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3 results on '"44G4"'

1. Anti-Human Endoglin (hCD105) Immunotoxin—Containing Recombinant Single Chain Ribosome- Inactivating Protein Musarmin 1.

Author

Barriuso, Begoña, Antolín, Pilar, Arias, F. Javier, Girotti, Alessandra, Jiménez, Pilar, Cordoba-Diaz, Manuel, Cordoba-Diaz, Damián, and Girbés, Tomás

Abstract

Endoglin (CD105) is an accessory component of the TGF-β receptor complex, which is expressed in a number of tissues and over-expressed in the endothelial cells of tumor neovasculature. Targeting endoglin with immunotoxins containing type 2 ribosome-inactivating proteins has proved an effective tool to reduce blood supply to B16 mice tumor xenografts. We prepared anti-endoglin immunotoxin (IT)—containing recombinant musarmin 1 (single chain ribosome-inactivating proteins) linked to the mouse anti-human CD105 44G4 mouse monoclonal antibody via N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP). The immunotoxin specifically killed L929 fibroblast mouse cells transfected with the short form of human endoglin with IC50 values in the range of 5 × 10–10 to 10–9 M. [ABSTRACT FROM AUTHOR]

Published
2016
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2. Anti-Human Endoglin (hCD105) Immunotoxin—Containing Recombinant Single Chain Ribosome-Inactivating Protein Musarmin 1

Author

Begoña Barriuso, Pilar Antolín, F. Javier Arias, Alessandra Girotti, Pilar Jiménez, Manuel Cordoba-Diaz, Damián Cordoba-Diaz, and Tomás Girbés

Subjects
recombinant musarmin, endoglin, CD105, 44G4, anti-endoglin monoclonal antibody, anti-tumor therapy, cancer therapy, Medicine
Abstract

Endoglin (CD105) is an accessory component of the TGF-β receptor complex, which is expressed in a number of tissues and over-expressed in the endothelial cells of tumor neovasculature. Targeting endoglin with immunotoxins containing type 2 ribosome-inactivating proteins has proved an effective tool to reduce blood supply to B16 mice tumor xenografts. We prepared anti-endoglin immunotoxin (IT)—containing recombinant musarmin 1 (single chain ribosome-inactivating proteins) linked to the mouse anti-human CD105 44G4 mouse monoclonal antibody via N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP). The immunotoxin specifically killed L929 fibroblast mouse cells transfected with the short form of human endoglin with IC50 values in the range of 5 × 10−10 to 10−9 M.

Published
2016
Full Text
View/download PDF

3. Anti-Human Endoglin (hCD105) Immunotoxin—Containing Recombinant Single Chain Ribosome-Inactivating Protein Musarmin 1

Author

Pilar Jiménez, Damián Cordoba-Diaz, Manuel Cordoba-Diaz, Alessandra Girotti, Tomás Girbés, Pilar Antolı́n, Begoña Barriuso, and Francisco Javier Arias

Subjects
0301 basic medicine, Receptor complex, Cell Survival, Health, Toxicology and Mutagenesis, lcsh:Medicine, Toxicology, Cell Line, law.invention, Mice, 03 medical and health sciences, Tecnología farmaceútica, 0302 clinical medicine, Immunotoxin, law, otorhinolaryngologic diseases, Animals, Humans, N-Glycosyl Hydrolases, anti-tumor therapy, Cancer, anti-endoglin monoclonal antibody, endoglin, Chemistry, Immunotoxins, Communication, Ribosome-inactivating protein, Terapia antitumoral, lcsh:R, Transfection, Endoglin, Cáncer, Molecular biology, CD105, 030104 developmental biology, recombinant musarmin, Cell culture, 030220 oncology & carcinogenesis, Recombinant DNA, cancer therapy, Anti-tumor therapy, 44G4, Transforming growth factor
Abstract

Producción Científica, Endoglin (CD105) is an accessory component of the TGF-β receptor complex, which is expressed in a number of tissues and over-expressed in the endothelial cells of tumor neovasculature. Targeting endoglin with immunotoxins containing type 2 ribosome-inactivating proteins has proved an effective tool to reduce blood supply to B16 mice tumor xenografts. We prepared anti-endoglin immunotoxin (IT)—containing recombinant musarmin 1 (single chain ribosome-inactivating proteins) linked to the mouse anti-human CD105 44G4 mouse monoclonal antibody via N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP). The immunotoxin specifically killed L929 fibroblast mouse cells transfected with the short form of human endoglin with IC50 values in the range of 5 × 10−10 to 10−9 M., Comisión Interministerial de Ciencia y Tecnología (grant CICYT BIO98-0727)

Published
2016

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