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1. Impact of age and cardiovascular risk factors on the incidence of adverse events in patients with rheumatoid arthritis treated with Janus Kinase inhibitors: data from a real-life multicentric cohort

Author

Gentileschi, Stefano, Gaggiano, Carla, Damiani, Arianna, Coccia, Carmela, Bernardini, Pamela, Cazzato, Massimiliano, D’Alessandro, Francesco, Vallifuoco, Giulia, Terribili, Riccardo, Bardelli, Marco, Baldi, Caterina, Cantarini, Luca, Mosca, Marta, Frediani, Bruno, and Guiducci, Serena

Published
2024
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2. Ocular Manifestations in Juvenile Behçet’s Disease: A Registry-Based Analysis from the AIDA Network

Author

Gaggiano, Carla, Tufan, Abdurrahman, Guerriero, Silvana, Ragab, Gaafar, Sota, Jurgen, Gentileschi, Stefano, Costi, Stefania, Almaghlouth, Ibrahim A., Hinojosa-Azaola, Andrea, Tharwat, Samar, Sfikakis, Petros P., Lopalco, Giuseppe, Piga, Matteo, Conti, Giovanni, Fragoulis, George, Mauro, Angela, Batu, Ezgi D., Ozen, Seza, Tarsia, Maria, La Torre, Francesco, Kawakami-Campos, Perla A., Vitale, Antonio, Caggiano, Valeria, Kardaş, Riza C., Tosi, Gian Marco, Frediani, Bruno, Avčin, Tadej, Hernández-Rodríguez, José, Cantarini, Luca, and Fabiani, Claudia

Published
2024
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4. Effectiveness and Safety of Biosimilars in Pediatric Non-infectious Uveitis: Real-Life Data from the International AIDA Network Uveitis Registry

Author

Tarsia, Maria, Vitale, Antonio, Gaggiano, Carla, Sota, Jurgen, Maselli, Anna, Bellantonio, Chiara, Guerriero, Silvana, Dammacco, Rosanna, La Torre, Francesco, Ragab, Gaafar, Hegazy, Mohamed Tharwat, Fonollosa, Alex, Paroli, Maria Pia, Del Giudice, Emanuela, Maggio, Maria Cristina, Cattalini, Marco, Fotis, Lampros, Conti, Giovanni, Mauro, Angela, Civino, Adele, Diomeda, Federico, de-la-Torre, Alejandra, Cifuentes-González, Carlos, Tharwat, Samar, Hernández-Rodríguez, José, Gómez-Caverzaschi, Verónica, Pelegrín, Laura, Babu, Kalpana, Gupta, Vishali, Minoia, Francesca, Ruscitti, Piero, Costi, Stefania, Breda, Luciana, La Bella, Saverio, Conforti, Alessandro, Mazzei, Maria Antonietta, Carreño, Ester, Amin, Rana Hussein, Grosso, Salvatore, Frediani, Bruno, Tosi, Gian Marco, Balistreri, Alberto, Cantarini, Luca, and Fabiani, Claudia

Published
2024
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5. Switching from rituximab originator to GP2013 or CT-P10 biosimilars in autoimmune rheumatic diseases: drug retention rate and safety data from a multicentric retrospective cohort

Author

Stefano Gentileschi, Cosimo Bruni, Carla Gaggiano, Roberto D’Alessandro, Giovanni Pacini, Jurgen Sota, Serena Guiducci, Marco Matucci Cerinic, and Bruno Frediani

Subjects
Diseases of the musculoskeletal system, RC925-935
Abstract

Background: Real-world evidence supporting a safe and effective transition from rituximab originator (RTX-O) to its biosimilars (RTX-B) in autoimmune rheumatic diseases (ARDs) is still limited. Objectives: The primary aims of this study were to evaluate the long-term persistence of RTX-B after the non-medical switch (NMS) from RTX-O in ARD patients, and to explore the RTX-B safety profile. The secondary aims were to evaluate the impact of different factors on RTX-B drug retention rate (DRR) and to identify any factors associated with RTX-B discontinuation. Design: Retrospective observational study. Methods: We included consecutive ARD patients undergoing NMS from RTX-O to GP2013 or CT-P10 from January 2018 to December 2020. RTX-B DRR was estimated by Kaplan–Meier plot analysis and compared according to different factors by the Log-rank test; the Cox proportional hazard model was used to detect factors associated with RTX-B discontinuation in the first 36 months. Results: We enrolled 181 patients switching to RTX-B: GP2013 in 143 (79.0%) cases and CT-P10 in 38 (21.0%). The estimated DRR for RTX-B was 81.5% at 12 months, 80.6% at 24 months, and 77.4% at 36 months. The incidence of adverse events with RTX-B was 12.6/100 patients/year. In the Log-rank test, no statistically significant differences were observed in the RTX-B DRR according to sex ( p = 0.171), ARD diagnosis ( p = 0.281), and concomitant immunosuppressive therapy ( p = 0.054); on the contrary, patients on GP2013 showed a higher DRR than those on CT-P10 ( p

Published
2024
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7. Corrigendum: Efficacy and safety of Janus kinase inhibitors in non-infectious inflammatory ocular diseases: a prospective cohort study from the international AIDA network registries

Author

Antonio Vitale, Judith Palacios-Olid, Valeria Caggiano, Gaafar Ragab, José Hernández-Rodríguez, Laura Pelegrín, Germán Mejía-Salgado, Laura Zarate-Pinzón, Stefano Gentileschi, Jurgen Sota, Alex Fonollosa, Ester Carreño, Carla Gaggiano, Rana Hussein Amin, Alberto Balistreri, Javier Narváez, Gian Marco Tosi, Bruno Frediani, Luca Cantarini, Alejandra de-la-Torre, and Claudia Fabiani

Subjects
baricitinib, scleritis, tofacitinib, upadacitinib, uveitis, Medicine (General), R5-920
Published
2024
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11. Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry

Author

Sota, Jurgen, Ragab, Gaafar, AlMaglouth, Ibrahim, Lopalco, Giuseppe, Tufan, Abdurrahman, Direskeneli, Haner, Hinojosa-Azaola, Andrea, Mayrink Giardini, Henrique Ayres, Guerriero, Silvana, Triggianese, Paola, Sfikakis, Petros P., Piga, Matteo, Ruscitti, Piero, Govoni, Marcello, Iagnocco, Annamaria, Carubbi, Francesco, Hernández-Rodríguez, José, Laymouna, Ahmed Hatem, Mahmoud, Ayman Abdel-Monem Ahmed, Ghanema, Mahmoud, Aboabat, Aos A., Asfina, Kazi Nur, Alanazi, Fehaid, Morrone, Maria, Spedicato, Veronica, Kucuk, Hamit, Kardas, Riza, Alibaz Öner, Fatma, Sevik, Gizem, Torres-Ruiz, Jiram, Kawakami-Campos, Perla Ayumi, Parente de Brito Antonelli, Isabelle, Dammacco, Rosanna, Chimenti, Maria Sole, Arida, Katerina, Floris, Alberto, Gentile, Martina, Ruffilli, Francesca, Bellis, Elisa, Alunno, Alessia, Espinosa, Gerard, Gentileschi, Stefano, Gaggiano, Carla, Vitale, Antonio, Caggiano, Valeria, Lopez, Roberta, Tarsia, Maria, Monti, Sara, Hatemi, Gülen, Karakoç, Alican, Frassi, Micol, Giacomelli, Roberto, Tharwat, Samar, Thabet, Maissa, Ciccia, Francesco, Emmi, Giacomo, Viapiana, Ombretta, Şahin, Ali, Sebastiani, Gian Domenico, Batu, Ezgi Deniz, Ozen, Seza, Sener, Seher, Opris-Belinski, Daniela, Costi, Stefania, Conforti, Alessandro, Cattalini, Marco, Bartoloni, Elena, Akkoç, Nurullah, Gunduz, Ozgul Soysal, Conti, Giovanni, Maier, Armin, Giardina, Annarita, Li Gobbi, Francesca, Parronchi, Paola, Sarzi Puttini, Piercarlo, Breda, Luciana, De Paulis, Amato, Carreño, Ester, La Torre, Francesco, Więsik-Scewczyk, Ewa, de-la Torre, Alejandra, Mejía-Salgado, Germán, Shahram, Farhad, Guiducci, Serena, Maggio, Maria Cristina, Aragona, Emma, Rigante, Donato, Ciavarro, Alessandro, Önen, Fatos, Erten, Şükran, Insalaco, Antonella, Del Giudice, Emanuela, Barone, Patrizia, Gicchino, Francesca, Brucato, Antonio, Lo Gullo, Alberto, Mauro, Angela, Karamanakos, Anastasios, Balistreri, Alberto, Mazzei, Maria Antonietta, Frediani, Bruno, Fabiani, Claudia, and Cantarini, Luca

Published
2025
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12. Knowledge and Current Practices in Monogenic Uveitis: An International Survey by IUSG and AIDA Network

Author

Gaggiano, Carla, Gupta, Vishali, Agrawal, Rupesh, De Smet, Marc D., Frediani, Bruno, Tosi, Gian Marco, Paroli, Maria Pia, Sridharan, Sudharshan, Pavesio, Carlos E., Pleyer, Uwe, Denisova, Ekaterina V., Babu, Kalpana, de-la-Torre, Alejandra, Yang, Peizeng, Davis, Janet L., Cunningham, Emmett T., Carreño, Ester, Goldstein, Debra, Fonollosa, Alex, Cantarini, Luca, Sobrin, Lucia, and Fabiani, Claudia

Published
2024
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14. Outcomes of off-the-shelf preloaded inner branch device for urgent endovascular thoraco-abdominal aortic repair in the ItaliaN Branched Registry of E-nside EnDograft

Author

Antonello, Michele, Piazza, Michele, Squizzato, Francesco, Spezia, Matteo, Grego, Franco, Pratesi, Giovanni, Spinella, Giovanni, Esposito, Davide, Bastianon, Martina, Tshomba, Yamume, Donati, Tommaso, Sica, Simona, Tinelli, Giovanni, Ferri, Michelangelo, Quaglino, Simone, Gaggiano, Andrea, Vento, Vincenzo, Carbonari, Luciano, Gatta, Emanuele, Lenti, Massimo, Simonte, Gioele, Isernia, Giacomo, Parlani, Giambattista, Piffaretti, Gabriele, Frigatti, Paolo, Scrivere, Paola, Furlan, Federico, Veraldi, Gian Franco, Mezzetto, Luca, Gennai, Stefano, Leone, Nicola, Silingardi, Roberto, Iacono, Gustavo, Turricchia, Giorgio Ubaldo, Angiletta, Domenico, Maione, Massimo, Apostolou, Dimitri, Pulli, Raffaele, Fargion, Aaron, Filippi, Federico, De Angelis, Filippo, Arici, Vittorio, Bozzani, Antonio, Luigi Molinari, Alessandro Carlo, Rossi, Giovanni, Costantini Brancadoro, Emidio, Ferraris, Matteo, Dorrucci, Vittorio, Derone, Graziana, Tolva, Valerio Stefano, Compagnoni, Nicola Monzio, Segramora, Vittorio Maria, Deleo, Gaetano, Bracale, Umberto, Guzzardi, Giuseppe, Ferrer, Ciro, Giudice, Rocco, Sbarigia, Enrico, Cuozzo, Simone, Gattuso, Roberto, Mansour, Wassim, Di Marzo, Luca, Grimaldi, Sabrina, Corona, Mario, Chisci, Emiliano, Mechelagnoli, Stefano, De Donato, Gianmarco, Palasciano, Giancarlo, Pasqui, Edoardo, Candeloro, Laura, Ricci, Carmelo, Neri, Eugenio, Mangialardi, Nicola, Orrico, Matteo, Ronchey, Sonia, Fazzini, Stefano, Ippoliti, Arnaldo, Discalzi, Andrea, Rossato, Denis, Vio, Elias, Galeazzi, Edoardo, Farneti, Fabrizio, Bertoglio, Luca, Volpe, Pietro, Massara, Mafalda, Milite, Domenico, and Xodo, Andrea

Published
2024
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15. Efficacy and safety of Janus kinase inhibitors in non-infectious inflammatory ocular diseases: a prospective cohort study from the international AIDA network registries

Author

Antonio Vitale, Judith Palacios-Olid, Valeria Caggiano, Gaafar Ragab, José Hernández-Rodríguez, Laura Pelegrín, Germán Mejía-Salgado, Laura Zarate-Pinzón, Stefano Gentileschi, Jurgen Sota, Alex Fonollosa, Ester Carreño, Carla Gaggiano, Rana Hussein Amin, Alberto Balistreri, Javier Narváez, Gian Marco Tosi, Bruno Frediani, Luca Cantarini, Alejandra de-la-Torre, and Claudia Fabiani

Subjects
baricitinib, scleritis, tofacitinib, upadacitinib, uveitis, Medicine (General), R5-920
Abstract

IntroductionNon-infectious inflammatory ocular diseases pose significant challenges in diagnosis and management, often requiring systemic immunosuppressive therapy. Since Janus kinase (JAK) inhibitors may represent a novel therapeutic option for these disorders, the present study aimed to expand current knowledge about their efficacy and safety in patients with these conditions.MethodsThis prospective cohort study included 12 adult patients from the international AutoInflammatory Disease Alliance (AIDA) Network registries dedicated to non-infectious ocular inflammatory conditions. We assessed ocular flares, visual acuity, disease course, and complications before and after initiating JAK inhibitor therapy.ResultsOcular inflammation was related to a systemic disease in 8 (66.7%) patients as follows: spondyloarthritis (n = 3), peripheral psoriatic arthritis (n = 1), rheumatoid arthritis (n = 1), antinuclear antibodies (ANA) positive juvenile idiopathic arthritis (n = 1), Behçet’s syndrome (n = 1), Vogt-Koyanagi-Harada syndrome (n = 1). In total, 4 patients received baricitinib, 1 patient received tofacitinib, and 7 patients underwent upadacitinib treatment. The overall average duration of JAK inhibitors treatment was 8.6 ± 5.5 months (ranging from 3 to 20 months). At the last assessment, ocular disease control was complete in 12/12 patients. One patient discontinued baricitinib due to poor compliance after a 12-month relapse-free period. The incidence of ocular flares was 125 episodes/1.000 person-months prior to the initiation of JAK inhibitors and 28.6 episodes/1.000 person-months thereafter. The incidence rate ratio for experiencing a relapse before starting a JAK inhibitor compared to the following period was 4.37 (95% CI 1.3–14.7, p-value: 0.02).ConclusionJAK inhibitors demonstrate efficacy and safety in controlling ocular inflammatory relapses, confirming that they represent a valuable treatment option for patients with non-infectious inflammatory ocular diseases resistant to conventional treatments.

Published
2024
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16. WP15 ConCorD state-of-the-art report (container corrosion under disposal conditions)

Author

Andrés G. Muñoz, Abdesselam Abdelouas, Ursula Alonso, Ana María Fernández, Rizlan Bernier-Latmani, Andrea Cherkouk, Roberto Gaggiano, James Hesketh, Nick Smart, Cristiano Padovani, Kristel Mijnendonckx, Vanessa Montoya, Andrés Idiart, Arnau Pont, Olga Riba, Nicolas Finck, Ashutosh R. Singh, Fraser King, and Nikitas Diomidis

Subjects
nuclear waste containers, disposal canisters, corrosion, radiation, microbiologically influenced corrosion, lifetime prediction, Plasma physics. Ionized gases, QC717.6-718.8, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

A sealed container for the geological disposal of spent nuclear fuel and vitrified high-level waste is the only component of a deep geological repository that provides complete containment of radionuclides. As such, attention is focused on its lifetime. The lifetime of the container is influenced by material degradation processes during disposal and is typically of the order of several millennia and, for some container materials, up to one million years. Designing, manufacturing, and predicting the performance of containers over such long periods requires an in-depth understanding of their material properties, fabrication processes, and degradation mechanisms. Scientific and technological progress can improve both the performance of containers and the robustness of lifetime predictions. Optimization of these aspects is of primary importance for many national radioactive waste disposal programs. In this article, the state of the art of complex coupled degradation processes, as well as the optimization potential of novel container materials, is presented. Furthermore, the existing tools allowing the prediction of long-term barrier integrity are discussed.

Published
2024
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17. Correction: Clinical and laboratory features associated with macrophage activation syndrome in Still’s disease: data from the international AIDA Network Still’s Disease Registry

Author

Triggianese, Paola, Vitale, Antonio, Lopalco, Giuseppe, Mayrink Giardini, Henrique Ayres, Ciccia, Francesco, Al-Maghlouth, Ibrahim, Ruscitti, Piero, Sfikakis, Petros Paul, Iannone, Florenzo, de Brito Antonelli, Isabele Parente, Patrone, Martina, Asfina, Kazi Nur, Di Cola, Ilenia, Laskari, Katerina, Gaggiano, Carla, Tufan, Abdurrahman, Sfriso, Paolo, Dagna, Lorenzo, Giacomelli, Roberto, Hinojosa-Azaola, Andrea, Ragab, Gaafar, Fotis, Lampros, Direskeneli, Haner, Spedicato, Veronica, Dagostin, Marilia Ambiel, Iacono, Daniela, Ali, Hebatallah Hamed, Cipriani, Paola, Sota, Jurgen, Kardas, Riza Can, Bindoli, Sara, Campochiaro, Corrado, Navarini, Luca, Gentileschi, Stefano, Martín-Nares, Eduardo, Torres-Ruiz, Jiram, Saad, Moustafa Ali, Kourtesi, Katerina, Alibaz-Oner, Fatma, Sevik, Gizem, Iagnocco, Annamaria, Makowska, Joanna, Govoni, Marcello, Monti, Sara, Maggio, Maria Cristina, La Torre, Francesco, Del Giudice, Emanuela, Hernández-Rodríguez, José, Bartoloni, Elena, Emmi, Giacomo, Chimenti, Maria Sole, Maier, Armin, Simonini, Gabriele, Conti, Giovanni, Olivieri, Alma Nunzia, Tarsia, Maria, De Paulis, Amato, Lo Gullo, Alberto, Więsik-Szewczyk, Ewa, Viapiana, Ombretta, Ogunjimi, Benson, Tharwat, Samar, Erten, Sukran, Nuzzolese, Rossana, Karamanakos, Anastasios, Frassi, Micol, Conforti, Alessandro, Caggiano, Valeria, Marino, Achille, Sebastiani, Gian Domenico, Gidaro, Antonio, Tombetti, Enrico, Carubbi, Francesco, Rubegni, Giovanni, Cartocci, Alessandra, Balistreri, Alberto, Fabiani, Claudia, Frediani, Bruno, and Cantarini, Luca

Published
2024
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18. Clinical and laboratory features associated with macrophage activation syndrome in Still’s disease: data from the international AIDA Network Still’s Disease Registry

Author

Triggianese, Paola, Vitale, Antonio, Lopalco, Giuseppe, Mayrink Giardini, Henrique Ayres, Ciccia, Francesco, Al-Maghlouth, Ibrahim, Ruscitti, Piero, Sfikakis, Petros Paul, Iannone, Florenzo, de Brito Antonelli, Isabele Parente, Patrone, Martina, Asfina, Kazi Nur, Di Cola, Ilenia, Laskari, Katerina, Gaggiano, Carla, Tufan, Abdurrahman, Sfriso, Paolo, Dagna, Lorenzo, Giacomelli, Roberto, Hinojosa-Azaola, Andrea, Ragab, Gaafar, Fotis, Lampros, Direskeneli, Haner, Spedicato, Veronica, Dagostin, Marilia Ambiel, Iacono, Daniela, Ali, Hebatallah Hamed, Cipriani, Paola, Sota, Jurgen, Kardas, Riza Can, Bindoli, Sara, Campochiaro, Corrado, Navarini, Luca, Gentileschi, Stefano, Martín-Nares, Eduardo, Torres-Ruiz, Jiram, Saad, Moustafa Ali, Kourtesi, Katerina, Alibaz-Oner, Fatma, Sevik, Gizem, Iagnocco, Annamaria, Makowska, Joanna, Govoni, Marcello, Monti, Sara, Maggio, Maria Cristina, La Torre, Francesco, Del Giudice, Emanuela, Hernández-Rodríguez, José, Bartoloni, Elena, Emmi, Giacomo, Chimenti, Maria Sole, Maier, Armin, Simonini, Gabriele, Conti, Giovanni, Olivieri, Alma Nunzia, Tarsia, Maria, De Paulis, Amato, Lo Gullo, Alberto, Więsik-Szewczyk, Ewa, Viapiana, Ombretta, Ogunjimi, Benson, Tharwat, Samar, Erten, Sukran, Nuzzolese, Rossana, Karamanakos, Anastasios, Frassi, Micol, Conforti, Alessandro, Caggiano, Valeria, Marino, Achille, Sebastiani, Gian Domenico, Gidaro, Antonio, Tombetti, Enrico, Carubbi, Francesco, Rubegni, Giovanni, Cartocci, Alessandra, Balistreri, Alberto, Fabiani, Claudia, Frediani, Bruno, and Cantarini, Luca

Published
2023
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19. Unfolding dermatologic spectrum of Behçet’s disease in Italy: real-life data from the International AIDA Network Behçet’s disease Registry

Author

D’Onghia, Martina, Cinotti, Elisa, Cartocci, Alessandra, Vitale, Antonio, Caggiano, Valeria, Tognetti, Linda, La Marca, Francesca, Sota, Jurgen, Gentileschi, Stefano, Rubegni, Giovanni, Lopalco, Giuseppe, Guerriero, Silvana, Govoni, Marcello, Monti, Sara, Ruscitti, Piero, Angeli, Fabrizio, Carubbi, Francesco, Giacomelli, Roberto, Ciccia, Francesco, Piga, Matteo, Emmi, Giacomo, Costi, Stefania, Sebastiani, Gian Domenico, Iannone, Florenzo, Spedicato, Veronica, Alessio, Giovanni, Ruffilli, Francesca, Milanesi, Alessandra, Gentile, Martina, Crisafulli, Francesca, Alunno, Alessia, Navarini, Luca, Iacono, Daniela, Cauli, Alberto, Ricci, Francesca, Gaggiano, Carla, Tarsia, Maria, Bartoloni, Elena, Conti, Giovanni, Viapiana, Ombretta, Gobbi, Francesca Li, de Paulis, Amato, Parronchi, Paola, Del Giudice, Emanuela, Barone, Patrizia, Olivieri, Alma Nunzia, Bizzi, Emanuele, Maggio, Maria Cristina, Balistreri, Alberto, Frediani, Bruno, Tosi, Gian Marco, Fabiani, Claudia, Rubegni, Pietro, and Cantarini, Luca

Published
2023
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21. Thrombotic manifestations in pediatric Behcet syndrome: A multicenter comparative study from the EUROFEVER registry

Author

Mastrolia, Maria Vincenza, Matucci-Cerinic, Caterina, Ozen, Seza, Kasapcopur, Ozgur, Gaggiano, Carla, Koné-Paut, Isabelle, Cantarini, Luca, Dusser, Perrine, Kaya-Akça, Ümmüşen, Yildiz, Mehmet, Brunner, Juergen, Filocamo, Giovanni, Gallizzi, Romina, Insalaco, Antonella, Pastore, Serena, Rigante, Donato, Sanchez-Manubens, Judith, Tsitsami, Elena, Ruperto, Nicola, Gattorno, Marco, and Simonini, Gabriele

Published
2024
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23. Efficacy and Safety of Adalimumab in Pediatric Non-infectious Non-anterior Uveitis: Real-life Experience From the International AIDA Network Uveitis Registry

Author

Vitale, Antonio, Casa, Francesca Della, Guerriero, Silvana, Ragab, Gaafar, Mauro, Angela, Caggiano, Valeria, Cattalini, Marco, Del Giudice, Emanuela, Favale, Rossella, Gaggiano, Carla, Bellicini, Irene, Paroli, Maria Pia, Hegazy, Mohamed Tharwat, Sota, Jurgen, Tufan, Abdurrahman, Balistreri, Alberto, Almaghlouth, Ibrahim, La Torre, Francesco, Więsik-Szewczyk, Ewa, Tarsia, Maria, Hinojosa-Azaola, Andrea, Martín-Nares, Eduardo, Frediani, Bruno, Tosi, Gian Marco, Fonollosa, Alex, Hernández-Rodríguez, José, Amin, Rana Hussein, Lopalco, Giuseppe, Rigante, Donato, Cantarini, Luca, and Fabiani, Claudia

Published
2023
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24. Risk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries

Author

Antonio Vitale, Valeria Caggiano, Abdurrahman Tufan, Gaafar Ragab, Ezgi Deniz Batu, Piero Portincasa, Emma Aragona, Jurgen Sota, Giovanni Conti, Amato De Paulis, Donato Rigante, Alma Nunzia Olivieri, Ali Şahin, Francesco La Torre, Giuseppe Lopalco, Marco Cattalini, Maria Cristina Maggio, Antonella Insalaco, Petros P. Sfikakis, Elena Verrecchia, Derya Yildirim, Hamit Kucuk, Riza Can Kardas, Ahmed Hatem Laymouna, Mahmoud Ghanema, Moustafa Ali Saad, Seher Sener, Hulya Ercan Emreol, Seza Ozen, Nour Jaber, Mohamad Khalil, Agostino Di Ciaula, Carla Gaggiano, Giuseppe Malizia, Andrea Affronti, Serena Patroniti, Meri Romeo, Jessica Sbalchiero, Francesca Della Casa, Ilaria Mormile, Sara Silvaroli, Maria Francesca Gicchino, Neşe Çabuk Çelik, Maria Tarsia, Anastasios Karamanakos, José Hernández-Rodríguez, Paola Parronchi, Daniela Opris-Belinski, Patrizia Barone, Andreas Recke, Stefania Costi, Paolo Sfriso, Henrique A. Mayrink Giardini, Stefano Gentileschi, Ewa Wiesik-Szewczyk, Ibrahim Vasi, Roberta Loconte, Karina Jahnz-Różyk, Eduardo Martín-Nares, Jiram Torres-Ruiz, Alberto Cauli, Alessandro Conforti, Giacomo Emmi, Francesca Li Gobbi, Giovanni Rosario Biasi, Riccardo Terribili, Piero Ruscitti, Emanuela Del Giudice, Samar Tharwat, Antonio Luca Brucato, Benson Ogunjimi, Andrea Hinojosa-Azaola, Alberto Balistreri, Claudia Fabiani, Bruno Frediani, and Luca Cantarini

Subjects
autoinflammatory diseases, FMF, tumor, neoplasm, rare diseases, treatment, Immunologic diseases. Allergy, RC581-607
Abstract

ObjectiveInflammation has been associated with an increased risk for cancer development, while innate immune system activation could counteract the risk for malignancies. Familial Mediterranean fever (FMF) is a severe systemic inflammatory condition and also represents the archetype of innate immunity deregulation. Therefore, the aim of this study is to investigate the risk for cancer development in FMF.MethodsThe risk ratio (RR) for malignancies was separately compared between FMF patients and fibromyalgia subjects, Still’s disease patients and Behçet’s disease patients. Clinical variables associated with cancer development in FMF patients were searched through binary logistic regression.Results580 FMF patients and 102 fibromyalgia subjects, 1012 Behçet’s disease patients and 497 Still’s disease patients were enrolled. The RR for the occurrence of malignant neoplasms was 0.26 (95% Confidence Interval [CI.] 0.10-0.73, p=0.006) in patients with FMF compared to fibromyalgia subjects; the RR for the occurrence of malignant cancer was 0.51 (95% CI. 0.23-1.16, p=0.10) in FMF compared to Still’s disease and 0.60 (95% CI. 0.29-1.28, p=0.18) in FMF compared to Behçet’s disease. At logistic regression, the risk of occurrence of malignant neoplasms in FMF patients was associated with the age at disease onset (β1 = 0.039, 95% CI. 0.001-0.071, p=0.02), the age at the diagnosis (β1 = 0.048, 95% CI. 0.039-0.085, p=0.006), the age at the enrolment (β1 = 0.05, 95% CI. 0.007-0.068, p=0.01), the number of attacks per year (β1 = 0.011, 95% CI. 0.001- 0.019, p=0.008), the use of biotechnological agents (β1 = 1.77, 95% CI. 0.43-3.19, p=0.009), the use of anti-IL-1 agents (β1 = 2.089, 95% CI. 0.7-3.5, p=0.002).ConclusionsThe risk for cancer is reduced in Caucasic FMF patients; however, when malignant neoplasms occur, this is more frequent in FMF cases suffering from a severe disease phenotype and presenting a colchicine-resistant disease.

Published
2024
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25. Feasibility and Safety of Using Carbon Dioxide Exclusively in Regular Endovascular Aortic Aneurysm Repair: Results of a Multicentre, Prospective, Zero Iodine Contrast Endovascular Aneurysm Repair Study

Author

Chisci, Emiliano, Ferrero, Emanuele, Antonello, Michele, Mezzetto, Luca, Pulli, Raffaele, Isernia, Giacomo, Gargiulo, Mauro, Pratesi, Giovanni, Angiletta, Domenico, Bertoglio, Luca, Simongini, Sara, Panci, Simone, Lazzarotto, Tommaso, Chiera, Lorenza, Ferri, Michelangelo, Gaggiano, Andrea, Marrocco, Simona, Colacchio, Elda Chiara, Piazza, Michele, Grego, Franco, Grosso, Lorenzo, Veraldi, Gian Franco, Fargion, Aaron Thomas, Falso, Roberto, Simonte, Gioele, Parlani, Gianbattista, Lenti, Massimo, Gallitto, Enrico, Mascoli, Chiara, Melani, Caterina, Zacà, Sergio, Di Stefano, Lucia, Bonardelli, Stefano, Verrengia, Apollonia, and Michelagnoli, Stefano

Published
2024
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27. Musculoskeletal manifestations in children with Behçet’s syndrome: data from the AIDA Network Behçet’s Syndrome Registry

Author

Gaggiano, Carla, Maselli, Anna, Sfikakis, Petros P., Laskari, Katerina, Ragab, Gaafar, Hegazy, Mohamed Tharwat, Laymouna, Ahmed Hatem, Lopalco, Giuseppe, Almaghlouth, Ibrahim A., Asfina, Kazi Nur, Alahmed, Ohoud, Giardini Mayrink, Henrique Ayres, Parente de Brito Antonelli, Isabele, Cattalini, Marco, Piga, Matteo, Sota, Jurgen, Gentileschi, Stefano, Maggio, Maria Cristina, Opris-Belinski, Daniela, Hatemi, Gülen, Insalaco, Antonella, Olivieri, Alma Nunzia, Tufan, Abdurrahman, Karadeniz, Hazan, Kardaş, Riza Can, La Torre, Francesco, Cardinale, Fabio, Marino, Achille, Guerriero, Silvana, Ruscitti, Piero, Tarsia, Maria, Vitale, Antonio, Caggiano, Valeria, Telesca, Salvatore, Iannone, Florenzo, Parretti, Veronica, Frassi, Micol, Aragona, Emma, Ciccia, Francesco, Wiesik-Szewczyk, Ewa, Ionescu, Ruxandra, Şahin, Ali, Akkoç, Nurullah, Hinojosa-Azaola, Andrea, Tharwat, Samar, Hernández-Rodríguez, José, Espinosa, Gerard, Conti, Giovanni, Del Giudice, Emanuela, Govoni, Marcello, Emmi, Giacomo, Fabiani, Claudia, Balistreri, Alberto, Frediani, Bruno, Rigante, Donato, and Cantarini, Luca

Published
2023
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28. Intensive training programme for ultrasound-guided minimally invasive synovial tissue biopsy on knees and wrists in different phases of inflammation

Author

Maria-Antonietta D’Agostino, Maria Sole Chimenti, Roberto Caporali, Giuliana Guggino, Francesco Ciccia, Elisa Gremese, Barbara Tolusso, Stefano Alivernini, Marco Gessi, Pietro Rubortone, Lavinia Agra Coletto, Laura Bui, Roberta Benvenuto, Clara Di Mario, Chiara Rizzo, Arianna D’Antonio, Valentina Marino, Natacha Goulas, Lucrezia Verardi, Emanuela Gaggiano, Dario Bruno, and Marco Maria Lizzio

Subjects
Medicine
Abstract

Objectives To develop an intensive training programme for ultrasound (US)-guided synovial tissue (ST) biopsy on knees and wrists in inflammatory arthritis and to assess the learning curve, patient tolerability, sample quality and trainees’ expectations.Methods Active or remission rheumatoid arthritis patients were enrolled. Nine trainees joined the 4-month programme in a centre experienced in performing US-guided ST biopsies consisting of four sequential phases: (1) observation, (2) performance of guided step-by-step phases, (3) execution of the whole procedure on paired joints (knees or wrists) of the same patient in parallel with the trainer and (4) performance of the procedure autonomously. Sample representativity was assessed by histology, and procedure-related adverse events were recorded. Before and after the programme, trainees’ expectations and perceptions were collected.Results 328 ST biopsy procedures were included. The rate of trainees’ informative samples was: (1) comparable to the trainers in active and remission knees, but lower in active wrists (70% for trainees vs 100% for trainers, p=0.06) in phase 3; (2) excellent on active knees and wrists (91.9% and 90.9% respectively) but lower (77.6%, p=0.0089) on remission knees in phase 4. Procedures performed by trainees did not affect patient tolerability. Trainees’ expectations about procedure-related invasiveness and pain infliction decreased while the difficulty of procedure execution on active wrists and remission knees remained perceived as moderately difficult.Conclusions This intensive training programme develops advanced skills in the performance of US-guided ST biopsy on knees and wrists, yielding high-quality specimens available for basic and translational studies on inflammatory joint diseases.

Published
2024
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29. Efficacy of canakinumab in patients with Still’s disease across different lines of biologic therapy: real-life data from the International AIDA Network Registry for Still’s Disease

Author

Antonio Vitale, Valeria Caggiano, Petros P. Sfikakis, Lorenzo Dagna, Giuseppe Lopalco, Gaafar Ragab, Francesco La Torre, Ibrahim A. Almaghlouth, Maria Cristina Maggio, Jurgen Sota, Abdurrahman Tufan, Andrea Hinojosa-Azaola, Florenzo Iannone, Roberta Loconte, Katerina Laskari, Haner Direskeneli, Piero Ruscitti, Maria Morrone, Henrique A. Mayrink Giardini, Alexandros Panagiotopoulos, Ilenia Di Cola, Eduardo Martín-Nares, Sara Monti, Ludovico De Stefano, Rıza Can Kardas, Rahime Duran, Corrado Campochiaro, Alessandro Tomelleri, Abdulaziz Mohammed Alabdulkareem, Carla Gaggiano, Maria Tarsia, Elena Bartoloni, Mery Romeo, Mohamed A. Hussein, Ahmed Hatem Laymouna, Isabele Parente de Brito Antonelli, Marilia Ambiel Dagostin, Lampros Fotis, Sara Bindoli, Luca Navarini, Fatma Alibaz-Oner, Gizem Sevik, Micol Frassi, Francesco Ciccia, Daniela Iacono, Francesca Crisafulli, Piero Portincasa, Nour Jaber, Perla Ayumi Kawakami-Campos, Ewa Wiesik-Szewczyk, Annamaria Iagnocco, Gabriele Simonini, Paolo Sfriso, Alberto Balistreri, Roberto Giacomelli, Giovanni Conti, Bruno Frediani, Claudia Fabiani, and Luca Cantarini

Subjects
AOSD, AutoInflammatory diseases, rare diseases, personalized medicine, treatment, Medicine (General), R5-920
Abstract

IntroductionThe effectiveness of canakinumab may change according to the different times it is used after Still’s disease onset. This study aimed to investigate whether canakinumab (CAN) shows differences in short- and long-term therapeutic outcomes, according to its use as different lines of biologic treatment.MethodsPatients included in this study were retrospectively enrolled from the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to Still’s disease. Seventy-seven (51 females and 26 males) patients with Still’s disease were included in the present study. In total, 39 (50.6%) patients underwent CAN as a first-line biologic agent, and the remaining 38 (49.4%) patients were treated with CAN as a second-line biologic agent or subsequent biologic agent.ResultsNo statistically significant differences were found between patients treated with CAN as a first-line biologic agent and those previously treated with other biologic agents in terms of the frequency of complete response (p =0.62), partial response (p =0.61), treatment failure (p >0.99), and frequency of patients discontinuing CAN due to lack or loss of efficacy (p =0.2). Of all the patients, 18 (23.4%) patients experienced disease relapse during canakinumab treatment, 9 patients were treated with canakinumab as a first-line biologic agent, and nine patients were treated with a second-line or subsequent biologic agent. No differences were found in the frequency of glucocorticoid use (p =0.34), daily glucocorticoid dosage (p =0.47), or concomitant methotrexate dosage (p =0.43) at the last assessment during CAN treatment.ConclusionCanakinumab has proved to be effective in patients with Still’s disease, regardless of its line of biologic treatment.

Published
2023
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30. The administration of methotrexate in patients with Still's disease, “real-life” findings from AIDA Network Still Disease Registry

Author

Ruscitti, Piero, Sota, Jurgen, Vitale, Antonio, Lopalco, Giuseppe, Iannone, Florenzo, Morrone, Maria, Giardini, Henrique Ayres Mayrink, D'Agostin, Marília Ambuel, Antonelli, Isabelle Parente de Brito, Almaghlouth, Ibrahim, Asfina, Kazi Nur, Khalil, Najma, Sfikakis, Petros P., Laskari, Katerina, Tektonidou, Maria, Ciccia, Francesco, Iacono, Daniela, Riccio, Flavia, Ragab, Gaafar, Hussein, Mohamed A., Govoni, Marcello, Ruffilli, Francesca, Direskeneli, Haner, Alibaz-Oner, Fatma, Giacomelli, Roberto, Navarini, Luca, Bartoloni, Elena, Riccucci, Ilenia, Martín-Nares, Eduardo, Torres-Ruiz, Jiram, Cipriani, Paola, Di Cola, Ilenia, Hernández-Rodríguez, José, Gómez-Caverzaschi, Verónica, Dagna, Lorenzo, Tomelleri, Alessandro, Makowska, Joanna, Brzezinska, Olga, Iagnocco, Annamaria, Bellis, Elisa, Caggiano, Valeria, Gaggiano, Carla, Tarsia, Maria, Mormile, Ilaria, Emmi, Giacomo, Sfriso, Paolo, Monti, Sara, Erten, Şükran, Del Giudice, Emanuela, Lubrano, Riccardo, Conti, Giovanni, Olivieri, Alma Nunzia, Lo Gullo, Alberto, Tharwat, Samar, Karamanakos, Anastasios, Gidaro, Antonio, Maggio, Maria Cristina, La Torre, Francesco, Cardinale, Fabio, Ogunjimi, Benson, Maier, Armin, Sebastiani, Gian Domenico, Opris-Belinski, Daniela, Frassi, Micol, Viapiana, Ombretta, Bizzi, Emanuele, Carubbi, Francesco, Fotis, Lampros, Tufan, Abdurrahman, Kardas, Riza Can, Więsik-Szewczyk, Ewa, Jahnz-Różyk, Karina, Fabiani, Claudia, Frediani, Bruno, Balistreri, Alberto, Rigante, Donato, and Cantarini, Luca

Published
2023
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33. Editor's Choice – Early Outcomes of a Novel Off the Shelf Preloaded Inner Branch Endograft for the Treatment of Complex Aortic Pathologies in the ItaliaN Branched Registry of E-nside EnDograft (INBREED)

Author

Forcella, Edoardo, Grego, Franco, Spinella, Giovanni, Di Gregorio, Sara, Donati, Tommaso, Sica, Simona, Tinelli, Giovanni, Ferri, Michelangelo, Quaglino, Simone, Vento, Vincenzo, Carbonari, Luciano, Lenti, Massimo, Isernia, Giacomo, Parlani, Giambattista, Scrivere, Paola, Furlan, Federico, Mezzetto, Luca, Mastrorilli, Davide, Gennai, Stefano, Leone, Nicola, Iacono, Gustavo, Turricchia, Giorgio Ubaldo, Angiletta, Domenico, Maione, Massimo, Apostolou, Dimitri, Pulli, Raffaele, Fargion, Aaron, Pratesi, Carlo, Filippi, Federico, De Angelis, Filippo, Arici, Vittorio, Bozzani, Antonio, Luigi Molinari, Alessandro Carlo, Rossi, Giovanni, Brancadoro, Emidio Costantini, Ferraris, Matteo, Dorrucci, Vittorio, Derone, Graziana, Tolva, Valerio Stefano, Segramora, Vittorio Maria, Deleo, Gaetano, Bracale, Umberto, Guzzardi, Giuseppe, Ferrer, Ciro, Giudice, Rocco, Sbarigia, Enrico, Cuozzo, Simone, Gattuso, Roberto, Mansour, Wassim, Di Marzo, Luca, Grimaldi, Sabrina, Corona, Mario, Chisci, Emiliano, Mechelagnoli, Stefano, De Donato, Gianmarco, Palasciano, Giancarlo, Pasqui, Edoardo, Candeloro, Laura, Ricci, Carmelo, Neri, Eugenio, Mangialardi, Nicola, Orrico, Matteo, Fazzini, Stefano, Ippoliti, Arnaldo, Discalzi, Andrea, Rossato, Denis, Vio, Elias, Galeazzi, Edoardo, Farneti, Fabrizio, Piazza, Michele, Squizzato, Francesco, Pratesi, Giovanni, Tshomba, Yamume, Gaggiano, Andrea, Gatta, Emanuele, Simonte, Gioele, Piffaretti, Gabriele, Frigatti, Paolo, Veraldi, Gian Franco, Silingardi, Roberto, and Antonello, Michele

Published
2023
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34. Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registry

Author

Micol Frassi, Marcello Govoni, Annamaria Iagnocco, Florenzo Iannone, Paola Triggianese, Corrado Campochiaro, Sara Monti, Maria G Tektonidou, Eduardo Martin-Nares, Piero Ruscitti, Roberto Giacomelli, Luca Cantarini, Giuseppe Lopalco, Lorenzo Dagna, Francesco Carubbi, Alma Nunzia Olivieri, Antonio Vitale, Ombretta Viapiana, Fatma Alibaz-Öner, Haner Direskeneli, Petros P Sfikakis, Giacomo Emmi, Claudia Fabiani, Gabriele Simonini, Francesco Ciccia, Elena Bartoloni, Alessandro Tomelleri, Daniela Iacono, Riza Can Kardas, Bruno Frediani, Benson Ogunjimi, Amato de Paulis, Onorina Berardicurti, Alessandro Conforti, Ilenia Di Cola, Anastasios Karamanakos, Katerina Laskari, Abdurrahman Tufan, Stefania Costi, José Hernández-Rodríguez, Lampros Fotis, Jurgen Sota, Antonio Gidaro, Ewa Wiesik-Szewczyk, Gian Domenico Sebastiani, Jiram Torres-Ruiz, Paolo Sfriso, Giovanni Conti, Luca Navarini, Francesco La Torre, Samar Tharwat, Andrea Hinojosa-Azaola, Alberto Lo Gullo, Valeria Caggiano, Ibrahim A Almaghlouth, Kazi Asfina, Gafaar Ragab, Maria Cristina Maggio, Joanna Makowska, Emanuela Del Giudice, Armin Maier, Sukran Erten, Henrique A Mayrink Giardini, Maria Morrone, Isabele Parente de Brito Antonelli, Marilia Ambiel Dagostin, Martina Patrone, Fehaid Alanazi, Carla Gaggiano, Hamit Kucuk, Ayman Abdel-Monem Ahmed Mahmoud, Katerina Kourtesi, Maria Tarsia, Verónica Gómez-Caverzaschi, Angela Mauro, and Alberto Balistreri

Subjects
Medicine
Abstract

Objective Still’s disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still’s disease represent expressions of the same disease continuum or different clinical entities is still a matter of controversy. The aim of this study is to search for any differences in demographic, clinical features and response to treatment between pediatric-onset, adult-onset and elderly-onset Still’s disease.Methods Subjects included in this study were drawn from the International AutoInflammatory Disease Alliance Network registry for patients with Still’s disease.Results A total of 411 patients suffering from Still’s disease were enrolled; the disease occurred in the childhood in 65 (15.8%) patients, in the adult 314 (76.4%) patients and in the elderly in 32 (7.8%) patients. No statistically significant differences at post-hoc analysis were observed in demographic features of the disease between pediatric-onset, adult-onset and elderly-onset Still’s disease. The salmon-coloured skin rash (p=0.004), arthritis (p=0.009) and abdominal pain (p=0.007) resulted significantly more frequent among paediatric patients than in adult cases, while pleuritis (p=0.015) and arthralgia (p

Published
2023
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35. Identification de matériaux par tomodensitométrie haute-énergie dans des objets bétonnés

Author

Nicolas Estre, Daniel Eck, Frédéric Moutet, Emmanuel Payan, Alix Sardet, Roberto Gaggiano, and Maarten van Geet

Subjects
Technology
Abstract

L’identification des matériaux présents dans des objets volumineux comme des colis de déchets nucléaires nécessite la plupart du temps soit une opération destructive (carottage, découpe) pour les colis bétonnés, soit une intervention humaine (tri, inventaire) sur des colis de faible activité dont le déchet n’est pas bloqué. Dans le cadre de ses activités de R&D sur la gestion des colis de déchets, l’ONDRAF/NIRAS (Belgique) a sollicité le CEA (Institut IRESNE) pour évaluer les performances et les limites de détection et d’identification de matériaux dans des colis bétonnés étalons de 400 l/ 900 kg. La technique mise en oeuvre est la tomographie par transmission au moyen d’un accélérateur linéaire dont l’énergie est réglable de 9 à 21 MeV (avec un maximum de dose à 15 MeV). Des essais ont ainsi été réalisés sur cinq fantômes spécialement conçus par l’ONDRAF/NIRAS pour refléter la gamme de matériaux devant être identifiés (plexiglas, cellulose, bois, métal, eau, huile, filtres, déchets compactés, etc). Les premières séries de mesures ont consisté en des tomographies demi-champ Cone-Beam (3D) afin d’avoir une vue globale des colis et de leur contenu. La diffusion Compton étant majoritaire à ces énergies, il n’a pas été possible, à cause du rayonnement diffusé parasite, de réaliser une calibration en densité. Une seconde série de mesures a alors visé à comprendre les perturbations observées afin de les corriger et obtenir la meilleure précision possible sur la densité à l’aide d’une géométrie collimatée Fan-Beam (2D). Les précisions obtenues sur la densité sont de l’ordre de quelques pourcents pour la majorité des matériaux, la sensibilité variant suivant leur nature. Par exemple, l’eau et l’huile contenues dans un même récipient sont distinguées autant par la valeur de leur densité que par leur stratification alors même que la nature des métaux est plus difficile à extraire à cause du durcissement de spectre. La tomographie 3D et la tomodensitométrie 2D apparaissent donc comme des examens efficaces pour identifier des matériaux contenus dans des objets volumineux et lourds comme des colis de déchets nucléaires.

Published
2023
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36. Development and implementation of the AIDA International Registry for patients with Behçet’s disease

Author

Vitale, Antonio, Della Casa, Francesca, Ragab, Gaafar, Almaghlouth, Ibrahim A., Lopalco, Giuseppe, Pereira, Rosa Maria, Guerriero, Silvana, Govoni, Marcello, Sfikakis, Petros P., Giacomelli, Roberto, Ciccia, Francesco, Monti, Sara, Ruscitti, Piero, Piga, Matteo, Lomater, Claudia, Tufan, Abdurrahman, Opris-Belinski, Daniela, Emmi, Giacomo, Hernández-Rodríguez, José, Şahin, Ali, Sebastiani, Gian Domenico, Bartoloni, Elena, Akkoç, Nurullah, Gündüz, Özgül Soysal, Cattalini, Marco, Conti, Giovanni, Hatemi, Gulen, Maier, Armin, Parronchi, Paola, Del Giudice, Emanuela, Erten, Sukran, Insalaco, Antonella, Li Gobbi, Francesca, Maggio, Maria Cristina, Shahram, Farhad, Caggiano, Valeria, Hegazy, Mohamed Tharwat, Asfina, Kazi Nur, Morrone, Maria, Prado, Leandro L., Dammacco, Rosanna, Ruffilli, Francesca, Arida, Aikaterini, Navarini, Luca, Pantano, Ilenia, Cavagna, Lorenzo, Conforti, Alessandro, Cauli, Alberto, Marucco, Elena Maria, Kucuk, Hamit, Ionescu, Ruxandra, Mattioli, Irene, Espinosa, Gerard, Araújo, Olga, Karkaş, Burak, Canofari, Claudia, Sota, Jurgen, Laymouna, Ahmed Hatem, Bedaiwi, Asma. A., Colella, Sergio, Giardini, Henrique Ayres M., Albano, Valeria, Lo Monaco, Andrea, Fragoulis, George E., Kardas, Riza Can, Berlengiero, Virginia, Hussein, Mohamed A., Ricci, Francesca, La Torre, Francesco, Rigante, Donato, Więsik-Szewczyk, Ewa, Frassi, Micol, Gentileschi, Stefano, Tosi, Gian Marco, Dagostin, Marilia Ambiel, Mahmoud, Ayman Abdel-Monem Ahmed, Tarsia, Maria, Alessio, Giovanni, Cimaz, Rolando, Giani, Teresa, Gaggiano, Carla, Iannone, Florenzo, Cipriani, Paola, Mourabi, Mariam, Spedicato, Veronica, Barneschi, Sara, Aragona, Emma, Balistreri, Alberto, Frediani, Bruno, Fabiani, Claudia, and Cantarini, Luca

Published
2022
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37. Efficacy and safety of tocilizumab in adult-onset Still's disease: Real-life experience from the international AIDA registry

Author

Sota, Jurgen, Vitale, Antonio, Lopalco, Giuseppe, Pereira, Rosa Maria R., Giordano, Heitor F., Antonelli, Isabele P.B., Makowska, Joanna, Brzezińska, Olga, Lewandowska-Polak, Anna, Ruscitti, Piero, Cipriani, Paola, Cola, Ilenia Di, Govoni, Marcello, Ruffili, Francesca, Sfikakis, Petros P., Laskari, Katerina, Ragab, Gaafar, Hussein, Mohamed A., Gentileschi, Stefano, Gaggiano, Carla, La Torre, Francesco, Maier, Armin, Emmi, Giacomo, Marino, Achille, Ciccia, Francesco, Sfriso, Paolo, Maggio, Maria Cristina, Bartoloni, Elena, Lomater, Claudia, Hegazy, Mohamed Tharwat, Tektonidou, Maria, Dagostin, Marília A., Opinc, Aleksandra, Sebastiani, Gian Domenico, Giacomelli, Roberto, Giudice, Emanuela Del, Olivieri, Alma Nunzia, Tufan, Abdurrahman, Kardas, Riza Kan, Nuzzolese, Rossana, Cardinale, Fabio, Więsik-Szewczyk, Ewa, Veronica, Parretti, Tarsia, Maria, Iannone, Florenzo, Della Casa, Francesca, Fabiani, Claudia, Frediani, Bruno, Balistreri, Alberto, Rigante, Donato, and Cantarini, Luca

Published
2022
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38. A patient-driven registry on Behçet’s disease: the AIDA for patients pilot project

Author

Carla Gaggiano, Alessandra Del Bianco, Jurgen Sota, Stefano Gentileschi, Piero Ruscitti, Roberto Giacomelli, Matteo Piga, Francesca Crisafulli, Sara Monti, Giacomo Emmi, Amato De Paulis, Antonio Vitale, Maria Tarsia, Valeria Caggiano, Rossana Nuzzolese, Veronica Parretti, Claudia Fabiani, Giuseppe Lopalco, Armin Maier, Marco Cattalini, Donato Rigante, Marcello Govoni, Francesca Li Gobbi, Serena Guiducci, Paola Parronchi, Achille Marino, Francesco Ciccia, Maria Cristina Maggio, Emma Aragona, Elena Bartoloni, Annamaria Iagnocco, Ombretta Viapiana, Gian Domenico Sebastiani, Silvana Guerriero, Antonella Insalaco, Emanuela Del Giudice, Giovanni Conti, Patrizia Barone, Alma Nunzia Olivieri, Antonio Brucato, Francesco Carubbi, Paola Triggianese, Angela Mauro, Gian Marco Tosi, Alex Fonollosa, Henrique Ayres Mayrink Giardini, Gaafar Ragab, Samar Tharwat, José Hernández-Rodríguez, Petros P. Sfikakis, Katerina Laskari, Anastasios Karamanakos, Gerard Espinosa, Farhad Shahram, Haner Direskeneli, Andrea Hinojosa-Azaola, Daniela Opris-Belinski, Ibrahim A. AlMaghlouth, Gülen Hatemi, Mehmet Akif Eksin, Fatos Önen, Ewa Więsik-Szewczyk, Nurullah Akkoç, Abdurrahman Tufan, Ali Şahin, Şükran Erten, Seza Ozen, Ezgi Deniz Batu, Bruno Frediani, Alberto Balistreri, and Luca Cantarini

Subjects
Behçet’s disease, patient-driven registries, rare diseases, autoinflammatory diseases, patient involvement, patient-reported outcomes, Medicine (General), R5-920
Abstract

IntroductionThis paper describes the creation and preliminary results of a patient-driven registry for the collection of patient-reported outcomes (PROs) and patient-reported experiences (PREs) in Behçet’s disease (BD).MethodsThe project was coordinated by the University of Siena and the Italian patient advocacy organization SIMBA (Associazione Italiana Sindrome e Malattia di Behçet), in the context of the AIDA (AutoInflammatory Diseases Alliance) Network programme. Quality of life, fatigue, socioeconomic impact of the disease and therapeutic adherence were selected as core domains to include in the registry.ResultsRespondents were reached via SIMBA communication channels in 167 cases (83.5%) and the AIDA Network affiliated clinical centers in 33 cases (16.5%). The median value of the Behçet’s Disease Quality of Life (BDQoL) score was 14 (IQR 11, range 0–30), indicating a medium quality of life, and the median Global Fatigue Index (GFI) was 38.7 (IQR 10.9, range 1–50), expressing a significant level of fatigue. The mean Beliefs about Medicines Questionnaire (BMQ) necessity-concern differential was 0.9 ± 1.1 (range – 1.8–4), showing that the registry participants prioritized necessity belief over concerns to a limited extent. As for the socioeconomic impact of BD, in 104 out of 187 cases (55.6%), patients had to pay from their own pocket for medical exams required to reach the diagnosis. The low family socioeconomic status (p

Published
2023
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42. Development and Implementation of the AIDA International Registry for Patients with Non-Infectious Uveitis

Author

Casa, Francesca Della, Vitale, Antonio, Guerriero, Silvana, Sota, Jurgen, Cimaz, Rolando, Ragab, Gaafar, Ruscitti, Piero, Pereira, Rosa Maria R., Minoia, Francesca, Del Giudice, Emanuela, Emmi, Giacomo, Lomater, Claudia, Monti, Sara, Canofari, Claudia, Gaggiano, Carla, Alessio, Giovanni, Miserocchi, Elisabetta, Conforti, Alessandro, Dagostin, Marilia A., Mapelli, Chiara, Paroli, Maria Pia, Parretti, Veronica, Albano, Valeria, Favale, Rosa, Marelli, Luca, Hegazy, Mohamed Tharwat, Cipriani, Paola, Antonelli, Isabele P. B., Caggiano, Valeria, Aragona, Emma, Laymouna, Ahmed Hatem, Tosi, Gian Marco, Tarsia, Maria, Cattalini, Marco, La Torre, Francesco, Lopalco, Giuseppe, Więsik-Szewczyk, Ewa, Frassi, Micol, Gentileschi, Stefano, Giordano, Heitor F., Frediani, Bruno, Shinjo, Samuel K., Rigante, Donato, Sfikakis, Petros P., Balistreri, Alberto, Hussein, Mohamed A., Amin, Rana Hussein, Cantarini, Luca, and Fabiani, Claudia

Published
2022
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43. Development and Implementation of the AIDA International Registry for Patients with Non-Infectious Scleritis

Author

Della Casa, Francesca, Vitale, Antonio, Pereira, Rosa Maria, Guerriero, Silvana, Ragab, Gaafar, Lopalco, Giuseppe, Cattalini, Marco, Mattioli, Irene, Parronchi, Paola, Paroli, Maria Pia, Del Giudice, Emanuela, Gaggiano, Carla, Dagostin, Marília A., Albano, Valeria, Soliman, Mahmoud M., Colella, Sergio, Nascimbeni, Giuseppe, Sota, Jurgen, Antonelli, Isabele P. B., Alessio, Giovanni, Caggiano, Valeria, Tufan, Abdurrahman, Amin, Rana Hussein, Tarsia, Maria, Ghanema, Mahmoud, Iannone, Florenzo, Ricci, Francesca, La Torre, Francesco, Więsik-Szewczyk, Ewa, Conticini, Edoardo, Gentileschi, Stefano, Dammacco, Rosanna, Cimaz, Rolando, Frediani, Bruno, Abbruzzese, Anna, Ruscitti, Piero, Tosi, Gian Marco, Giordano, Heitor F., Conforti, Alessandro, Balistreri, Alberto, Rigante, Donato, Cantarini, Luca, and Fabiani, Claudia

Published
2022
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44. Axial spondyloarthritis in patients with recurrent fever attacks: data from the AIDA network registry for undifferentiated autoInflammatory diseases (USAIDs)

Author

Antonio Vitale, Valeria Caggiano, Isabel Silva, Daniel G. Oliveira, Piero Ruscitti, Francesco Ciccia, Ibrahim Vasi, Abdurrahman Tufan, Giuseppe Lopalco, Ibrahim A. AlMaghlouth, Jurgen Sota, Ewa Wiesik-Szewczyk, Carla Gaggiano, Henrique Ayres Mayrink Giardini, Veronica Spedicato, Gaafar Ragab, Florenzo Iannone, Alberto Balistreri, Micol Frassi, José Hernández-Rodríguez, Claudia Fabiani, Paolo Falsetti, Nunzia Di Meglio, Bruno Frediani, Maria Antonietta Mazzei, Donato Rigante, Raquel Faria, and Luca Cantarini

Subjects
arthritis, autoinflammatory diseases, diagnosis, outcome, SpA, treatment, Medicine (General), R5-920
Abstract

BeckgroundDespite the recent advances in the field of autoinflammatory diseases, most patients with recurrent fever episodes do not have any defined diagnosis. The present study aims at describing a cohort of patients suffering from apparently unexplained recurrent fever, in whom non-radiographic axial spondylarthritis (SpA) represented the unique diagnosis identified after a complete clinical and radiologic assessment.Materials and methodsPatients’ data were obtained from the international registry on Undifferentiated Systemic AutoInflammatory Diseases (USAIDs) developed by the AutoInflammatory Disease Alliance (AIDA) network.ResultsA total of 54 patients with recurrent fever episodes were also affected by non-radiographic axial SpA according to the international classification criteria. SpA was diagnosed after the start of fever episodes in all cases; the mean age at the diagnosis of axial SpA was 39.9 ± 14.8 years with a diagnostic delay of 9.3 years. The highest body temperature reached during flares was 42°C, with a mean temperature of 38.8 ± 1.1°C. The most frequent manifestations associated to fever were: arthralgia in 33 (61.1%) cases, myalgia in 24 (44.4%) cases, arthritis in 22 (40.7%) cases, headache in 15 (27.8%) cases, diarrhea in 14 (25.9%) cases, abdominal pain in 13 (24.1%) cases, and skin rash in 12 (22.1%) cases. Twenty-four (44.4%) patients have taken daily or on-demand non-steroidal anti-inflammatory drugs (NSAIDs) and 31 (57.4%) patients have been treated with daily or on demand oral glucocorticoids. Colchicine was used in 28 (51.8%) patients, while other conventional disease modifying anti-rheumatic drugs (cDMARDs) were employed in 28 (51.8%) patients. Forty (74.1%) patients underwent anti-tumor necrosis factor (TNF) agents and 11 (20.4%) were treated with interleukin (IL)-1 inhibitors. The response to TNF inhibitors on recurrent fever episodes appeared more effective than that observed with anti-IL-1 agents; colchicine and other cDMARDs were more useful when combined with biotechnological agents.ConclusionSigns and symptoms referring to axial SpA should be inquired in patients with apparently unexplained recurrent fever episodes. The specific treatment for axial SpA may lead to a remarkable improvement in the severity and/or frequency of fever episodes in patients with unexplained fevers and concomitant axial SpA.

Published
2023
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45. Preliminary data revealing efficacy of Streptococcus salivarius K12 (SSK12) in Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome: A multicenter study from the AIDA Network PFAPA syndrome registry

Author

Francesco La Torre, Jurgen Sota, Antonella Insalaco, Giovanni Conti, Emanuela Del Giudice, Riccardo Lubrano, Luciana Breda, Maria Cristina Maggio, Adele Civino, Violetta Mastrorilli, Roberta Loconte, Marco Francesco Natale, Camilla Celani, Mery Romeo, Serena Patroniti, Cristina Gentile, Antonio Vitale, Valeria Caggiano, Carla Gaggiano, Federico Diomeda, Marco Cattalini, Giuseppe Lopalco, Giacomo Emmi, Paola Parronchi, Stefano Gentileschi, Fabio Cardinale, Emma Aragona, Farhad Shahram, Achille Marino, Patrizia Barone, Carla Moscheo, Burcugul Ozkiziltas, Francesco Carubbi, Ohoud Alahmed, Ludovica Iezzi, Benson Ogunjimi, Angela Mauro, Maria Tarsia, Ayman Abdel-Monem Ahmed Mahmoud, Henrique Ayres Mayrink Giardini, Petros P. Sfikakis, Katerina Laskari, Ewa Więsik-Szewczyk, José Hernández-Rodríguez, Bruno Frediani, Verónica Gómez-Caverzaschi, Abdurrahman Tufan, Ibrahim A. Almaghlouth, Alberto Balistreri, Gaafar Ragab, Claudia Fabiani, Luca Cantarini, and Donato Rigante

Subjects
PFAPA syndrome, autoinflammatory disease, International Registry, Streptococcus salivarius K12, probiotic, tonsillitis, Medicine (General), R5-920
Abstract

ObjectiveTo evaluate the potential role of Streptococcus salivarius K12 (SSK12) in controlling febrile flares in patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome. Further aims were to assess the impact of SSK12 on (i) flare duration, (ii) variation in the degree of the highest body temperature during flares, (iii) steroid-sparing effect, and (iv) change of PFAPA accompanying symptoms before and after SSK12 introduction.Patients and methodsThe medical charts from 85 pediatric patients with PFAPA syndrome (49 males and 36 females) enrolled in the AIDA registry and treated with SSK12 for a median period of 6.00 ± 7.00 months in the period between September 2017 and May 2022 were examined. Children recruited had a median time of disease duration of 19.00 ± 28.00 months.ResultsThe number of febrile flares significantly decreased comparing the 12 months before [median (IQR), 13.00 (6.00)] and after SSK12 initiation [median (IQR), 5.50 (8.00), p < 0.001]. The duration of fever was significantly reduced from 4.00 (2.00) days to 2.00 (2.00) days [p < 0.001]. Similarly, the highest temperature in°C was found significantly lower in the last follow-up assessment [median (IQR), 39.00 (1.00)] compared to the period prior to SSK12 start [median (IQR), 40.00 (1.00), p < 0.001]. Steroid load (mg/year) of betamethasone (or any equivalent steroid) significantly decreased between 12 months before treatment with SSK12 [median (IQR), 5.00 (8.00) mg/year] and the last follow-up visit [median (IQR), 2.00 (4.00) mg/year, p < 0.001]. The number of patients experiencing symptoms including pharyngitis/tonsillitis (p < 0.001), oral aphthae (p < 0.001) and cervical lymphadenopathy (p < 0.001) significantly decreased following SSK12.ConclusionSSK12 prophylaxis given for at least 6.00 months was found to reduce febrile flares of PFAPA syndrome: in particular, it halved the total number per year of fever flares, shortened the duration of the single febrile episode, lowered body temperature by 1°C in the febrile flare, provided a steroid-sparing effect, and significantly reduced the accompanying symptoms related to the syndrome.

Published
2023
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46. Canakinumab as first-line biological therapy in Still’s disease and differences between the systemic and the chronic-articular courses: Real-life experience from the international AIDA registry

Author

Antonio Vitale, Valeria Caggiano, Maria Cristina Maggio, Giuseppe Lopalco, Giacomo Emmi, Jurgen Sota, Francesco La Torre, Piero Ruscitti, Elena Bartoloni, Giovanni Conti, Claudia Fabiani, Irene Mattioli, Carla Gaggiano, Fabio Cardinale, Lorenzo Dagna, Corrado Campochiaro, Roberto Giacomelli, Alberto Balistreri, Katerina Laskari, Abdurrahman Tufan, Gaafar Ragab, Ibrahim A. Almaghlouth, Ewa Więsik-Szewczyk, Rosa Maria Pereira, Bruno Frediani, Florenzo Iannone, Petros P. Sfikakis, and Luca Cantarini

Subjects
AOSD, adult onset Still’s disease, sJIA, systemic juvenile idiopathic arthritis, autoinflammatory diseases, biological therapy, Medicine (General), R5-920
Abstract

ObjectiveInterleukin (IL)-1 inhibitors are largely employed in patients with Still’s disease; in cases with refractory arthritis, IL-6 inhibitors have shown to be effective on articular inflammatory involvement. The aim of the present study is to assess any difference in the effectiveness of the IL-1β antagonist canakinumab prescribed as first-line biologic agent between the systemic and the chronic-articular Still’s disease.MethodsData were drawn from the retrospective phase of the AutoInflammatory Disease Alliance (AIDA) international registry dedicated to Still’s disease. Patients with Still’s disease classified according to internationally accepted criteria (Yamaguchi criteria and/or Fautrel criteria) and treated with canakinumab as first-line biologic agent were enrolled.ResultsA total of 26 patients (17 females, 9 males; 18 patients developing Still’s disease after the age of 16 years) were enrolled; 16 (61.5%) patients suffered from the systemic pattern of the disease; 10 (38.5%) patients suffered from the chronic-articular type. No differences were observed between the systemic and the chronic-articular Still’s disease in the frequency of complete response, of flares after the start of canakinumab (p = 0.701) and in the persistence in therapy (p = 0.62). No statistical differences were observed between the two groups after 3 months, 12 months and at the last assessment in the decrease of: the systemic activity score (p = 0.06, p = 0.17, p = 0.17, respectively); the disease activity score on 28 joints (p = 0.54, p = 0.77, p = 0.98, respectively); the glucocorticoid dosage (p = 0.15, p = 0.50, and p = 0.50, respectively); the use of concomitant disease modifying anti-rheumatic drugs (p = 0.10, p = 1.00, and p = 1.00, respectively). No statistically significant differences were observed in the decrease of erythrocyte sedimentation rate (p = 0.34), C reactive protein (p = 0.48), and serum ferritin levels (p = 0.34) after the start of canakinumab.ConclusionCanakinumab used for Still’s disease has been effective in controlling both clinical and laboratory manifestations disregarding the type of disease course when used as first-line biotechnological agent. These excellent results might have been further enhanced by the early start of IL-1 inhibition.

Published
2022
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47. Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

Author

Halliday, Alison, Bulbulia, Richard, Bonati, Leo H, Peto, Richard, Pan, Hongchao, Potter, John, Henning Eckstein, Hans, Farrell, Barbara, Flather, Marcus, Mansfield, Averil, Mihaylova, Boby, Rahimi, Kazim, Simpson, David, Thomas, Dafydd, Sandercock, Peter, Gray, Richard, Molyneux, Andrew, Shearman, Cliff P, Rothwell, Peter, Belli, Anna, Herrington, Will, Judge, Parminder, Leopold, Peter, Mafham, Marion, Gough, Michael, Cao, Piergiorgio, MacDonald, Sumaira, Bari, Vasha, Berry, Clive, Bradshaw, S, Brudlo, Wojciech, Clarke, Alison, Chester, Johanna, Cox, Robin, Cradduck-Bamford, Andrea, Fathers, Susan, Gaba, Kamran, Gray, Mo, Hayter, Elizabeth, Holliday, Constance, Kurien, Rijo, Lay, Michael, le Conte, Steffi, McManus, Jessica, Madgwick, Zahra, Morris, Dylan, Munday, Andrew, Pickworth, Sandra, Ostasz, Wiktor, Poorthuis, Michiel, Richards, Sue, Teixeira, Louisa, Tochlin, Sergey, Tully, Lynda, Wallis, Carol, Willet, Monique, Young, Alan, Casana, Renato, Malloggi, Chiara, Odero Jr, Andrea, Silani, Vincenzo, Parati, Gianfranco, Malchiodi, Giuseppe, Malferrari, Giovanni, Strozzi, Francesco, Tusini, Nicola, Vecchiati, Enrico, Coppi, Gioacchino, Lauricella, Antonio, Moratto, Roberto, Silingardi, Roberto, Veronesi, Jessica, Zini, Andrea, Ferrero, Emanuele, Ferri, Michelangelo, Gaggiano, Andrea, Labate, Carmelo, Nessi, Franco, Psacharopulo, Daniele, Viazzo, Andrea, Malacrida, Giovanni, Mazzaccaro, Daniela, Meola, Giovanni, Modafferi, Alfredo, Nano, Giovanni, Occhiuto, Maria Teresa, Righini, Paolo, Stegher, Silvia, Chiarandini, Stefano, Griselli, Filippo, Lepidi, Sandro, Pozzi Mucelli, Fabio, Naccarato, Marcello, D'Oria, Mario, Ziani, Barbara, Stella, Andrea, Dieng, Mortalla, Faggioli, Gianluca, Gargiulo, Mauro, Palermo, Sergio, Pini, Rodolfo, Puddu, Giovanni Maria, Vacirca, Andrea, Angiletta, Domenico, Desantis, Claudio, Marinazzo, Davide, Mastrangelo, Giovanni, Regina, Guido, Pulli, Raffaele, Bianchi, Paolo, Cireni, Lea, Coppi, Elisabetta, Pizzirusso, Rocco, Scalise, Filippo, Sorropago, Giovanni, Tolva, Valerio, Caso, Valeria, Cieri, Enrico, DeRango, Paola, Farchioni, Luca, Isernia, Giacomo, Lenti, Massimo, Parlani, Gian Battista, Pupo, Guglielmo, Pula, Grazia, Simonte, Gioele, Verzini, Fabio, Carimati, Federico, Delodovici, Maria Luisa, Fontana, Federico, Piffaretti, Gabriele, Tozzi, Matteo, Civilini, Efrem, Poletto, Giorgio, Reimers, Bernhard, Praquin, Barbara, Ronchey, Sonia, Capoccia, Laura, Mansour, Wassim, Sbarigia, Enrico, Speziale, Francesco, Sirignano, Pasqualino, Toni, Danilo, Galeotti, Roberto, Gasbarro, Vincenzo, Mascoli, Francesco, Rocca, Tiberio, Tsolaki, Elpiniki, Bernardini, Giulia, DeMarco, Ester, Giaquinta, Alessia, Patti, Francesco, Veroux, Massimiliano, Veroux, Pierfrancesco, Virgilio, Carla, Mangialardi, Nicola, Orrico, Matteo, Di Lazzaro, Vincenzo, Montelione, Nunzio, Spinelli, Francesco, Stilo, Francesco, Cernetti, Carlo, Irsara, Sandro, Maccarrone, Giuseppe, Tonello, Diego, Visonà, Adriana, Zalunardo, Beniamino, Chisci, Emiliano, Michelagnoli, Stefano, Troisi, Nicola, Masato, Maela, Dei Negri, Massimo, Pacchioni, Andrea, Saccà, Salvatore, Amatucci, Giovanni, Cannizzaro, Alfredo, Accrocca, Federico, Ambrogi, Cesare, Barbazza, Renzo, Marcucci, Giustino, Siani, Andrea, Bajardi, Guido, Savettieri, Giovanni, Argentieri, Angelo, Corbetta, Riccardo, Odero, Attilio, Quaretti, Pietro, Thyrion, Federico Z, Cappelli, Alessandro, Benevento, Domenico, De Donato, Gianmarco, Mele, Maria Agnese, Palasciano, Giancarlo, Pieragalli, Daniela, Rossi, Alessandro, Setacci, Carlo, Setacci, Francesco, Palombo, Domenico, Perfumo, Maria Cecilia, Martelli, Edoardo, Paolucci, Aldo, Trimarchi, Santi, Grassi, Viviana, Grimaldi, Luigi, La Rosa, Giuliana, Mirabella, Domenico, Scialabba, Matteo, Sichel, Leonildo, D'Angelo, Costantino L, Fadda, Gian Franco, Kasemi, Holta, Marino, Mario, Burzotta, Francesco, Codispoti, Francesco Alberto, Ferrante, Angela, Tinelli, Giovanni, Tshomba, Yamume, Vincenzoni, Claudio, Amis, Deborah, Anderson, Dawn, Catterson, Martin, Clarke, Mike, Davis, Michelle, Dixit, Anand, Dyker, Alexander, Ford, Gary, Jackson, Ralph, Kappadath, Sreevalsan, Lambert, David, Lees, Tim, Louw, Stephen, McCaslin, James, Parr, Noala, Robson, Rebecca, Stansby, Gerard, Wales, Lucy, Wealleans, Vera, Wilson, Lesley, Wyatt, Michael, Baht, Hardeep, Balogun, Ibrahim, Burger, Ilse, Cosier, Tracy, Cowie, Linda, Gunathilagan, Gunaratnam, Hargroves, David, Insall, Robert, Jones, Sally, Rudenko, Hannah, Schumacher, Natasha, Senaratne, Jawaharlal, Thomas, George, Thomson, Audrey, Webb, Tom, Brown, Ellen, Esisi, Bernard, Mehrzad, Ali, MacSweeney, Shane, McConachie, Norman, Southam, Alison, Sunman, Wayne, Abdul-Hamiq, Ahmed, Bryce, Jenny, Chetter, Ian, Ettles, Duncan, Lakshminarayan, Raghuram, Mitchelson, Kim, Rhymes, Christopher, Robinson, Graham, Scott, Paul, Vickers, Alison, Ashleigh, Ray, Butterfield, Stephen, Gamble, Ed, Ghosh, Jonathan, McCollum, Charles N, Welch, Mark, Welsh, Sarah, Wolowczyk, Leszek, Donnelly, Mary, D'Souza, Stephen, Egun, Anselm A, Gregary, Bindu, Joseph, Thomas, Kelly, Christine, Punekar, Shuja, Rahi, M Asad, Raj, Sonia, Seriki, Dare, Thomson, George, Brown, James, Durairajan, Ragunath, Grunwald, Iris, Guyler, Paul, Harman, Paula, Jakeways, Matthew, Khuoge, Christopher, Kundu, Ashish, Loganathan, Thayalini, Menon, Nisha, Prabakaran, Raji O, Sinha, Devesh, Thompson, Vicky, Tysoe, Sharon, Briley, Dennis, Darby, Chris, Hands, Linda, Howard, Dominic, Kuker, Wilhelm, Schulz, Ursula, Teal, Rachel, Barer, David, Brown, Andrew, Crawford, Susan, Dunlop, Paul, Krishnamurthy, Ramesh, Majmudar, Nikhil, Mitchell, Duncan, Myint, Min P, O'Brien, Richard, O'Connell, Janice, Sattar, Naweed, Vetrivel, Shanmugam, Beard, Jonathan, Cleveland, Trevor, Gaines, Peter, Humphreys, John, Jenkins, Alison, King, Craig, Kusuma, Daniel, Lindert, Ralph, Lonsdale, Robbie, Nair, Raj, Nawaz, Shah, Okhuoya, Faith, Turner, Douglas, Venables, Graham, Dorman, Paul, Hughes, Andrea, Jones, Deborah, Mendelow, David, Rodgers, Helen, Raudoniitis, Aidas, Enevoldson, Peter, Nahser, Hans, O'Brien, Imelda, Torella, Francesco, Watling, Dave, White, Richard, Brown, Pauline, Dutta, Dipankar, Emerson, Lorraine, Hilltout, Paula, Kulkarni, Sachin, Morrison, Jackie, Poskitt, Keith, Slim, Fiona, Smith, Sarah, Tyler, Amanda, Waldron, Joanne, Whyman, Mark, Bajoriene, Milda, Baker, Lucy, Colston, Amanda, Eliot-Jones, Bekky, Gramizadeh, Gita, Lewis-Clarke, Catherine, McCafferty, Laura, Oliver, Deborah, Palmer, Debbie, Patil, Abhijeet, Pegler, Suzannah, Ramadurai, Gopi, Roberts, Aisling, Sargent, Tracey, Siddegowda, Shivaprasad, Singh-Ranger, Ravi, Williams, Akintunde, Williams, Lucy, Windebank, Steve, Zuromskis, Tadas, Alwis, Lanka, Angus, Jane, Asokanathan, Asaipillai, Fornolles, Caroline, Hardy, Diana, Hunte, Sophy, Justin, Frances, Phiri, Duke, Mitabouana-Kibou, Marie, Sekaran, Lakshmanan, Sethuraman, Sakthivel, Tate, Margaret L, Akyea-Mensah, Joyce, Ball, Stephen, Chrisopoulou, Angela, Keene, Elizabeth, Phair, Alison, Rogers, Steven, Smyth, John V, Bicknell, Colin, Chataway, Jeremy, Cheshire, Nicholas, Clifton, Andrew, Eley, Caroline, Gibbs, Richard, Hamady, Mohammad, Hazel, Beth, James, Alex, Jenkins, Michael, Khanom, Nyma, Lacey, Austin, Mireskandari, Maz, O'Reilly, Joanna, Pereira, Antony, Sachs, Tina, Wolfe, John, Davey, Philip, Rogers, Gill, Smith, Gemma, Tervit, Gareth, Nichol, Ian, Parry, Andrew, Young, Gavin, Ashley, Simon, Barwell, James, Dix, Francis, Nor, Azlisham M, Parry, Chris, Birt, Angela, Davies, Paul, George, Jim, Graham, Anne, Jonker, Leon, Kelsall, Nicci, Potts, Caroline, Wilson, Toni, Crinnion, Jamie, Cuenoud, Larissa, Aleksic, Nikola, Babic, Srdan, Ilijevski, Nenad, Radak, Đorde, Sagic, Dragan, Tanaskovic, Slobodan, Colic, Momcilo, Cvetic, Vladimir, Davidovic, Lazar, Jovanovic, Dejana R, Koncar, Igor, Mutavdžic, Perica, Sladojevic, Miloš, Tomic, Ivan, Debus, Eike S, Grzyska, Ulrich, Otto, Dagmar, Thomalla, Götz, Barlinn, Jessica, Gerber, Johannes, Haase, Kathrin, Hartmann, Christian, Ludwig, Stefan, Pütz, Volker, Reeps, Christian, Schmidt, Christine, Weiss, Norbert, Werth, Sebastian, Winzer, Simon, Gemper, Janine, Günther, Albrecht, Heiling, Bianka, Jochmann, Elisabeth, Karvouniari, Panagiota, Klingner, Carsten, Mayer, Thomas, Schubert, Julia, Schulze-Hartung, Friederike, Zanow, Jürgen, Bausback, Yvonne, Borger, Franka, Botsios, Spiridon, Branzan, Daniela, Bräunlich, Sven, Hölzer, Henryk, Lenzer, Janin, Piorkowski, Christopher, Richter, Nadine, Schuster, Johannes, Scheinert, Dierk, Schmidt, Andrej, Staab, Holger, Ulrich, Matthias, Werner, Martin, Berger, Hermann, Biró, Gábor, Eckstein, Hans-Henning, Kallmayer, Michael, Kreiser, Kornelia, Zimmermann, Alexander, Berekoven, Bärbel, Frerker, Klaus, Gordon, Vera, Torsello, Giovanni, Arnold, Sebastian, Dienel, Cora, Storck, Martin, Biermaier, Bernhard, Gissler, Hans Martin, Klötzsch, Christof, Pfeiffer, Tomas, Schneider, Ralph, Söhl, Leander, Wennrich, Michael, Alonso, Angelika, Keese, Michael, Groden, Christoph, Cöster, Andreas, Engelhardt, Andreas, Ratusinski, Christoph-Maria, Berg, Bengt, Delle, Martin, Formgren, Johan, Gillgren, Peter, Jarl, Lotta, Kall, Torbjörn B, Konrad, Peter, Nyman, Niklas, Skiöldebrand, Claes, Steuer, Johnny, Takolander, Rabbe, Malmstedt, Jonas, Acosta, Stefan, Björses, Katarina, Brandt, Kerstin, Dias, Nuno, Gottsäter, Anders, Holst, Jan, Kristmundsson, Thorarinn, Kühme, Tobias, Kölbel, Tilo, Lindblad, Bengt, Lindh, Mats, Malina, Martin, Ohrlander, Tomas, Resch, Tim, Rönnle, Viola, Sonesson, Björn, Warvsten, Margareta, Zdanowski, Zbigniew, Campbell, Erik, Kjellin, Per, Lindgren, Hans, Nyberg, Johan, Petersen, Björn, Plate, Gunnar, Pärsson, Håkan, Qvarfordt, Peter, Ignatenko, Pavel, Karpenko, Andrey, Starodubtsev, Vladimir, Chernyavsky, Mikhail A, Golovkova, Maria S, Komakha, Boris B, Zherdev, Nikolay N, Belyasnik, Andrey, Chechulov, Pavel, Kandyba, Dmitry, Stepanishchev, Igor, Csobay-Novák, Csaba, Dósa, Edit, Entz, László, Nemes, Balázs, Szeberin, Zoltán, Barzó, Pál, Bodosi, Mihaly, Fákó, Eniko, Fülöp, Béla, Németh, Tamás, Pazdernyik, Szilárd, Skoba, Krisztina, Vörös, Erika, Chatzinikou, Eleni, Giannoukas, Athanasios, Karathanos, Christos, Koutsias, Stylianos, Kouvelos, Georgios, Matsagkas, Miltiadis, Ralli, Styliani, Rountas, Christos, Rousas, Nikolaos, Spanos, Konstantinos, Brountzos, Elias, Kakisis, John D, Lazaris, Andreas, Moulakakis, Konstantinos G, Stefanis, Leonidas, Tsivgoulis, Georgios, Vasdekis, Spyros, Antonopoulos, Constantine N, Bellenis, Ion, Maras, Dimitrios, Polydorou, Antonios, Polydorou, Victoria, Tavernarakis, Antonios, Ioannou, Nikolaos, Terzoudi, Maria, Lazarides, Miltos, Mantatzis, Michalis, Vadikolias, Kostas, Dzieciuchowicz, Lukasz, Gabriel, Marcin, Krasinski, Zbigniew, Oszkinis, Grzegorz, Pukacki, Fryderyk, Slowinski, Maciej, Stanišic, Michal-Goran, Staniszewski, Ryszard, Tomczak, Jolanta, Zielinski, Maciej, Myrcha, Piotr, Rózanski, Dorota, Drelichowski, Stanislaw, Iwanowski, Wojciech, Koncewicz, Katarzyna, Bialek, Pawel, Biejat, Zbigniew, Czepel, Wojciech, Czlonkowska, Anna, Dowzenko, Anatol, Jedrzejewska, Julia, Kobayashi, Adam, Leszczynski, Jerzy, Malek, Andrzej, Polanski, Jerzy, Proczka, Robert, Skorski, Maciej, Szostek, Mieczyslaw, Andziak, Piotr, Dratwicki, Maciej, Gil, Robert, Nowicki, Miroslaw, Pniewski, Jaroslaw, Rzezak, Jaroslaw, Seweryniak, Piotr, Dabek, Pawel, Juszynski, Michal, Madycki, Grzegorz, Pacewski, Bartosz, Raciborski, Witold, Slowinski, Piotr, Staszkiewicz, Walerian, Bombic, Martin, Chlouba, Vladimír, Fiedler, Jirí, Hes, Karel, Koštál, Petr, Sova, Jindrich, Kríž, Zdenek, Prívara, Mojmír, Reif, Michal, Staffa, Robert, Vlachovský, Robert, Vojtíšek, Bohuslav, Hrbác, Tomáš, Kuliha, Martin, Procházka, Václav, Roubec, Martin, Školoudík, David, Netuka, David, Šteklácová, Anna, Beneš III, Vladimír, Buchvald, Pavel, Endrych, Ladislav, Šercl, Miroslav, Campos Jr, Walter, Casella, Ivan B, de Luccia, Nelson, Estenssoro, André E V, Presti, Calógero, Puech-Leão, Pedro, Neves, Celso R B, da Silva, Erasmo S, Sitrângulo Jr, Cid J, Monteiro, José A T, Tinone, Gisela, Bellini Dalio, Marcelo, Joviliano, Edwaldo E, Pontes Neto, Octávio M, Serra Ribeiro, Mauricio, Cras, Patrick, Hendriks, Jeroen M H, Hoppenbrouwers, Mieke, Lauwers, Patrick, Loos, Caroline, Yperzeele, Laetitia, Geenens, Mia, Hemelsoet, Dimitri, van Herzeele, Isabelle, Vermassen, Frank, Astarci, Parla, Hammer, Frank, Lacroix, Valérie, Peeters, André, Verhelst, Robert, Cirelli, Silvana, Dormal, Pol, Grimonprez, Annelies, Lambrecht, Bart, Lerut, Philipe, Thues, Eddy, De Koster, Guy, Desiron, Quentin, Maertens de Noordhout, Alain, Malmendier, Danielle, Massoz, Mireille, Saad, Georges, Bosiers, Marc, Callaert, Joren, Deloose, Koen, Blanco Cañibano, Estrella, García Fresnillo, Beatriz, Guerra Requena, Mercedes, Morata Barrado, Pilar C, Muela Méndez, Miguel, Yusta Izquierdo, Antonio, Aparici Robles, Fernando, Blanes Orti, Paula, García Dominguez, Luis, Martínez López, Rafael, Miralles Hernández, Manuel, Tembl Ferrairo, José I, Chamorro, Ángel, Macho, Juan, Obach, Víctor, Riambau, Vincent, San Román, Luis, Ahlhelm, Frank J, Blackham, Kristine, Engelter, Stefan, Eugster, Thomas, Gensicke, Henrik, Gürke, Lorenz, Lyrer, Philippe, Mariani, Luigi, Maurer, Marina, Mujagic, Edin, Müller, Mandy, Psychogios, Marios, Stierli, Peter, Stippich, Christoph, Traenka, Christopher, Wolff, Thomas, Wagner, Benjamin, Wiegert, Martina M, Clarke, Sandra, Diepers, Michael, Gröchenig, Ernst, Gruber, Philipp, Isaak, Andrej, Kahles, Timo, Marti, Regula, Nedeltchev, Krassen, Remonda, Luca, Tissira, Nadir, Valença Falcão, Martina, de Borst, Gert J, Lo, Rob H, Moll, Frans L, Toorop, Raechel, van der Worp, Bart H, Vonken, Evert J, Kappelle, Jaap L, Jahrome, Ommid, Vos, Floris, Schuiling, Wouter, van Overhagen, Hendrik, Keunen, Rudolf W M, Knippenberg, Bob, Wever, Jan J, Lardenoije, Jan W, Reijnen, Michel, Smeets, Luuk, van Sterkenburg, Steven, Fraedrich, Gustav, Gizewski, Elke, Gruber, Ingrid, Knoflach, Michael, Kiechl, Stefan, Rantner, Barbara, Abdulamit, Timur, Bergeron, Patrice, Padovani, Raymond, Trastour, Jean-Christophe, Cardon, Jean-Marie, Le Gallou-Wittenberg, Anne, Allaire, Eric, Becquemin, Jean-Pierre, Cochennec-Paliwoda, Frédéric, Desgranges, Pascal, Hosseini, Hassan, Kobeiter, Hicham, Marzelle, Jean, Almekhlafi, Mohammed A, Bal, Simerpreet, Barber, Phillip A, Coutts, Shelagh B, Demchuk, Andrew M, Eesa, Muneer, Gillies, Michelle, Goyal, Mayank, Hill, Michael D, Hudon, Mark E, Jambula, Anitha, Kenney, Carol, Klein, Gary, McClelland, Marie, Mitha, Alim, Menon, Bijoy K, Morrish, William F, Peters, Steven, Ryckborst, Karla J, Samis, Greg, Save, Supriya, Smith, Eric E, Stys, Peter, Subramaniam, Suresh, Sutherland, Garnette R, Watson, Tim, Wong, John H, Zimmel, L, Flis, Vojko, Matela, Jože, Miksic, Kazimir, Milotic, Franko, Mrdja, Božidar, Stirn, Barbara, Tetickovic, Erih, Gasparini, Mladen, Grad, Anton, Kompara, Ingrid, Miloševic, Zoren, Palmiste, Veronika, Toomsoo, Toomas, Aidashova, Balzhan, Kospanov, Nursultan, Lyssenko, Roman, Mussagaliev, Daulet, Beyar, Rafi, Hoffman, Aaron, Karram, Tony, Kerner, Arthur, Nikolsky, Eugenia, Nitecki, Samy, Andonova, Silva, Bachvarov, Chavdar, Petrov, Vesko, Cvjetko, Ivan, Vidjak, Vinko, Halužan, Damir, Petrunic, Mladen, Liu, Bao, Liu, Chang-Wei, Bartko, Daniel, Beno, Peter, Rusnák, František, Zelenák, Kamil, Ezura, Masayuki, Inoue, Takashi, Kimura, Naoto, Kondo, Ryushi, Matsumoto, Yasushi, Shimizu, Hiroaki, Endo, Hidenori, Furui, Eisuke, Bakke, Søren, Krohg-Sørensen, Kristen, Nome, Terje, Skjelland, Mona, Tennøe, Bjørn, Albuquerque e Castro, João, Alves, Gonçalo, Bastos Gonçalves, Frederico, de Aragão Morais, José, Garcia, Ana C, Valentim, Hugo, Vasconcelos, Leonor, Belcastro, Fernando, Cura, Fernando, Zaefferer, Patricio, Abd-Allah, Foad, Eldessoki, Mohamed H, Heshmat Kassem, Hussein, Soliman Gharieb, Haytham, Colgan, Mary P, Haider, Syed N, Harbison, Joe, Madhavan, Prakash, Moore, Dermot, Shanik, Gregor, Kazan, Viviane, Nazzal, Munier, and Ramsey-Williams, Vicki

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2021
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50. Clinical profile and evolution of patients with juvenile-onset Behçet’s syndrome over a 25-year period: insights from the AIDA network

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Sota, Jurgen, Rigante, Donato, Lopalco, Giuseppe, Emmi, Giacomo, Gentileschi, Stefano, Gaggiano, Carla, Ciarcia, Luisa, Berlengiero, Virginia, Mourabi, Mariam, Ricco, Nicola, Barneschi, Sara, Mattioli, Irene, Tosi, Gian Marco, Frediani, Bruno, Tarsia, Maria, di Scala, Gerardo, Vitale, Antonio, Iannone, Florenzo, Fabiani, Claudia, and Cantarini, Luca

Published
2021
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