11 results on '"Özsüt, Halit"'
Search Results
2. HIDDEN DANGER OF SARS-COV-2; MULTISYSTEM INFLAMMATORY SYNDROME IN ADULTS (MIS-A): FIRST CASE SERIES IN A SINGLE CENTER FROM TURKIYE.
- Author
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BENLİ, Aysun, TOR, Yavuz Burak, ŞİMŞEK-YAVUZ, Serap, BAŞARAN, Seniha, ÇAĞATAY, Atahan, ÖZSÜT, Halit, GÜL, Ahmet, and ERAKSOY, Haluk
- Subjects
MULTISYSTEM inflammatory syndrome ,LOW-molecular-weight heparin ,SARS-CoV-2 ,ADULTS ,PEPTIDES ,LYMPHOPENIA - Abstract
Copyright of Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi is the property of Istanbul Tip Fakultesi Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
3. STAPHYLOCOCCUS AUREUS BAKTERİYEMİLERİNDE MORTALİTE RİSK FAKTÖRLERİNİN ANALİZİ: SEFAZOLİN DAHA İYİ SONUÇLA İLİŞKİLİ
- Author
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BAŞARAN, Seniha, ŞİMŞEK YAVUZ, Serap, SADIÇ ÇOPUR, Betül, YİR, Asiye, ÇAĞATAY, Atahan, ÖNCÜL, Oral, ÖZSÜT, Halit, and ERAKSOY, Haluk
- Subjects
Methicillin-sensitive Staphylococcus aureus,healthcare associated bacteraemia,cefazolin ,Health Care Sciences and Services ,Metisiline duyarlı Staphylococcus aureus,sağlık bakımı ile ilişkili bakteriyemi,sefazolin ,Sağlık Bilimleri ve Hizmetleri - Abstract
Objective: Methicillin-sensitive Staphylococcus aureus (MSSA) is frequent cause of bacteraemias and associated with substantial mortality. We defined risk factors for mortality among patients with either community-acquired (CA) or healthcare-associated (HCA) MSSA bacteraemia with special emphasis on treatment options including cefazolin and other antimicrobials (mainly ampicillin-sulbactam). Material and Method: All adult patients who were hospitalized and whose blood cultures were positive for MSSA between 2009 and 2014 were included. Patients with CA and HCA MSSA bacteraemia were compared. Results: 83% of the 127 patients with MSSA bacteraemia had HCA. The mortality rate of patients was 20.5% and this did not differ between patients with either CA or HCA MSSA bacteraemia. In the multivariate analysis, higher comorbidity index (HR 1.557), presence of metastatic foci (HR 2.883), and requirement for ICU support (HR 16.239) were found as independent risk factors for mortality, and cefazolin use was found to be protective against mortality (HR 0.178). Conclusion: Patients with MSSA bacteraemia should be treated with cefazolin instead of other antimicrobial options, especially in countries where anti-staphylococcal penicillins are not available or in patients who cannot tolerate anti-staphylococcal penicillins, as cefazolin was found to be protective against mortality, Amaç: Metisiline duyarlı Staphylococcus aureus (MSSA), önemli bir bakteriyemi etkeni olup, hastalarda ciddi mortaliteye neden olur. Bu çalışmada, toplum kaynaklı (TK) veya sağlık bakımı (SB)’yla ilişkili MSSA bakteriyemilerinde mortaliteye etki eden risk faktörlerinin belirlenmesi amaçlanmıştır. Ayrıca MSSA bakteriyemilerinin tedavi seçeneklerinden sefazolin ve özellikle ampisilin-sulbaktam olmak üzere diğer antimikrobiklerin tedavideki yeterlikleri karşılaştıırlmıştır. Gereç ve Yöntem: 2009-2014 yılları arasında hastanemizde yatarak tedavi edilen ve MSSA bakteriyemisi tanısı konulan erişkin hastalar çalışmaya dahil edildi. TK veya SB ilişkili MSSA bakteriyemisi olan hastalar karşılaştırıldı. Bulgular: Toplam 127 MSSA bakteriyemili hastanın %83’ü SB ile ilişkiliydi. Mortalite oranı %20,5 olup, TK ve SB MSSA bakteriyemili hastalar arasında fark yoktu. Çok değişkenli analizde yüksek komorbidite indeksi (HR 1,557), metastatik infeksiyon odağı varlığı (HR 2,883) ve yoğun bakım desteğine ihtiyacın olması (HR 16,239) mortalite için bağımsız risk faktörleri, tedavide sefazolin kullanımı ise mortaliteyi azaltan bir faktör olarak saptandı (HR 0,178). Sonuç: Diğer antimikrobiyallerle karşılaştırıldığında sefazolinle tedavi edilen MSSA bakteriyemilerinde klinik sonuçlar daha iyi belirlendiği için, özellikle antistafilokoksik penisilinlerin bulunmadığı yerlerde veya bu ajanları tolere edemeyen hastalarda diğer antimikrobiklerin yerine sefazolin tercih edilmelidir.
- Published
- 2019
4. Central venous catheter related infections: Risk factors and the effect of glycopeptide antibiotics
- Author
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Eraksoy Haluk, Çakar Nahit, Ay Pinar, Yildirim Ayşe, Özsüt Halit, Öncü Serkan, and Çalangu Semra
- Subjects
Central venous catheter ,infection ,risk ,glycopeptide ,Therapeutics. Pharmacology ,RM1-950 ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Abstract Backround We undertook a prospective study of all new central venous catheters inserted into patients in the intensive care units, in order to identify the risk factors and to determine the effect of glycopeptide antibiotics on catheter – related infections. Methods During the study period 300 patients with central venous catheters were prospectively studied. The catheters used were nontunneled, noncuffed, triple lumen and made of polyurethane material. Catheters were cultured by semiquantitative method and blood cultures done when indicated. Data were obtained on patient age, gender, unit, primary diagnosis on admission, catheter insertion site, duration of catheterization, whether it was the first or a subsequent catheter and glycopeptide antibiotic usage. Results Ninety-one (30.3%) of the catheters were colonized and infection was found with 50 (16.7%) catheters. Infection was diagnosed with higher rate in catheters inserted via jugular vein in comparison with subclavian vein (95% CI: 1.32–4.81, p = 0.005). The incidence of infection was higher in catheters which were kept in place for more than seven days (95% CI 1.05–3.87, p = 0.03). The incidence of infection was lower in patients who were using glycopeptide antibiotic during catheterization (95% CI: 1.49–5.51, p = 0.005). The rate of infection with Gram positive cocci was significantly lower in glycopeptide antibiotic using patients (p = 0.01). The most commonly isolated organism was Staphylococcus aureus (n = 52, 37.1%). Conclusion Duration of catheterization and catheter insertion site were independent risk factors for catheter related infection. Use of glycopeptide antibiotic during catheterization seems to have protective effect against catheter related infection.
- Published
- 2003
- Full Text
- View/download PDF
5. Rhinocerebral mucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: a case report
- Author
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Özsüt Halit H, Yildirmak Taner T, Çalangu Semra S, Öncü Serkan S, Çagatay Atahan A, and Eraksoy Haluk H
- Subjects
Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible individuals, notably patients with diabetes and leukemia. Rhinocerebral mucormycosis most commonly manifests itself in the setting of poorly controlled diabetes, especially with ketoacidosis. Case Presentation A 31-year-old diabetic man presented to the outpatient clinic with the following signs and symptoms: headache, periorbital pain, swelling and loss of vision in the right eye. On physical examination his right eye was red and swollen. There was periorbital cellulitis and the conjunctiva was edematous. KOH preparation of purulent discharge showed broad, ribbonlike, aseptate hyphae when examined under a fluorescence microscope. Cranial MRI showed involvement of the right orbit, thrombosis in cavernous sinus and infiltrates at ethmoid and maxillary sinuses. Mucormycosis was diagnosed based on these findings. Amphotericin B (AmBisome®; 2 mg/kg.d) was initiated after the test doses. Right orbitectomy and right partial maxillectomy were performed; the lesions in ethmoid and maxillary sinuses were removed. The duration of the liposomal amphotericin B therapy was approximately 6 months and the total dose of liposomal amphotericin B used was 32 grams. Liposomal amphotericin B therapy was stopped six months later and oral fluconazole was started. Conclusions Although a total surgical debridement of the lesions could not be performed, it is remarkable that regression of the disease could be achieved with medical therapy alone.
- Published
- 2001
- Full Text
- View/download PDF
6. ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLINSENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME.
- Author
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BAŞARAN, Seniha, YAVUZ, Serap ŞİMŞEK, ÇOPUR, Betül SADIÇ, YİR, Asiye, ÇAĞATAY, Atahan, ÖNCÜL, Oral, ÖZSÜT, Halit, and ERAKSOY, Haluk
- Subjects
STAPHYLOCOCCUS aureus ,BACTEREMIA ,CEFAZOLIN ,MORTALITY ,RISK assessment ,BACTEREMIA treatment - Abstract
Copyright of Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi is the property of Istanbul Tip Fakultesi Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
- Full Text
- View/download PDF
7. Hematologic Adverse Effects of Prolonged Piperacillin- Tazobactam Use in Adults.
- Author
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Benli, Aysun, Şimşek-Yavuz, Serap, Başaran, Seniha, Çağatay, Atahan, Özsüt, Halit, and Eraksoy, Haluk
- Subjects
ANTIBIOTICS ,LEUCOPENIA ,NEUTROPENIA ,EOSINOPHILIA ,ALLERGIES ,BLOOD diseases ,COMBINATION drug therapy ,ENZYME inhibitors ,DISEASE incidence ,AMPICILLIN ,LEUKOCYTE count ,ADULTS ,DISEASE risk factors - Abstract
Copyright of Turkish Journal of Hematology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
8. Risk Factors for Mortality of Nosocomial Bacteraemia in Intensive Care Units.
- Author
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Çağatay, A. Atahan, Özcan, Perihan Ergin, Gulec, Leyla, Ince, Nurhan, Tugrul, Simru, Özsüt, Halit, Cakar, Nahit, Esen, Figen, Eraksoy, Haluk, and Calangu, Semra
- Subjects
CRITICAL care medicine ,INTENSIVE care units ,BACTEREMIA ,BACTERIAL diseases ,MORTALITY ,NOSOCOMIAL infections - Abstract
Objective: The aim of this study was to follow critically ill patients prospectively in intensive care units (ICUs) to determine risk factors for mortality and outcome associated with nosocomial bacteraemia (NB). Subjects and Methods: A case-control study of 176 patients was conducted to identify the risk factors for mortality of NB in ICU patients. The study was performed in emergency, surgical and general surgical ICUs with 23 beds during a 15-month period. A total of 1,450 patients were admitted to the ICUs during the study period. The USA Center for Disease Control and Prevention definitions were used to diagnose nosocomial infections. Nosocomial bacteraemia was defined as the isolation of one or more organisms from blood cultures taken at least 48 h after admission, which were not related to a problem present on admission. An assessment of whether the isolated organisms represented true bacteraemia rather than contamination was made by clinical or laboratory evidence of infection. Results: A total of 214 bacteraemia episodes were found in the 176 patients (64 female, 112 male; 51.3 ± 21.3 years old), 90 of whom died and 86 survived. The bacteraemia rate was 12.1%. The most common etiological agents of bacteraemia were Klebsiella pneumoniae: 46 (21.5%), methicillin-resistant Staphylococcus aureus: 46 (21.5%), Pseudomonas aeruginosa: 32 (14.9%), and Escherichia coli: 20 (9.3%). Multivariate analysis showed that the requirement of mechanical ventilation for more than 7 days (p < 0.001), total parenteral nutrition (p = 0.034), inotropic drug (p < 0.001), and increased creatinine level (p = 0.034) were independent risk factors for mortality of NB in ICUs. Conclusions: Nosocomial infections caused by Gram-negative bacteria continue to be one of the major sources of morbidity and mortality. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
9. Central venous catheter related infections: Risk factors and the effect of glycopeptide antibiotics.
- Author
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Öncü, Serkan, Özsüt, Halit, Yildirim, Ayşe, Ay, Pinar, Çakar, Nahit, Eraksoy, Haluk, and Çalangu, Semra
- Subjects
LONGITUDINAL method ,INTRAVENOUS catheterization complications ,GLYCOPEPTIDE antibiotics ,CATHETERS ,STAPHYLOCOCCUS aureus - Abstract
Backround: We undertook a prospective study of all new central venous catheters inserted into patients in the intensive care units, in order to identify the risk factors and to determine the effect of glycopeptide antibiotics on catheter -- related infections. Methods: During the study period 300 patients with central venous catheters were prospectively studied. The catheters used were nontunneled, noncuffed, triple lumen and made of polyurethane material. Catheters were cultured by semiquantitative method and blood cultures done when indicated. Data were obtained on patient age, gender, unit, primary diagnosis on admission, catheter insertion site, duration of catheterization, whether it was the first or a subsequent catheter and glycopeptide antibiotic usage. Results: Ninety-one (30.3%) of the catheters were colonized and infection was found with 50 (16.7%) catheters. Infection was diagnosed with higher rate in catheters inserted via jugular vein in comparison with subclavian vein (95% CI: 1.32-4.81, p = 0.005). The incidence of infection was higher in catheters which were kept in place for more than seven days (95% CI 1.05-3.87, p = 0.03). The incidence of infection was lower in patients who were using glycopeptide antibiotic during catheterization (95% CI: 1.49-5.51, p = 0.005). The rate of infection with Gram positive cocci was significantly lower in glycopeptide antibiotic using patients (p = 0.01). The most commonly isolated organism was Staphylococcus aureus (n = 52, 37.1%). Conclusion: Duration of catheterization and catheter insertion site were independent risk factors for catheter related infection. Use of glycopeptide antibiotic during catheterization seems to have protective effect against catheter related infection. [ABSTRACT FROM AUTHOR]
- Published
- 2003
10. Rhinocerebral mucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: a case report.
- Author
-
Çagatay, Atahan A., Öncü, Serkan S., Çalangu, Semra S., Yildirmak, Taner T., Özsüt, Halit H., and Eraksoy, Haluk H.
- Subjects
MUCORMYCOSIS ,AMPHOTERICIN B ,SURGERY ,DIABETES ,THERAPEUTICS - Abstract
Background: Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible individuals, notably patients with diabetes and leukemia. Rhinocerebral mucormycosis most commonly manifests itself in the setting of poorly controlled diabetes, especially with ketoacidosis. Case Presentation: A 31-year-old diabetic man presented to the outpatient clinic with the following signs and symptoms: headache, periorbital pain, swelling and loss of vision in the right eye. On physical examination his right eye was red and swollen. There was periorbital cellulitis and the conjunctiva was edematous. KOH preparation of purulent discharge showed broad, ribbonlike, aseptate hyphae when examined under a fluorescence microscope. Cranial MRI showed involvement of the right orbit, thrombosis in cavernous sinus and infiltrates at ethmoid and maxillary sinuses. Mucormycosis was diagnosed based on these findings. Amphotericin B (AmBisome®; 2 mg/kg.d) was initiated after the test doses. Right orbitectomy and right partial maxillectomy were performed; the lesions in ethmoid and maxillary sinuses were removed. The duration of the liposomal amphotericin B therapy was approximately 6 months and the total dose of liposomal amphotericin B used was 32 grams. Liposomal amphotericin B therapy was stopped six months later and oral fluconazole was started. Conclusions: Although a total surgical debridement of the lesions could not be performed, it is remarkable that regression of the disease could be achieved with medical therapy alone. [ABSTRACT FROM AUTHOR]
- Published
- 2001
11. An adult case of fatal hemolysis induced by ceftriaxone.
- Author
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Punar M, Özsüt H, Eraksoy H, Çalangu S, and Dilmener M
- Published
- 1999
- Full Text
- View/download PDF
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