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The article focuses on remarkable aspect of the COVID-19 pandemic is the intensity of the search for novel diagnostic and therapeutic tools. Topics include the recognition that COVID-19 is a novel disease with a multitude of clinical manifestations and unexpected respiratory phenotypes, overwhelming number of severely ill patients with COVID-19 pneumonia has generated a lot of information, and the data has poured out of country after country has passed many problems of COVID-19.

The authors convey their thoughts about indwelling pleural catheters (IPCs) for malignant pleural effusions. Topics mentioned include the practice of offering pleural interventions to patients who are truly asymptomatic, the impact of IPCs on the need for further pleural interventions and the number of days spent in hospital, and the use of a low-cost alternative to the current commercially available IPCs.

Kenneth E. Kirk is regarded as the person who revived moral theology in the Anglican tradition in the early to mid-twentieth century. This article argues that a renewal of interest in mysticism, led especially by W.R. Inge and Evelyn Underhill in the first two decades of the twentieth century, was influential upon Kirk’s outlook, especially his association of moral theology with ascetic theology (or mystical theology), and linking of personal holiness with ethics. Kirk made prayer – especially contemplative prayer – and worship primary in the education of the soul, the forging of Christian character and therefore the creation of a moral agent. [ABSTRACT FROM AUTHOR]

Tuberculosis (TB) is the leading infectious cause of death worldwide, and the commonest cause of death in people living with HIV. Globally, pleural TB remains one of the most frequent causes of pleural exudates, particularly in TB-endemic areas and in the HIV positive population. Most TB pleural effusions are exudates with high adenosine deaminase (ADA), lymphocyte-rich, straw-coloured and free flowing, with a low yield on mycobacterial culture. TB pleurisy can also present as loculated neutrophilpredominant effusions which mimic parapneumonic effusions. Rarely, they can present as frank TB empyema, containing an abundance of mycobacteria. Up to 80% of patients have parenchymal involvement on chest imaging. The diagnosis is simple if M. tuberculosis is detected in sputum, pleural fluid or biopsy specimens, and the recent advent of liquid medium culture techniques has increased the microbiological yield dramatically. Where the prevalence of TB is high the presence of a lymphocytepredominant exudate with a high ADA has a positive predictive value of 98%. In low prevalence areas, the absence of an elevated ADA and lymphocyte predominance makes TB very unlikely, and pleural biopsy should be performed to confirm the diagnosis. Pleural biopsy for liquid culture and susceptibility testing must also be considered where the prevalence of drug resistant TB is high. Treatment regimens are identical to those administered for pulmonary TB. Initial pleural drainage may have a role in symptom relief and in hastening the resolution of the effusion. Surgical intervention may be required in loculated effusions and empyemas. [ABSTRACT FROM AUTHOR]

Summary: Peptide hormones are implicated in many important aspects of plant life and are usually synthesized as precursor proteins. In contrast to animals, data for plant peptide hormone maturation are scarce and the specificity of processing enzyme(s) is largely unknown. Here we tested a hypothesis that processing of prosystemin, a precursor of tomato (Solanum lycopersicum) wound hormone systemin, is performed by phytaspases, aspartate‐specific proteases of the subtilase family. Following the purification of phytaspase from tomato leaves, two tomato phytaspase genes were identified, the cDNAs were cloned and the recombinant enzymes were obtained after transient expression in Nicotiana benthamiana. The newly identified tomato phytaspases hydrolyzed prosystemin at two aspartate residues flanking the systemin sequence. Site‐directed mutagenesis of the phytaspase cleavage sites in prosystemin abrogated not only the phytaspase‐mediated processing of the prohormone in vitro, but also the ability of prosystemin to trigger the systemic wound response in vivo. The data show that the prohormone prosystemin requires processing for signal biogenesis and biological activity. The identification of phytaspases as the proteases involved in prosystemin maturation provides insight into the mechanisms of wound signaling in tomato. Our data also suggest a novel role for cell death‐related proteases in mediating defense signaling in plants. [ABSTRACT FROM AUTHOR]

Revascularization of an amputated limb within 4–6 h is essential to avoid extensive ischemia/reperfusion (I/R) injury leading to vascular leakage, edema and tissue necrosis. I/R injury is a pathological inflammatory condition that occurs during reperfusion of an organ or tissue after prolonged ischemia. It is characterized by a complex crosstalk between endothelial cell activation and the activation of plasma cascades. Vasculoprotective pharmacological intervention to prevent I/R injury might be an option to prolong the time window between limb amputation and successful replantation. We used C1-easterase inhibitor (C1-INH) in this study because of its known inhibitory effects on the activation of the complement, coagulation and kinin cascades. Forelimbs of 8 large white pigs were amputated, subjected to ischemia, and then reperfused with autologous whole blood. All limbs were exposed to 9 h of cold ischemia at 4 °C. After 2 h of cold ischemia the limbs were either perfused with of C1-INH (1U/ml in hydroxyethyl starch, n = 8) or hydroxyethyl starch alone (n = 7). After completion of the 9-h ischemia period, all limbs were ex vivo perfused with heparinized autologous whole blood for 12 h using a pediatric heart lung machine to simulate in vivo revascularization. Our results show that I/R injury in the control group led to a significant elevation of tissue deposition of IgG and IgM, complement C3b/c, C5b-9 and MBL. Also, activation of the kinin system was significantly increased, namely bradykinin in plasma, and expression of bradykinin receptors 1 and 2 in tissue. In addition, markers for endothelial integrity like expression of CD31, VE-cadherin and heparan sulfate proteoglycans were decreased in reperfused tissue. Limb I/R injury also led to activation of the coagulation cascade with a significant elevation of fibrin and thrombin deposition and increased fibrinogen-like protein-2 expression. C1-INH treated limbs showed much less activation of plasma cascades and better protection of endothelial integrity compared to the reperfused control limbs. In conclusion, the use of the cytoprotective drug C1-INH significantly reduced I/R injury by protecting the vascular endothelium as well as the muscle tissue from deposition of immunoglobulins, complement and fibrin. [ABSTRACT FROM AUTHOR]

Whereas research in the craniosacral field tends to focus on the benefits for the individual, in this paper I go a step further to argue that because of its psychoid nature, biodynamic craniosacral therapy (BCST) acts as an embodied practice to raise earth consciousness at both the collective and individual levels. The therapy is a light-touch practice grounded in empathetic presence in which practitioners work to attune the subtle rhythms of their own body, the client's body, and the "body" of the environment and natural world in which they meet. Referencing my clinical experience, the essay proposes that craniosacral biodynamics, bringing consciousness to the human organism, may offer a felt experience of the interconnectedness of all being, even bringing to consciousness our relationship with the earth itself. This essay highlights where Jungian theory and BCST not only overlap but also where they might support each other to revision our relationship to the planet. [ABSTRACT FROM AUTHOR]

In 1902, William James gave his Gifford Lectures in Edinburgh, entitled The Varieties of Religious Experience, in which he claimed that such experience was a part of human nature, and was necessarily the foundation of all institutional religion. His work has often been singled out as leading to an increasingly private and individualistic understanding of religion, but this paper places his work in a broader movement of the early twentieth century that heralded a revival of interest in religious experience and, especially, mysticism. It explores the work of two English writers, W.R. Inge and Evelyn Underhill, in relation to James, and argues that the revival of interest in mysticism was a significant response to the intellectual challenges to faith in modernity. [ABSTRACT FROM AUTHOR]

The article reflects on the study "Exploring the Impact of Toxic Attitudes and a Toxic Environment on the Veterinary Healthcare Team" which offers suggestions for optimizing team performance. It mentions that a satisfied team can be created through several measures which include maintaining effective communication, setting achievable goals, and dividing work load.

OBJECTIVE To evaluate veterinarian-client communication and veterinarian and client satisfaction with veterinary visits before and after veterinarians underwent a 6-month communication skills training program in a practice setting. DESIGN Case-based pretest-posttest intervention study. SAMPLE I purposely selected companion-animal practice. PROCEDURES The practice team (3 veterinarians. 5 veterinary technicians. I receptionist. and I office manager) participated m a 6-month educational program (intervention) that included interactive communication modules, individual coaching, and a communication laboratory. For each of the veterinarians. 6 appontments were video recorded and 30 additional clients completed a visit satisfaction survey both before and after the intervention. The Roier interaction analysis system was used to analyze the video-recorded appointments. RESULTS After the intervention, appointments were S.4 minutes longer and veterinarians asked 60% fewer elosed-ended lifestyle-social questions, provided M times as much biomedically related client education, and used I S and 1.25 times as much faciliutive and emotional rapport communication, respectively. compared with before the intervention. Clients provided veterinarians with 1.3 times as much biomedically related information and engaged in twice as much social conversation. After the intervention, veterinarians perceived their clients as complaining less and being more personable and trusting, and clients felt more involved in the appointment and reported that the veterinarian expressed greater interest in their opinion. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that the intervention resulted in veterinarians who spent more time educating and building rapport with their clients and facilitating client input in an unhurried environment, which enhanced overall veterinarian visit satisfaction and various aspects of client visit satisfaction. [ABSTRACT FROM AUTHOR]

The article offers information no a study related to the effects of transthoracic ultrasound (TUS) of ultrasonography on daily clinical practitioners. Topics discussed include use of TUS for the assessment of pleural effusions (PE), pneumothoraces, pneumonia, and lung cancer; the role of aetiology and chronicity of an effusion in variations in the TUS appearance of a PE; and the results showing that the echogenicity of a PE have low specificity for identifying an underlying exudate.

The article focuses on significance of role playing in management of communication skills among veterinary team members. Topics discussed include exploration of different qualities associated with team members such as confidentiality, establishment of rapport among team members for stimulation of spontaneity in members, reenactments of different scenarios for enhancement of communication and development of professionalism by role-playing in non-judgmental environment.

We genetically modified tobacco mosaic virus (TMV) to surface display a characterized peptide with potent metal ion binding and reducing capacity (MBP TMV), and demonstrate that unlike wild type TMV, this construct can lead to the formation of discrete 10-40 nm gold nanoparticles when mixed with 3 mM potassium tetrachloroaurate. Using a variety of analytical physicochemical approaches it was found that these nanoparticles were crystalline in nature and stable. Given that the MBP TMV can produce metal nanomaterials in the absence of chemical reductants, it may have utility in the green production of metal nanomaterials. [ABSTRACT FROM AUTHOR]

THE EFFECTIVENESS OF BOOSTER SEATS FOR CHILDREN BETWEEN THE AGES FOUR TO NINE YEARS. Jane A. Shaw and Eugene de Silva, Lincoln Memorial University, Harrogate, Tennessee. This research was conducted [...]

The article looks at the treatment of diseases related to ornamental fish. Topics discussed include instruction on transporting fish, evaluation of fish patients and testing of basic water quality, and use of disposable gloves to minimize possible zoonotic disease transmission and to avoid damage to the fish's skin.

Background: End-stage renal disease is the irreversible final stage of chronic kidney disease and is fatal when not managed by either transplantation or dialysis. Transplantation is generally preferred over dialysis. However, to prevent graft rejection or loss, lifelong immunosuppression is required. Tacrolimus is currently the cornerstone of post-transplantation immunosuppression. The study aim was to carry out an economic evaluation of immunosuppression, including more recent agents such as a once-daily prolonged-release formulation of tacrolimus (Advagraf™) and belatacept, relative to a twice-daily immediate-release formulation of tacrolimus (Prograf™). Methods: A model was constructed comprising six states: onset of biopsy-confirmed acute rejection, functioning graft with or without a biopsy-confirmed acute rejection, non-functioning graft (dialysis), re-transplantation, and death. Data on clinical effectiveness were derived from a systematic literature review and the model captured the effects of patient adherence to immunosuppressant therapy on graft survival using relative risk of graft survival and published data on adherence in patients using Advagraf and Prograf. In the base case, the time horizon was 25 years and one-way and probabilistic sensitivity analyses were conducted. Results: The analysis demonstrated that Prograf was cost-effective when compared with cyclosporin and belatacept and was more effective than sirolimus, but would not be considered cost-effective against sirolimus. The modeled improvement in the adherence profile of patients using Advagraf relative to Prograf resulted in both improved clinical outcomes and reduced costs. Conclusion: Prograf was more clinically effective than cyclosporin, belatacept, and sirolimus, supporting its current positioning as the mainstay of immunosuppressive therapy in renal transplant recipients. Based on improved patient adherence with Advagraf, the model projected that Advagraf would be both more effective and less costly than Prograf. Replacing Prograf with Advagraf as the standard of care for post-transplant immunosuppression could likely result in both cost savings and improved clinical outcomes. [ABSTRACT FROM AUTHOR]

The article offers information on the concept of men who cry in the workplace. Topics discussed include the difference between men and women in expressing emotion, the expectation in men as strong, breadwinners, and leaders, and the research which found out that expression of emotions is associated with power and status in workplace relationships. Also mentioned the battle against societal constraints and cultural norms of showing emotions by men.

Cajal bodies (CBs) are distinct nuclear bodies physically and functionally associated with the nucleolus. In addition to their traditional function in coordinating maturation of certain nuclear RNAs, CBs participate in cell cycle regulation, development, and regulation of stress responses. A key “signature” component of CBs is coilin, the scaffolding protein essential for CB formation and function. Using an RNA silencing (loss-of-function) approach, we describe here new phenomena whereby coilin also affects, directly or indirectly, a variety of interactions between host plants and viruses that have RNA or DNA genomes. Moreover, the effects of coilin on these interactions are manifested differently: coilin contributes to plant defense against tobacco rattle virus (tobravirus), tomato black ring virus (nepovirus), barley stripe mosaic virus (hordeivirus), and tomato golden mosaic virus (begomovirus). In contrast with potato virus Y (potyvirus) and turnip vein clearing virus (tobamovirus), coilin serves to increase virus pathogenicity. These findings show that interactions with coilin (or CBs) may involve diverse mechanisms with different viruses and that these mechanisms act at different phases of virus infection. Thus, coilin (CBs) has novel, unexpected natural functions that may be recruited or subverted by plant viruses for their own needs or, in contrast, are involved in plant defense mechanisms that suppress host susceptibility to the viruses. [ABSTRACT FROM AUTHOR]

This paper highlights five major deficiencies of the introductory economics courses typically taught in the United States: (1) inattention to the key role of private ownership, (2) neglect of the competitive process, (3) lack of coverage of entrepreneurship, (4) neglect of the insights of public choice economics, and (5) inaccurate portrayal of economic central planning. The paper shows how these deficiencies could be remedied with a greater emphasis on economic freedom in introductory courses. The paper also reports on an innovative new course design intended to improve the content and enliven the presentation of basic economics. [ABSTRACT FROM AUTHOR]