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Prior longitudinal work suggests that blood pressure (BP) reactivity to the cold pressor test (CPT) helps predict hypertension; yet the impact of age and sex on hemodynamic and neural responsiveness to CPT remains equivocal. Forty-three young (21 ± 1yr, means ± SE) men (YM, n = 20) and women (YW, n = 23) and 16 older (60 ± 1yr) men (OM, n = 9) and women (OW, n = 7) participated in an experimental visit where continuous BP (finger plethysmography) and muscle sympathetic nerve activity (MSNA; microneurography) were recorded during a 3- to 5-min baseline and 2-min CPT. Baseline mean arterial pressure (MAP) was greater in OM than in YM (92 ± 4 vs. 77 ± 1 mmHg, P < 0.01), but similar in women (P = 0.12). Baseline MSNA incidence was greater in OM [69 ± 6 bursts/100 heartbeats (hb)] than in OW (44 ± 7 bursts/100 hb, P = 0.02) and lower in young adults (YM: 17 ± 3 vs. YW: 16 ± 2 bursts/100 hb, P < 0.01), but similar across the sexes (P = 0.83). However, when exposed to the CPT, MSNA increased more rapidly in OW (Δ43 ± 6 bursts/100 hb; group × time, P = 0.01) compared with OM (Δ15 ± 3 bursts/100 hb) but was not different between YW (Δ30 ± 3 bursts/100 hb) and YM (Δ33 ± 4 bursts/100 hb, P = 1.0). There were no differences in MAP with CPT between groups (group × time, P = 0.33). These findings suggest that OW demonstrate a more rapid initial rise in MSNA responsiveness to a CPT compared with OM. This greater sympathetic reactivity in OW may be a contributing mechanism to the increased hypertension risk in postmenopausal women. [ABSTRACT FROM AUTHOR]

Cardiovascular disease (CVD) and sleep disturbances are both common and associated with significant morbidity and mortality. Compared with men, women are more likely to report insufficient sleep. During the 2018 Research Conference on Sleep and the Health of Women sponsored by the National Heart, Lung, and Blood Institute, researchers in cardiology, integrative physiology and sleep medicine reviewed the current understanding of how sleep and sleep disturbances influence CVD in women across the lifespan. Women may be particularly vulnerable to the negative effects of sleep disturbances at important stages of their life, including during pregnancy and after menopause. The proposed pathways linking sleep disturbances and adverse cardiovascular outcomes in women are numerous and the complex interaction between them is not well understood. Future research focused on understanding the scope of sleep disorders in women, defining the underlying mechanisms, and testing interventions to improve sleep are critical for improving the cardiovascular health of all women. [ABSTRACT FROM AUTHOR]

Numerous conceptual models are used to describe the dynamic responsiveness of physiological systems to environmental pressures, originating with Claude Bernard's milieu intérieur and extending to more recent models such as allostasis. The impact of stress and anxiety upon these regulatory processes has both basic science and clinical relevance, extending from the pioneering work of Hans Selye who advanced the concept that stress can significantly impact physiological health and function. Of particular interest within the current article, anxiety is independently associated with cardiovascular risk, yet mechanisms underlying these associations remain equivocal. This link between anxiety and cardiovascular risk is relevant given the high prevalence of anxiety in the general population, as well as its early age of onset. Chronically anxious populations, such as those with anxiety disorders (i.e., generalized anxiety disorder, panic disorder, specific phobias, etc.) offer a human model that interrogates the deleterious effects that chronic stress and allostatic load can have on the nervous system and cardiovascular function. Further, while many of these disorders do not appear to exhibit baseline alterations in sympathetic neural activity, reactivity to mental stress offers insights into applicable, real-world scenarios in which heightened sympathetic reactivity may predispose those individuals to elevated cardiovascular risk. This article also assesses behavioral and lifestyle modifications that have been shown to concurrently improve anxiety symptoms, as well as sympathetic control. Lastly, future directions of research will be discussed, with a focus on better integration of psychological factors within physiological studies examining anxiety and neural cardiovascular health. © 2022 American Physiological Society. Compr Physiol 12:1-33, 2022., (Copyright © 2022 American Physiological Society. All rights reserved.)

Understanding how genomic variation gives rise to phenotypic variation is essential for elucidating mechanisms of adaptive evolution, plant and animal breeding, and precision medicine. However, identifying causal links between DNA sequence variants and variation in phenotypes is challenging in human populations, due to large blocks of linkage disequilibrium in the genome and heterogeneous developmental histories, lifestyles, and social and physical environments. Drosophila melanogaster presents a powerful genetic model, since linkage disequilibrium decays rapidly, facilitating assignment of causality to polymorphisms associated with phenotypic variation, and large numbers of individuals can be reared under defined environmental conditions, economically, and without regulatory restrictions. The D. melanogaster Genetic Reference Panel (DGRP), a population of 205 sequenced, inbred wild-derived flies, has enabled genome-wide association studies of morphological, physiological, behavioral, and life history traits, and demonstrated that genetic architectures of complex traits are highly polygenic, sexually dimorphic, and context dependent with extensive sex-, environment-, and genetic background (epistatic) effects. These features together with a modular organization of the transcriptome illustrate a dynamic integrative genetic architecture for complex traits. The complexity of the genetic architectures for complex traits in Drosophila provides important caveats for the interpretation of genetic studies in human populations. Aspects of the genetic underpinnings of complex traits can be represented as simplified gene networks on which human orthologues can be superimposed to provide blueprints for subsequent studies on analogous traits in human populations. Fundamental principles of the genetic architectures of Drosophila complex traits are likely applicable across phyla, from the DGRP to human populations. [ABSTRACT FROM AUTHOR]

The purpose of the current study was to identify latent profiles of COVID-19 fear, depression, anxiety, stress, mindfulness, and resilience among university students. A total of 506 university undergraduate and graduate students from various universities were recruited through online platforms in Turkey. Data were collected utilizing self-report scales and were analyzed utilizing latent profile analysis. Results indicated significant relationships among COVID-19 fear, depression, anxiety, stress, resilience, and mindfulness. A three-class solution was adapted to fit the current data. Findings revealed that 46% of the participants were classified into the high COVID-19 fear and medium psychological symptoms profile. Also, 38% of the participants were identified as low psychological symptoms and high mindfulness and resilience. Additionally, 16% of the participants were classified as high COVID-19 fear, psychological symptoms and low mindfulness and resilience. Female gender was positively associated with COVID-19 fear, depression, anxiety, and stress. Life satisfaction and social support were positively associated with the mindfulness and resilience, and were negatively related to COVID-19 fear, depression, anxiety, and stress., Author(s): Ilhan Yalçin [sup.1] [sup.2], Nesime Can [sup.1], Öykü Mançe Çalisir [sup.1], Seher Yalçin [sup.3], Burçin Çolak [sup.4] Author Affiliations: (1) grid.7256.6, 0000000109409118, Department of Guidance and Psychological Counseling, Ankara [...]