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The present study examined the relationship between the worsening of symptoms across a 3-5-year period of time and self-reported physical activity in a sample of 51 individuals with multiple sclerosis (MS). Of the 51 participants, 35 reported a worsening of symptoms over the 3-5-year period of time. The worsening of symptoms was associated with significantly and moderately lower levels of selfreported physical activity independent of depression and EDSS scores and MS-disease course (P=0.04). This study provides novel evidence that a worsening of symptoms is associated with lower levels of physical activity in individuals with MS. [ABSTRACT FROM AUTHOR]

Background: Theoretically, self-regulatory strategies (e.g., goal setting, self-monitoring) are an important influence of behavior change, but very little research has examined the relationship between self-regulation and physical activity (PA) behavior. Petosa's (1993) 43-item PA self-regulation scale (PASR-43) affords the opportunity for studying this construct in the context of PA; however the PASR-43 has not been tested for structural aspects of validity. Therefore, this study examines the structural validity of the PASR-43 in older adults., Methods: The structural validity of the PASR-43 was tested in a large sample of older adults from North and South Carolina and Ohio (N = 460) using maximum likelihood estimation and confirmatory factor analysis in AMOS 5.0., Results: The original 6-factor model for the PASR-43 scale did not represent an acceptable fit to the data (chi2 = 4732.25, df = 845, P < .0001, RMSEA = 0.10, NNFI = 0.67, CFI = 0.71). Based on a post hoc specification search, iterative model modifications resulted in a 12-item PA self-regulation scale (PASR-12) that represented an excellent fit to the data (chi2 = 70.75, df = 39, P = .001, RMSEA = 0.04, NNFI = 0.98, CFI = 0.99)., Conclusions: The PASR-12 provides a concise and valid measure of PA self-regulation for use with older adults. Future studies should cross-validate the PASR-12 and examine invariance across time and between age, ethnic, gender, and geographical groups.

Multiple sclerosis (MS) is the most common neurological disorder in young adults. The prevalence of walking impairment in people with MS (pwMS) is estimated between 41% and 75%. To evaluate the walking capacity in pwMS, the patient reported outcomes (PROs) and performance-based tests (i.e., the 2-minute walk test, the 6-minute walk test, the Timed 25-Foot Walk Test, the Timed Up and Go Test, and the Six Spot Step Test) could be used. However, some studies point out that the results of both performance-based tests and objective measures (i.e., by accelerometer) could not reflect patient reports of walking performance and impact of MS on daily life. This review analyses different motion sensors embedded in smartphones and motion wearable device (MWD) that can be useful to measure free-living walking behavior, to evaluate falls, fatigue, sedentary lifestyle, exercise, and quality of sleep in everyday life of pwMS. Caveats and limitations of MWD such as variable accuracy, user adherence, power consumption and recharging, noise susceptibility, and data management are discussed as well. [ABSTRACT FROM AUTHOR]

Switching attention between or within tasks is part of the implementation and maintenance of executive control processes and plays an indispensable role in our daily lives: It allows us to perform on distinct tasks and with variable objects, enabling us to adapt to and respond in dynamically changing environments. Here, we tested if yoga could benefit switching of attention between distinct objects of one's focus (e.g., through practicing switching between one's own body, feelings, and different postures) in particular and executive control in general. We therefore conducted a randomized controlled trial with 98 participants and a waitlisted control group. In the intervention group, healthy yoga novices practiced Hatha yoga 3x a week, for 8 weeks. We conducted two experiments: A purely behavioral task investigating changes in behavioral costs during switching between attentional control sets (74 participants analyzed), and a modality-switching task focusing on electrophysiology (EEG data of 47 participants analyzed). At the electrophysiological level, frequency-tagging indicated no interventional effect on participants' ability to switch between the auditory and visual modalities. However, increases in task-related frontocentral theta activity, resulting from the intervention, indicated an ability to increasingly deploy executive resources to the prioritized task when needed. At the behavioral level, our intervention resulted in more efficient holding of target representations in working memory, indicated by decreased mixing costs. Again, however, intervention effects on switching costs were missing. We, thus, conclude that Hatha yoga has a positive influence on executive control, potentially through improvements in working memory rather than directly on switching. Clinical trial registration: clinicaltrials.gov , identifier [NCT05232422]. [ABSTRACT FROM AUTHOR]

Background: Dysfunctions of the hypothalamic‐pituitary‐adrenal (HPA) axis can trigger multiple sclerosis (MS) symptoms. Mood disorders comorbid with MS are implicated in the HPA axis activation in most people with MS (pwMS). This study purposed to examine salivary cortisol (SC) levels and their association with mood disorders in pwMS. Methods: Forty‐three men as pwMS and sixteen men as healthy controls (HC) were included in this study. pwMS and HC completed the Beck Depression Inventory (BDI), 36‐Item Short Form Survey (SF‐36), Fatigue Severity Scale (FSS), Depression Anxiety and Stress Scale, and Hospital Anxiety and Depression Scale questionnaires. SC levels were also measured in pwMS and HC. A linear regression model was used to analyze the relationship between the Expanded Disability Status Scale (EDSS) and mood disorders and SC levels. Pearson's or Spearman's tests examined the correlation between SC levels and mood disorders. Results: The SC level, anxiety, depression, fatigue, and stress were significantly higher in pwMS than in HC (p < 0.05). pwMS also showed significant correlations between SC levels and role physical (r = 0.3, p < 0.05) and emotional (r = 0.34, p < 0.05) in SF‐36. Among SF‐36 domains, only general health (β = −0.72, p < 0.05) and physical functioning (β = −1.61, p < 0.05) were negatively associated with disease duration. No correlation was found between SC levels and anxiety, depression, and fatigue (p > 0.05). Conclusions: The pwMS showed mild to moderate depression, anxiety, and fatigue. Only general health and physical functioning as aspects of quality of life were related to disease duration, while SC levels, mood disorders, and other quality‐of‐life domains were not associated with clinical characteristics. Also, this study failed to find a significant role for SC as a valuable marker in approaching mood disorders in pwMS. [ABSTRACT FROM AUTHOR]

Background: Self-esteem is a psychological term that, since its emergence in 1890 with William James, has been widely studied. Furthermore, this construct has been examined in different areas of psychology, including the clinical field, where its relationship with mental health and low levels of depression has been demonstrated. In the realm of positive psychology, its connection to resilience and life satisfaction has also been established. Evaluating self-esteem in military personnel is essential, as healthy self-esteem can enhance resilience, improve performance, and promote emotional well-being. Objective: To evaluate validity based on internal structure from the perspective of Classical Test Theory (CTT) and Item Response Theory (IRT), to obtain evidence of validity based on the relationship with other variables, and to estimate the reliability of the Rosenberg Self-Esteem Scale (RSES). Method: To this end, 584 military personnel from the three ranks of the Spanish Army (officers, non-commissioned officers, and professional soldiers and sailors) were evaluated, of which 511 were men (87.70%) and 72 were women (12.30%), with an age range of 18 to 66 years (M = 33.17, SD = 7.38). Results: The results indicate that the unidimensional structure of the RSES shows adequate fit indices (CFI = 0.94, TLI = 0.91, SRMR = 0.05), while the difficulty and discrimination parameters exhibited favorable values. Additionally, an acceptable reliability value was found (ɷ = 0.81; α = 0.80). Conclusions: Therefore, it is concluded that the RSES-JGA presents adequate psychometric properties of validity and reliability, making it a useful and relevant instrument for measuring self-esteem in military personnel of the Spanish Army. This will make it possible to measure the level of self-esteem in military personnel, i.e., the set of perceptions, thoughts, evaluations, feelings, and behavioral tendencies directed towards oneself, one's own way of being, and towards one's own body and character traits. [ABSTRACT FROM AUTHOR]

Background/Objectives: Individuals with subjective cognitive decline (SCD) have an increased risk of developing dementia, while non-pharmacological multicomponent lifestyle interventions are recommended for prevention/management. The Greek Interventional Geriatric Initiative to Prevent Cognitive Impairment and Disability (GINGER) is such a multicomponent approach, encompassing simultaneous interventions (cognitive training, depression and sleep management, etc.). Exercise/Physical activity (PA) is suggested as one such intervention. This study (i) presents the exercise protocol developed for GINGER and (ii) explores its feasibility (acceptability, applicability, adherence, users' satisfaction and reliability). Methods: Exercise/PA protocol development, targeting SCD individuals aged > 55 years, utilized relevant guidelines/literature followed by focus group involving exercise specialists. Data were synthesized through consensus to design optimal exercise interventions prescribed on participant's physical capacity (heart rate, exertion, etc.), comprising 6-month combined aerobic, strengthening, balance and dual-task exercises, delivered 3 times/weekly in two group-based supervised sessions (in-person and online) and one home-based session. Physical outcomes include balance, aerobic capacity [2-Minute Walk Test (2 MWT), IPAQ-7], strength [Hand Grip Strength (HGS), Sit-to-Stand], fear of falling. Eligibility for entering intervention is low IPAQ-7, 2 MWT or HGS scoring. Feasibility was explored with adherence (exercise diaries and Exercise Adherence Rating Scale) and satisfaction (Patient Satisfaction Questionnaire) Results: Intervention was easily delivered with good reliability across testers' assessments on 13 SCD participants (ICCs = 0.62–0.99), and improved physical outcomes, whereas users' adherence and satisfaction scored highly. Conclusions: The exercise protocol for SCD was feasible, acceptable, applicable, reliable, demonstrating adherence and satisfaction, while improving physical parameters. It is thus integrated in the GINGER study, where multiple simultaneous interventions will take place to prevent/enhance cognitive function. [ABSTRACT FROM AUTHOR]

Objective: To explore the relationship between mental health and physical activity (PA) in middle school students, and examining the roles of negative emotions and self-efficacy in the relationship. Methods: Data from 1,134 Chinese middle school students (50.2% females, 49.8% males; M age = 15.18, SDage = 2.00) were collected using the Physical Activity Rating Scale (PARS-3), Positive and Negative Affect Scale (PANAS), General Self-Efficacy Scale (GSES), and Middle School Student Mental Health Scale (MSSMHS). Results: (1) There is a significant positive correlation between PA and mental health (r = 0.16, p < 0.01), and the direct path of PA on mental health is significant (t = 2.101, p < 0.01). (2) PA negatively predicts negative emotions (r = −0.12, p < 0.01), and is significantly positively correlated with self-efficacy (r = 0.24, p < 0.01). Negative emotions negatively predict self-efficacy (r = −0.23, p < 0.01) and mental health (r = −0.67, p < 0.01). Self-efficacy positively predicts mental health (r = 0.30, p < 0.01). (3) Negative emotions and self-efficacy play a significant mediating role between PA and mental health. The mediating effect includes three paths: PA → negative emotion → mental health (effect value: 0.130); PA → self-efficacy → mental health (effect size: 0.052); PA → negative emotions → self-efficacy → mental health (effect size: 0.006). Conclusion: PA among middle school students can indirectly affect mental health through negative emotions and self-efficacy. Middle school students should be encouraged to participate in PA to reduce their negative emotions and increase their self-efficacy, thus improving their mental health. [ABSTRACT FROM AUTHOR]

Researchers often combine both positively and negatively worded items when constructing Likert scales. This combination, however, may introduce method effects due to the variances in item wording. Although previous studies have tried to quantify these effects by using factor analysis on scales with different content, the impact of varied item wording on participants' choices among specific options remains unexplored. To address this gap, we utilized four versions of the Undergraduate Learning Burnout (ULB) scale, each characterized by a unique valence of item wording. After collecting responses from 1,131 college students, we employed unidimensional, multidimensional, and bi-factor Graded Response Models for analysis. The results suggested that the ULB scale supports a unidimensional structure for the learning burnout trait. However, the inclusion of different valences of wording within items introduced additional method factors, explaining a considerable degree of variance. Notably, positively worded items demonstrated greater discriminative power and more effectively counteracted the biased outcomes associated with negatively worded items, especially between the "Strongly Disagree" and "Disagree" options. While there were no substantial differences in the overall learning burnout traits among respondents of different scale versions, slight variations were noted in their distributions. The integration of both positive and negative wordings reduced the reliability of the learning burnout trait measurement. Consequently, it is recommended to use exclusively positively worded items and avoid a mix in item wording during scale construction. If a combination is essential, the bi-factor IRT model might help segregate the method effects resulting from the wording valence. [ABSTRACT FROM AUTHOR]

Introduction: This study investigates the confounding effects of reverse-coded items on the measurement of confidence in mathematics using data from the 2019 Trends in International Mathematics and Science Study (TIMSS). Methods: The sample came from the Saudi Arabian cohort of 8th graders in 2019 involving 4,515 students. Through mixture modeling, two subgroups responding in similar ways to reverse-coded items were identified representing approximately 9% of the sample. Results: Their response to positively valenced and negatively valenced items showed inconsistency and the observed unexpected response patterns were further verified using Lz*, U3, and the number of Guttman errors person fit indicators. Psychometric analyses on the full sample and the truncated sample after deleting the aberrant responders indicated significant improvements in both internal consistency reliability and factorial validity. Discussion: It was concluded that reverse-coded items contribute to systematic measurement error that is associated with distorted item level parameters that compromised the scale's reliability and validity. The study underscores the need for reconsideration of reverse-coded items in survey design, particularly in contexts involving younger populations and low-achieving students. [ABSTRACT FROM AUTHOR]

An increasing body of evidence confirms the effectiveness of physical exercise (PE) in promoting brain health by preventing age-related cognitive decline and reducing the risk of neurodegenerative diseases. The benefits of PE are attributed to neuroplasticity processes which have been reported to enhance cerebral health. However, moderate to high-intensity PE is necessary to induce these responses and these intensities cannot always be achieved especially by people with physical limitations. As a countermeasure, electrical stimulation (ES) offers several benefits, particularly for improving physical functions, for various neurological diseases. This review aims to provide an overview of key mechanisms that could contribute to the enhancement in brain health in response to ES-induced exercise, including increases in cerebral blood flow, neuronal activity, and humoral pathways. This narrative review also focuses on the effects of ES protocols, applied to both humans and animals, on cognition. Despite a certain paucity of research when compared to the more classical aerobic exercise, it seems that ES could be of interest for improving cerebral health, particularly in people who have difficulty engaging in voluntary exercise. [ABSTRACT FROM AUTHOR]

Background: There is a growing body of evidence showing the benefits to coaches and players in adopting a game-based pedagogical approach. Whilst the evidence in support of a game-based pedagogy continues to rise it is acknowledged that the complex art form of coaching is a uniquely personal one, where the coach may draw on previous first-hand experiences and traditional coaching practices regarding training methods rather than the use of current evidence-based best practice techniques. Purpose: The aim of this randomised control trial was to evaluate the impact of a coach development intervention (MASTER) on game-based coaching practices of football coaches. Methods: Four clubs were recruited, and 20 coaches were randomised to two groups, MASTER intervention (n = 10) and 10 usual practice (waitlist, n = 10); NSW Australia) which included 200 junior footballers (aged 8–16years). Intervention coaches participated in an 8-week multi-component intervention (which included a coach education workshop focused on positive game-based pedagogy, mentoring, peer evaluations and an online discussion forum) underpinned by positive coaching and game-based coaching practices. Pre- and post-intervention assessments occurred at baseline and 10 weeks. The primary aim was to investigate if the MASTER intervention could increase playing form (PF) and active learning time within training sessions. Three coaching sessions per coach were filmed at baseline and follow-up and assessed using the MASTER assessment tool. Secondary aims investigation included coach confidence and competence to coach (assessed by questionnaire), player game play and decision making (videoed during structured game play using a Game Performance Assessment Instrument), a range of player well-being measures including enjoyment, self-perception, and various motivations (questionnaire) and the parent's perception of their child's enjoyment was assessed by the completion of a questionnaire. Intervention effects were analysed using linear mixed models. Findings: Significant effects were found for the primary outcome which was the percentage of training time devoted to playing-form activities (22.63%; 95% CI 9.07–36.19; P = 0.002, d = 1.78). No significant effect was observed for ALT. Significant interventions effects were also observed for the secondary outcomes of coach perceptions of confidence and confidence; player game skills including defence, support and decision making, wellbeing, physical self-perceptions, enjoyment, learning and performance orientations and motivation; and parent's perception of child's enjoyment (P < 0.05). Conclusions: The MASTER programme was effective in improving game-based coaching practices of football coaches during training sessions, and in facilitating improvements in multiple coach and player outcomes. [ABSTRACT FROM AUTHOR]

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system CNS characterized by demyelination, inflammation, and neurodegenerative changes, making it the most common nontraumatic disabling neurological disease in young adults. While current pharmacological treatments primarily target immunomodulation or immunosuppression, exercise is gaining increasing attention from the scientific community as an adjunctive therapy. This review explores the potential biological mechanisms of exercise in animal models of MS, focusing on its effects on neuroprotection and inflammation. The review examines how exercise inhibits pro-inflammatory microglial reactivity, stabilizes the blood–brain barrier, and enhances neurotrophic factor expression in animal studies. Future research directions are proposed by summarizing the evidence and limitations of existing animal models of MS, emphasizing the need to further validate these mechanisms in humans to better integrate exercise into the comprehensive management of MS. Additionally, investigating exercise-induced biomarkers for MS symptom reduction may provide a scientific basis for new therapeutic strategies. [ABSTRACT FROM AUTHOR]

Introduction: Physical exercise (PE) improves symptoms and quality of life in people with multiple sclerosis (pwMS). However, incorporating PE into daily lives of pwMS pose difficulties. As an alternative to in-person PE, e-based PE has been proposed because of its advantages in terms of accessibility and convenience. Objective: To synthesize existing evidence on e-based PE at home in adults MS and discuss study designs, rehabilitation programs, intervention effects and possible knowledge gaps. Methods: In this scoping review, a systematic search in electronic databases including Embase, Medline, CINAHL and Cochrane Library was conducted following the PRISMA guidelines. Peer-reviewed articles in English on e-based PE interventional studies at home involving adult pwMS, published from 2008 until April 2023, were identified and exported to Covidence. Data from the included studies were extracted and synthesized. This scoping review identified different types of e-based PE interventions used in pwMS across different study designs, but when evaluating intervention effects, this review focused solely on randomized controlled trials (RCTs). Results: A total of 3,006 studies were retrieved and 179 studies were screened in full text, resulting in the inclusion of 54 studies with a total of 2,359 pwMS. Of those, 33 were RCTs and three were qualitative studies. The studies reported on various e-based interventions including video-based programs. telerehabilitation, and web-based programs. The interventions evaluated muscle strength, cardiorespiratory fitness, walking speed, endurance, balance, and fatigue, as well as symptoms of depression and cognitive dysfunction. E-based PE interventions at home in RCTs demonstrated improvement of depressive symptoms and anxiety, while inconsistent results were reported for fatigue, walking speed and balance. No significant benefits were observed regarding dexterity. Results were generally heterogeneous and were limited by small sample sizes. Several limitations were identified, such as lack of physical activity assessment prior to the intervention and poor reporting of duration, intensity, frequency and adherence to e-based PE interventions. Conclusion: E-based PE interventions in pwMS may improve MS-related symptoms, but the study quality is generally low, and findings are often inconsistent. Several important limitations of the existing literature have been identified in the present review, which can guide future research. [ABSTRACT FROM AUTHOR]

Background: The gait function in adults with cerebral palsy (CP) deteriorates rapidly with age. Dance has been used as an effective intervention to improve balance, postural control, and gait. This study aimed to investigate the feasibility and effects of an adapted dance program (ADP) on the gait in adults with CP. The ADP, which consists of floor and barre workouts, was designed to be adapted for individuals with CP. Method: Ten female adults with spastic diplegic CP (mean age 52.3 ± 6.34, Gross Motor Function Classification System level II) participated in this study. Outcome measures, examined using 3D gait analysis, included spatiotemporal gait parameters and the Gait Deviation Index (GDI) based on nine kinematic variables in all planes of motion. To assess feasibility, we conducted postquestionnaires and a group interview. The ADP, each lasting 90 min, was held twice per week for 12 weeks. Results: A statistically significant improvement was observed in GDI (Δ5.74 points, p = 0.014), with a large effect size (d = 0.76). Foot off (Δ-0.72%), first double support (Δ-0.2%), second double support (Δ1.5%), and single support (Δ0.64%) showed no significant differences. Step length (Δ1.48 cm), cadence (Δ3.95 steps/min), and walking speed (Δ6.41 cm/s) tended to increase, though the differences were not statistically significant. Participants expressed high levels of physical and emotional satisfaction, suggesting a need for early intervention. Conclusion: The ADP may improve gait patterns in adults with spastic diplegic CP. The feasibility results indicated that the ADP is suitable for adults with spastic diplegic CP. This study provides evidence for improvement in gait patterns through dance, which has not been reported in previous dance studies on individuals with CP, offering additional information on the benefits of dance. [ABSTRACT FROM AUTHOR]

Objective: Psychological interventions are pivotal in enhancing the Quality of Life for breast cancer survivors, with a primary focus on addressing affective and cognitive challenges through group discussions among those diagnosed with the disease. While the influence of Body Image on overall well-being is well-documented, research on interventions specifically designed to address Body Image concerns in this demographic remains scarce. The present study aimed to fill this gap by evaluating the outcomes of a psychological intervention focused on fostering a positive Body Image among 25 breast cancer survivors. Method: Participants were divided into an experimental group, which received the intervention (n = 13), and a control group that did not receive any psychological support (n = 12). Results: Our findings highlight significant disparities in emotional regulation strategies, specifically cognitive reappraisal and expressive suppression, with the intervention group reporting enhanced emotional regulation. Contrary to initial hypotheses, the analysis unveiled statistically significant differences in both negative (social physique anxiety) and positive (functionality appreciation) body image dimensions, indicating elevated levels of social physique anxiety and reduced functionality appreciation among intervention participants. Conclusion: The total results may suggest that the intervention, while effective in enhancing emotional regulation, heightened awareness of body image issues, leading to increased social physique anxiety and diminished functionality appreciation. The paper further discusses practical implications arising from these insights. [ABSTRACT FROM AUTHOR]

Virtual community-based programming for people with disabilities has become a popular method for advocating for health promotion, specifically exercise, for people with disabilities (PWD). Using theoretical frameworks to better understand the perspective of PWD who participate in virtual exercise programs allows strategies of implementation following completion of virtual exercise programs. The objective of this study was to examine the effect adherence had on perceptions, experiences, and post-program exercise maintenance in participants with disabilities. Eight qualitative interviews were conducted in highly adherent participants using the Social Cognitive Theory (SCT). Interviews were recorded on Zoom, transcribed using Microsoft 365, and analyzed using NVivo software. Data were analyzed by the primary author and an independent coder to increase rigor and reduce bias. Thirty-five unique codes were generated from transcribed interviews. Member-checking was employed to increase internal validity; 100% of participants agreed with the findings. Results demonstrate an overall positive experience in the virtual exercise program, noting specific facilitators (i.e., knowledgeable instructor, program provided equipment, etc.) and barriers (i.e., limited physical space at home to exercise, other participant's attitudes, etc.) of participating. Impressionably, 100% of participants maintained exercise following their time within the virtual exercise program. [ABSTRACT FROM AUTHOR]

Researchers often combine both positively and negatively worded items when constructing Likert scales. This combination, however, may introduce method effects due to the variances in item wording. Although previous studies have tried to quantify these effects by using factor analysis on scales with different content, the impact of varied item wording on participants' choices among specific options remains unexplored. To address this gap, we utilized four versions of the Undergraduate Learning Burnout (ULB) scale, each characterized by a unique valence of item wording. After collecting responses from 1,131 college students, we employed unidimensional, multidimensional, and bi-factor Graded Response Models for analysis. The results suggested that the ULB scale supports a unidimensional structure for the learning burnout trait. However, the inclusion of different valences of wording within items introduced additional method factors, explaining a considerable degree of variance. Notably, positively worded items demonstrated greater discriminative power and more effectively counteracted the biased outcomes associated with negatively worded items, especially between the "Strongly Disagree" and "Disagree" options. While there were no substantial differences in the overall learning burnout traits among respondents of different scale versions, slight variations were noted in their distributions. The integration of both positive and negative wordings reduced the reliability of the learning burnout trait measurement. Consequently, it is recommended to use exclusively positively worded items and avoid a mix in item wording during scale construction. If a combination is essential, the bi-factor IRT model might help segregate the method effects resulting from the wording valence. [ABSTRACT FROM AUTHOR]

Falls among older adults represent a critical global public health problem, as they are one of the main causes of disability in this age group. We have developed an automated approach to identifying fall risk using low-cost, accessible technology. Trunk movement patterns were collected from 181 older people, with and without a history of falls, during the execution of the Mini-BESTest. Data were captured using smartphone sensors (an accelerometer, a gyroscope, and a magnetometer) and classified based on fall history using deep learning algorithms (LSTM). The classification model achieved an overall accuracy of 88.55% a precision of 90.14%, a recall of 87.93%, and an F1 score of 89.02% by combining all signals from the Mini-BESTest tasks. The performance outperformed the metrics we obtained from individual tasks, demonstrating that aggregating all cues provides a more complete and robust assessment of fall risk in older adults. The results suggest that combining signals from multiple tasks allowed the model to better capture the complexities of postural control and dynamic gait, leading to better prediction of falls. This highlights the potential of integrating multiple assessment modalities for more effective fall risk monitoring. [ABSTRACT FROM AUTHOR]

The effectiveness of any physical exercise (PE) program is elementary based on one's interest, while that interest depends on personal experience. This study explored the PE-preferences and -experiences of individuals with Multiple Sclerosis (MS). Study included 79 individuals (13 males, and 66 females) diagnosed with MS, aged 38.99±10.72 years. The PE-preferences and -experiences were evaluated using the newly developed Physical Exercise Preferences in Multiple Sclerosis Questionnaire (PEPMSQ). The reliability of the PEPMSQ was checked with Intraclass Correlation Coefficients (ICC), while the validity was checked by determining the differences in PEPMSQ scores between males and females and between individuals who are exercising and those who are not exercising, all using the Mann-Whittney U test (MW) and Receiver Operating Characteristics curves (Area Under the Curve - AUC). The PEPMSQ demonstrated acceptable test-retest reliability (ICC values of 0.71 to 0.95 for most of the items). Analysis of differences evidenced no gender differences in PEPMSQ scores, while exercising-participants perceive: (i) greater health benefits (MW=-2.57, p=0.01), and (ii) benefits from strength exercises (MW=-2.75, p=0.01; AUC=0.71), compared to non-exercising participants. It seems that strength training should be a key component of exercise programs tailored for MS patients. Future studies are encouraged to refine the PEPMSQ and explore the dynamic relationship between MS symptoms, exercise preferences over time, and various health-indices. [ABSTRACT FROM AUTHOR]

Physical activity identity represents an important determinant of sustained physical activity behavior. The purpose of this investigation was to examine whether intention, behavioral regulation, and moderate-to-vigorous physical activity (MVPA) behavior explain significant variation in physical activity identity across time. Using a repeated measures observational design, lower-active adults new or returning to physical activity participation (N = 66) completed measures of study variables every three weeks over the course of a nine-week period (four assessments total). Based on the results of mixed-effects regression modelling, there was a small, non-significant increase in physical activity identity across time (b = 0.07, p = 0.13). Intention, MVPA, and behavioral regulation mostly had significant (ps < 0.05) bivariate correlations with physical activity identity at the same time point of assessment. Behavioral regulation explained significant variation in physical activity identity across time (b = 0.26, p < 0.0001), but intention and MVPA were non-significant (ps > 0.05) after including a random intercept and controlling for behavioral regulation. Identity was resistant to change among new physical activity initiates in this study and longer time frames of assessment are needed (e.g., six months). Behavioral regulation should be examined as a determinant of physical activity identity in future investigations. [ABSTRACT FROM AUTHOR]

As Attention-Deficit/Hyperactivity Disorder (ADHD) may have an unknown influence on the self-reports of physical activity of adults with ADHD and there is a need for high quality self-report assessments of this kind, we examined the test-retest reliability and construct validity of the Godin Leisure-Time Exercise Questionnaire–Health Contributions Score (GLTEQ–HCS) in its use with 35 adults with Attention-Deficit/Hyperactivity Disorder (ADHD) (26 females, 9 males; M age = 28.7, SD = 6.3 years). Participants completed the GLTEQ twice and wore an ActiGraph GT9X–accelerometer for seven-days. An intraclass correlation coefficient (ICC) determined test-retest reliability, and we determined construct validity based on correlations between the GLTEQ–HCS and minutes/day of sedentary behavior (SB), light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA), as well as differences in SB, LPA, and MVPA among the three GLTEQ–HCS subgroups. The GLTEQ-HCS had excellent test-retest reliability [ICC = 0.98, 0.95 to 0.99], and it was positively correlated with MVPA (r = 0.47, p =.006; r s = 0.52, p =.002). There was a significant and large difference in minutes/day of device-measured MVPA between the three GLTEQ–HCS groups [ F (2,32) = 7.30, p =.003, η 2 = 0.33]. These results provide psychometric support for using the GLTEQ-HCS with adults who have been diagnosed with ADHD. [ABSTRACT FROM AUTHOR]

Shame-proneness refers to one's dispositional tendency to experience shame across a variety of situations. Shame-proneness is significantly related to a wide range of mental health disorders including depression, anxiety, post-traumatic stress, substance abuse, and more. Attachment theory and interpersonal neurobiology suggest that secure attachment protects against shame-proneness, whereas insecure attachment contributes to shame-proneness. However, there is scant empirical research exploring this relationship. This study explored childhood attachment with primary caregivers as a predictor of shame-proneness in adulthood. A sample of 340 adults, U.S. residents aged 18 and over, was recruited through Amazon Mechanical Turk (MTurk), an online crowdsourcing platform. Multiple regression analyses revealed that certain insecure attachment styles, specifically anxiety and disorganization, significantly related to shame-proneness, whereas avoidance did not. Secure attachment was negatively related to shame-proneness, but the relationship was statistically insignificant. Social workers and other mental health professionals can benefit from an increased understanding of the relationship between childhood attachment and shame-proneness that this study provides. [ABSTRACT FROM AUTHOR]

Older adults in assisted living facilities (ALF) are at risk for low physical activity (PA) and high sedentary behavior (SB), both of which place them at risk for negative health outcomes. The purpose of this scoping review was to synthesize evidence describing the volume of device-measured PA/SB, factors associated with PA/SB, and interventions designed to change PA/SB in older adults living in ALF. Twenty articles representing 15 unique studies were identified from eight electronic databases and grey literature. Residents in ALF spent 96–201 min/day in light PA (n = 2 studies), 1–9.74 min/day in moderate to vigorous PA (n = 2 studies), and 8.5–11.01 hr/day of SB during waking hours (n = 3 studies). Factors associated with PA included 16 personal factors (n = 6 articles), one social factor (n = 2 articles), and two environmental factors (n = 2 articles). Factors associated with SB included 14 personal factors (n = 4 articles) and one social factor (n = 1 article). No intervention successfully changed PA/SB. [ABSTRACT FROM AUTHOR]

Multiple Sclerosis (MS) is a persistent autoimmune condition marked by inflammation, the loss of myelin, and the degeneration of the central nervous system. While traditional pharmacological interventions focus on symptom management and disease progression, there is a growing recognition of the potential benefits of physical exercise in improving the overall well-being of individuals with MS. This review aims to thoroughly explore the multifaceted advantages and underlying mechanisms associated with physical exercise in the context of MS. Numerous studies indicate that regular physical exercise can have a positive impact on various aspects of MS, such as fatigue, mobility, cognitive function, and overall quality of life. This review consolidates evidence from recent studies to provide a comprehensive overview of the significant, albeit modest, improvements observed in walking, balance, cognition, depression, and fatigue among MS patients engaging in physical training. [ABSTRACT FROM AUTHOR]

This study aimed to compare sensory processing skills and occupational performance between participants with multiple sclerosis and healthy controls. Eighty participants were enrolled in this study, 40 with multiple sclerosis and 40 with healthy controls. Participants were between 18 and 65 years of age and asked to complete the Adult Sensory Profile, and Canadian Occupational Performance Measure. The findings of the study revealed that participants with multiple sclerosis had a lower ability to register sensory input, a higher sensory sensitivity, and avoidance, as well as lower levels of performance and satisfaction in their daily occupations, compared to the healthy controls (p < 0.05). People with multiple sclerosis often experience difficulties with sensory processing and occupational performance in daily life. More research and practice are needed on the role of sensory processing and occupational performance in daily life in people with multiple sclerosis. [ABSTRACT FROM AUTHOR]

Background: Physical and psychological problems are common among individuals with multiple sclerosis (MS), thus emphasizing the need for the evaluation of the effectiveness of different psychological therapies for these patients. Thus, this study aimed to compare the efficacy of group cognitive behavioral therapy (GCBT) with group acceptance and commitment therapy (GACT) in the treatment of fear beliefs related to panic disorder in MS patients, focusing on the revised sensitivity theory of brainbehavioral systems. Methods: This experimental study was conducted employing a pretest-posttest design with a control group. The statistical population consisted of MS patients with panic disorder who sought treatment at the Khorasan MS Association in Mashhad, Iran. Through the convenience sampling method, 36 women who met the inclusion criteria were selected from among 3200 patients. The participants were randomly divided into 3 groups: GCBT (N = 12), GACT (N = 12), and the control group (N = 12). Pretest and posttest intervention assessments were conducted using Jackson's five-factor questionnaire and the Panic Belief Inventory (PBI). Descriptive methods and repeated measures analysis of variance were utilized for data analysis. Results: The results revealed a significant reduction in fear beliefs among participants in the intervention groups compared to the control group (P < 0.05). Furthermore, significant changes were observed in the behavioral-brain systems of the participants in the intervention group compared to the control group (P < 0.05). Comparing the intervention groups revealed that the impact of GACT is higher than GCBT on the behavioral activation system (BAS) and panic beliefs (P = 0.04). Conclusion: It can be concluded that GCBT and GACT were effective in improving the fear beliefs of patient and changing their brain-behavioral systems. Comparing two interventions showed higher efficacy of GACT. [ABSTRACT FROM AUTHOR]

Frequent or chronic cannabis use can have negative effects on the adolescent and young adult (AYA) brain and psychosocial development. This study investigated the psychosocial impact of frequent cannabis use in a prospective study of sexually active female AYA patients. Participants completed questionnaires at three separate visits over a period of one year. A total of 545 AYA women were included in our analysis. Most (94%) identified as individuals of color, including 37% as non-Black Hispanic, 16% as Hispanic Black, and 41% as non-Hispanic Black. Multivariable regression analyses showed that using cannabis 20 or more times in the prior month was significantly associated with a higher likelihood of being suspended (OR = 2.71, 95%CI:1.48, 4.57; p <.001), as well as with increased number of depressive symptoms (β = 0.48, 95%CI:0.23, 0.75; p <.001) and delinquent behaviors (β = 0.81, 95%CI:0.56–1.06; p <.001). Cross-lagged models showed that frequent cannabis use was associated with increased depressive symptoms six months later (β = 0.09, p <.05), and higher levels of delinquency six months (β = 0.20, p <.001) and 12 months later (β = 0.12, p <.05). This study demonstrated that frequent cannabis use was prospectively associated with negative psychosocial outcomes for AYA women of color, including depression and delinquency. [ABSTRACT FROM AUTHOR]

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system (CNS) with subsequent axonal and neuronal degeneration. These changes are associated with a broad range of symptoms including skeletal muscle dysfunction. Importantly, musculoskeletal impairments manifest in various ways, compromise the quality of life and often precede the later development of mobility disability. As current standard disease modifying therapies for MS predominantly act on neuroinflammation, practitioners and patients face an unmet medical need for adjunct therapies specifically targeting skeletal muscle function. This review is intended to detail the nature of the skeletal muscle dysfunctions common in people with MS (pwMS), describe underlying intramuscular alterations and outline evidence-based therapeutic approaches. Particularly, we discuss the emerging role of aerobic and resistance exercise for reducing the perception of fatigue and increasing muscle strength in pwMS. By integrating the most recent literature, we conclude that both exercise interventions should ideally be implemented as early as possible as they can address MS-specific muscle impairments. Aerobic exercise is particularly beneficial for pwMS suffering from fatigue and metabolic impairments, while resistance training efficiently counters muscle weakness and improves the perception of fatigue. Thus, these lifestyle interventions or possible pharmacological mimetics have the potential for improving the general well-being and delaying the functional declines that are relevant to mobility. [ABSTRACT FROM AUTHOR]

Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by central nervous system demyelination and axonal degeneration. Fatigue affects a major portion of MS patients, significantly impairing their daily activities and quality of life. Despite its prevalence, the mechanisms underlying fatigue in MS are poorly understood, and measuring fatigue remains a challenging task. This study evaluates the efficacy of automated speech analysis in detecting fatigue in MS patients. MS patients underwent a detailed clinical assessment and performed a comprehensive speech protocol. Using features from three different free speech tasks and a proprietary cognition score, our support vector machine model achieved an AUC on the ROC of 0.74 in detecting fatigue. Using only free speech features evoked from a picture description task we obtained an AUC of 0.68. This indicates that specific free speech patterns can be useful in detecting fatigue. Moreover, cognitive fatigue was significantly associated with lower speech ratio in free speech (p = -0.283, p = 0.001), suggesting that it may represent a specific marker of fatigue in MS patients. Together, our results show that automated speech analysis, of a single narrative free speech task, offers an objective, ecologically valid and low-burden method for fatigue assessment. Speech analysis tools offer promising potential applications in clinical practice for improving disease monitoring and management. [ABSTRACT FROM AUTHOR]

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by demyelination in the central nervous system (CNS), affecting individuals globally. The pathological mechanisms underlying MS remain unclear, but current evidence suggests that inflammation and immune dysfunction play a critical role in the pathogenesis of MS disease. Adipose tissue (AT) is a dynamic multifunctional organ involved in various immune diseases, including MS, due to its endocrine function and the secretion of adipokines, which can influence inflammation and immune responses. Physical activity represents an efficacious non-pharmacological strategy for the management of a spectrum of conditions that not only improves inflammatory and immune functions but also directly affects the status and function of AT. Additionally, the exploration of nutritional supplementation represents an important field of MS research aimed at enhancing clinical symptoms and is closely tied to the regulation of metabolic responses, including adipokine secretion. This review, therefore, aims to elucidate the intricate relationship between lifestyle and MS by providing an overview of the latest published data about the involvement of AT and the main adipokines, such as adiponectin, leptin, and tumor necrosis factor α (TNFα) in the pathogenesis of MS. Furthermore, we explore whether physical activity and dietary management could serve as useful strategies to improve the quality of life of MS patients. [ABSTRACT FROM AUTHOR]

Background: The development of a stable society is closely linked to a prevalent sense of social fairness. Participating in physical activities, which are inherently social, plays a crucial role in fostering mental stability within social contexts. Objective: This study aims to examine how physical exercise influences the sense of social fairness among college students, focusing on the potential mediating effects of perceived social support and life satisfaction. Methods: The study surveyed 496 Chinese college students using several scales: the Physical Activity Rating Scale-3 (PARS-3), Perceived Social Support Scale (PSSS), Satisfaction with Life Scale (SWLS), and Social Justice Scale (SJS). Results: (1) A positive correlation was found between physical exercise and sense of social fairness (r=0.151, p < 0.01). A significant direct effect of physical exercise on sense of social fairness was also observed (β=0.151, t=3.971, p < 0.01). (2) Physical exercise was a positive predictor of perceived social support (β=0.113, t=4.062, p < 01), which in turn positively influenced both life satisfaction (β=0.333, t=18.047, p < 0.01) and sense of social fairness (β=0.485, t=6.931, p < 0.01). Additionally, life satisfaction had a positive effect on sense of social fairness (β=0.431, t=3.247, p < 0.01). (3) Both perceived social support and life satisfaction significantly mediated the relationship between physical exercise and sense of social fairness through two pathways: physical exercise → perceived social support → sense of social fairness (mediating effect: 0.055); and physical exercise → perceived social support → life satisfaction → sense of social fairness (mediating effect: 0.016). Conclusion: (1) Physical exercise enhances both perceived social support and the sense of social fairness among college students, suggesting that it not only directly contributes to an enhanced sense of social fairness but also fosters supportive social relationships. (2) The influence of physical exercise on the sense of social fairness operates both directly and indirectly through the mediating roles of perceived social support and, sequentially, life satisfaction. [ABSTRACT FROM AUTHOR]

Introduction: Perturbation walking (PW) has been shown to improve gait, however its effect on the cortical control of gait might provide insights on neural mechanisms underlying falls in adults with osteoarthritis. The objective of this study is to investigate the effect of PW on prefrontal cortical (PFC) activation in older women with (OA) and without osteoarthritis (HOA). We hypothesized that there would be an increase in PFC activation during PW relative to comfortable walking (CW) and higher increase in PFC activation during PW in HOA compared to OA. Methods: Twenty community-dwelling older women (66.7 ± 5.41 years old) walked on an instrumented treadmill that provided perturbations at pseudorandom intervals between 5-25 s using a counterbalanced design. Functional Near Infrared Spectroscopy was used to quantify PFC oxygenated hemoglobin (HbO2) and deoxyhemoglobin (Hb) levels, while standing prior to the task as a baseline. A linear mixed effects model was conducted to investigate the effects of cohort (HOA vs OA), task (PW vs CW), and their interaction on HbO2 (mM) and Hb (mM) levels. Results: HbO2 and Hb levels differed significantly between CW and PW tasks for both cohorts (P < 0.001) and demonstrated significant task by cohort interaction (P < 0.05). In addition, we found changes in walking performance (stride time, stride length, stride width and stance time) during and after PW. Spearman correlation demonstrated a strong association between increased stance time, increased body mass index and decreased PFC activation during PW. No other significant results were found. Discussion: This study found increase in PFC activation during PW and gait adaptation after a short bout of PW in HOA and OA. This increase in PFC activation was higher in HOA compared to OA, particularly during PW tasks, and was consistent with theory of limitations in mobility affecting neural activation in older adults. Further work remains to examine how pain, obesity, and mobility impacts cortical control in older adults with and without osteoarthritis. [ABSTRACT FROM AUTHOR]

Objective: To examine the effects of instructor-led exercise on depression symptoms in adults with multiple sclerosis, with a focus on moderating factors to treatment response. Data sources: Cochrane Library, Embase, PEDro, PsycINFO and PubMed databases were searched until 21 April 2024. Review methods: The reporting quality of included studies assessed (PEDro and TESTEX scales). Hedges' g effect sizes were calculated and pooled using random and mixed-effects modelling. Results: Twenty-two independent studies (k), representing 785 participants with relapsing remitting or progressive MS, were included. Individual studies varied in their reporting quality (PEDro range: 3–8) and did not routinely detail exercise parameters (TESTEX range: 5–13). Nonetheless, exercise reduced core symptoms of depression (g w =.52, CI:.30–.73, P <.01). Treatment effects were, however, not maintained once training had ceased (g w = −.53, CI: −.80 to.24, P ≤.01, k = 5). Both aerobic and non-aerobic exercise groups experienced a significant (P <.01) reduction in depression scores. Larger gains were noted by those with better ambulation at baseline (P =.03). Conclusion: Regular exercise can help to stabilise mood for people living with multiple sclerosis, regardless of session frequency or duration. Treatment efficacy could be maximised by addressing potential barriers for those with limited mobility, including exercise type, delivery and intensity. Protocol registered on Open Science Framework [https://osf.io/zfymq/]. [ABSTRACT FROM AUTHOR]

The study introduces the revised Relationship Assessment Scale (RAS-R) in response to discrepancies identified within existing RAS models. The first phase involved grammatical revisions, bias removal, and standardization of response options for the Spanish version of the RAS. The subsequent phase evaluated the psychometric properties of both the RAS and the RAS-R, as well as the specification of common models from the literature, using data from 547 participants for the RAS and 285 for the RAS-R. In contrast to the RAS, which required adjustments due to correlated error or item elimination, the RAS-R demonstrated optimal fit without requiring model respecification. Further analysis using the Graded Response Model (GRM) indicated a better fit for the RAS-R, with consistent item discrimination across items, particularly for Item 2. Evaluation of test and item curves revealed a wide range of responses, highlighting the reliability of the instrument. In conclusion, the RAS-R was found to be a robust instrument that addresses the factorial structure challenges encountered in the RAS literature. [ABSTRACT FROM AUTHOR]

Cucumber (Cucumis sativus L.) and celery (Apium graveolens L.) are among the most widely cultivated vegetable crops, belonging to the melon and leafy vegetable categories, respectively. This study aims to provide predictions for the quality formation of greenhouse cucumber and celery, as well as technical support for intelligent vegetable production management. Based on the light and temperature response characteristics of cucumber and celery growth and development and using the experimental varieties 'Jinsheng 206' for cucumber and 'Juventus' for celery, the observational data from a five-cropping season trial over 2 years were utilized. By analyzing the relationship between the growth and development of vegetables and key meteorological factors (radiation and temperature), simulation models for quality formation were constructed using the day–night temperature difference method (ATD) and the product of thermal effectiveness and the photosynthetically active method (TEP) as independent variables. The model parameters were determined and the model was validated using independent trial data. The results showed the following: (1) There exist quantifiable relationships between different quality indicators and ATD or TEP. These relationships are mainly presented through linear functions, exponential functions, logarithmic function, and logical functions. (2) The normalized root mean square error (NRMSE) of the cucumber quality model ranges from 1.13% to 29.53%, and the NRMSE of the celery quality model ranges from 1.63% to 31.47%. (3) Based on two kinds of normalization methods, the average NRMSE of the VQSM model is 13.72%, demonstrating a relatively high level of accuracy in simulation. These results demonstrate that the proposed model can dynamically and accurately simulate the quality formation process of vegetables, providing a theoretical basis and data support for the research on productivity and the economic benefits of greenhouse crops. [ABSTRACT FROM AUTHOR]

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Research investigating potential pathways from Adverse Childhood Experiences (ACEs) to later self-harming and offending behaviours has inconsistent findings. Past research, however, has not fully explored the interplay between ACEs and modifiable psychological factors, such as shame and self-compassion. The present study explored the relationship between ACE, shame, and self-compassion to identify their role in explaining the variance in later harm in a sample of individuals who have committed sexual offences. Two hundred and fifty adults incarcerated for sexual offences participated. Multiple Regression and Mediation Analyses were applied to establish if ACE, shame and self-compassion explained the variance in harm and explore potential psychological pathways between ACE and harm, with shame and self-compassion as potential modifiable mediators. ACE, shame and self-compassion explained 55% of self-harm and 52% of psychological and physical harm variance. A more complex relationship was indicated for sexual harm, with only 19% of the variance explained by the model. The study increases our understanding of the relationship between variables and potential modifiable pathways between ACEs and later harming behaviours in a sample of individuals with sexual convictions. These modifiable psychological factors could be targeted to increase resilience, post-traumatic growth and reduce the risk of harm in later life. [ABSTRACT FROM AUTHOR]

People with multiple sclerosis (MS) often have to cope with high levels of stress. Lazarus and Folkman's (1984) stress–appraisal–coping theory emphasizes the relationship between the individual and the environment, suggesting that a stress response is highly influenced by individual appraisal processes. This study aimed to evaluate constructs of Lazarus and Folkman's stress–appraisal–coping theory and positive human traits as predictors of perceived stress in a sample of 477 adults with MS. Hierarchical regression analysis was used to determine the incremental variance in perceived stress accounted for by demographic covariates, functional disabilities, challenge appraisal, and positive human traits. Core self-evaluations, challenge appraisal, limitations in social/cognitive functioning, agency hope, and age were significant predictors in the final model, accounting for 68% of the variance in perceived stress scores (R 2 =.68, f 2 = 2.13; large effect size). Core self-evaluations and challenge appraisal were the strongest predictors of perceived stress. The findings from this study will help rehabilitation professionals develop empirically supported stress management and well-being interventions, enabling people with MS to cope effectively with stressors and challenges and improve their health and well-being. [ABSTRACT FROM AUTHOR]

Although many studies have attempted to identify mediators and moderators of changes in physical activity involvement, the literature is inconclusive regarding which variable(s) relate to physical activity behavior change. The Cooper 2001 Conference series dedicated a session to discussing measurement and statistical methods that could contribute to advancing this research agenda. This article focuses on four such methodologic approaches: qualitative; psychometric; latent-variable, structural equation modeling; and multilevel modeling. The article presents a brief overview of these methods and discusses potential advantages and limitations of using them.

The Physical Activity Scale for Individuals with Physical Disabilities (PASIPD) is not available to Portuguese-Brazil. This study translates, cross-culturally adapts, and validates the PASIPD for Brazilian individuals with Parkinson's disease. The translation process followed guidelines: initial translation, synthesis, back translation, expert committee, and pretest. The validation and reliability processes were conducted with 40 individuals (15 men and 25 women) with Parkinson's disease. Concurrent validity was evaluated between PASIPD to Brazilian Portuguese, International Physical Activity Questionnaire, and Human Activity Profile. PASIPD to Brazilian Portuguese was found to be moderately correlated with International Physical Activity Questionnaire (r =.474, p <.05); however, there was no correlation with Human Activity Profile (r =.271, p <.05). We used the intrarater reliability with intraclass correlation coefficient and test–retest. Intrarater reliability was high (intraclass correlation coefficient =.80). Internal consistency was considered adequate by Cronbach's alpha (α =.70). PASIPD to Brazilian Portuguese is a valid and reliable instrument for evaluating physical activity levels in Brazilian individuals with Parkinson's disease. [ABSTRACT FROM AUTHOR]

This brief research note examined the reliability of scores from an accelerometer as measures of sedentary and physical activity behaviors in persons with multiple sclerosis (MS). The analysis was performed on a combined data set from 2 previous longitudinal investigations of physical activity in MS. We focused on the number of days required to reliably estimate sedentary behavior, based on time spent in sedentary behavior per day and number of sedentary breaks, number of long sedentary bouts, and average length of sedentary bouts per day. We further examined the number of days required to reliably estimate physical activity behavior, based on time spent in light and moderate-to-vigorous physical activity and average length of activity bouts per day. Between 4-6 days of monitoring and 3-7 days of monitoring were necessary for good reliability of scores from all sedentary outcomes and physical activity outcomes, respectively. These results should guide research and practice examining sedentary and physical activity behaviors using accelerometry in persons with MS. [ABSTRACT FROM AUTHOR]

A mixed-methods approach was used to study an individually-tailored community exercise program for people with a range of chronic neurological conditions (e.g., stroke, spinal cord injury, brain injury, multiple sclerosis, Parkinson's disease) and abilities. The program was delivered to older adults (mean age: 62 ± 9 years) with chronic neurological conditions across a 12-week and an 8-week term. Participants attended 88% of sessions and completed 89% of prescribed exercises in those sessions. There were no adverse events. Clinically important improvements were achieved by all evaluated participants (n = 8) in at least one testing domain (grip strength, lower-extremity strength, aerobic endurance, and balance). Interviews with participants identified key program elements as support through supervision, social connection, individualized programming, and experiential learning. Findings provide insight into elements that enable a community exercise program to meet the needs of a complex and varied group. Further study will support positive long-term outcomes for people aging with neurological conditions. [ABSTRACT FROM AUTHOR]

Objective: The Eating Disorder-15 (ED-15) is a brief measure developed for the routine assessment of eating disorder (EDs), despite its use in research settings having increased over the last few years. To assess the psychometric properties of the ED-15 in a nonclinical sample of Chilean women., Method: A multicultural Spanish-language version was developed through combined translation techniques. University female students (N = 380) (M age 22.32, SD = 2.48) were recruited through social media. After providing their informed consent, participants completed a battery of questionnaires online., Results: A bi-factor model replicating the bi-factor structure and providing support for the general factor showed the best fit to the data. Moderate-to-strong correlations with measures of EDs, physical comparison, body appreciation, social physique anxiety, and depressive symptoms are presented as evidence of concurrent and convergent validity. Items analyses revealed strong correlations between manifest variables, their correspondent latent variable and the general factor (r s  = .60 to .89, ps < .001). Additionally, current findings provide support for the internal consistency of the scale (Cronbach's alpha and Omega values were ≥ .80) and test-retest reliability (ICCs = .84 to .89, ps < .001)., Discussion: Like previous findings, the current study provides validity to the original bi-factor structure of the ED-15 and additional validity to a general factor. The availability of this multicultural Spanish-language version would provide session-by-session assessment, providing crucial information throughout treatment. Also, the availability of the current measure would contribute to further research efforts in a yet understudied population such as Hispanic women., Public Significance: The Eating Disorder-15 (ED-15) is a promising measure meant to assess session-by-session change for clinical and research purposes. The availability of a Multicultural Spanish language version of the ED-15 allows for routine clinical assessment and represents a contribution for research efforts in a yet understudied populations such as Hispanic women., (© 2022 Wiley Periodicals LLC.)

High levels of sedentary behaviour are associated with poor health outcomes in people with multiple sclerosis (MS). Identifying modifiable correlates of sedentary behaviour for people with MS is essential to design effective intervention strategies to minimise sedentary time. This study aimed to quantify patterns and identify correlates of sedentary behaviour among adults with MS. Fatigue, self-efficacy, walking capability, the physical and psychological impact of MS, health-related quality of life, and participation and autonomy were assessed by questionnaire. Participants wore an activPAL monitor. Total (min/day), prolonged bouts (≥ 30 min) and breaks in sedentary time were calculated. Associations were examined using regression analysis adjusted for demographic and clinical confounders. Fifty-six adults with MS participated (mean ± SD age: 57.0 ± 9.25 years; 66% female). Self-efficacy for control over MS was associated with sedentary time (β = 0.16, 95% CI 0.01, 0.30). Self-efficacy in function maintenance (β = 0.02, 95% CI 0.00, 0.04), health-related quality of life (EuroQol-5D) (β = 31.60, 95% CI 7.25, 55.96), and the autonomy indoors subscale of the Impact on Participation and Autonomy Questionnaire (β = − 5.11, 95% CI − 9.74, − 0.485) were associated with breaks in sedentary time. Future studies should consider self-efficacy, health-related quality of life and participation and autonomy as potential components of interventions to reduce sedentary behaviour. [ABSTRACT FROM AUTHOR]

Background and Purpose: The flexible exercise participation program (FEPP) is a novel intervention developed to enable individuals with multiple sclerosis (MS) participate and progress in an exercise or sport of their choice. The FEPP is underpinned by guidelines on aerobic exercise for individuals with MS and is supported by a physiotherapist using behaviour change techniques. As part of a FEPP feasibility trial, the aim of this nested study was to explore the experience of participation in the FEPP from the perspective of individuals with MS. The objectives were to (i) determine the acceptability of the FEPP and (ii) identify recommendations for improvement. Methods: A mixed methods study using a sequential explanatory design was conducted. Part I consisted of a quantitative participant survey. Survey data were analysed descriptively using SPSS and informed the protocol for part II – qualitative interviews. Interview data were analysed thematically using NVivo. Part III consisted of integration of quantitative and qualitative data to allow greater explanation of survey responses. Individuals with MS who had participated in the FEPP feasibility trial were invited to take part in the study. Results: The FEPP was highly acceptability to the 10 participants. Five themes emerged to describe the experience of participating in the FEPP: (i) exploring exercise boundaries, (ii) measuring energy, (iii) acknowledging accountability, (iv) adjusting to exercising in a pandemic and (v) sustaining participation. Recommendations for improving the FEPP included changes to energy level monitoring and incorporation of peer support mechanisms. Discussion: Participants found the FEPP highly acceptable and valued the flexibility to choose their own activity and the health professional support. Based on participant recommendations, future versions of the FEPP will include daily rather than weekly monitoring of exercise and peer support to further enable individuals with MS to find the right balance with exercise and sport. [ABSTRACT FROM AUTHOR]

Background: Impairments in speech and social cognition have been reported in people with multiple sclerosis (pwMS), although their relationships with neuropsychological outcomes and their clinical utility in MS are unclear., Objectives: To evaluate word finding, prosody and social cognition in pwMS relative to healthy controls (HC)., Methods: We recruited people with relapsing MS (RMS, n = 21), progressive MS (PMS, n = 24) and HC (n = 25) from an outpatient MS clinic. Participants completed a battery of word-finding, social cognitive, neuropsychological and clinical assessments and performed a speech task for prosodic analysis., Results: Of 45 pwMS, mean (SD) age was 49.4 (9.4) years, and median (range) Expanded Disability Severity Scale score was 3.5 (1.0-6.5). Compared with HC, pwMS were older and had slower information processing speed (measured with the Symbol Digit Modalities Test, SDMT) and higher depression scores. Most speech and social cognitive measures were associated with information processing speed but not with depression. Unlike speech, social cognition consistently correlated with intelligence and memory. Visual naming test mean response time (VNT-MRT) demonstrated worse outcomes in MS versus HC (p = .034, Nagelkerke's R 2  = 65.0%), and in PMS versus RMS (p = .009, Nagelkerke's R 2  = 50.2%). Rapid automatised object naming demonstrated worse outcomes in MS versus HC (p = .014, Nagelkerke's R 2  = 49.1%). These word-finding measures showed larger effect sizes than that of the SDMT (MS vs. HC, p = .010, Nagelkerke's R 2  = 40.6%; PMS vs. RMS, p = .023, Nagelkerke's R 2  = 43.5%). Prosody and social cognition did not differ between MS and HC., Conclusions: Word finding, prosody and social cognition in MS are associated with information processing speed and largely independent of mood. Impairment in visual object meaning perception is potentially a unique MS disease-related deficit that could be further explored and cautiously considered as an adjunct disability metric for MS., (© 2022 The British Psychological Society.)

Axons wrapped around the myelin sheath enable fast transmission of neuronal signals in the Central Nervous System (CNS). Unfortunately, myelin can be damaged by injury, viral infection, and inflammatory and neurodegenerative diseases. Remyelination is a spontaneous process that can restore nerve conductivity and thus movement and cognition after a demyelination event. Cumulative evidence indicates that remyelination can be pharmacologically stimulated, either by targeting natural inhibitors of Oligodendrocyte Precursor Cells (OPCs) differentiation or by reactivating quiescent Neural Stem Cells (qNSCs) proliferation and differentiation in myelinating Oligodendrocytes (OLs). Although promising results were obtained in animal models for demyelination diseases, none of the compounds identified have passed all the clinical stages. The significant number of patients who could benefit from remyelination therapies reinforces the urgent need to reassess drug selection approaches and develop strategies that effectively promote remyelination. Integrating Artificial Intelligence (AI)-driven technologies with patient-derived cell-based assays and organoid models is expected to lead to novel strategies and drug screening pipelines to achieve this goal. In this review, we explore the current literature on these technologies and their potential to enhance the identification of more effective drugs for clinical use in CNS remyelination therapies. [ABSTRACT FROM AUTHOR]