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1. Metabolically defined body size and body shape phenotypes and risk of postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Y. Mahamat‐Saleh, S. Rinaldi, R. Kaaks, C. Biessy, E. M. Gonzalez‐Gil, N. Murphy, C. Le Cornet, J. M. Huerta, S. Sieri, A. Tjønneland, L. Mellemkjær, M. Guevara, K. Overvad, A. Perez‐Cornago, S. Tin Tin, L. Padroni, V. Simeon, G. Masala, A. May, E. Monninkhof, S. Christakoudi, A. K. Heath, K. Tsilidis, A. Agudo, M. B. Schulze, J. Rothwell, C. Cadeau, S. Severi, E. Weiderpass, M. J. Gunter, and L. Dossus

Subjects
body mass index, breast cancer, concentrations of C‐peptide, metabolic health, waist circumference, waist‐to‐hip ratio, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Excess body fatness and hyperinsulinemia are both associated with an increased risk of postmenopausal breast cancer. However, whether women with high body fatness but normal insulin levels or those with normal body fatness and high levels of insulin are at elevated risk of breast cancer is not known. We investigated the associations of metabolically defined body size and shape phenotypes with the risk of postmenopausal breast cancer in a nested case–control study within the European Prospective Investigation into Cancer and Nutrition. Methods Concentrations of C‐peptide—a marker for insulin secretion—were measured at inclusion prior to cancer diagnosis in serum from 610 incident postmenopausal breast cancer cases and 1130 matched controls. C‐peptide concentrations among the control participants were used to define metabolically healthy (MH; in first tertile) and metabolically unhealthy (MU; >1st tertile) status. We created four metabolic health/body size phenotype categories by combining the metabolic health definitions with normal weight (NW; BMI

Published
2023
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2. The Impact of Different Uses of the Internet on Students' Performance Progression throughout Primary Education

Author

María Ladrón de Guevara Rodríguez, Luis Alejandro Lopez-Agudo, and Oscar David Marcenaro-Gutierrez

Abstract

The present research analyses the impact that the time spent on the Internet by primary school (3rd and 6th grade) students may have on their academic progression in terms of test scores. In order to go beyond a correlational analysis, we have applied a time fixed-effects estimation using a recent longitudinal database of 15,974 students from the Spanish region of the Canary Islands. Our results show that, in general, an increasingly frequent use of the Internet has a negative influence on students' academic achievement progression, with higher use of instant messaging applications being particularly linked to girls' poorer mathematics academic performance progression. This negative influence may be a consequence of replacing time to academic activities (e.g., reading books or homework) with time using the Internet, which can also ultimately lead students to adopt unhealthy study habits that can affect their future academic success. Furthermore, we find that there is not a negative impact of playing videogames on the mathematics competence, as the development of spatial-visual (digital) skills possibly counterbalances the negative influence of time substitution between academically oriented tasks and the Internet.

Published
2024
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3. Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study

Author

F. Perrier, V. Viallon, S. Ambatipudi, A. Ghantous, C. Cuenin, H. Hernandez-Vargas, V. Chajès, L. Baglietto, M. Matejcic, H. Moreno-Macias, T. Kühn, H. Boeing, A. Karakatsani, A. Kotanidou, A. Trichopoulou, S. Sieri, S. Panico, F. Fasanelli, M. Dolle, C. Onland-Moret, I. Sluijs, E. Weiderpass, J. R. Quirós, A. Agudo, J. M. Huerta, E. Ardanaz, M. Dorronsoro, T. Y. N. Tong, K. Tsilidis, E. Riboli, M. J. Gunter, Z. Herceg, P. Ferrari, and I. Romieu

Subjects
DNA methylation, Dietary folate, Alcohol intake, DMR, Fused lasso, EPIC cohort, Medicine, Genetics, QH426-470
Abstract

Abstract Background There is increasing evidence that folate, an important component of one-carbon metabolism, modulates the epigenome. Alcohol, which can disrupt folate absorption, is also known to affect the epigenome. We investigated the association of dietary folate and alcohol intake on leukocyte DNA methylation levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Leukocyte genome-wide DNA methylation profiles on approximately 450,000 CpG sites were acquired with Illumina HumanMethylation 450K BeadChip measured among 450 women control participants of a case-control study on breast cancer nested within the EPIC cohort. After data preprocessing using surrogate variable analysis to reduce systematic variation, associations of DNA methylation with dietary folate and alcohol intake, assessed with dietary questionnaires, were investigated using CpG site-specific linear models. Specific regions of the methylome were explored using differentially methylated region (DMR) analysis and fused lasso (FL) regressions. The DMR analysis combined results from the feature-specific analysis for a specific chromosome and using distances between features as weights whereas FL regression combined two penalties to encourage sparsity of single features and the difference between two consecutive features. Results After correction for multiple testing, intake of dietary folate was not associated with methylation level at any DNA methylation site, while weak associations were observed between alcohol intake and methylation level at CpG sites cg03199996 and cg07382687, with q val = 0.029 and q val = 0.048, respectively. Interestingly, the DMR analysis revealed a total of 24 and 90 regions associated with dietary folate and alcohol, respectively. For alcohol intake, 6 of the 15 most significant DMRs were identified through FL. Conclusions Alcohol intake was associated with methylation levels at two CpG sites. Evidence from DMR and FL analyses indicated that dietary folate and alcohol intake may be associated with genomic regions with tumor suppressor activity such as the GSDMD and HOXA5 genes. These results were in line with the hypothesis that epigenetic mechanisms play a role in the association between folate and alcohol, although further studies are warranted to clarify the importance of these mechanisms in cancer.

Published
2019
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4. Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study

Author

Castro-Espin, Carlota, Cairat, Manon, Navionis, Anne-Sophie, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Mellemkjær, Lene, Mancini, Francesca Romana, Hajji-Louati, Mariem, Severi, Gianluca, Le Cornet, Charlotte, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Agnoli, Claudia, Sacerdote, Carlotta, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Smith-Byrne, Karl, Heath, Alicia K., Christakoudi, Sofia, Gunter, Marc J., Rinaldi, Sabina, Agudo, Antonio, and Dossus, Laure

Published
2024
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9. CLIL Realities through the Lens of English and Content Teachers

Author

Fielden Burns, Laura V. and Martínez Agudo, Juan de Dios

Abstract

This research investigated six established areas for quality (Ortega-Martín et al., 2018) in the implementation of CLIL programmes in a Spanish monolingual autonomous community from the perspective of its teachers, in particular focusing on possible differences of opinion between content and English language teachers, an understudied area. Both quantitative and qualitative data were collected from 36 teachers at four secondary schools in urban Extremadura so as to assess the perceptions of the execution and the effectiveness of current CLIL education programmes, identifying specifically their potential challenges. Significant differences between content teachers and English teachers' perceptions in six areas under study are examined, from programme management to academic results. Data results indicate that although programmes are viewed quite positively by both groups of teachers, some important areas of difference exist, including the amount of time the L2 is used in a content class and the language skills that are worked in a CLIL environment. To address this gap, suggestions are made to establish more widely accepted standards for CLIL programme objectives.

Published
2023

10. Detailed study of a rare hyperluminous rotating disk in an Einstein ring 10 billion years ago

Author

Liu, Daizhong, Förster Schreiber, Natascha M., Harrington, Kevin C., Lee, Lilian L., Kamieneski, Patrick S., Davies, Richard I., Lutz, Dieter, Renzini, Alvio, Wuyts, Stijn, Tacconi, Linda J., Genzel, Reinhard, Burkert, Andreas, Herrera-Camus, Rodrigo, Alcalde Pampliega, Belén, Vishwas, Amit, Kaasinen, Melanie, Wang, Q. Daniel, Jiménez-Andrade, Eric F., Lowenthal, James, Foo, Nicholas, Frye, Brenda L., Shangguan, Jinyi, Cao, Yixian, Agapito, Guido, Berbel, Alex Agudo, Barfety, Capucine, Baruffolo, Andrea, Berman, Derek, Black, Martin, Bonaglia, Marco, Briguglio, Runa, Carbonaro, Luca, Chapman, Lee, Chen, Jianhang, Cikota, Aleksandar, Concas, Alice, Cooper, Olivia, Cresci, Giovanni, Dallilar, Yigit, Deysenroth, Matthias, Di Antonio, Ivan, Di Cianno, Amico, Di Rico, Gianluca, Doelman, David, Dolci, Mauro, Eisenhauer, Frank, Espejo, Juan, Esposito, Simone, Fantinel, Daniela, Ferruzzi, Debora, Feuchtgruber, Helmut, Gao, Xiaofeng, Garcia Diaz, Carlos, Gillessen, Stefan, Grani, Paolo, Hartl, Michael, Henry, David, Huber, Heinrich, Jolly, Jean-Baptiste, Keller, Christoph U., Kenworthy, Matthew, Kravchenko, Kateryna, Lee, Minju M., Lightfoot, John, Lunney, David, Macintosh, Mike, Mannucci, Filippo, Ott, Thomas, Pascale, Massimo, Pastras, Stavros, Pearson, David, Puglisi, Alfio, Pulsoni, Claudia, Rabien, Sebastian, Rau, Christian, Riccardi, Armando, Salasnich, Bernardo, Shimizu, Taro, Snik, Frans, Sturm, Eckhard, Taylor, William, Valentini, Angelo, Waring, Christopher, Wiezorrek, Erich, Xompero, Marco, and Yun, Min S.

Published
2024
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11. Complex rotational dynamics of the neutron star in Hercules X-1 revealed by X-ray polarization

Author

Heyl, Jeremy, Doroshenko, Victor, González-Caniulef, Denis, Caiazzo, Ilaria, Poutanen, Juri, Mushtukov, Alexander, Tsygankov, Sergey S., Kirmizibayrak, Demet, Bachetti, Matteo, Pavlov, George G., Forsblom, Sofia V., Malacaria, Christian, Suleimanov, Valery F., Agudo, Iván, Antonelli, Lucio Angelo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Bucciantini, Niccolò, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, Costa, Enrico, De Rosa, Alessandra, Del Monte, Ettore, Di Gesu, Laura, Di Lalla, Niccolò, Di Marco, Alessandro, Donnarumma, Immacolata, Dovčiak, Michal, Ehlert, Steven R., Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Garcia, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Iwakiri, Wataru, Jorstad, Svetlana G., Kaaret, Philip, Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Krawczynski, Henric, La Monaca, Fabio, Latronico, Luca, Liodakis, Ioannis, Maldera, Simone, Manfreda, Alberto, Marin, Frédéric, Marinucci, Andrea, Marscher, Alan P., Marshall, Herman L., Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Mizuno, Tsunefumi, Muleri, Fabio, Negro, Michela, Ng, C.-Y., O’Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Peirson, Abel Lawrence, Perri, Matteo, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Pilia, Maura, Possenti, Andrea, Puccetti, Simonetta, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Romani, Roger W., Sgrò, Carmelo, Slane, Patrick, Soffitta, Paolo, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Tavecchio, Fabrizio, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Turolla, Roberto, Vink, Jacco, Weisskopf, Martin C., Wu, Kinwah, Xie, Fei, and Zane, Silvia

Published
2024
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12. Cygnus X-3 revealed as a Galactic ultraluminous X-ray source by IXPE

Author

Veledina, Alexandra, Muleri, Fabio, Poutanen, Juri, Podgorný, Jakub, Dovčiak, Michal, Capitanio, Fiamma, Churazov, Eugene, De Rosa, Alessandra, Di Marco, Alessandro, Forsblom, Sofia V., Kaaret, Philip, Krawczynski, Henric, La Monaca, Fabio, Loktev, Vladislav, Lutovinov, Alexander A., Molkov, Sergey V., Mushtukov, Alexander A., Ratheesh, Ajay, Rodriguez Cavero, Nicole, Steiner, James F., Sunyaev, Rashid A., Tsygankov, Sergey S., Weisskopf, Martin C., Zdziarski, Andrzej A., Bianchi, Stefano, Bright, Joe S., Bursov, Nikolaj, Costa, Enrico, Egron, Elise, Garcia, Javier A., Green, David A., Gurwell, Mark, Ingram, Adam, Kajava, Jari J. E., Kale, Ruta, Kraus, Alex, Malyshev, Denys, Marin, Frédéric, Matt, Giorgio, McCollough, Michael, Mereminskiy, Ilya A., Nizhelsky, Nikolaj, Piano, Giovanni, Pilia, Maura, Pittori, Carlotta, Rao, Ramprasad, Righini, Simona, Soffitta, Paolo, Shevchenko, Anton, Svoboda, Jiri, Tombesi, Francesco, Trushkin, Sergei A., Tsybulev, Peter, Ursini, Francesco, Wu, Kinwah, Agudo, Iván, Antonelli, Lucio A., Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Bucciantini, Niccolò, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, Del Monte, Ettore, Di Gesu, Laura, Di Lalla, Niccolò, Donnarumma, Immacolata, Doroshenko, Victor, Ehlert, Steven R., Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Gunji, Shuichi, Hayashida, Kiyoshi, Heyl, Jeremy, Iwakiri, Wataru, Jorstad, Svetlana G., Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Latronico, Luca, Liodakis, Ioannis, Maldera, Simone, Manfreda, Alberto, Marinucci, Andrea, Marscher, Alan P., Marshall, Herman L., Massaro, Francesco, Mitsuishi, Ikuyuki, Mizuno, Tsunefumi, Negro, Michela, Ng, Chi-Yung, O’Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel L., Perri, Matteo, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Possenti, Andrea, Puccetti, Simonetta, Ramsey, Brian D., Rankin, John, Roberts, Oliver, Romani, Roger W., Sgrò, Carmelo, Slane, Patrick, Spandre, Gloria, Swartz, Doug, Tamagawa, Toru, Tavecchio, Fabrizio, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Trois, Alessio, Turolla, Roberto, Vink, Jacco, Xie, Fei, and Zane, Silvia

Published
2024
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13. Randomised, double-blind, placebo-controlled, parallel-group, multicentric, phase IIA clinical trial for evaluating the safety, tolerability, and therapeutic efficacy of daily oral administration of NFX88 to treat neuropathic pain in individuals with spinal cord injury

Author

Escribá, Pablo V., Gil-Agudo, Ángel M., Vidal Samsó, Joan, Sánchez-Raya, Judith, Salvador-de la Barrera, Sebastián, Soto-León, Vanesa, León-Álvarez, Natacha, Méndez Ferrer, Bosco, Membrilla-Mesa, Miguel David, Redondo Galán, Carolina, Benito-Penalva, Jesús, Montoto-Marqués, Antonio, Medel Rebollo, Javier, Palazón García, Ramiro, Gutiérrez Henares, Francisco, Miralles, Marc, Torres, Manuel, Nieto-Librero, Ana B., García Marco, David, Gómez, Carmela, Jimeno, David, and Oliviero, Antonio

Published
2024
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14. Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes

Author

You, Yuanyuan, Dunst, Josefine, Ye, Kewei, Sandoz, Patrick A., Reinhardt, Annika, Sandrock, Inga, Comet, Natalia R., Sarkar, Rupak Dey, Yang, Emily, Duprez, Estelle, Agudo, Judith, Brown, Brian D., Utz, Paul J., Kastenmüller, Wolfgang, Gerlach, Carmen, Prinz, Immo, Önfelt, Björn, and Kreslavsky, Taras

Published
2024
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16. Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study

Author

Thakral, Abhinav, Lee, John JW., Hou, Tianzhichao, Hueniken, Katrina, Dudding, Tom, Gormley, Mark, Virani, Shama, Olshan, Andrew, Diergaarde, Brenda, Ness, Andrew R., Waterboer, Tim, Smith-Byrne, Karl, Brennan, Paul, Hayes, D. Neil, Sanderson, Eleanor, Brown, M. Catherine, Huang, Sophie, Bratman, Scott V., Spreafico, Anna, De Almeida, John, Davies, Joel C., Bierut, Laura, Macfarlane, Gary J., Lagiou, Pagona, Lagiou, Areti, Polesel, Jerry, Agudo, Antonio, Alemany, Laia, Ahrens, Wolfgang, Healy, Claire M., Conway, David I., Nygard, Mari, Canova, Cristina, Holcatova, Ivana, Richiardi, Lorenzo, Znaor, Ariana, Goldstein, David P., Hung, Rayjean J., Xu, Wei, Liu, Geoffrey, and Espin-Garcia, Osvaldo

Published
2024
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19. Circulating free insulin-like growth factor-I and prostate cancer: a case-control study nested in the European prospective investigation into cancer and nutrition

Author

Cheng, Tuck Seng, Noor, Urwah, Watts, Eleanor, Pollak, Michael, Wang, Ye, McKay, James, Atkins, Joshua, Masala, Giovanna, Sánchez, Maria-Jose, Agudo, Antonio, Castilla, Jesús, Aune, Dagfinn, Colorado-Yohar, Sandra M., Manfredi, Luca, Gunter, Marc J., Pala, Valeria, Josefsson, Andreas, Key, Timothy J., Smith-Byrne, Karl, and Travis, Ruth C.

Published
2024
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20. Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy

Author

Blaya-Cánovas, José L., Griñán-Lisón, Carmen, Blancas, Isabel, Marchal, Juan A., Ramírez-Tortosa, César, López-Tejada, Araceli, Benabdellah, Karim, Cortijo-Gutiérrez, Marina, Cano-Cortés, M. Victoria, Graván, Pablo, Navarro-Marchal, Saúl A., Gómez-Morales, Jaime, Delgado-Almenta, Violeta, Calahorra, Jesús, Agudo-Lera, María, Sagarzazu, Amaia, Rodríguez-González, Carlos J., Gallart-Aragón, Tania, Eich, Christina, Sánchez-Martín, Rosario M., and Granados-Principal, Sergio

Published
2024
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23. First-in-human demonstration of floating EMG sensors and stimulators wirelessly powered and operated by volume conduction

Author

Becerra-Fajardo, Laura, Minguillon, Jesus, Krob, Marc Oliver, Rodrigues, Camila, González-Sánchez, Miguel, Megía-García, Álvaro, Galán, Carolina Redondo, Henares, Francisco Gutiérrez, Comerma, Albert, del-Ama, Antonio J., Gil-Agudo, Angel, Grandas, Francisco, Schneider-Ickert, Andreas, Barroso, Filipe Oliveira, and Ivorra, Antoni

Published
2024
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24. Transmission risk of vector-borne bacterial diseases (Anaplasma spp. and Ehrlichia canis) in Spain and Portugal

Author

Alfonso Balmori-de la Puente, Iván Rodríguez-Escolar, Manuel Collado-Cuadrado, Elena Infante González-Mohino, María Carmen Vieira Lista, Ricardo Enrique Hernández-Lambraño, José Ángel Sánchez-Agudo, and Rodrigo Morchón

Subjects
Ecological niche models, Future projections, Transmission risk, Rhipicephalus sanguineus, Ixodes ricinus, Anaplasma spp., Veterinary medicine, SF600-1100
Abstract

Abstract Background Ehrlichiosis and anaplasmosis are vector-borne bacterial diseases produced by intracellular rickettsial species of the genus Ehrlichia and Anaplasma. Ehrlichia canis and Anaplasma spp. (A. platys and A. phagocytophilum) have reported cases of zoonotic transmision and are the main bacterial agents of canine ehrlichiosis and anaplasmosis. They normally present an asymptomatic or mild course in domestic and wild animals with some lethal cases reported. The main vector of these diseases in Europe are the castor bean tick (Ixodes ricinus) and the brown dog tick (Rhipicephalus sanguineus), although only in the latter, the main host is the domestic dogs. The aim of this work is to apply an integrative approach to convert ecological niche models (ENMs) into potential transmission risk models and understand the relative contribution of the two potential vectors (R. sanguineus and I. ricinus) to spread both diseases in the Iberian Peninsula and Balearic Islands. Results Two ENMs meeting all criteria were successfully generated for R. sanguineus and I. ricinus with human footprint being the most relevant explanatory variable. The novelty of the study lies in the combination of independent ENMs for both species to estimate the disease transmission risk of specific bacteria (E. canis, A. platys and A. phagocytophilum). Only the transmission risk maps that had higher contribution of R. sanguineus than I. ricinus showed relevant and positive significant correlations between risk and seroprevalence in either of the two species of bacteria (R ≥ 0.4; p

Published
2024
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25. Psychological and Emotional Impact of COVID-19 on TESOL: Learning to Teach EFL in a VUCA Environment

Author

Juan de Dios Martínez Agudo

Abstract

Purpose: Since a thorough understanding of the impact of the COVID-19 crisis on the teaching profession in general and on TESOL teacher education in particular will take some time, this paper sheds some light on the associated psychological and emotional challenges faced by EFL student teachers in learning to teach in a practicum setting under pandemic conditions. Design/methodology/approach: Drawing on Vygotskian sociocultural theory as a framework for teacher professional development and based on a narrative qualitative research design, this study explores and makes sense of 36 EFL student teachers' narratives or reflections on their perceived psycho-emotional challenges when adapting to the complex, ever-changing, uncertain and challenging reality of the crisis. Findings: The study reported perceptions of uncertainty, psychological pressure and stress, as well as feelings of emotional vulnerability such as being overwhelmed by heavy workload, time pressure or constraints, frustration, powerlessness and anxiety among EFL student teachers during their learning-to-teach process. Originality/value: This study concludes that student teachers must prepare themselves for a VUCA world in terms of reflective practice and emotional flexibility to effectively manage their psychological pressures and emotional vulnerability in uncertain and challenging times.

Published
2024
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26. Early Dropout, Earnings and Skills in Later Life: Evidence from Spain

Author

Oscar David Marcenaro-Gutierrez and Luis Alejandro Lopez-Agudo

Abstract

Most education systems have set a minimum age until which students must stay at school. In the case of Spain, students can drop out the same day they reach that age, even without finishing that academic year. In the present research work, we intend to analyse the influence of early dropout on later life outcomes for the Spanish population, i.e. literacy and numerical skills and earnings. In order to do this, we employ PIAAC 2012 data and a fuzzy regression discontinuity design, focusing on a transition period between education laws: a first period without minimum dropout age and a second period (law approved in 1970) which obligated students to be at least 14 years-old to dropout. Our results show, for this particular cohort of the Spanish population, that dropping out is substantially negatively associated with literacy and numerical skills in around 1.5 standard deviations, while it did not influence future earnings.

Published
2024
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27. Parents' (Dis)satisfaction with Schools: Evidence from Longitudinal Administrative Data from Spain

Author

John Jerrim, Claudia Prieto-Latorre, Luis Alejandro Lopez-Agudo, and Oscar D. Marcenaro-Gutierrez

Abstract

This study uses longitudinal census data to explore the correlates of school satisfaction among parents of 3rd and 6th grade students from the Canary Islands, a large administrative region in Spain. We use logistic regression to model parental dissatisfaction with their children's school and teachers. Our results illustrate how parents value academic performance in reading and mathematics equally, while also placing equal emphasis on the development of cognitive and non-cognitive skills. Yet, we find that what matters the most to parents is their children's happiness at school, rather than their educational progress. We also find that teachers may be able to improve parental satisfaction by providing regular feedback to parents about their children's progress. Lastly, we discuss some implications for schools to meet parental needs; for example, schools should promote activities such as specialised workshops for parents on various topics ranging from child development to emotional development, stress management and self-confidence.

Published
2024
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28. The Impact of AI Errors in a Human-in-the-Loop Process

Author

Ujué Agudo, Karlos G. Liberal, Miren Arrese, and Helena Matute

Abstract

Automated decision-making is becoming increasingly common in the public sector. As a result, political institutions recommend the presence of humans in these decision-making processes as a safeguard against potentially erroneous or biased algorithmic decisions. However, the scientific literature on human-in-the-loop performance is not conclusive about the benefits and risks of such human presence, nor does it clarify which aspects of this human--computer interaction may influence the final decision. In two experiments, we simulate an automated decision-making process in which participants judge multiple defendants in relation to various crimes, and we manipulate the time in which participants receive support from a supposed automated system with Artificial Intelligence (before or after they make their judgments). Our results show that human judgment is affected when participants receive incorrect algorithmic support, particularly when they receive it before providing their own judgment, resulting in reduced accuracy. The data and materials for these experiments are freely available at the Open Science Framework: https://osf.io/b6p4z/ Experiment 2 was preregistered.

Published
2024
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29. Grade Retention in Spain: The Right Way?

Author

Luis Alejandro Lopez-Agudo, Claudia Prieto Latorre, and Oscar David Marcenaro-Gutierrez

Abstract

There is a wide debate on the convenience of grade retention for students' future cognitive development. Nevertheless, due to the endogenous characteristics of grade retention to explain students' academic performance, most of the literature fails in capturing its actual influence. In the present research, we intend to get as close as possible to the causal effect of grade retention on lower secondary education students' academic competences. In order to do this, we employ rich administrative census and longitudinal data from the most populated region of Spain (Andalusia) using Ordinary Least Squares (OLS) estimation method with student fixed-effects within-students between-academic years. Our results show a positive influence of grade retention on students' academic competences in the short term in mathematics but a null one in reading.

Published
2024
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30. Do School Preferences Differ between Mothers and Fathers? International Evidence from PISA

Author

John Jerrim, Claudia Prieto-Latorre, Luis Alejandro Lopez-Agudo, and Oscar David Marcenaro-Gutierrez

Abstract

A sizeable literature -- spanning education, sociology and economics -- has investigated the issue of parental school preferences and school choice. A notable gap in the existing evidence base is an exploration of how such preferences differ between mothers and fathers. We present new cross-national findings on this matter, drawing on survey data collected from more than 300,000 parents across 25 countries. Our findings suggest that mothers rate the school environment -- whether the school is safe and has a pleasant atmosphere -- to be more important than fathers. Differences are also observed with respect to the school's reputation and whether it has a high level of achievement. Clearer evidence of such differences emerges for industrialised Western nations than for countries that are not members of the OECD. In most countries, mothers' and fathers' preferences do not vary substantially between sons and daughters.

Published
2024
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31. How Did Spain Perform in PISA 2018? New Estimates of Children's PISA Reading Scores

Author

John Jerrim, Luis Alejandro Lopez-Agudo, and Oscar David Marcenaro-Gutierrez

Abstract

International large-scale assessments have gained much attention since the beginning of the twenty-first century, influencing education legislation in many countries. This includes Spain, where they have been used by successive governments to justify education policy change. Unfortunately, there was a problem with the PISA 2018 reading scores for this country, meaning the OECD refused to initially release the results. Therefore, in this paper we attempt to estimate the likely PISA 2018 reading scores for Spain, and for each region within. The figure finally published by the OECD for Spain - in terms of reading scores - was 476.5 points, which is between the lower and upper bound of the interval we find (475 to 483 test points in 2018). Additionally, we report some robustness checks for the OCED countries participating in PISA 2018, which show that the difference between the actual scores and the ones we found with the imputation methods are quite close.

Published
2024
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34. Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis

Author

Morales-Berstein, Fernanda, Biessy, Carine, Viallon, Vivian, Goncalves-Soares, Ana, Casagrande, Corinne, Hémon, Bertrand, Kliemann, Nathalie, Cairat, Manon, Blanco Lopez, Jessica, Al Nahas, Aline, Chang, Kiara, Vamos, Eszter, Rauber, Fernanda, Bertazzi Levy, Renata, Barbosa Cunha, Diana, Jakszyn, Paula, Ferrari, Pietro, Vineis, Paolo, Masala, Giovanna, Catalano, Alberto, Sonestedt, Emily, Borné, Yan, Katzke, Verena, Bajracharya, Rashmita, Agnoli, Claudia, Guevara, Marcela, Heath, Alicia, Radoï, Loredana, Mancini, Francesca, Weiderpass, Elisabete, Huerta, José María, Sánchez, María-José, Tjønneland, Anne, Kyrø, Cecilie, Schulze, Matthias B., Skeie, Guri, Lukic, Marko, Braaten, Tonje, Gunter, Marc, Millett, Christopher, Agudo, Antonio, Brennan, Paul, Borges, M. Carolina, Richmond, Rebecca C., Richardson, Tom G., Davey Smith, George, Relton, Caroline L., and Huybrechts, Inge

Published
2024
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36. Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition

Author

Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Hoff, Geir, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Dossus, Laure, Johansson, Mattias, Freisling, Heinz, Matta, Komodo, Huybrechts, Inge, Chen, Sairah L. F., B. Borch, Kristin, Sandanger, Torkjel M., H. Nøst, Therese, Dahm, Christina C., Antoniussen, Christian S., Tin Tin, Sandar, Fournier, Agnès, Marques, Chloé, Artaud, Fanny, Sánchez, Maria-José, Guevara, Marcela, Santiuste, Carmen, Agudo, Antonio, Bajracharya, Rashmita, Katzke, Verena, Ricceri, Fulvio, Agnoli, Claudia, Bergmann, Manuela M., Schulze, Matthias B., Panico, Salvatore, Masala, Giovanna, Tjønneland, Anne, Olsen, Anja, Stocks, Tanja, Manjer, Jonas, Aizpurua-Atxega, Amaia, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., and Ferrari, Pietro

Published
2024
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38. Relationship between exposure to parabens and benzophenones and prostate cancer risk in the EPIC-Spain cohort

Author

Fernández-Martínez, Nicolás Francisco, Rodríguez-Barranco, Miguel, Zamora-Ros, Raúl, Guevara, Marcela, Colorado-Yohar, Sandra Milena, Jiménez-Zabala, Ana, Arrebola, Juan Pedro, Iribarne-Durán, Luz María, Molina, Germán, Agudo, Antonio, Trobajo-Sanmartín, Camino, Chirlaque, María Dolores, Amiano, Pilar, and Sánchez, María-José

Published
2024
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40. Diferencias sociodemográficas en la adhesión al patrón de dieta mediterránea en poblaciones de España Sociodemographic differences in adherence to the Mediterranean dietary pattern in Spanish populations

Author

C.A. González, S. Argilaga, A. Agudo, P. Amiano, A. Barricarte, J.M. Beguiristain, M.D. Chirlaque, M. Dorronsoro, C. Martinez, C. Navarro, J.R. Quirós, M. Rodriguez, and M.J. Tormo

Subjects
Dieta mediterránea, Diferencias sociales, Estudio transversal, Mediterranean diet, Social differences, Cross-sectional study, Public aspects of medicine, RA1-1270
Abstract

Objetivos: Los grupos de nivel social más bajo tienen habitualmente una dieta menos saludable. El objetivo de este estudio es comparar la adhesión al patrón de dieta mediterránea entre diferentes grupos demográficos y sociales de la población adulta. Métodos: Se realizó un estudio transversal en regiones del sur y norte de España, en voluntarios sanos (15.634 varones y 25.812 mujeres) de 29 a 69 años de edad, miembros de la cohorte EPIC en España. Se tuvo en cuenta el consumo de nueve grupos de alimentos para definir el patrón de dieta mediterránea: vegetales, frutas, legumbres, cereales, carne roja, pescado, aceite de oliva, leche y productos lácteos y vino. Se aplicaron dos técnicas de análisis: comparación de la media diaria de consumo de cada grupo, y el cálculo de un escore global para todos los alimentos, por nivel educacional y clase social de origen. Resultados: Los grupos de nivel educacional más bajo consumen mas cereales y legumbres, pero menos vegetales, aceite de oliva (las mujeres), leche y productos lácteos (los varones). El consumo de vino está positivamente asociado con la educación en las mujeres y negativamente asociado en los varones. Calculando una puntuación para medir la adhesión global al patrón de dieta mediterránea, las diferencias por cada grupo de alimentos se compensan, y no hay variaciones según el nivel educacional, aunque existen pequeñas diferencias en la clase social de origen (22,52 en la clase más baja y 21,98 en la clase más alta). El índice de adhesión es más bajo en los adultos jóvenes y mujeres, y ligeramente más alto en las poblaciones del sur (23,53 en Murcia) que en las del norte de España (21,64 en Asturias). Conclusiones: Los resultados sugieren que el patrón de dieta mediterránea es bastante uniforme, al menos en las poblaciones adultas de las áreas incluidas en el estudio.Objectives: Lower social classes tend to eat a less healthy diet. The aim of this study was to compare adherence to the Mediterranean dietary pattern among different demographic and social groups in the adult population. Methods: A cross-sectional study was performed in southern and northern regions of Spain in healthy volunteers (15,634 men and 25,812 women), aged 29-69 years, who were members of the European Prospective Investigation on Cancer cohort in Spain. Nine groups of food were included in the definition of the Mediterranean diet: vegetables and garden products, fruits, pulses, cereals, red meat, fish, olive oil, milk and milk products, and wine. Two techniques were used in the analysis: comparison of the mean daily intake of each group and calculation of an overall score for all the foods according to educational level ang original social class. Results: Groups with the lowest educational levels consumed more cereals and pulses and lower quantities of vegetables, olive oil (women), milk and milk products (men). Wine consumption was positively associated with education in women and was negatively associated in men. Calculation of a score to measure overall adherence to the Mediterranean dietary pattern eliminated differences according to each food category. No variations were found according to educational level, but small differences were found in original social class. The adherence score was lowest in young adults and women and was slightly higher in the south than in the north of Spain. Conclusions: The results suggest that the Mediterranean dietary pattern is fairly uniform, at least in the adult population of the regions included in this study.

Published
2002

42. The Power of Expectations on Students' Years of Schooling

Author

Lopez-Agudo, Luis Alejandro, Prieto-Latorre, Claudia, and Marcenaro-Gutierrez, Óscar David

Abstract

Both students and parents have expectations about students' academic future. The present study analyses the influence of both sets of expectations when students are at age 15-16 on the level of education achieved by students when they are 23-24 years old. For this purpose, a structural equation model is estimated by three-stage least squares, using panel data for the most populated Spanish region (Andalusia). Results show that when both students and parents expect degree level education (i.e. 16 years of schooling) the student appears to come quite close to achieving that level. They also show that socio-cultural variables, together with students' cognitive and non-cognitive outcomes, seem to explain the mechanism of formation of expectations and students' completed years of schooling.

Published
2021

45. Genetic Characterization of Kidney Failure of Unknown Etiology in Spain: Findings From the GENSEN Study

Author

Eugenia García Montemayor, Victoria, Salgueira Lazo, Mercedes, Mazuecos Blanca, Auxiliadora, Jiménez Salcedo, Tamara, José Espigares Huete, María, Araceli Jiménez Vibora, Elena, Álamo Caballero, Concepción, Banegas Deras, Eduardo J., Alonso Bethencourt, Alejandro, Rodríguez García, Alejandra, Fernández Granados, Saulo, Fernández Fresnedo, Gema, Calle García, Leonardo, Martín García, Jesús, Estifan Kasabji, Jorge, Jesús Izquierdo, María, Mouzo Mirco, Ricardo, García Agudo, Rebeca, de Arriba de la Fuente, Gabriel, Facundo Molas, Carme, Xipell Font, Marc, Yugueros González, Alejandra, Antóns, Paula, Ibernon Vilaro, Meritxell, de la Fuente Fernández, Vanessa, González Galván, Yussel, Cabezas, Antonio, Castro Alonso, Cristina, Juan García, Isabel, Garín Cascales, Eduardo, Sebastiá Morant, Josepa, Luna Complejo, Enrique, María Díaz Campillejo, Rosa, González Sanchidrián, Silvia, Cao Vilariño Complejo, Mercedes, Sierra Carpio, Milagros, Ortega Díaz, Mayra, Sánchez Hernández, Rosa, Ossorio González, Marta, Vega Martínez, Almudena, Teresa López Picasso, María, Goma, Elena, Giorgi, Martín, Martínez Miguel, Patricia, Gutiérrez Martínez, Eduardo, Paraíso Cuevas, Vicente, Echarri, Rocío, Martínez, Víctor, Pérez Arnedo, Mario, Juliana Castañeda Infante, Laura, Antonio Menacho Miguel, Jose, Blasco, Miquel, Quiroga, Borja, García-Aznar, José M., Castro-Alonso, Cristina, Fernández-Granados, Saulo J., Luna, Enrique, Ossorio, Marta, Izquierdo, María Jesús, Sanchez-Ospina, Didier, Castañeda-Infante, Laura, Mouzo, Ricardo, Cao, Mercedes, Besada-Cerecedo, María L., Pan-Lizcano, Ricardo, Torra, Roser, Ortiz, Alberto, and de Sequera, Patricia

Published
2024
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46. Clinical impact of remote heart failure management using the multiparameter ICD HeartLogic alert

Author

de Juan Bagudá, Javier, Cózar León, Rocío, Gavira Gómez, Juan J., Pachón, Marta, Goirigolzarri Artaza, Josebe, Martínez Mateo, Virgilio, Escolar Pérez, Vanessa, Iniesta Manjavacas, Ángel Manuel, Rivas Gándara, Nuria, Álvarez-García, Jesús, Sánchez Ramos, Jesús Gabriel, Aguilera Agudo, Cristina, Rubín López, José Manuel, Macías Gallego, Alfonso, López Fernández, Silvia, González Torres, Luis, Martínez, Juan Gabriel, Marrero Negrín, Natalia, Ramos Maqueda, Javier, Cabrera Ramos, Mercedes, Medina Gil, José María, De Diego Rus, Carlos, Bermúdez Jiménez, Francisco José, Madrazo, Inés, Díaz Molina, Beatriz, Cobo Marcos, Marta, Ruiz Duthil, Ana Delia, Cordero, David, Méndez Fernández, Ana Belén, Peña Conde, Laura, Arcocha Torres, María F., Pérez Castellano, Nicasio, Arias, Miguel Á., García Bolao, Ignacio, Díaz Infante, Ernesto, Campari, Monica, Arribas Ynsaurriaga, Fernando, Delgado Jiménez, Juan F., Valsecchi, Sergio, and Salguero Bodes, Rafael

Published
2024
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47. Nutritional quality of diet characterized by the Nutri-Score profiling system and cardiovascular disease risk: a prospective study in 7 European countries

Author

Deschasaux-Tanguy, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Sarda, Barthélémy, Fialon, Morgane, Arnault, Nathalie, Srour, Bernard, Kesse-Guyot, Emmanuelle, Fezeu, Léopold K., Biessy, Carine, Casagrande, Corinne, Hemon, Bertrand, Weiderpass, Elisabete, Pinho, Maria G.M., Murphy, Neil, Freisling, Heinz, Ferrari, Pietro, Tjønneland, Anne, Nielsen Petersen, Kristina Elin, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Ricceri, Fulvio, Verschuren, W.M.Monique, Boer, Jolanda M.A., van der Schouw, Yvonne T., Skeie, Guri, Agudo, Antonio, Molina-Montes, Esther, Huerta, José María, Moreno-Iribas, Conchi, Ericson, Ulrika, Sonestedt, Emily, Strid, Anna, Oskarsson, Viktor, Tong, Tammy Y.N., Heath, Alicia K., Aglago, Elom K., Danesh, John, Riboli, Elio, Gunter, Marc J., and Touvier, Mathilde

Published
2024
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48. Standardised formats and open-source analysis tools for the MAGIC telescopes data

Author

Abe, S., Abhir, J., Abhishek, A., Acciari, V.A., Aguasca-Cabot, A., Agudo, I., Aniello, T., Ansoldi, S., Antonelli, L.A., Arbet Engels, A., Arcaro, C., Artero, M., Asano, K., Babić, A., Barres de Almeida, U., Barrio, J.A., Batković, I., Bautista, A., Baxter, J., Becerra González, J., Bednarek, W., Bernardini, E., Bernete, J., Berti, A., Besenrieder, J., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Bronzini, E., Burelli, I., Busetto, G., Campoy-Ordaz, A., Carosi, A., Carosi, R., Carretero-Castrillo, M., Castro-Tirado, A.J., Cerasole, D., Ceribella, G., Chai, Y., Cifuentes, A., Colombo, E., Contreras, J.L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., de Menezes, R., Delfino, M., Delgado, J., Di Pierro, F., Di Tria, R., Di Venere, L., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Escudero, J., Fariña, L., Fattorini, A., Foffano, L., Font, L., Fröse, S., Fukami, S., Fukazawa, Y., García López, R.J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giesbrecht Paiva, J.G., Giglietto, N., Giordano, F., Gliwny, P., Gradetzke, T., Grau, R., Green, D., Green, J.G., Günther, P., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera Llorente, J., Hrupec, D., Hütten, M., Imazawa, R., Ishio, K., Jiménez Martínez, I., Jormanainen, J., Kayanoki, T., Kerszberg, D., Kluge, G.W., Kobayashi, Y., Kouch, P.M., Kubo, H., Kushida, J., Láinez, M., Lamastra, A., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Lorini, A., Lyard, E., Machado de Oliveira Fraga, B., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mangano, S., Mannheim, K., Mariotti, M., Martínez, M., Martínez-Chicharro, M., Mas-Aguilar, A., Mazin, D., Menchiari, S., Mender, S., Miceli, D., Miener, T., Miranda, J.M., Mirzoyan, R., Molero González, M., Molina, E., Mondal, H.A., Moralejo, A., Morcuende, D., Nakamori, T., Nanci, C., Neustroev, V., Nickel, L., Nievas Rosillo, M., Nigro, C., Nikolić, L., Nishijima, K., Njoh Ekoume, T., Noda, K., Nozaki, S., Ohtani, Y., Okumura, A., Otero-Santos, J., Paiano, S., Paneque, D., Paoletti, R., Paredes, J.M., Peresano, M., Persic, M., Pihet, M., Pirola, G., Podobnik, F., Prada Moroni, P.G., Prandini, E., Principe, G., Priyadarshi, C., Rhode, W., Ribó, M., Rico, J., Righi, C., Sahakyan, N., Saito, T., Saturni, F.G., Schmidt, K., Schmuckermaier, F., Schubert, J.L., Schweizer, T., Sciaccaluga, A., Silvestri, G., Sitarek, J., Sliusar, V., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Suutarinen, S., Tajima, H., Takahashi, M., Takeishi, R., Temnikov, P., Terauchi, K., Terzić, T., Teshima, M., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vazquez Acosta, M., Ventura, S., Viale, I., Vigorito, C.F., Vitale, V., Vovk, I., Walter, R., Will, M., Wunderlich, C., Yamamoto, T., Jouvin, L., Linhoff, L., and Linhoff, M.

Published
2024
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