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296 results on '"Cristen J. Willer"'

201. Researchers' Work from Radboud University Medical Center Focuses on Science (Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications)

Subjects
Thyrotropin -- Health aspects, Thyroid gland -- Health aspects, Genome-wide association studies -- Evaluation, Health
Abstract

2024 MAR 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on science have been presented. According to news reporting from [...]

Published
2024

202. Findings on Abdominal Aortic Aneurysm Reported by Investigators at University of Michigan (Genome-wide Association Meta-analysis Identifies Risk Loci for Abdominal Aortic Aneurysm and Highlights Pcsk9 As a Therapeutic Target)

Subjects
United States. National Institutes of Health, Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Genomics -- Health aspects, Abdominal aneurysm -- Health aspects, Cardiovascular diseases -- Health aspects, Physical fitness -- Health aspects, Health, University of Michigan
Abstract

2023 DEC 16 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Cardiovascular Diseases and Conditions - Abdominal Aortic [...]

Published
2023

203. Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

Author

Beaumont, Robin N., Flatley, Christopher, Vaudel, Marc, Wu, Xiaoping, Chen, Jing, Moen, Gunn-Helen, Skotte, Line, Helgeland, Øyvind, Solé-Navais, Pol, Banasik, Karina, Albiñana, Clara, Ronkainen, Justiina, Fadista, João, Stinson, Sara Elizabeth, Trajanoska, Katerina, Wang, Carol A., Westergaard, David, Srinivasan, Sundararajan, Sánchez-Soriano, Carlos, Bilbao, Jose Ramon, Allard, Catherine, Groleau, Marika, Kuulasmaa, Teemu, Leirer, Daniel J., White, Frédérique, Jacques, Pierre-Étienne, Cheng, Haoxiang, Hao, Ke, Andreassen, Ole A., Åsvold, Bjørn Olav, Atalay, Mustafa, Bhatta, Laxmi, Bouchard, Luigi, Brumpton, Ben Michael, Brunak, Søren, Bybjerg-Grauholm, Jonas, Ebbing, Cathrine, Elliott, Paul, Engelbrechtsen, Line, Erikstrup, Christian, Estarlich, Marisa, Franks, Stephen, Gaillard, Romy, Geller, Frank, Grove, Jakob, Hougaard, David M., Kajantie, Eero, Morgen, Camilla S., Nohr, Ellen A., Nyegaard, Mette, Palmer, Colin N. A., Pedersen, Ole Birger, Rivadeneira, Fernando, Sebert, Sylvain, Shields, Beverley M., Stoltenberg, Camilla, Surakka, Ida, Thørner, Lise Wegner, Ullum, Henrik, Vaarasmaki, Marja, Vilhjalmsson, Bjarni J., Willer, Cristen J., Lakka, Timo A., Gybel-Brask, Dorte, Bustamante, Mariona, Hansen, Torben, Pearson, Ewan R., Reynolds, Rebecca M., Ostrowski, Sisse R., Pennell, Craig E., Jaddoe, Vincent W. V., Felix, Janine F., Hattersley, Andrew T., Melbye, Mads, Lawlor, Deborah A., Hveem, Kristian, Werge, Thomas, Nielsen, Henriette Svarre, Magnus, Per, Evans, David M., Jacobsson, Bo, Järvelin, Marjo-Riitta, Zhang, Ge, Hivert, Marie-France, Johansson, Stefan, Freathy, Rachel M., Feenstra, Bjarke, and Njølstad, Pål R.

Published
2023
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204. Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps

Author

Adeyemo, Adebowale, Balaconis, Mary K., Darnes, Deanna R., Fatumo, Segun, Granados Moreno, Palmira, Hodonsky, Chani J., and Inouye, Michael

Subjects
Medicine -- Practice, Genetic susceptibility -- Analysis, Medical ethics -- Demographic aspects, Health risk assessment -- Genetic aspects -- Demographic aspects, Company business management, Biological sciences, Health
Abstract

Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human genome to estimate the risk of a disease or disease-related trait for an individual. The potential benefits of PRSs include cost-effective enhancement of primary disease prevention, more refined diagnoses and improved precision when prescribing medicines. However, these must be weighed against the potential risks, such as uncertainties and biases in PRS performance, as well as potential misunderstanding and misuse of these within medical practice and in wider society. By addressing key issues including gaps in best practices, risk communication and regulatory frameworks, PRSs can be used responsibly to improve human health. Here, the International Common Disease Alliance's PRS Task Force, a multidisciplinary group comprising expertise in genetics, law, ethics, behavioral science and more, highlights recent research to provide a comprehensive summary of the state of polygenic score research, as well as the needs and challenges as PRSs move closer to widespread use in the clinic. As polygenic risk scores move closer to widespread clinical use, this Perspective summarizes the benefits, risks and challenges to be overcome., Author(s): Adebowale Adeyemo [sup.1] [sup.1] , Mary K. Balaconis [sup.2] , Deanna R. Darnes [sup.3] , Segun Fatumo [sup.4] [sup.5] [sup.6] , Palmira Granados Moreno [sup.7] , Chani J. Hodonsky [...]

Published
2021
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205. Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program

Author

Klarin, Derek, Devineni, Poornima, Sendamarai, Anoop K., Angueira, Anthony R., Graham, Sarah E., Shen, Ying H., Levin, Michael G., Pirruccello, James P., Surakka, Ida, Karnam, Purushotham R., Roychowdhury, Tanmoy, Li, Yanming, Wang, Minxian, Aragam, Krishna G., Paruchuri, Kaavya, Zuber, Verena, Shakt, Gabrielle E., Tsao, Noah L., Judy, Renae L., Vy, Ha My T., Verma, Shefali S., Rader, Daniel J., Do, Ron, Bavaria, Joseph E., Nadkarni, Girish N., Ritchie, Marylyn D., Burgess, Stephen, Guo, Dong-chuan, Ellinor, Patrick T., LeMaire, Scott A., Milewicz, Dianna M., Willer, Cristen J., Natarajan, Pradeep, Tsao, Philip S., Pyarajan, Saiju, and Damrauer, Scott M.

Published
2023
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206. Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis

Author

Hindy, George, Tyrrell, Daniel J., Vasbinder, Alexi, Wei, Changli, Presswalla, Feriel, Wang, Hui, Blakely, Pennelope, Ozel, Ayse Bilge, Graham, Sarah, Holton, Grace H., Dowsett, Joseph, Fahed, Akl C., Amadi, Kingsley-Michael, Erne, Grace K., Tekmulla, Annika, Ismail, Anis, Launius, Christopher, Sotoodehnia, Nona, Pankow, James S., Thorner, Lise Wegner, Erikstrup, Christian, Pedersen, Ole Birger, Banasik, Karina, Brunak, Soren, Ullum, Henrik, Eugen-Olsen, Jesper, Ostrowski, Sisse Rye, Haas, Mary E., Nielsen, Jonas B., Lotta, Luca A., Engstrom, Gunnar, Melander, Olle, Orho-Melander, Marju, Zhao, Lili, Murthy, Venkatesh L., Pinsky, David J., Willer, Cristen J., Heckbert, Susan R., Reiser, Jochen, Goldstein, Daniel R., Desch, Karl C., and Hayek, Salim S.

Subjects
Immune response -- Genetic aspects, Cell receptors -- Health aspects, Atherosclerosis -- Genetic aspects -- Development and progression -- Care and treatment, Health care industry
Abstract

People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which are strongly associated with cardiovascular outcomes. We assessed suPAR's pathogenic involvement in atherosclerosis using epidemiologic, genetic, and experimental approaches. We found serum suPAR levels to be predictive of coronary artery calcification and cardiovascular events in 5,406 participants without known coronary disease. In a genome-wide association meta-analysis including over 25,000 individuals, we identified a missense variant in the plasminogen activator, urokinase receptor (PLAUR) gene (rs4760), confirmed experimentally to lead to higher suPAR levels. Mendelian randomization analysis in the UK Biobank using rs4760 indicated a causal association between genetically predicted suPAR levels and atherosclerotic phenotypes. In an experimental model of atherosclerosis, proprotein convertase subtilisin/kexin-9 (Pcsk9) transfection in mice overexpressing suPAR ([suPAR.sup.Tg]) led to substantially increased atherosclerotic plaques with necrotic cores and macrophage infiltration compared with those in WT mice, despite similar cholesterol levels. Prior to induction of atherosclerosis, aortas of [suPAR.sup.Tg] mice excreted higher levels of CCL2 and had higher monocyte counts compared with WT aortas. Aortic and circulating [suPAR.sup.Tg] monocytes exhibited a proinflammatory profile and enhanced chemotaxis. These findings characterize suPAR as a pathogenic factor for atherosclerosis acting at least partially through modulation of monocyte function., Introduction People with chronic kidney disease (CKD) are disproportionately affected by cardiovascular disease (CVD), with two-thirds of patients having at least one form of CVD, atherosclerosis being the most common [...]

Published
2022
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207. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

Author

Taliun, Daniel, Harris, Daniel N., Kessler, Michael D., Carlson, Jedidiah, Szpiech, Zachary A., Torres, Raul, and Taliun, Sarah A. Gagliano

Subjects
Nucleotide sequencing -- Usage, DNA sequencing -- Usage, Phenotype -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of improving diagnosis, treatment and prevention of these diseases. The initial phases of the programme focused on whole-genome sequencing of individuals with rich phenotypic data and diverse backgrounds. Here we describe the TOPMed goals and design as well as the available resources and early insights obtained from the sequence data. The resources include a variant browser, a genotype imputation server, and genomic and phenotypic data that are available through dbGaP (Database of Genotypes and Phenotypes).sup.1. In the first 53,831 TOPMed samples, we detected more than 400 million single-nucleotide and insertion or deletion variants after alignment with the reference genome. Additional previously undescribed variants were detected through assembly of unmapped reads and customized analysis in highly variable loci. Among the more than 400 million detected variants, 97% have frequencies of less than 1% and 46% are singletons that are present in only one individual (53% among unrelated individuals). These rare variants provide insights into mutational processes and recent human evolutionary history. The extensive catalogue of genetic variation in TOPMed studies provides unique opportunities for exploring the contributions of rare and noncoding sequence variants to phenotypic variation. Furthermore, combining TOPMed haplotypes with modern imputation methods improves the power and reach of genome-wide association studies to include variants down to a frequency of approximately 0.01%. The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history., Author(s): Daniel Taliun [sup.1] [sup.2] , Daniel N. Harris [sup.3] [sup.4] [sup.5] , Michael D. Kessler [sup.3] [sup.4] [sup.5] , Jedidiah Carlson [sup.6] [sup.7] , Zachary A. Szpiech [sup.8] [sup.9] [...]

Published
2021
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208. Business Data Science: Combining Machine Learning and Economics to Optimize, Automate, and Accelerate Business Decisions

Author

Matt Taddy and Matt Taddy

Subjects
Decision making--Econometric models, Machine learning
Abstract

Use machine learning to understand your customers, frame decisions, and drive value The business analytics world has changed, and Data Scientists are taking over. Business Data Science takes you through the steps of using machine learning to implement best-in-class business data science. Whether you are a business leader with a desire to go deep on data, or an engineer who wants to learn how to apply Machine Learning to business problems, you'll find the information, insight, and tools you need to flourish in today's data-driven economy. You'll learn how to: Use the key building blocks of Machine Learning: sparse regularization, out-of-sample validation, and latent factor and topic modeling Understand how use ML tools in real world business problems, where causation matters more that correlation Solve data science programs by scripting in the R programming language Today's business landscape is driven by data and constantly shifting. Companies live and die on their ability to make and implement the right decisions quickly and effectively. Business Data Science is about doing data science right. It's about the exciting things being done around Big Data to run a flourishing business. It's about the precepts, principals, and best practices that you need know for best-in-class business data science.

Published
2019

209. Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies

Author

Li, Xihao, Quick, Corbin, Zhou, Hufeng, Gaynor, Sheila M., Liu, Yaowu, Chen, Han, Selvaraj, Margaret Sunitha, Sun, Ryan, Dey, Rounak, Arnett, Donna K., Bielak, Lawrence F., Bis, Joshua C., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Brody, Jennifer A., Cade, Brian E., Correa, Adolfo, Cupples, L. Adrienne, Curran, Joanne E., de Vries, Paul S., Duggirala, Ravindranath, Freedman, Barry I., Göring, Harald H. H., Guo, Xiuqing, Haessler, Jeffrey, Kalyani, Rita R., Kooperberg, Charles, Kral, Brian G., Lange, Leslie A., Manichaikul, Ani, Martin, Lisa W., McGarvey, Stephen T., Mitchell, Braxton D., Montasser, May E., Morrison, Alanna C., Naseri, Take, O’Connell, Jeffrey R., Palmer, Nicholette D., Peyser, Patricia A., Psaty, Bruce M., Raffield, Laura M., Redline, Susan, Reiner, Alexander P., Reupena, Muagututi’a Sefuiva, Rice, Kenneth M., Rich, Stephen S., Sitlani, Colleen M., Smith, Jennifer A., Taylor, Kent D., Vasan, Ramachandran S., Willer, Cristen J., Wilson, James G., Yanek, Lisa R., Zhao, Wei, Rotter, Jerome I., Natarajan, Pradeep, Peloso, Gina M., Li, Zilin, and Lin, Xihong

Published
2023
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210. A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

Author

Li, Zilin, Li, Xihao, Zhou, Hufeng, Gaynor, Sheila M., Selvaraj, Margaret Sunitha, Arapoglou, Theodore, Quick, Corbin, Liu, Yaowu, Chen, Han, Sun, Ryan, Dey, Rounak, Arnett, Donna K., Auer, Paul L., Bielak, Lawrence F., Bis, Joshua C., Blackwell, Thomas W., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Brody, Jennifer A., Cade, Brian E., Conomos, Matthew P., Correa, Adolfo, Cupples, L. Adrienne, Curran, Joanne E., de Vries, Paul S., Duggirala, Ravindranath, Franceschini, Nora, Freedman, Barry I., Göring, Harald H. H., Guo, Xiuqing, Kalyani, Rita R., Kooperberg, Charles, Kral, Brian G., Lange, Leslie A., Lin, Bridget M., Manichaikul, Ani, Manning, Alisa K., Martin, Lisa W., Mathias, Rasika A., Meigs, James B., Mitchell, Braxton D., Montasser, May E., Morrison, Alanna C., Naseri, Take, O’Connell, Jeffrey R., Palmer, Nicholette D., Peyser, Patricia A., Psaty, Bruce M., Raffield, Laura M., Redline, Susan, Reiner, Alexander P., Reupena, Muagututi’a Sefuiva, Rice, Kenneth M., Rich, Stephen S., Smith, Jennifer A., Taylor, Kent D., Taub, Margaret A., Vasan, Ramachandran S., Weeks, Daniel E., Wilson, James G., Yanek, Lisa R., Zhao, Wei, Rotter, Jerome I., Willer, Cristen J., Natarajan, Pradeep, Peloso, Gina M., and Lin, Xihong

Published
2022
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211. Above the Gene, Beyond Biology : Toward a Philosophy of Epigenetics

Author

Jan Baedke and Jan Baedke

Subjects
Epigenetics--Methodology, Epigenetics--Philosophy, Medicine--Philosophy
Abstract

Epigenetics is currently one of the fastest-growing fields in the sciences. Epigenetic information not only controls DNA expression but links genetic factors with the environmental experiences that influence the traits and characteristics of an individual. What we eat, where we work, and how we live affects not only the activity of our genes but that of our offspring as well. This discovery has imposed a revolutionary theoretical shift on modern biology, especially on evolutionary theory. It has helped to uncover the developmental processes leading to cancer, obesity, schizophrenia, alcoholism, and aging, and to facilitate associated medial applications such as stem cell therapy and cloning. Above the Gene, Beyond Biology explores how biologists in this booming field investigate and explain living systems. Jan Baedke offers the first comprehensive philosophical discussion of epigenetic concepts, explanations, and methodologies so that we can better understand this “epigenetic turn” in the life sciences from a philosophical perspective.

Published
2018

212. Foundations and Applications of Statistics

Author

Randall Pruim and Randall Pruim

Subjects
Mathematical statistics--Data processing, R (Computer program language)
Abstract

Foundations and Applications of Statistics simultaneously emphasizes both the foundational and the computational aspects of modern statistics. Engaging and accessible, this book is useful to undergraduate students with a wide range of backgrounds and career goals. The exposition immediately begins with statistics, presenting concepts and results from probability along the way. Hypothesis testing is introduced very early, and the motivation for several probability distributions comes from p-value computations. Pruim develops the students'practical statistical reasoning through explicit examples and through numerical and graphical summaries of data that allow intuitive inferences before introducing the formal machinery. The topics have been selected to reflect the current practice in statistics, where computation is an indispensible tool. In this vein, the statistical computing environment $\mathsf{R}$ is used throughout the text and is integral to the exposition. Attention is paid to developing students'mathematical and computational skills as well as their statistical reasoning. Linear models, such as regression and ANOVA, are treated with explicit reference to the underlying linear algebra, which is motivated geometrically. Foundations and Applications of Statistics discusses both the mathematical theory underlying statistics and practical applications that make it a powerful tool across disciplines. The book contains ample material for a two-semester course in undergraduate probability and statistics. A one-semester course based on the book will cover hypothesis testing and confidence intervals for the most common situations. In the second edition, the $\mathsf{R}$ code has been updated throughout to take advantage of new $\mathsf{R}$ packages and to illustrate better coding style. New sections have been added covering bootstrap methods, multinomial and multivariate normal distributions, the delta method, numerical methods for Bayesian inference, and nonlinear least squares. Also, the use of matrix algebra has been expanded, but remains optional, providing instructors with more options regarding the amount of linear algebra required.

Published
2018

213. Reports Outline Cholelithiasis Study Results from Queen Mary University of London (Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis)

Subjects
Genetic variation -- Physiological aspects, Pleiotropy -- Physiological aspects, Blood lipids -- Genetic aspects -- Measurement -- Health aspects, Dimorphism (Biology) -- Physiological aspects, Health
Abstract

2023 JAN 21 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on cholelithiasis. According to news reporting out of [...]

Published
2023

214. Report Summarizes Atherosclerosis Study Findings from University of Michigan (Clinical, Genetic, and Experimental Increase In Soluble Urokinase Plasminogen Activator Receptor Levels Promotes Atherosclerosis)

Subjects
Thrombolytic drugs -- Health aspects, Atherosclerosis -- Genetic aspects -- Development and progression -- Care and treatment, Health
Abstract

2022 DEC 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Cardiovascular Diseases and Conditions - Atherosclerosis is now [...]

Published
2022

215. American Shame : Stigma and the Body Politic

Author

Myra Mendible and Myra Mendible

Subjects
Shame--Social aspects--United States, Shame--Political aspects--United States, Popular culture--United States, Political culture--United States
Abstract

Essays examining the role of shame as an American cultural practice and how public shaming enforces conformity and group coherence.On any given day in America's news cycle, stories and images of disgraced politicians and celebrities solicit our moral indignation, their misdeeds fueling a lucrative economy of shame and scandal. Shame is one of the most coercive, painful, and intriguing of human emotions. Only in recent years has interest in shame extended beyond a focus on the subjective experience of this emotion and its psychological effects. The essays collected here consider the role of shame as cultural practice and examine ways that public shaming practices enforce conformity and group coherence. Addressing abortion, mental illness, suicide, immigration, and body image among other issues, this volume calls attention to the ways shaming practices create and police social boundaries; how shaming speech is endorsed, judged, or challenged by various groups; and the distinct ways that shame is encoded and embodied in a nation that prides itself on individualism, diversity, and exceptionalism. Examining shame through a prism of race, sexuality, ethnicity, and gender, these provocative essays offer a broader understanding of how America's discourse of shame helps to define its people as citizens, spectators, consumers, and moral actors.“An eclectic anthology, it offers the readers more than one argument and perspective, which makes the volume itself lively and rich.” —Ron Scapp, coeditor of Fashion Statements: On Style, Appearance, and Reality

Published
2016

216. Nutritional Biochemistry : Current Topics in Nutrition Research

Author

Chad Cox and Chad Cox

Subjects
Nutritional Physiological Phenomena, Biochemical Phenomena, Diet Therapy--methods, Nutrition Disorders--etiology
Abstract

This title includes a number of Open Access chapters. Nutrition is becoming ever more central to our understanding of metabolic processes. Nutritional biochemistry offers insight into the mechanisms by which diet influences human health and disease. This book focuses on five aspects of this complex field of study: nutritional genomics, clinical nut

Published
2015

217. Postgenomics : Perspectives on Biology After the Genome

Author

Sarah S. Richardson, Hallam Stevens, Sarah S. Richardson, and Hallam Stevens

Subjects
Genetic markers, Transgenic organisms, Gene mapping, Human gene mapping, Genetic engineering--Moral and ethical aspects, Genomics--Moral and ethical aspects
Abstract

Ten years after the Human Genome Project's completion the life sciences stand in a moment of uncertainty, transition, and contestation. The postgenomic era has seen rapid shifts in research methodology, funding, scientific labor, and disciplinary structures. Postgenomics is transforming our understanding of disease and health, our environment, and the categories of race, class, and gender. At the same time, the gene retains its centrality and power in biological and popular discourse. The contributors to Postgenomics analyze these ruptures and continuities and place them in historical, social, and political context. Postgenomics, they argue, forces a rethinking of the genome itself, and opens new territory for conversations between the social sciences, humanities, and life sciences.Contributors. Russ Altman, Rachel A. Ankeny, Catherine Bliss, John Dupré, Michael Fortun, Evelyn Fox Keller, Sabina Leonelli, Adrian Mackenzie, Margot Moinester, Aaron Panofsky, Sarah S. Richardson, Sara Shostak, Hallam Stevens

Published
2015

218. Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Author

Howe, Laurence J., Nivard, Michel G., Morris, Tim T., Hansen, Ailin F., Rasheed, Humaira, Cho, Yoonsu, Chittoor, Geetha, Ahlskog, Rafael, Lind, Penelope A., Palviainen, Teemu, van der Zee, Matthijs D., Cheesman, Rosa, Mangino, Massimo, Wang, Yunzhang, Li, Shuai, Klaric, Lucija, Ratliff, Scott M., Bielak, Lawrence F., Nygaard, Marianne, Giannelis, Alexandros, Willoughby, Emily A., Reynolds, Chandra A., Balbona, Jared V., Andreassen, Ole A., Ask, Helga, Baras, Aris, Bauer, Christopher R., Boomsma, Dorret I., Campbell, Archie, Campbell, Harry, Chen, Zhengming, Christofidou, Paraskevi, Corfield, Elizabeth, Dahm, Christina C., Dokuru, Deepika R., Evans, Luke M., de Geus, Eco J. C., Giddaluru, Sudheer, Gordon, Scott D., Harden, K. Paige, Hill, W. David, Hughes, Amanda, Kerr, Shona M., Kim, Yongkang, Kweon, Hyeokmoon, Latvala, Antti, Lawlor, Deborah A., Li, Liming, Lin, Kuang, Magnus, Per, Magnusson, Patrik K. E., Mallard, Travis T., Martikainen, Pekka, Mills, Melinda C., Njølstad, Pål Rasmus, Overton, John D., Pedersen, Nancy L., Porteous, David J., Reid, Jeffrey, Silventoinen, Karri, Southey, Melissa C., Stoltenberg, Camilla, Tucker-Drob, Elliot M., Wright, Margaret J., Hewitt, John K., Keller, Matthew C., Stallings, Michael C., Lee, James J., Christensen, Kaare, Kardia, Sharon L. R., Peyser, Patricia A., Smith, Jennifer A., Wilson, James F., Hopper, John L., Hägg, Sara, Spector, Tim D., Pingault, Jean-Baptiste, Plomin, Robert, Havdahl, Alexandra, Bartels, Meike, Martin, Nicholas G., Oskarsson, Sven, Justice, Anne E., Millwood, Iona Y., Hveem, Kristian, Naess, Øyvind, Willer, Cristen J., Åsvold, Bjørn Olav, Koellinger, Philipp D., Kaprio, Jaakko, Medland, Sarah E., Walters, Robin G., Benjamin, Daniel J., Turley, Patrick, Evans, David M., Davey Smith, George, Hayward, Caroline, Brumpton, Ben, Hemani, Gibran, and Davies, Neil M.

Published
2022
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219. Recent Research from University of Michigan Highlight Findings in Aortic Dissection (Aortic Progression and Reintervention In Patients With Pathogenic Variants After a Thoracic Aortic Dissection)

Subjects
Dissecting aneurysm -- Care and treatment -- Genetic aspects -- Development and progression, Cardiovascular research, Genetic variation -- Research, Health
Abstract

2022 MAR 12 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Cardiovascular Diseases and Conditions - Aortic Dissection are discussed [...]

Published
2022

220. Findings from University of Cambridge Broaden Understanding of Medical Research (Responsible Use of Polygenic Risk Scores In the Clinic: Potential Benefits, Risks and Gaps)

Subjects
United Kingdom. Economic and Social Research Council, United States. National Institutes of Health, Medical research -- Usage, Medicine, Experimental -- Usage, Physical fitness -- Usage, Health, University of Cambridge
Abstract

2021 DEC 18 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Health and Medicine - Medical Research are discussed in [...]

Published
2021

221. New Molecular Genetics Data Have Been Reported by Investigators at Peking University (An Asian-specific Mpl Genetic Variant Alters Jak-stat Signaling and Influences Platelet Count In the Population)

Subjects
Medical research, Medicine, Experimental, Genomics -- Research, Genetic research, Physical fitness -- Research, Health, Beijing University
Abstract

2021 DEC 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Life Science Research - Molecular Genetics. According [...]

Published
2021

222. Reports from NTNU - Norwegian University of Science and Technology Provide New Insights into Muscle Proteins (Genome-wide Association Study of Cardiac Troponin I In the General Population)

Subjects
United States. National Institutes of Health, Heart diseases, Medical research, Medicine, Experimental, Genomics, Genetic research, Physical fitness, Health
Abstract

2021 DEC 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Proteins - Muscle Proteins have been published. According [...]

Published
2021

224. Studies from Massachusetts General Hospital Add New Findings in the Area of Heart Disease (Discovery and Systematic Characterization of Risk Variants and Genes for Coronary Artery Disease In Over a Million Participants)

Subjects
United States. National Institutes of Health -- Reports, Coronary heart disease -- Genetic aspects, Medical research -- Reports, Medicine, Experimental -- Reports, Genetic research -- Reports -- Genetic aspects, Genes -- Reports -- Genetic aspects, Health, Massachusetts General Hospital -- Reports
Abstract

2023 JUL 3 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Research findings on Heart Disorders and Diseases - Heart Disease are discussed in a new [...]

Published
2023

226. New Heart Failure Findings Has Been Reported by Investigators at Weill Cornell Medicine (Complex and Potentially Harmful Medication Patterns In Heart Failure With Preserved Ejection Fraction)

Subjects
Medical research, Medicine, Experimental, Drugs -- Research, Physical fitness -- Research, Heart failure -- Drug therapy -- Research, Health
Abstract

2021 MAY 1 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Heart Disorders and Diseases - Heart Failure have [...]

Published
2021

227. New Findings from University of Michigan Update Understanding of Cardiovascular Drugs and Therapies (Translating Genetic Association of Lipid Levels for Biological and Clinical Application)

Subjects
Medical research, Medicine, Experimental, Cardiovascular agents, Genetic research, Physical fitness, Health, University of Michigan
Abstract

2021 APR 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Drugs and Therapies - Cardiovascular Drugs and Therapies [...]

Published
2021

228. Findings on Science Detailed by Investigators at University of Michigan (Sequencing of 53,831 Diverse Genomes From the Nhlbi Topmed Program)

Subjects
United States. National Heart, Lung and Blood Institute -- Reports, Genomics -- Reports -- Research, Genomes -- Research -- Reports, Physical fitness -- Research -- Reports, Health, University of Michigan -- Reports
Abstract

2021 MAR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Science are presented in a new report. According to [...]

Published
2021

229. Reports from University of Michigan Advance Knowledge in Atherosclerosis (Increased Soluble Urokinase Plasminogen Activator Levels Modulate Monocyte Function To Promote Atherosclerosis)

Subjects
United States. National Institutes of Health, United States. National Heart, Lung and Blood Institute, Medical research, Medicine, Experimental, Urokinase -- Research, Cardiovascular diseases -- Research, Kidney diseases -- Research, Atherosclerosis -- Research, Health, University of Michigan
Abstract

2023 MAR 31 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Cardiovascular Diseases and Conditions - Atherosclerosis. According to [...]

Published
2023

230. Findings on Life Science Discussed by Investigators at Harvard T.H. Chan School of Public Health (Powerful, Scalable and Resource-efficient Meta-analysis of Rare Variant Associations In Large Whole Genome Sequencing Studies)

Subjects
Nucleotide sequencing -- Methods, Meta-analysis -- Usage, Genetic research -- Methods, DNA sequencing -- Methods, Biological sciences, Health
Abstract

2023 MAR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Life Science. According to news reporting originating in Boston, [...]

Published
2023

231. New Heart Disease Findings from Massachusetts General Hospital Discussed (Association of Rare Protein-truncating Dna Variants In Apob or Pcsk9 With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease)

Subjects
United States. National Heart, Lung and Blood Institute, Medical research, Medicine, Experimental, Blood cholesterol -- Research, Coronary heart disease -- Risk factors -- Research, DNA -- Research, Trans fatty acids -- Research, Low density lipoproteins -- Research, Health, Massachusetts General Hospital
Abstract

2023 MAR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Data detailed on Heart Disorders and Diseases - Heart Disease have been presented. According to [...]

Published
2023

232. Study Findings from Norwegian University of Science and Technology (NTNU) Provide New Insights into Obesity [Genetic Associations With Temporal Shifts In Obesity and Severe Obesity During the Obesity Epidemic In Norway: a Longitudinal ...]

Subjects
Medical research, Medicine, Experimental, Obesity, Physical fitness, Health, Public Library of Science
Abstract

2021 JAN 30 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Nutritional and Metabolic Diseases and Conditions - Obesity [...]

Published
2021

233. Investigators at University of Cambridge Describe Findings in Genetics (Discovery of Rare Variants Associated With Blood Pressure Regulation Through Meta-analysis of 1.3 Million Individuals)

Subjects
Blood pressure -- Laws, regulations and rules -- Analysis, Genetic research -- Laws, regulations and rules -- Analysis, Physical fitness -- Laws, regulations and rules -- Analysis, Government regulation, Health, University of Cambridge
Abstract

2021 JAN 2 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Life Science Research - Genetics. According to [...]

Published
2021

234. Data from University of Michigan Provide New Insights into Osteoporosis (Mepe Loss-of-function Variant Associates With Decreased Bone Mineral Density and Increased Fracture Risk)

Subjects
Osteoporosis -- Risk factors -- Research, Physical fitness -- Research, Fractures (Injuries) -- Research -- Risk factors, Medical research, Genomics -- Research, Health, University of Michigan. Medical School
Abstract

2020 DEC 5 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Musculoskeletal Diseases and Conditions - Osteoporosis is now [...]

Published
2020

235. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

Author

Li, Xihao, Li, Zilin, Zhou, Hufeng, Gaynor, Sheila M., Liu, Yaowu, Chen, Han, Sun, Ryan, Dey, Rounak, Arnett, Donna K., Aslibekyan, Stella, Ballantyne, Christie M., Bielak, Lawrence F., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Broome, Jai G., Conomos, Matthew P., Correa, Adolfo, Cupples, L. Adrienne, Curran, Joanne E., Freedman, Barry I., Guo, Xiuqing, Hindy, George, Irvin, Marguerite R., Kardia, Sharon L. R., Kathiresan, Sekar, Khan, Alyna T., Kooperberg, Charles L., Laurie, Cathy C., Liu, X. Shirley, Mahaney, Michael C., Manichaikul, Ani W., Martin, Lisa W., Mathias, Rasika A., McGarvey, Stephen T., Mitchell, Braxton D., Montasser, May E., Moore, Jill E., Morrison, Alanna C., O’Connell, Jeffrey R., Palmer, Nicholette D., Pampana, Akhil, Peralta, Juan M., Peyser, Patricia A., Psaty, Bruce M., Redline, Susan, Rice, Kenneth M., Rich, Stephen S., Smith, Jennifer A., Tiwari, Hemant K., Tsai, Michael Y., Vasan, Ramachandran S., Wang, Fei Fei, Weeks, Daniel E., Weng, Zhiping, Wilson, James G., Yanek, Lisa R., Neale, Benjamin M., Sunyaev, Shamil R., Abecasis, Gonçalo R., Rotter, Jerome I., Willer, Cristen J., Peloso, Gina M., Natarajan, Pradeep, and Lin, Xihong

Published
2020
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237. Researchers from Regeneron Pharmaceuticals Report Details of New Studies and Findings in the Area of Science (Exome Sequencing and Characterization of 49,960 Individuals In the Uk Biobank)

Subjects
Regeneron Pharmaceuticals Inc. -- Reports, Physical fitness -- Research -- Reports, Pharmaceutical industry -- Reports -- Research, Health
Abstract

2020 NOV 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Science have been published. According to news reporting [...]

Published
2020

238. Findings from University of Michigan Broaden Understanding of Thyroid Cancer (Gwas of Thyroid Stimulating Hormone Highlights Pleiotropic Effects and Inverse Association With Thyroid Cancer)

Subjects
Thyroid cancer -- Reports -- Physiological aspects, Physical fitness -- Physiological aspects -- Reports, Glycoproteins -- Reports -- Physiological aspects, Pituitary hormones -- Reports -- Physiological aspects, Genetic markers -- Reports -- Physiological aspects, Genomics -- Physiological aspects -- Reports, Health, University of Michigan -- Reports
Abstract

2020 SEP 19 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Oncology - Thyroid Cancer. According to news [...]

Published
2020

239. New Heart Disease Findings from University of Michigan Published (Sex-Specific Survival Bias and Interaction Modeling in Coronary Artery Disease Risk Prediction)

Subjects
Medical research -- Models, Medicine, Experimental -- Models, Coronary heart disease -- Risk factors -- Research, Health, University of Michigan
Abstract

2023 JAN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Data detailed on heart disease have been presented. According to news reporting out of the [...]

Published
2023

240. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production

Author

Guo, Yanhong, Fan, Yanbo, Zhang, Jifeng, Lomberk, Gwen A., Zhou, Zhou, Sun, Lijie, Mathison, Angela J., Garcia-Barrio, Minerva T., Zhang, Ji, Zeng, Lixia, Li, Lei, Pennathur, Subramaniam, Willer, Cristen J., Rader, Daniel J., Urrutia, Raul, and Chen, Y. Eugene

Subjects
Apolipoproteins, Transcription factors -- Health aspects, Atherosclerosis, Health care industry
Abstract

Recent genome-wide association studies have revealed that variations near the gene locus encoding the transcription factor Kruppel-like factor 14 (KLF14) are strongly associated with HDL cholesterol (HDL-C) levels, metabolic syndrome, and coronary heart disease. However, the precise mechanisms by which KLF14 regulates lipid metabolism and affects atherosclerosis remain largely unexplored. Here, we report that KLF14 is dysregulated in the liver of 2 dyslipidemia mouse models. We evaluated the effects of both KLF14 overexpression and genetic inactivation and determined that KLF14 regulates plasma HDL-C levels and cholesterol efflux capacity by modulating hepatic ApoA-I production. Hepatic-specific Klf14 deletion in mice resulted in decreased circulating HDL-C levels. In an attempt to pharmacologically target KLF14 as an experimental therapeutic approach, we identified perhexiline, an approved therapeutic small molecule presently in clinical use to treat angina and heart failure, as a KLF14 activator. Indeed, in WT mice, treatment with perhexiline increased HDL-C levels and cholesterol efflux capacity via KLF14-mediated upregulation of ApoA-I expression. Moreover, perhexiline administration reduced atherosclerotic lesion development in apolipoprotein E-deficient mice. Together, these results provide comprehensive insight into the KLF14-dependent regulation of HDL-C and subsequent atherosclerosis and indicate that interventions that target the KLF14 pathway should be further explored for the treatment of atherosclerosis., Introduction Atherosclerosis-related cardiovascular disease (CVD), including coronary heart disease (CHD), ischemic stroke, and peripheral arterial disease, is the most common cause of death and disability worldwide. Epidemiologic studies and experimental [...]

Published
2015
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241. New genetic loci link adipose and insulin biology to body fat distribution

Author

Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M.W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., and Song, Ci

Subjects
Quantitative trait loci -- Physiological aspects -- Discovery and exploration, Adipose tissues -- Genetic aspects -- Distribution -- Physiological aspects, Insulin -- Physiological aspects -- Genetic aspects, Company distribution practices, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10.sup.-8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution. Cardiometabolic traits linked to body fat distribution In the first of a pair of Articles in this issue from the GIANT Consortium, genome-wide association meta-analyses of waist and hip circumference-related traits in more than 200,000 individuals have been used to identify 49 loci -- 33 of them new -- associated with waist-to-hip ratio adjusted for body mass index and an additional 19 loci associated with related waist and hip circumference measures. A subset of these loci shows significant sexual dimorphism, with many showing a stronger effect in women. Analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms and offer potential targets for interventions in the risks associated with abdominal fat accumulation., Author(s): Dmitry Shungin [sup.1] [sup.2] [sup.3] , Thomas W. Winkler [sup.4] , Damien C. Croteau-Chonka [sup.5] [sup.6] , Teresa Ferreira [sup.7] , Adam E. Locke [sup.8] , Reedik Mägi [sup.7] [...]

Published
2015
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242. Genetic studies of body mass index yield new insights for obesity biology

Subjects
Obesity -- Genetic aspects, Gene expression -- Research, Genetic research, Diabetes -- Research, Body mass index -- Genetic aspects -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x [10.sup.28]), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis., A list of authors and their affiliations appears at the end of the paper Obesity is a worldwide epidemic associated with increased morbidity and mortality that imposes an enormous burden [...]

Published
2015
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243. New genetic loci link adipose and insulin biology to body fat distribution

Subjects
Metabolism -- Genetic aspects, Quantitative trait loci -- Research, Genetic research, Adipose tissues -- Genetic aspects -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P, Depot-specific accumulation of fat, particularly in the central abdomen, confers an increased risk of metabolic and cardiovascular diseases and mortality (1). An easily accessible measure of body fat distribution is [...]

Published
2015
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244. Studies from Harvard T.H. Chan School of Public Health in the Area of Life Science Reported (A Framework for Detecting Noncoding Rare-variant Associations of Large-scale Whole-genome Sequencing Studies)

Subjects
Nucleotide sequencing -- Methods, DNA sequencing -- Methods, Biological sciences, Health
Abstract

2022 NOV 29 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Life Science. According to news originating from Boston, Massachusetts, [...]

Published
2022

245. New Findings from Lung and Blood Institute in the Area of Venous Thromboembolism Described (Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors)

Subjects
Genomics -- Investigations -- Analysis, Thromboembolism -- Analysis -- Investigations, Company legal issue, Health
Abstract

2022 OCT 31 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Investigators discuss new findings in venous thromboembolism. According to news originating from the Lung and [...]

Published
2022

246. Findings in Life Science Reported from University of Pennsylvania (A Multi-layer Functional Genomic Analysis To Understand Noncoding Genetic Variation In Lipids)

Subjects
Lipids -- Genetic aspects, Genetic variation -- Physiological aspects, Genome-wide association studies, Biological sciences, Health
Abstract

2022 OCT 11 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Life Science are presented in a new report. According to news [...]

Published
2022

248. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Author

Justice, Anne E., Karaderi, Tugce, Highland, Heather M., Young, Kristin L., Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L., Fine, Rebecca S., Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W., Locke, Adam E., Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie C. Y., Heard-Costa, Nancy L., Feitosa, Mary F., Manning, Alisa K., Willems, Sara M., Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S., Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Broer, Linda, Burt, Amber A., Butterworth, Adam S., Caulfield, Mark J., Cesana, Giancarlo, Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Collins, Francis S., Cook, James P., Cox, Amanda J., Crosslin, David S., Danesh, John, de Bakker, Paul I. W., Denus, Simon de, Mutsert, Renée de, Dedoussis, George, Demerath, Ellen W., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Dörr, Marcus, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Fornage, Myriam, Fox, Caroline S., Franks, Paul W., Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Girotto, Giorgia, Gorski, Mathias, Grallert, Harald, Grarup, Niels, Grove, Megan L., Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T., Hayward, Caroline, Heid, Iris M., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jarvik, Gail P., Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M., Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kovacs, Peter, Krämer, Bernhard K., Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Luan, Jian’an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas G. D., McCarthy, Mark I., Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O., Morgan, Anna, Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Ntalla, Ioanna, O’Connell, Jeffrey R., Owen, Katharine R., Pedersen, Oluf, Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T., Rasheed, Asif, Raulerson, Chelsea K., Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Ridker, Paul M., Rivas, Manuel A., Robertson, Neil R., Robino, Antonietta, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Blair H., Smith, Jennifer A., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin M. A., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van Duijn, Cornelia M., Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H., Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M. Carola, Rivadeneira, Fernando, Borecki, Ingrid B., Pospisilik, J. Andrew, Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, Mohlke, Karen L., Rotter, Jerome I., Kutalik, Zoltán, Hirschhorn, Joel N., Cupples, L. Adrienne, Loos, Ruth J. F., North, Kari E., and Lindgren, Cecilia M.

Published
2019
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249. Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease

Author

Nielsen, Jonas B., Rom, Oren, Surakka, Ida, Graham, Sarah E., Zhou, Wei, Roychowdhury, Tanmoy, Fritsche, Lars G., Gagliano Taliun, Sarah A., Sidore, Carlo, Liu, Yuhao, Gabrielsen, Maiken E., Skogholt, Anne Heidi, Wolford, Brooke, Overton, William, Zhao, Ying, Chen, Jin, Zhang, He, Hornsby, Whitney E., Acheampong, Akua, Grooms, Austen, Schaefer, Amanda, Zajac, Gregory J. M., Villacorta, Luis, Zhang, Jifeng, Brumpton, Ben, Løset, Mari, Rai, Vivek, Lundegaard, Pia R., Olesen, Morten S., Taylor, Kent D., Palmer, Nicholette D., Chen, Yii-Der, Choi, Seung H., Lubitz, Steven A., Ellinor, Patrick T., Barnes, Kathleen C., Daya, Michelle, Rafaels, Nicholas, Weiss, Scott T., Lasky-Su, Jessica, Tracy, Russell P., Vasan, Ramachandran S., Cupples, L. Adrienne, Mathias, Rasika A., Yanek, Lisa R., Becker, Lewis C., Peyser, Patricia A., Bielak, Lawrence F., Smith, Jennifer A., Aslibekyan, Stella, Hidalgo, Bertha A., Arnett, Donna K., Irvin, Marguerite R., Wilson, James G., Musani, Solomon K., Correa, Adolfo, Rich, Stephen S., Guo, Xiuqing, Rotter, Jerome I., Konkle, Barbara A., Johnsen, Jill M., Ashley-Koch, Allison E., Telen, Marilyn J., Sheehan, Vivien A., Blangero, John, Curran, Joanne E., Peralta, Juan M., Montgomery, Courtney, Sheu, Wayne H-H, Chung, Ren-Hua, Schwander, Karen, Nouraie, Seyed M., Gordeuk, Victor R., Zhang, Yingze, Kooperberg, Charles, Reiner, Alexander P., Jackson, Rebecca D., Bleecker, Eugene R., Meyers, Deborah A., Li, Xingnan, Das, Sayantan, Yu, Ketian, LeFaive, Jonathon, Smith, Albert, Blackwell, Tom, Taliun, Daniel, Zollner, Sebastian, Forer, Lukas, Schoenherr, Sebastian, Fuchsberger, Christian, Pandit, Anita, Zawistowski, Matthew, Kheterpal, Sachin, Brummett, Chad M., Natarajan, Pradeep, Schlessinger, David, Lee, Seunggeun, Kang, Hyun Min, Cucca, Francesco, Holmen, Oddgeir L., Åsvold, Bjørn O., Boehnke, Michael, Kathiresan, Sekar, Abecasis, Goncalo R., Chen, Y. Eugene, Willer, Cristen J., and Hveem, Kristian

Published
2020
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250. Experimental Models of Multiple Sclerosis

Author

Ehud Lavi, Cris S. Constantinescu, Ehud Lavi, and Cris S. Constantinescu

Subjects
Diseases--Animal models, Pathology, Multiple sclerosis, Multiple sclerosis--Animal models
Abstract

Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It's aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.

Published
2005

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