François, Rozenberg, Flore, Podglajen, Isabelle, Marot, Stéphane, Petit, Heloïse, Burrel, Sonia, Akhavan, Sepideh, Leruez-Ville, Marianne, Avettand-Fenoel, Véronique, Fourgeaud, Jacques, Guilleminot, Tiffany, Gardiennet, Elise, Bonacorsi, Stéphane, Carol, Agnès, Carcelain, Guislaine, Villemonteix, Juliette, Boukli, Narjis, Gozlan, Joël, Morand-Joubert, Laurence, Legoff, Jérome, Delaugerre, Constance, Chaix, Marie-Laure, Roque-Afonso, Ana-Maria, Dortet, Laurent, Naas, Thierry, Ronat, Jean-Baptiste, Lepape, Samuel, Marcelin, Anne-Geneviève, and Descamps, Diane
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- 2021
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19. Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial
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Chochrad, Didier, Dive, Alain, Foret, Frédéric, Simon, Marc, Spapen, Herbert, Creteur, Jacques, Bouckaert, Yves, Biston, Patrick, Bourgeois, Marc, Novacek, Martin, Vymazal, Tomas, Svoboda, Petr, Pachl, Jan, Sramek, Vladimir, Hanauer, Michal, Hruby, Tomas, Balik, Martin, Suchy, Tomas, Lepape, Alain, Argaud, Laurent, Dailler, Frédéric, Desachy, Arnaud, Guitton, Christophe, Mercat, Alain, Meziani, Ferhat, Navellou, Jean-Christophe, Robert, Rene, Souweine, Bertrand, Tadie, Jean-Marc, Maamar, Adel, Annane, Djillali, Tamion, Fabienne, Gros, Antoine, Nseir, Saad, Schwebel, Carole, Francony, Gilles, Lefrant, Jean-Yves, Schneider, Francis, Gründling, Matthias, Motsch, Johann, Reill, Lorenz, Rolfes, Caroline, Welte, Tobias, Cornely, Oliver, Bloos, Frank, Deja, Maria, Schmidt, Katrin, Wappler, Frank, Meier-Hellmann, Andreas, Komnos, Apostolos, Bekos, Vasileios, Koulouras, Vasilios, Soultati, Ioanna, Baltopoulos, Georgios, Filntisis, Georgios, Zakynthinos, Epaminondas, Zakynthinos, Spyros, Pnevmatikos, Ioannis, Krémer, Ildikó, Szentkereszty, Zoltán, Sarkany, Agnes, Marjanek, Zsuzsa, Moura, Pedro, Pintado Delgado, Maria Consuelo, Montejo González, Juan Carlos, Ramirez, Paula, Torres Marti, Antonio, Valia, Juan Carlos, Lorente, Jose, Loza Vazquez, Ana, De Pablo Sanchez, Raúl, Escudero, Dolores, Ferrer Roca, Ricard, Pagani, Jean-Luc, Maggiorini, Marco, François, Bruno, Jafri, Hasan S, Chastre, Jean, Sánchez-García, Miguel, Eggimann, Philippe, Dequin, Pierre-François, Huberlant, Vincent, Viña Soria, Lucia, Boulain, Thierry, Bretonnière, Cédric, Pugin, Jérôme, Trenado, Josep, Hernandez Padilla, Ana Catalina, Ali, Omar, Shoemaker, Kathryn, Ren, Pin, Coenjaerts, Frank E, Ruzin, Alexey, Barraud, Olivier, Timbermont, Leen, Lammens, Christine, Pierre, Vadryn, Wu, Yuling, Vignaud, Julie, Colbert, Susan, Bellamy, Terramika, Esser, Mark T, Dubovsky, Filip, Bonten, Marc J, Goossens, Herman, and Laterre, Pierre-François
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- 2021
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20. PRAISE: providing a roadmap for automated infection surveillance in Europe
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van Mourik, Maaike S.M., van Rooden, Stephanie M., Abbas, Mohamed, Aspevall, Olov, Astagneau, Pascal, Bonten, Marc J.M., Carrara, Elena, Gomila-Grange, Aina, de Greeff, Sabine C., Gubbels, Sophie, Harrison, Wendy, Humphreys, Hilary, Johansson, Anders, Koek, Mayke B.G., Kristensen, Brian, Lepape, Alain, Lucet, Jean-Christophe, Mookerjee, Siddharth, Naucler, Pontus, Palacios-Baena, Zaira R., Presterl, Elisabeth, Pujol, Miquel, Reilly, Jacqui, Roberts, Christopher, Tacconelli, Evelina, Teixeira, Daniel, Tängdén, Thomas, Valik, John Karlsson, Behnke, Michael, and Gastmeier, Petra
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- 2021
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21. Information technology aspects of large-scale implementation of automated surveillance of healthcare-associated infections
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van Mourik, Maaike S.M., van Rooden, Stephanie M., Abbas, Mohamed, Aspevall, Olov, Astagneau, Pascal, Bonten, Marc J.M., Carrara, Elena, Gomila-Grange, Aina, de Greeff, Sabine C., Gubbels, Sophie, Harrison, Wendy, Humphreys, Hilary, Johansson, Anders, Koek, Mayke B.G., Kristensen, Brian, Lepape, Alain, Lucet, Jean-Christophe, Mookerjee, Siddharth, Naucler, Pontus, Palacios-Baena, Zaira R., Presterl, Elisabeth, Pujol, Miquel, Reilly, Jacqui, Roberts, Christopher, Tacconelli, Evelina, Teixeira, Daniel, Tängdén, Thomas, Valik, John Karlsson, Behnke, Michael, and Gastmeier, Petra
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- 2021
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22. Association between mortality and highly antimicrobial-resistant bacteria in intensive care unit-acquired pneumonia
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Ines Lakbar, Sophie Medam, Romain Ronflé, Nadim Cassir, Louis Delamarre, Emmanuelle Hammad, Alexandre Lopez, Alain Lepape, Anaïs Machut, Mohamed Boucekine, Laurent Zieleskiewicz, Karine Baumstarck, Anne Savey, Marc Leone, and REA RAISIN Study Group
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Medicine ,Science - Abstract
Abstract Data on the relationship between antimicrobial resistance and mortality remain scarce, and this relationship needs to be investigated in intensive care units (ICUs). The aim of this study was to compare the ICU mortality rates between patients with ICU-acquired pneumonia due to highly antimicrobial-resistant (HAMR) bacteria and those with ICU-acquired pneumonia due to non-HAMR bacteria. We conducted a multicenter, retrospective cohort study using the French National Surveillance Network for Healthcare Associated Infection in ICUs (“REA-Raisin”) database, gathering data from 200 ICUs from January 2007 to December 2016. We assessed all adult patients who were hospitalized for at least 48 h and presented with ICU-acquired pneumonia caused by S. aureus, Enterobacteriaceae, P. aeruginosa, or A. baumannii. The association between pneumonia caused by HAMR bacteria and ICU mortality was analyzed using the whole sample and using a 1:2 matched sample. Among the 18,497 patients with at least one documented case of ICU-acquired pneumonia caused by S. aureus, Enterobacteriaceae, P. aeruginosa, or A. baumannii, 3081 (16.4%) had HAMR bacteria. The HAMR group was associated with increased ICU mortality (40.3% vs. 30%, odds ratio (OR) 95%, CI 1.57 [1.45–1.70], P
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- 2021
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23. Respiratory response to finger clamping in dogs under general anesthesia: A descriptive pilot study
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Lepape Sylvain, Sredensek Jerneja, and Portier Karine
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nociception ,Drive ,Timing ,dog ,anesthesia ,ventilation ,Veterinary medicine ,SF600-1100 - Abstract
Aim of the studyThe aim of this study was to assess the effects of a nociceptive stimulus on respiratory variables in anesthetized dogs.Material and methodEleven dogs received acepromazine administered intramuscularly (IM) at a dose of 0.04 mg kg−1 45 mins before induction of anesthesia. Loss of consciousness was obtained with midazolam at 0.2 mg kg−1 and propofol administered at a dose of 2 mg kg−1 intravenously (IV). Orotracheal intubation was performed and anesthesia was maintained with isoflurane in 100% oxygen. Inspired (VTi) and expired (VTe) tidal volume (VT), minute volume (VM), inspiratory and expiratory time (Ti; Te) were measured and recorded twice a second by a spirometer. The Drive (VT/Ti) and Timing [Ti/(Ti+ Te)] were calculated.After stabilizing the depth of anesthesia the variables measured by the spirometer were recorded for 5 mins [T0−5-T0]. Then (T0) interdigital clamping of the hind leg was performed until a withdrawal movement was observed. If no reaction occurred, the clamp was left in place for 60s. After removal of the clamp, respiratory variables were measured continuously for another 5 mins [T0-T0+5]. At T0+5 morphine (0.2 mg kg−1 IV) was administered. Five minutes later (T0+10), a second clamp test was performed, using the same procedure. At T0+15 the data recording was stopped.ResultThe results showed a large variation in the individual values of Drive and Timing and are presented in a descriptive manner. The observation of Drive values over time showed variations following nociceptive stimuli. Drive appears to have increased only for those dogs that did not move during the stimulus, and were therefore pinched for a full 60 s. In contrast, the study of the Timing values revealed no difference between the data before and after nociceptive stimulation. However Timing seems to increase after morphine administration.ConclusionDrive remains a parameter that needs to be studied in depth to determine its sensitivity and precocity to monitor acute nociception.
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- 2022
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24. Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study
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Jérôme Pugin, Thomas Daix, Jean-Luc Pagani, Davide Morri, Angelo Giacomucci, Pierre-François Dequin, Christophe Guitton, Yok-Ai Que, Gianluca Zani, David Brealey, Alain Lepape, Ben Creagh-Brown, Duncan Wyncoll, Daniela Silengo, Irina Irincheeva, Laurie Girard, Fabien Rebeaud, Iwan Maerki, Philippe Eggimann, and Bruno François
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Pancreatic stone protein ,Sepsis ,Diagnostic ,Procalcitonin ,C-reactive protein ,Biomarker ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background The early recognition and management of sepsis improves outcomes. Biomarkers may help in identifying earlier sub-clinical signs of sepsis. We explored the potential of serial measurements of C-reactive protein (CRP), procalcitonin (PCT) and pancreatic stone protein (PSP) for the early recognition of sepsis in patients hospitalized in the intensive care unit (ICU). Methods This was a multicentric international prospective observational clinical study conducted in 14 ICUs in France, Switzerland, Italy, and the United Kingdom. Adult ICU patients at risk of nosocomial sepsis were included. A biomarker-blinded adjudication committee identified sepsis events and the days on which they began. The association of clinical sepsis diagnoses with the trajectories of PSP, CRP, and PCT in the 3 days preceding these diagnoses of sepsis were tested for markers of early sepsis detection. The performance of the biomarkers in sepsis diagnosis was assessed by receiver operating characteristic (ROC) analysis. Results Of the 243 patients included, 53 developed nosocomial sepsis after a median of 6 days (interquartile range, 3–8 days). Clinical sepsis diagnosis was associated with an increase in biomarkers value over the 3 days preceding this diagnosis [PSP (p = 0.003), PCT (p = 0.025) and CRP (p = 0.009)]. PSP started to increase 5 days before the clinical diagnosis of sepsis, PCT 3 and CRP 2 days, respectively. The area under the ROC curve at the time of clinical sepsis was similar for all markers (PSP, 0.75; CRP, 0.77; PCT, 0.75). Conclusions While the diagnostic accuracy of PSP, CRP and PCT for sepsis were similar in this cohort, serial PSP measurement demonstrated an increase of this marker the days preceding the onset of signs necessary to clinical diagnose sepsis. This observation justifies further evaluation of the potential clinical benefit of serial PSP measurement in the management of critically ill patients developing nosocomial sepsis. Trial registration The study has been registered at ClinicalTrials.gov (no. NCT03474809), on March 16, 2018. https://www.clinicaltrials.gov/ct2/show/NCT03474809?term=NCT03474809&draw=2&rank=1 .
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- 2021
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25. Optimization of capsule dopant levels to improve fuel areal density*
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Hinkel, D.E., Döppner, T., Masse, L.P., Widmann, K., Divol, L., Bachmann, B., Berzak Hopkins, L.F., LePape, S., Weber, C.R., MacLaren, S.A., Zylstra, A.B., Ralph, J.E., Benedetti, L.R., Moore, A.S., Thomas, C.A., Casey, D.T., Smalyuk, V.A., Robey, H.F., Celliers, P.M., MacDonald, M.J., Krauland, C.M., Thorn, D.B., Rosen, M.D., Patel, P.K., MacGowan, B.J., Schneider, M.B., Clark, D.S., Pak, A.E., Edwards, M.J., Landen, O.L., Callahan, D.A., and Hurricane, O.A.
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- 2020
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26. Recent and planned hydrodynamic instability experiments on indirect-drive implosions on the National Ignition Facility
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Smalyuk, V.A., Weber, C.R., Landen, O.L., Ali, S., Bachmann, B., Celliers, P.M., Dewald, E., Fernandez, A., Hammel, B.A., Hall, G., MacPhee, A.G., Pickworth, L., Robey, H.F., Alfonso, N., Baker, K.L., Hopkins, L.F. Berzak, Carlson, L., Casey, D.T., Clark, D.S., Crippen, J., Divol, L., Döppner, T., Edwards, J., Farrell, M., Felker, S., Field, J.E., Haan, S.W., Hamza, A.V., Havre, M., Herrmann, M.C., Hsing, W.W., Khan, S., Kline, J., Kroll, J.J., LePape, S., Loomis, E., MacGowan, B.J., Martinez, D., Masse, L., Mauldin, M., Milovich, J.L., Moore, A.S., Nikroo, A., Pak, A., Patel, P.K., Peterson, J.L., Raman, K., Remington, B.A., Rice, N., Schoff, M., Stadermann, M., and Yi, S.A.
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- 2020
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27. Yield and compression trends and reproducibility at NIF*
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Landen, O.L., Casey, D.T., DiNicola, J.M., Doeppner, T., Hartouni, E.P., Hinkel, D.E., Berzak Hopkins, L.F., Hohenberger, M., Kritcher, A.L., LePape, S., MacGowan, B.J., Maclaren, S., Meaney, K.D., Millot, M., Patel, P.K., Park, J., Pickworth, L.A., Robey, H.F., Ross, J.S., Yang, S.T., Zylstra, A.B., Baker, K.L., Callahan, D.A., Celliers, P.M., Edwards, M.J., Hurricane, O.A., Lindl, J.D., Moody, J.D., Ralph, J., Smalyuk, V.A., Thomas, C.A., Van Wonterghem, B.M., and Weber, C.R.
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- 2020
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28. A new simplified and accurate sa-SOFA score
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Vacheron, Charles-Hervé, Friggeri, Arnaud, Iwaz, Jean, Allaouchiche, Bernard, Bohe, Julien, Monneret, Guillaume, Venet, Fabienne, Cour, Martin, Argaud, Laurent, Aubrun, Frédéric, Rimmele, Thomas, Pachot, Alexandre, Piriou, Vincent, Lepape, Alain, and Maucort-Boulch, Delphine
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- 2020
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29. Exogenous acquisition of Pseudomonas aeruginosa in intensive care units: a prospective multi-centre study (DYNAPYO study)
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Coppry, M., Leroyer, C., Saly, M., Venier, A-G., Slekovec, C., Bertrand, X., Parer, S., Alfandari, S., Cambau, E., Megarbane, B., Lawrence, C., Clair, B., Lepape, A., Cassier, P., Trivier, D., Boyer, A., Boulestreau, H., Asselineau, J., Dubois, V., Thiébaut, R., and Rogues, A-M.
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- 2020
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30. Gravure en Clair-Obscur : Cranach, Raphaël, Rubens
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Lepape, Séverine and Bindman, Catherine
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- 2019
31. Expert consensus-based clinical practice guidelines management of intravascular catheters in the intensive care unit
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Jean-François Timsit, Julien Baleine, Louis Bernard, Silvia Calvino-Gunther, Michael Darmon, Jean Dellamonica, Eric Desruennes, Marc Leone, Alain Lepape, Olivier Leroy, Jean-Christophe Lucet, Zied Merchaoui, Olivier Mimoz, Benoit Misset, Jean-Jacques Parienti, Jean-Pierre Quenot, Antoine Roch, Matthieu Schmidt, Michel Slama, Bertrand Souweine, Jean-Ralph Zahar, Walter Zingg, Laetitia Bodet-Contentin, and Virginie Maxime
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Catheter ,Critically ill ,Sepsis ,Infection ,Bacteremia ,Prevention ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract The French Society of Intensive Care Medicine (SRLF), jointly with the French-Speaking Group of Paediatric Emergency Rooms and Intensive Care Units (GFRUP) and the French-Speaking Association of Paediatric Surgical Intensivists (ADARPEF), worked out guidelines for the management of central venous catheters (CVC), arterial catheters and dialysis catheters in intensive care unit. For adult patients: Using GRADE methodology, 36 recommendations for an improved catheter management were produced by the 22 experts. Recommendations regarding catheter-related infections’ prevention included the preferential use of subclavian central vein (GRADE 1), a one-step skin disinfection(GRADE 1) using 2% chlorhexidine (CHG)-alcohol (GRADE 1), and the implementation of a quality of care improvement program. Antiseptic- or antibiotic-impregnated CVC should likely not be used (GRADE 2, for children and adults). Catheter dressings should likely not be changed before the 7th day, except when the dressing gets detached, soiled or impregnated with blood (GRADE 2− adults). CHG dressings should likely be used (GRADE 2+). For adults and children, ultrasound guidance should be used to reduce mechanical complications in case of internal jugular access (GRADE 1), subclavian access (Grade 2) and femoral venous, arterial radial and femoral access (Expert opinion). For children, an ultrasound-guided supraclavicular approach of the brachiocephalic vein was recommended to reduce the number of attempts for cannulation and mechanical complications. Based on scarce publications on diagnostic and therapeutic strategies and on their experience (expert opinion), the panel proposed definitions, and therapeutic strategies.
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- 2020
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32. Dynamic LTR retrotransposon transcriptome landscape in septic shock patients
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Marine Mommert, Olivier Tabone, Audrey Guichard, Guy Oriol, Elisabeth Cerrato, Mélanie Denizot, Valérie Cheynet, Alexandre Pachot, Alain Lepape, Guillaume Monneret, Fabienne Venet, Karen Brengel-Pesce, Julien Textoris, François Mallet, MIPrea Study Group, and REALISM Study Group
- Subjects
HERV transcriptome ,Whole blood ,Septic shock patients ,mHLA-DR expression ,Immunosuppression ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Numerous studies have explored the complex and dynamic transcriptome modulations observed in sepsis patients, but a large fraction of the transcriptome remains unexplored. This fraction could provide information to better understand sepsis pathophysiology. Multiple levels of interaction between human endogenous retroviruses (HERV) and the immune response have led us to hypothesize that sepsis is associated with HERV transcription and that HERVs may contribute to a signature among septic patients allowing stratification and personalized management. Methods We used a high-density microarray and RT-qPCR to evaluate the HERV and Mammalian Apparent Long Terminal Repeat retrotransposons (MaLR) transcriptome in a pilot study that included 20 selected septic shock patients, stratified on mHLA-DR expression, with samples collected on day 1 and day 3 after inclusion. We validated the results in an unselected, independent cohort that included 100 septic shock patients on day 3 after inclusion. We compared septic shock patients, according to their immune status, to describe the transcriptional HERV/MaLR and conventional gene expression. For differential expression analyses, moderated t tests were performed and Wilcoxon signed-rank tests were used to analyze RT-qPCR results. Results We showed that 6.9% of the HERV/MaLR repertoire was transcribed in the whole blood, and septic shock was associated with an early modulation of a few thousand of these loci, in comparison to healthy volunteers. We provided evidence that a subset of HERV/MaLR and conventional genes were differentially expressed in septic shock patients, according to their immune status, using monocyte HLA-DR (mHLA-DR) expression as a proxy. A group of 193 differentially expressed HERV/MaLR probesets, tested in an independent septic shock cohort, identified two groups of patients with different immune status and severity features. Conclusion We demonstrated that a large, unexplored part of our genome, which codes for HERV/MaLR, may be linked to the host immune response. The identified set of HERV/MaLR probesets should be evaluated on a large scale to assess the relevance of these loci in the stratification of septic shock patients. This may help to address the heterogeneity of these patients.
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- 2020
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33. European intensive care physicians’ experience of infections due to antibiotic-resistant bacteria
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Alain Lepape, Astrid Jean, Jan De Waele, Arnaud Friggeri, Anne Savey, Philippe Vanhems, Marie Paule Gustin, Dominique L. Monnet, José Garnacho-Montero, and Anke Kohlenberg
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Antimicrobial resistance ,Intensive care ,Antimicrobial treatment ,Third-generation-cephalosporin-resistant Enterobacteriaceae ,Carbapenem-resistant Enterobacteriaceae ,Meticillin-resistant Staphylococcus aureus ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Antimicrobial resistance (AMR) compromises the treatment of patients with serious infections in intensive care units (ICUs), and intensive care physicians are increasingly facing patients with bacterial infections with limited or no adequate therapeutic options. A survey was conducted to assess the intensive care physicians’ perception of the AMR situation in the European Union/European Economic Area (EU/EEA). Methods Between May and July 2017, physicians working in European ICUs were invited to complete an online questionnaire hosted by the European Society of Intensive Care Medicine. The survey included 20 questions on hospital and ICU characteristics, frequency of infections with multidrug-resistant (MDR) bacteria and relevance of AMR in the respondent’s ICU, management of antimicrobial treatment as well as the use of last-line antibiotics in the six months preceding the survey. For the analysis of regional differences, EU/EEA countries were grouped into the four sub-regions of Eastern, Northern, Southern and Western Europe. Results Overall, 1062 responses from four European sub-regions were analysed. Infections with MDR bacteria in their ICU were rated as a major problem by 257 (24.2%), moderate problem by 360 (33.9%) and minor problem by 391 (36.8%) respondents. Third-generation cephalosporin-resistant Enterobacteriaceae were the most frequently encountered MDR bacteria followed by, in order of decreasing frequency, meticillin-resistant Staphylococcus aureus, carbapenem-resistant Enterobacteriaceae, carbapenem-resistant Pseudomonas aeruginosa and vancomycin-resistant enterococci. Perception of the relevance of the AMR problem and the frequency of specific MDR bacteria varied by European sub-region. Bacteria resistant to all or almost all available antibiotics were encountered by 132 (12.4%) respondents. Many physicians reported not having access to specific last-line antibiotics. Conclusions The percentage of European ICU physicians perceiving AMR as a substantial problem in their ICU is high with variation by sub-region in line with epidemiological studies. The reports of bacteria resistant to almost all available antibiotics and the limited availability of last-line antibiotics in ICUs in the EU/EEA are of concern.
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- 2020
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34. Herpes DNAemia and TTV Viraemia in Intensive Care Unit Critically Ill Patients: A Single-Centre Prospective Longitudinal Study
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François Mallet, Léa Diouf, Boris Meunier, Magali Perret, Frédéric Reynier, Philippe Leissner, Laurence Quemeneur, Andrew D. Griffiths, Virginie Moucadel, Alexandre Pachot, Fabienne Venet, Guillaume Monneret, Alain Lepape, Thomas Rimmelé, Lionel K. Tan, Karen Brengel-Pesce, and Julien Textoris
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herpesviruses ,TTV ,intensive care unit ,sepsis ,mortality ,acquired infection ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionWe analysed blood DNAemia of TTV and four herpesviruses (CMV, EBV, HHV6, and HSV-1) in the REAnimation Low Immune Status Marker (REALISM) cohort of critically ill patients who had presented with either sepsis, burns, severe trauma, or major surgery. The aim was to identify common features related to virus and injury-associated pathologies and specific features linking one or several viruses to a particular pathological context.MethodsOverall and individual viral DNAemia were measured over a month using quantitative PCR assays from the 377 patients in the REALISM cohort. These patients were characterised by clinical outcomes [severity scores, mortality, Intensive Care Unit (ICU)-acquired infection (IAI)] and 48 parameters defining their host response after injury (cell populations, immune functional assays, and biomarkers). Association between viraemic event and clinical outcomes or immune markers was assessed using χ2-test or exact Fisher’s test for qualitative variables and Wilcoxon test for continuous variables.ResultsThe cumulative incidence of viral DNAemia increased from below 4% at ICU admission to 35% for each herpesvirus during the first month. EBV, HSV1, HHV6, and CMV were detected in 18%, 12%, 10%, and 9% of patients, respectively. The incidence of high TTV viraemia (>10,000 copies/ml) increased from 11% to 15% during the same period. Herpesvirus viraemia was associated with severity at admission; CMV and HHV6 viraemia correlated with mortality during the first week and over the month. The presence of individual herpesvirus during the first month was significantly associated (p < 0.001) with the occurrence of IAI, whilst herpesvirus DNAemia coupled with high TTV viraemia during the very first week was associated with IAI. Herpesvirus viraemia was associated with a lasting exacerbated host immune response, with concurrent profound immune suppression and hyper inflammation, and delayed return to immune homeostasis. The percentage of patients presenting with herpesvirus DNAemia was significantly higher in sepsis than in all other groups. Primary infection in the hospital and high IL10 levels might favour EBV and CMV reactivation.ConclusionIn this cohort of ICU patients, phenotypic differences were observed between TTV and herpesviruses DNAemia. The higher prevalence of herpesvirus DNAemia in sepsis hints at further studies that may enable a better in vivo understanding of host determinants of herpesvirus viral reactivation. Furthermore, our data suggest that EBV and TTV may be useful as additional markers to predict clinical deterioration in ICU patients.
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- 2021
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35. Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study
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Pugin, Jérôme, Daix, Thomas, Pagani, Jean-Luc, Morri, Davide, Giacomucci, Angelo, Dequin, Pierre-François, Guitton, Christophe, Que, Yok-Ai, Zani, Gianluca, Brealey, David, Lepape, Alain, Creagh-Brown, Ben, Wyncoll, Duncan, Silengo, Daniela, Irincheeva, Irina, Girard, Laurie, Rebeaud, Fabien, Maerki, Iwan, Eggimann, Philippe, and François, Bruno
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- 2021
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36. Antibioprophylaxis in surgery and interventional medicine (adult patients). Update 2017
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Martin, C., Auboyer, C., Boisson, M., Dupont, H., Gauzit, R., Kitzis, M., Leone, M., Lepape, A., Mimoz, O., Montravers, P., and Pourriat, J.L.
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- 2019
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37. Increased Incidence of Ventilator-Acquired Pneumonia in Coronavirus Disease 2019 Patients: A Multicentric Cohort Study*
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Vacheron, Charles-Hervé, Lepape, Alain, Savey, Anne, Machut, Anaïs, Timsit, Jean Francois, Vanhems, Philippe, Le, Quoc Viet, Egbeola, Julia, Martin, Maelle, Maxime, Virginie, Pugliesi, Paul-Simon, Maucort-Boulch, Delphine, and Friggeri, Arnaud
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- 2022
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38. Non-invasive study of 16th century Northern European chiaroscuro woodcuts: First insights
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Laclavetine, K., Boust, C., Clivet, L., Le Hô, A.S., Laval, E., Mathis, R., Menu, M., Pagliano, E., Salmon, X., Selbach, V., Vrand, C., and Lepape, S.
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- 2019
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39. Risk factors associated with day-30 mortality in patients over 60 years old admitted in ICU for severe COVID-19: the Senior-COVID-Rea Multicentre Survey protocol
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Thomas Rimmele, Julien Berthiller, Anne-Claire Lukaszewicz, Laurent Jallades, Jean-Baptiste Pialat, Céline Monard, Laurent Argaud, Christophe Leroy, Vincent Collange, Arnaud Friggeri, Mélanie Roche, Christine Ravot, Amélie Malapert, Max Haïne, David Dayde, Claire Falandry, Marie Simon, Céline Guichon, Paul Abraham, Fabien Subtil, Camille Boin, Justine Dubreuil, Laurent Bitker, Baptiste Balança, Sylvie Goutte, Emilie Gadea, Alain Lepape, Fabrice Thiollière, Hodane Yonis, Antoine Garnier-Crussard, Loredana Baboi, Valérie Cerro, Carlos El Khoury, Emilie Gadéa-Deschamps, Marie-Catherine Fromont, Audrey Gelot, Anthéa Loïez, Maya Perrou, Laetitia Paradisi-Prieur, Marion Provent, Gulsum Sahin, Ghyslaine Thao, and Marine Thieux
- Subjects
Medicine - Abstract
Introduction With the spread of COVID-19 epidemic, health plans must be adapted continuously. There is an urgent need to define the best care courses of patients with COVID-19, especially in intensive care units (ICUs), according to their individualised benefit/risk ratio. Since older age is associated with poorer short-term and long-term outcomes, prediction models are needed, that may assist clinicians in their ICU admission decision. Senior-COVID-Rea was designed to evaluate, in patients over 60 years old admitted in ICU for severe COVID-19 disease, the impact of age and geriatric and paraclinical parameters on their mortality 30 days after ICU admission.Methods and analysis This is a multicentre survey protocol to be conducted in seven hospitals of the Auvergne-Rhône-Alpes region, France. All patients over 60 years old admitted in ICU for severe COVID-19 infection (or their legally acceptable representative) will be proposed to enter the study and to fill in a questionnaire regarding their functional and nutritional parameters 1 month before COVID-19 infection. Paraclinical parameters at ICU admission will be collected: lymphocytes and neutrophils counts, high-fluorescent lymphoid cells and immature granulocytes percentages (Sysmex data), D-dimers, C-reactive protein, lactate dehydrogenase (LDH), creatinine, CT scan for lung extension rate as well as clinical resuscitation scores, and the delay between the first signs of infection and ICU admission. The primary outcome will be the overall survival at day 30 post-ICU admission. The analysis of factors predicting mortality at day 30 will be carried out using univariate and multivariate logistic regressions. Multivariate logistic regression will consider up to 15 factors.The ambition of this trial, which takes into account the different approaches of geriatric vulnerability, is to define the respective abilities of different operational criteria of frailty to predict patients’ outcomes.Ethics and dissemination The study protocol was ethically approved. The results of the primary and secondary objectives will be published in peer-reviewed journals.Trial registration number NCT04422340.
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- 2021
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40. Early herpes and TTV DNAemia in septic shock patients: a pilot study
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François Mallet, Magali Perret, Trang Tran, Boris Meunier, Audrey Guichard, Olivier Tabone, Marine Mommert, Karen Brengel-Pesce, Fabienne Venet, Alexandre Pachot, Guillaume Monneret, Frederic Reynier, Christophe Védrine, Philippe Leissner, Virginie Moucadel, Alain Lepape, Julien Textoris, MIPrea group, and REALISM group
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Sepsis ,Immunosuppression ,Mortality ,Biomarker ,Herpes viruses ,EBV ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Septic shock patients exhibit an increased incidence of viral reactivation. Precise timing of such reactivation—as an early marker of immune suppression, or as a consequence of the later—is not known precisely. Here, using a fully designed nucleic acid extraction automated procedure together with tailored commercial PCR kits, we focused on the description of early reactivation within the first week of ICU admission of several herpes viruses and Torque Teno virus (TTV) in 98 septic shock patients. Results Most of septic shock patients had at least one viremia event during the first week (88%). TTV and herpesviruses were detected in 56% and 53% of septic shock patient, respectively. The two most frequent herpesviruses detected within the first week were EBV (35%) and HSV1 (26%). Different kinetic were observed among herpesviruses, faster for EBV and HSV1 than for CMV and HHV6. Although no association was found between herpes viremia and secondary infections, patients with herpesviridae-related viremia were more severe, e.g., higher SOFA scores and plasma lactate levels. While reactivating only 1 virus was not associated with mortality, patients with multiple viremia events had higher ICU mortality. Surprisingly, EBV + TTV early reactivation seemed associated with a lower D28 mortality. No clear association was observed between viremia and immune biomarkers. Conclusion Applying a semi-automated process of viral DNAemia determination to this cohort of 98 patients with septic shock, we observed that the number of patients with positive viremia increased during the first week in the ICU. Of note, there was no improvement in predicting the outcome when using viremia status. Nevertheless, this pilot study, introducing standardized procedures from extraction to detection, provides the basis for future standardized diagnostic criteria. A prospective longitudinal clinical study using these procedures will enable determination of whether such viremia is due to a lack of a latent virus control by the immune system or a true clinical viral infection.
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- 2019
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41. Can cashew nut allergy resolve spontaneously?
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Guiddir, Tamazoust, Siberil, Audrey, Lepape, Françoise, Hacker, Marion, and Nemni, Ariane
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FOOD allergy ,ANAPHYLAXIS ,NATURAL history ,CASHEW tree ,IMMUNOGLOBULIN E - Abstract
This article discusses the natural history of cashew nut allergy (CNA) in children. The study reports on a cohort of five children who experienced severe anaphylaxis to cashew nut but were able to recover and consume cashew nut after a successful oral food challenge. The children had no allergies or sensitizations to peanuts or tree nuts, and during a mean follow-up of 2.4 years, their skin prick tests and cashew-specific IgEs became negative. The study suggests that clinicians should continue to monitor cashew-specific IgEs and perform oral food challenges to confirm recovery, as CNA may resolve spontaneously. [Extracted from the article]
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- 2024
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42. Drug incompatibilities in intravenous therapy: evaluation and proposition of preventive tools in intensive care and hematology units
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Maison, Ophélie, Tardy, Cléa, Cabelguenne, Delphine, Parat, Stéphanie, Ducastelle, Sophie, Piriou, Vincent, Lepape, Alain, and Lalande, Laure
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- 2019
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43. The production of prints in France at the time of Hieronymus Cock
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Lepape, Séverine
- Published
- 2017
44. ICU-acquired candidaemia in France: Epidemiology and temporal trends, 2004–2013 – A study from the REA-RAISIN network
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Baldesi, Olivier, Bailly, Sébastien, Ruckly, Stéphane, Lepape, Alain, L'Heriteau, François, Aupee, Martine, Boussat, Sandrine, Bervas, Caroline, Machut, Anais, Berger-Carbonne, Anne, Savey, Anne, and Timsit, Jean François
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- 2017
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45. Modulation of LILRB2 protein and mRNA expressions in septic shock patients and after ex vivo lipopolysaccharide stimulation
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Venet, Fabienne, Schilling, Jeremy, Cazalis, Marie-Angélique, Demaret, Julie, Poujol, Fanny, Girardot, Thibaut, Rouget, Christelle, Pachot, Alexandre, Lepape, Alain, Friggeri, Arnaud, Rimmelé, Thomas, Monneret, Guillaume, and Textoris, Julien
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- 2017
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46. Impact of echinocandin on prognosis of proven invasive candidiasis in ICU: A post-hoc causal inference model using the AmarCAND2 study
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Aait, Hssain, Adda, Allaouchiche, Ammenouche, Angel, Argaud, Badetti, Baldesi, Barthet, Bastien, Baudin, Bellec, Blasco, Bollaert, Bonadona, Bretonnière, Brocas, Brua, Bruder, Brunin, Cabaret, Carpentier, Cartier, Cerf, Chabanne, Charles, Cheval, Cinotti, Cohen, Constantin, Cousson, Delpierre, Demory, Diconne, Du Cheyron, Dubost, Dumenil, Durand, Duroy, Forel, Foucher-Lezla, Fratea, Gally, Gaudard, Geffe, Gergaud, Gette, Girault, Goubaux, Gouin, Grenot, Grossmith, Guelon, Guerin-Robardey, Guervilly, Hayl-Slayman, Hilbert, Houissa, Hraiech, Ichai, Jung, Kaidomar, Karoubi, Kherchache, Lambiotte, Lamhaut, Launoy, Lebreton, Lefrant, Lemaire, Lepape, Lepoivre, Leroy, Lesieur, Levy, Luyt, Mahe, Mahul, Mateu, Megarbane, Merle, Mira, Montcriol, Mootien, Navellou, Ouattara, Page, Perrigault, Petitpas, Plantefeve, Quinart, Quintard, Ragonnet, Roquilly, Ruiz, Saliba, Samba, Schmitt, Seguin, Sejourne, Tellier, Thevenot, Tonnelier, Van Grunderbeek, Vincent, Wiramus, Zogheib, Bailly, Sébastien, Leroy, Olivier, Azoulay, Elie, Montravers, Philippe, Constantin, Jean-Michel, Dupont, Hervé, Guillemot, Didier, Lortholary, Olivier, Mira, Jean-Paul, Perrigault, Pierre-François, Gangneux, Jean-Pierre, and Timsit, Jean-François
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- 2017
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47. Can we consider immediate complications after thyroidectomy as a quality metric of operation?
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Arnalsteen, Laurent, Caizzo, Robert, Carnaille, Bruno, Dezfoulian, Guelareh, Eberle, Carole, El Khatib, Ziad, Fernandez, Emmanuel, Lamblin, Antoine, Pattou, François, Six, Marie-France, Bourdy, Stéphanie, Bouveret, Laetitia, Colin, Cyrille, Duclos, Antoine, Guibert, Benoît, Le Pogam, Marie-Annick, Lifante, Jean-Christophe, Peix, Jean-Louis, Singier, Gaétan, Soardo, Pietro, Touzet, Sandrine, Voirin, Nicolas, Auquier, Pascal, Henry, Jean-François, Morando, Claire, Sebag, Frédéric, Van Slycke, Sam, Akrout, Inès, Benmiloud, Fares, Chigot, Jean-Paul, Colombet, Isabelle, Godiris-Petit, Gaëlle, Leyre, Pierre, Ménégaux, Fabrice, Noullet, Séverine, Royer, Benoît, Tresallet, Christophe, Desurmont, Thibault, Dominguez, Claudia, Kraimps, Jean-Louis, Odasso, Chiara, Rouleau, Laetitia, Chapuis, Yves-Louis, Durieux, Pierre, Lepape, Alain, Triponez, Frédéric, and Payet, Cécile
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- 2017
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48. Expert consensus-based clinical practice guidelines management of intravascular catheters in the intensive care unit
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Timsit, Jean-François, Baleine, Julien, Bernard, Louis, Calvino-Gunther, Silvia, Darmon, Michael, Dellamonica, Jean, Desruennes, Eric, Leone, Marc, Lepape, Alain, Leroy, Olivier, Lucet, Jean-Christophe, Merchaoui, Zied, Mimoz, Olivier, Misset, Benoit, Parienti, Jean-Jacques, Quenot, Jean-Pierre, Roch, Antoine, Schmidt, Matthieu, Slama, Michel, Souweine, Bertrand, Zahar, Jean-Ralph, Zingg, Walter, Bodet-Contentin, Laetitia, and Maxime, Virginie
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- 2020
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49. European intensive care physicians’ experience of infections due to antibiotic-resistant bacteria
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Lepape, Alain, Jean, Astrid, De Waele, Jan, Friggeri, Arnaud, Savey, Anne, Vanhems, Philippe, Gustin, Marie Paule, Monnet, Dominique L., Garnacho-Montero, José, and Kohlenberg, Anke
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- 2020
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50. Reply to: Reconsidering X-ray plasmons
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Fletcher, L. B., Lee, H. J., Döppner, T., Galtier, E., Nagler, B., Heimann, P., Fortmann, C., LePape, S., Ma, T., Millot, M., Pak, A., Turnbull, D., Chapman, D. A., Gericke, D. O., Vorberger, J., White, T., Gregori, G., Wei, M., Barbrel, B., Falcone, R. W., Kao, C.-C., Nuhn, H., Welch, J., Zastrau, U., Neumayer, P., Hastings, J. B., and Glenzer, S. H.
- Published
- 2019
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