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101. Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells

Author

Barszczyk, Mark, Buczkowicz, Pawel, Castelo-Branco, Pedro, Mack, Stephen C., Ramaswamy, Vijay, Mangerel, Joshua, Agnihotri, Sameer, Remke, Marc, Golbourn, Brian, Pajovic, Sanja, Elizabeth, Cynthia, Yu, Man, Luu, Betty, Morrison, Andrew, Adamski, Jennifer, Nethery-Brokx, Kathleen, Li, Xiao-Nan, Van Meter, Timothy, Dirks, Peter B., Rutka, James T., Taylor, Michael D., Tabori, Uri, and Hawkins, Cynthia

Published
2014
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102. Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors

Author

Mangerel, Joshua, Price, Aryeh, Castelo-Branco, Pedro, Brzezinski, Jack, Buczkowicz, Pawel, Rakopoulos, Patricia, Merino, Diana, Baskin, Berivan, Wasserman, Jonathan, Mistry, Matthew, Barszczyk, Mark, Picard, Daniel, Mack, Stephen, Remke, Marc, Starkman, Hava, Elizabeth, Cynthia, Zhang, Cindy, Alon, Noa, Lees, Jodi, Andrulis, Irene L., Wunder, Jay S., Jabado, Nada, Johnston, Donna L., Rutka, James T., Dirks, Peter B., Bouffet, Eric, Taylor, Michael D., Huang, Annie, Malkin, David, Hawkins, Cynthia, and Tabori, Uri

Published
2014
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103. Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma

Author

Witt, Hendrik, Mack, Stephen C., Ryzhova, Marina, Bender, Sebastian, Sill, Martin, Isserlin, Ruth, Benner, Axel, Hielscher, Thomas, Milde, Till, Remke, Marc, Jones, David T.W., Northcott, Paul A., Garzia, Livia, Bertrand, Kelsey C., Wittmann, Andrea, Yao, Yuan, Roberts, Stephen S., Massimi, Luca, Van Meter, Tim, Weiss, William A., Gupta, Nalin, Grajkowska, Wiesia, Lach, Boleslaw, Cho, Yoon-Jae, von Deimling, Andreas, Kulozik, Andreas E., Witt, Olaf, Bader, Gary D., Hawkins, Cynthia E., Tabori, Uri, Guha, Abhijit, Rutka, James T., Lichter, Peter, Korshunov, Andrey, Taylor, Michael D., and Pfister, Stefan M.

Published
2011
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106. CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity

Author

Spence, Tara, Sin-Chan, Patrick, Picard, Daniel, Barszczyk, Mark, Hoss, Katharina, Lu, Mei, Kim, Seung-Ki, Ra, Young-Shin, Nakamura, Hideo, Fangusaro, Jason, Hwang, Eugene, Kiehna, Erin, Toledano, Helen, Wang, Yin, Shi, Qing, Johnston, Donna, Michaud, Jean, La Spina, Milena, Buccoliero, Anna Maria, Adamek, Dariusz, Camelo-Piragua, Sandra, Peter Collins, V., Jones, Chris, Kabbara, Nabil, Jurdi, Nawaf, Varlet, Pascale, Perry, Arie, Scharnhorst, David, Fan, Xing, Muraszko, Karin M., Eberhart, Charles G., Ng, Ho-Keung, Gururangan, Sridharan, Van Meter, Timothy, Remke, Marc, Lafay-Cousin, Lucie, Chan, Jennifer A., Sirachainan, Nongnuch, Pomeroy, Scott L., Clifford, Steven C., Gajjar, Amar, Shago, Mary, Halliday, William, Taylor, Michael D., Grundy, Richard, Lau, Ching C., Phillips, Joanna, Bouffet, Eric, Dirks, Peter B., Hawkins, Cynthia E., and Huang, Annie

Published
2014
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108. Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study

Author

Krishnatry, Rahul, Zhukova, Nataliya, Guerreiro Stucklin, Ana S., Pole, Jason D., Mistry, Matthew, Fried, Iris, Ramaswamy, Vijay, Bartels, Ute, Huang, Annie, Laperriere, Normand, Dirks, Peter, Nathan, Paul C., Greenberg, Mark, Malkin, David, Hawkins, Cynthia, Bandopadhayay, Pratiti, Kieran, Mark W., Manley, Peter E., Bouffet, Eric, and Tabori, Uri

Published
2016
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109. Divergent clonal selection dominates medulloblastoma at recurrence

Author

Morrissy, Sorana A., Garzia, Livia, Shih, David J. H., Zuyderduyn, Scott, Huang, Xi, Skowron, Patryk, Remke, Marc, Cavalli, Florence M. G., Ramaswamy, Vijay, Lindsay, Patricia E., Jelveh, Salomeh, Donovan, Laura K., Wang, Xin, Luu, Betty, Zayne, Kory, Li, Yisu, Mayoh, Chelsea, Thiessen, Nina, Mercier, Eloi, Mungall, Karen L., Ma, Yusanne, Tse, Kane, Zeng, Thomas, Shumansky, Karey, Roth, Andrew J. L., Shah, Sohrab, Farooq, Hamza, Kijima, Noriyuki, Holgado, Borja L., Lee, John J. Y., Matan-Lithwick, Stuart, Liu, Jessica, Mack, Stephen C., Manno, Alex, Michealraj, K. A., Nor, Carolina, Peacock, John, Qin, Lei, Reimand, Juri, Rolider, Adi, Thompson, Yuan Y., Wu, Xiaochong, Pugh, Trevor, Ally, Adrian, Bilenky, Mikhail, Butterfield, Yaron S. N., Carlsen, Rebecca, Cheng, Young, Chuah, Eric, Corbett, Richard D., Dhalla, Noreen, He, An, Lee, Darlene, Li, Haiyan I., Long, William, Mayo, Michael, Plettner, Patrick, Qian, Jenny Q., Schein, Jacqueline E., Tam, Angela, Wong, Tina, Birol, Inanc, Zhao, Yongjun, Faria, Claudia C., Pimentel, José, Nunes, Sofia, Shalaby, Tarek, Grotzer, Michael, Pollack, Ian F., Hamilton, Ronald L., Li, Xiao-Nan, Bendel, Anne E., Fults, Daniel W., Walter, Andrew W., Kumabe, Toshihiro, Tominaga, Teiji, Collins, Peter V., Cho, Yoon-Jae, Hoffman, Caitlin, Lyden, David, Wisoff, Jeffrey H., Garvin, James H., Stearns, Duncan S., Massimi, Luca, Schüller, Ulrich, Sterba, Jaroslav, Zitterbart, Karel, Puget, Stephanie, Ayrault, Olivier, Dunn, Sandra E., Tirapelli, Daniela P. C., Carlotti, Carlos G., Wheeler, Helen, Hallahan, Andrew R., Ingram, Wendy, MacDonald, Tobey J., Olson, Jeffrey J., Van Meir, Erwin G., Lee, Ji-Yeoun, Wang, Kyu-Chang, Kim, Seung-Ki, Cho, Byung-Kyu, Pietsch, Torsten, Fleischhack, Gudrun, Tippelt, Stephan, Ra, Young Shin, Bailey, Simon, Lindsey, Janet C., Clifford, Steven C., Eberhart, Charles G., Cooper, Michael K., Packer, Roger J., Massimino, Maura, Garre, Maria Luisa, Bartels, Ute, Tabori, Uri, Hawkins, Cynthia E., Dirks, Peter, Bouffet, Eric, Rutka, James T., Wechsler-Reya, Robert J., Weiss, William A., Collier, Lara S., Dupuy, Adam J., Korshunov, Andrey, Jones, David T. W., Kool, Marcel, Northcott, Paul A., Pfister, Stefan M., Largaespada, David A., Mungall, Andrew J., Moore, Richard A., Jabado, Nada, Bader, Gary D., Jones, Steven J. M., Malkin, David, Marra, Marco A., and Taylor, Michael D.

Published
2016
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111. Expression and Clinical Correlation of PD-1/PD-L1 and VE1(BRAFp.V600E) in Pediatric Langerhans Cell Histiocytosis.

Author

Tandon, Sneha, Weitzman, Sheila, Joyce, Brooklyn, Mcguire, Bryan, Stephens, Derek, Whitlock, James, Hawkins, Cynthia, Bo Yee Ngan, and Abla, Oussama

Subjects
LANGERHANS-cell histiocytosis, PROGRAMMED death-ligand 1, PROGRAMMED cell death 1 receptors, MUTANT proteins
Abstract

Background And Objectives: Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm with a wide spectrum of clinical presentations. Programmed Cell Death-1 (PD- 1) receptor and its ligand (PD-L1) are overexpressed in LCH, but their clinical significance is unknown. We performed a clinical correlation study of PD-1/PD-L1 and VE1(BRAFp.V600E) expression in 131 children with LCH. Methods: A total of 111 samples were tested for PD-1/PD-L1 and 109 for VE1(BRAFp.V600E) mutant protein by immunohistochemistry. Results: PD-1, PD-L1 and VE1(BRAFp.V600E) positivity was observed in 40.5%, 31.53% and 55%, respectively. PD-1/PD-L1 expression showed no significant effect on the rate of disease reactivations, early response to therapy or late sequelae. The 5-year EFS was not statistically different between patients with PD-1 positive compared to those with PD-1 negative tumours (47.7% vs.58.8%, p=0.17). Similar 5-year EFS rates were also seen in those who were PD-L1 positive compared to PD-L1 negative cases (50.5% vs.55.5%, p=0.61). VE1(BRAFp.V600E) positivity was associated with a significantly higher frequency of risk-organ involvement (p=0.0053), but no significant effect on early response to therapy or rates of reactivations or late sequelae. Conclusions: Our study showed no significant correlation between VE1(BRAFp.V600E) expression, PD-1 and PD-L1 and clinical outcome in pediatric LCH. [ABSTRACT FROM AUTHOR]

Published
2023
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112. DNA methylation for central nervous system.

Author

Ryall, Scott, Ku, Michelle, Bennett, Julie, Tabori, Uri, and Hawkins, Cynthia

Subjects
MOLECULAR diagnosis, CENTRAL nervous system tumors, MOLECULAR pathology, DNA methylation
Abstract

Copyright of Canadian Journal of Pathology is the property of Canadian Association of Pathologists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

114. A road map for the treatment of pediatric diffuse midline glioma

Author

Koschmann, Carl, Al-Holou, Wajd N., Alonso, Marta M., Anastas, Jamie, Bandopadhayay, Pratiti, Barron, Tara, Becher, Oren, Cartaxo, Rodrigo, Castro, Maria G., Chung, Chan, Clausen, Madison, Dang, Derek, Doherty, Robert, Duchatel, Ryan, Dun, Matthew, Filbin, Mariella, Franson, Andrea, Galban, Stefanie, Garcia Moure, Marc, Garton, Hugh, Gowda, Pruthvi, Marques, Joana Graca, Hawkins, Cynthia, Heath, Allison, Hulleman, Esther, Ji, Sunjong, Jones, Chris, Kilburn, Lindsay, Kline, Cassie, Koldobskiy, Michael A., Lim, Daniel, Lowenstein, Pedro R., Lu, Q. Richard, Lum, Joanna, Mack, Stephen, Magge, Suresh, Marini, Bernard, Martin, Donna, Marupudi, Neena, Messinger, Dana, Mody, Rajen, Morgan, Meredith, Mota, Mateus, Muraszko, Karin, Mueller, Sabine, Natarajan, Siva Kumar, Nazarian, Javad, Niculcea, Michael, Nuechterlein, Nicholas, Okada, Hideho, Opipari, Valerie, Pai, Manjunath P., Pal, Sharmistha, Peterson, Erik, Phoenix, Timothy, Prensner, John R., Pun, Matthew, Raju, G. Praveen, Reitman, Zachary J., Resnick, Adam, Rogawski, David, Saratsis, Amanda, Sbergio, Stefanie G., Souweidane, Mark, Stafford, James M., Tzaridis, Theophilos, Venkataraman, Sujatha, Vittorio, Orazio, Wadden, Jack, Wahl, Daniel, Wechsler-Reya, Robert J., Yadav, Viveka Nand, Zhang, Xu, Zhang, Qiang, and Venneti, Sriram

Published
2024
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115. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

Author

Remke, Marc, Ramaswamy, Vijay, Peacock, John, Shih, David J. H., Koelsche, Christian, Northcott, Paul A., Hill, Nadia, Cavalli, Florence M. G., Kool, Marcel, Wang, Xin, Mack, Stephen C., Barszczyk, Mark, Morrissy, A. Sorana, Wu, Xiaochong, Agnihotri, Sameer, Luu, Betty, Jones, David T. W., Garzia, Livia, Dubuc, Adrian M., Zhukova, Nataliya, Vanner, Robert, Kros, Johan M., French, Pim J., Van Meir, Erwin G., Vibhakar, Rajeev, Zitterbart, Karel, Chan, Jennifer A., Bognár, László, Klekner, Almos, Lach, Boleslaw, Jung, Shin, Saad, Ali G., Liau, Linda M., Albrecht, Steffen, Zollo, Massimo, Cooper, Michael K., Thompson, Reid C., Delattre, Oliver O., Bourdeaut, Franck, Doz, François F., Garami, Miklós, Hauser, Peter, Carlotti, Carlos G., Van Meter, Timothy E., Massimi, Luca, Fults, Daniel, Pomeroy, Scott L., Kumabe, Toshiro, Ra, Young Shin, Leonard, Jeffrey R., Elbabaa, Samer K., Mora, Jaume, Rubin, Joshua B., Cho, Yoon-Jae, McLendon, Roger E., Bigner, Darell D., Eberhart, Charles G., Fouladi, Maryam, Wechsler-Reya, Robert J., Faria, Claudia C., Croul, Sidney E., Huang, Annie, Bouffet, Eric, Hawkins, Cynthia E., Dirks, Peter B., Weiss, William A., Schüller, Ulrich, Pollack, Ian F., Rutkowski, Stefan, Meyronet, David, Jouvet, Anne, Fèvre-Montange, Michelle, Jabado, Nada, Perek-Polnik, Marta, Grajkowska, Wieslawa A., Kim, Seung-Ki, Rutka, James T., Malkin, David, Tabori, Uri, Pfister, Stefan M., Korshunov, Andrey, von Deimling, Andreas, and Taylor, Michael D.

Published
2013
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118. Frequent Amplification of a chr19q13.41 MicroRNA Polycistron in Aggressive Primitive Neuroectodermal Brain Tumors

Author

Li, Meihua, Lee, Kyle F., Lu, Yuntao, Clarke, Ian, Shih, David, Eberhart, Charles, Collins, V. Peter, Van Meter, Tim, Picard, Daniel, Zhou, Limei, Boutros, Paul C., Modena, Piergiorgio, Liang, Muh-Lii, Scherer, Steve W., Bouffet, Eric, Rutka, James T., Pomeroy, Scott L., Lau, Ching C., Taylor, Michael D., Gajjar, Amar, Dirks, Peter B., Hawkins, Cynthia E., and Huang, Annie

Published
2009
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119. EZH2 Expression Is a Prognostic Factor in Childhood Intracranial Ependymoma: A Canadian Pediatric Brain Tumor Consortium Study

Author

Li, Amanda M., Dunham, Christopher, Tabori, Uri, Carret, Anne-Sophie, McNeely, Daniel P., Johnston, Donna, Lafay-Cousin, Lucie, Wilson, Beverly, Eisenstat, David D., Jabado, Nada, Zelcer, Shayna, Silva, Mariana, Scheinemann, Katrin, Fryer, Christopher, Hendson, Glenda, Fotovati, Abbas, Hawkins, Cynthia, Yip, Stephen, Dunn, Sandra E., and Hukin, Juliette

Published
2015
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122. Molecular testing for adolescent and young adult central nervous system tumors: A Canadian guideline.

Author

Lim-Fat, Mary Jane, Macdonald, Maria, Lapointe, Sarah, Climans, Seth Andrew, Cacciotti, Chantel, Chahal, Manik, Perreault, Sebastien, Tsang, Derek S., Gao, Andrew, Yip, Stephen, Keith, Julia, Bennett, Julie, Ramaswamy, Vijay, Detsky, Jay, Tabori, Uri, Das, Sunit, and Hawkins, Cynthia

Subjects
YOUNG adults, CENTRAL nervous system tumors, TUMOR classification, TEENAGERS, PHASE transitions, MEDICAL care
Abstract

The 2021 World Health Organization (WHO) classification of CNS tumors incorporates molecular signatures with histology and has highlighted differences across pediatric vs adult-type CNS tumors. However, adolescent and young adults (AYA; aged 15-39), can suffer fromtumors across this spectrum and is a recognized orphan population that requires multidisciplinary, specialized care, and often through a transition phase. To advocate for a uniform testing strategy in AYAs, pediatric and adult specialists from neuro-oncology, radiation oncology, neuropathology, and neurosurgery helped develop this review and testing framework through the Canadian AYA Neuro-Oncology Consortium. We propose a comprehensive approach to molecular testing in this unique population, based on the recent tumor classification and within the clinical framework of the provincial health care systems in Canada. Contributions to the field: While there are guidelines for testing in adult and pediatric CNS tumor populations, there is no consensus testing for AYA patients whose care occur in both pediatric and adult hospitals. Our review of the literature and guideline adopts a resource-effective and clinically-oriented approach to improve diagnosis and prognostication of brain tumors in the AYA population, as part of a nation-wide initiative to improve care for AYA patients. [ABSTRACT FROM AUTHOR]

Published
2022
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123. Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma

Author

Dubuc, Adrian M., Remke, Marc, Korshunov, Andrey, Northcott, Paul A., Zhan, Shing H., Mendez-Lago, Maria, Kool, Marcel, Jones, David T. W., Unterberger, Alexander, Morrissy, A. Sorana, Shih, David, Peacock, John, Ramaswamy, Vijay, Rolider, Adi, Wang, Xin, Witt, Hendrik, Hielscher, Thomas, Hawkins, Cynthia, Vibhakar, Rajeev, Croul, Sidney, Rutka, James T., Weiss, William A., Jones, Steven J. M., Eberhart, Charles G., Marra, Marco A., Pfister, Stefan M., and Taylor, Michael D.

Published
2013
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126. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

Author

Khuong-Quang, Dong-Anh, Buczkowicz, Pawel, Rakopoulos, Patricia, Liu, Xiao-Yang, Fontebasso, Adam M., Bouffet, Eric, Bartels, Ute, Albrecht, Steffen, Schwartzentruber, Jeremy, Letourneau, Louis, Bourgey, Mathieu, Bourque, Guillaume, Montpetit, Alexandre, Bourret, Genevieve, Lepage, Pierre, Fleming, Adam, Lichter, Peter, Kool, Marcel, von Deimling, Andreas, Sturm, Dominik, Korshunov, Andrey, Faury, Damien, Jones, David T., Majewski, Jacek, Pfister, Stefan M., Jabado, Nada, and Hawkins, Cynthia

Published
2012
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128. Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

Author

Agnihotri, Sameer, Gajadhar, Aaron S., Ternamian, Christian, Gorlia, Thierry, Diefes, Kristin L., Mischel, Paul S., Kelly, Joanna, McGown, Gail, Thorncroft, Mary, Carlson, Brett L., Sarkaria, Jann N., Margison, Geoffrey P., Aldape, Kenneth, Hawkins, Cynthia, Hegi, Monika, and Guha, Abhijit

Subjects
Methylation -- Research, Glioblastoma multiforme -- Research -- Patient outcomes -- Diagnosis -- Care and treatment, Radiotherapy -- Health aspects -- Research, Health care industry
Abstract

Glioblastoma multiforme (GBM) is the most common and lethal of all gliomas. The current standard of care includes surgery followed by concomitant radiation and chemotherapy with the DNA alkylating agent temozolomide (TMZ). [O.sup.6]-methylguanine-DNA methyltransferase (MGMT) repairs the most cytotoxic of lesions generated by TMZ, [O.sup.6]-methylguanine. Methylation of the MGMT promoter in GBM correlates with increased therapeutic sensitivity to alkylating agent therapy. However, several aspects of TMZ sensitivity are not explained by MGMT promoter methylation. Here, we investigated our hypothesis that the base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions [N.sup.3]-methyladenine and [N.sup.7]-methylguanine, may contribute to TMZ resistance. Silencing of APNG in established and primary TMZ-resistant GBM cell lines endogenously expressing MGMT and APNG attenuated repair of TMZ-induced DNA damage and enhanced apoptosis. Reintroducing expression of APNG in TMZ-sensitive GBM lines conferred resistance to TMZ in vitro and in orthotopic xenograft mouse models. In addition, resistance was enhanced with coexpression of MGMT. Evaluation of APNG protein levels in several clinical datasets demonstrated that in patients, high nuclear APNG expression correlated with poorer overall survival compared with patients lacking APNG expression. Loss of APNG expression in a subset of patients was also associated with increased APNG promoter methylation. Collectively, our data demonstrate that APNG contributes to TMZ resistance in GBM and may be useful in the diagnosis and treatment of the disease., Introduction The most common primary adult human brain tumors are gliomas, with grade IV glioblastoma multiforme (GBM) astrocytoma being most common and malignant (1-3). With the current standard of treatment [...]

Published
2012
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134. International Society of Neuropathology-Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading

Author

Louis, David N., Perry, Arie, Burger, Peter, Ellison, David W., Reifenberger, Guido, von Deimling, Andreas, Aldape, Kenneth, Brat, Daniel, Collins, Peter V., Eberhart, Charles, Figarella-Branger, Dominique, Fuller, Gregory N., Giangaspero, Felice, Giannini, Caterina, Hawkins, Cynthia, Kleihues, Paul, Korshunov, Andrey, Kros, Johan M., Lopes, Beatriz M., Ng, Ho-Keung, Ohgaki, Hiroko, Paulus, Werner, Pietsch, Torsten, Rosenblum, Marc, Rushing, Elisabeth, Soylemezoglu, Figen, Wiestler, Otmar, and Wesseling, Pieter

Published
2014
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140. CAP-ACP Workload Model for Advanced Diagnostics in Precision Medicine.

Author

Park, Paul C, Kurek, Kyle C, DeCoteau, John, Howlett, Christopher J, Hawkins, Cynthia, Izevbaye, Iyare, Carter, Michael D, Redpath, Margaret, Lo, Bryan, Alex, Deepu, Yousef, George, Yip, Stephen, and Maung, Raymond

Subjects
EMPLOYEES' workload, TUMORS, ONCOLOGY
Abstract

Objectives: In precision medicine, where oncologic management is tailored to the individual's clinical and genetic profiles, advanced diagnostic testing provides prognostic information and guides management in a growing number of malignancies. There is a need to capture the work pathologists perform to meet this demand by providing medically relevant, timely, and accurate testing results. This work includes not only direct patient consults (interpretation of results and issuing reports) but the administrative and medical oversight as well as the research needed to provide the necessary quality assurance, quality control, direction, and framework for the laboratory.Methods: An expert panel of Canadian pathologists involved in advanced diagnostics was convened to establish and beta test a model for workload assessment in advanced diagnostics.Results: All aspects of the advanced diagnostics workload were detailed and applied to models based on members' experience, including medical oversight, administration, and the introduction of new testing and platforms. Models for biomarker testing were developed for simple and complex or multiplexed assays, and a detailed model was developed to assess the workload for next-generation sequencing-based assays.Conclusions: This paper provides the first detailed proposal for capturing an advanced diagnostic workload to enable appropriate pathologist allotment for performing all the steps required to run an advanced diagnostic service. [ABSTRACT FROM AUTHOR]

Published
2022
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147. Identification of human brain tumour initiating cells

Author

Singh, Sheila K., Hawkins, Cynthia, Clarke, Ian D., Squire, Jeremy A., Bayani, Jane, Hide, Takuichiro, Henkelman, R. Mark, Cusimano, Michael D., and Dirks, Peter B.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Sheila K. Singh [1, 2, 3]; Cynthia Hawkins [1, 4]; Ian D. Clarke [1, 2]; Jeremy A. Squire [6]; Jane Bayani [6]; Takuichiro Hide [1, 2]; R. Mark Henkelman [...]

Published
2004
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148. Rapidly progressive dementia due to Mycobacterium neoaurum meningoencephalitis

Author

Heckman, George A., Hawkins, Cynthia, Morris, Andrew, Burrows, Lori L., and Bergeron, Catherine

Subjects
Meningoencephalitis -- Research, Mycobacteria -- Research, Dementia -- Care and treatment, Mycobacterium -- Research
Abstract

Dementia developed in a patient with widespread neurologic manifestations; she died within 5 months. Pathologic findings showed granulomatous inflammation with caseation necrosis, foreign body-type giant cells, and proliferative endarteritis with [...]

Published
2004

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