413 results on '"Ken Hashimoto"'
Search Results
52. Genetic characteristics of loggerhead turtles in the coastal corridor of the North West Pacific, around the Cape Muroto, Japan.
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Takashi Ishihara, Naoki Kamezaki, Saya Hirai, Yoshimasa Matsuzawa, Tomoko Hamabata, Asuka Ishizaki, and Dutton, Peter H.
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LOGGERHEAD turtle ,HAPLOTYPES ,MITOCHONDRIAL DNA ,PUBERTY ,ANIMAL migration ,TURTLES - Abstract
Genetic characteristics of North Pacific loggerhead turtles captured as bycatch in pound nets operating inMuroto, Kochi, Japan were sampled to identify and estimate stock structure of coastal foraging aggregations. Tissue samples were obtained from juvenile, subadult and adult turtles from 2005-2006 and 2008-2010. For each of the years, 100 samples were processed and approximately 820 bp of mitochondrial DNA control region were sequenced. Straight carapace length of the turtles ranged from 56.3-99.1 cmand their life stages were identified based on previous estimates of the size at puberty (66.0cm) and maturity (82.1cm). A total of 487 out of the 500 samples yielded sequences of sufficient quality to identify five different haplotypes. We conducted mixed stock analysis (MSA) using Bayesian approaches to estimate the contributions of three potential source nesting Management Units (MU) to the Muroto foraging aggregation. There were no significant differences between haplotype frequencies among the different size classes and life stages, nor among the different years, thus the haplotype frequencies were combined for the MSA. The MSA was runwith and without consideration of MUsize and distance, which resulted in similar MSA estimates. A >50% contribution was estimated from the Yakushima MU, and 40% from the Mainland MU, with only minor contribution from the Ryukyu MU. The estimated contribution from Mainland MU and Yakushima MU were disproportionately larger than the relative abundance of nesting at these MUs compared with Ryukyu MU, demonstrating that closer MUs had a greater contribution than those from further away. The lack of differences found in haplotype frequency among life stages, suggests that both juvenile and mature loggerhead turtles that remigrate to Japanese waters have the tendency to utilize foraging grounds and migration routes near their natal waters. [ABSTRACT FROM AUTHOR]
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- 2024
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53. Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.
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Hashimoto, Ken, Ohira, Momoko, Kodama, Aya, Kimoto, Misaki, Inoue, Mariko, Toné, Shigenobu, Usui, Yuu, Hanashima, Akira, Goto, Takato, Ogura, Yuhei, Ujihara, Yoshihiro, and Mohri, Satoshi
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NUCLEAR nonproliferation ,CONNECTIN ,HEART diseases ,HEART ,MUSCLE proteins ,STRIATED muscle ,PATIENT-ventilator dyssynchrony ,TUBULINS - Abstract
Connectin (also known as titin) is a giant striated muscle protein that functions as a molecular spring by providing elasticity to the sarcomere. Novex-3 is a short splice variant of connectin whose physiological function remains unknown. We have recently demonstrated using in vitro analyses that in addition to sarcomere expression, novex-3 was also expressed in cardiomyocyte nuclei exclusively during fetal life, where it provides elasticity/compliance to cardiomyocyte nuclei and promotes cardiomyocyte proliferation in the fetus, suggesting a non-sarcomeric function. Here, we analyzed novex-3 knockout mice to assess the involvement of this function in cardiac pathophysiology in vivo. Deficiency of novex-3 compromised fetal cardiomyocyte proliferation and induced the enlargement of individual cardiomyocytes in neonates. In adults, novex-3 deficiency resulted in chamber dilation and systolic dysfunction, associated with Ca
2+ dysregulation, resulting in a reduced life span. Mechanistic analyses revealed a possible association between impaired proliferation and abnormal nuclear mechanics, including stiffer nuclei positioned peripherally with stabilized circumnuclear microtubules in knockout cardiomyocytes. Although the underlying causal relationships were not fully elucidated, these data show that novex-3 has a vital non-sarcomeric function in cardiac pathophysiology and serves as an early contributor to cardiomyocyte proliferation. [ABSTRACT FROM AUTHOR]- Published
- 2024
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54. Integrating an infectious disease programme into the primary health care service: a retrospective analysis of Chagas disease community-based surveillance in Honduras
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Jiro Nakamura, Kyo Hanada, Concepción Zúniga, and Ken Hashimoto
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Male ,Health Knowledge, Attitudes, Practice ,Social Work ,medicine.medical_specialty ,Adolescent ,Psychological intervention ,Pilot Projects ,Health informatics ,Health administration ,Acquired immunodeficiency syndrome (AIDS) ,Nursing ,Seroepidemiologic Studies ,Environmental health ,medicine ,Humans ,Chagas Disease ,Child ,Retrospective Studies ,Primary Health Care ,Social work ,Delivery of Health Care, Integrated ,business.industry ,Public health ,Nursing research ,Health Policy ,medicine.disease ,Honduras ,Child, Preschool ,Population Surveillance ,Community health ,Female ,business ,Research Article - Abstract
Background Integration of disease-specific programmes into the primary health care (PHC) service has been attempted mostly in clinically oriented disease control such as HIV/AIDS and tuberculosis but rarely in vector control. Chagas disease is controlled principally by interventions against the triatomine vector. In Honduras, after successful reduction of household infestation by vertical approach, the Ministry of Health implemented community-based vector surveillance at the PHC services (health centres) to prevent the resurgence of infection. This paper retrospectively analyses the effects and process of integrating a Chagas disease vector surveillance system into health centres. Methods We evaluated the effects of integration at six pilot sites in western Honduras during 2008–2011 on; surveillance performance; knowledge, attitude and practice in schoolchildren; reports of triatomine bug infestation and institutional response; and seroprevalence among children under 15 years of age. The process of integration of the surveillance system was analysed using the PRECEDE-PROCEED model for health programme planning. The model was employed to systematically determine influential and interactive factors which facilitated the integration process at different levels of the Ministry of Health and the community. Results Overall surveillance performance improved from 46 to 84 on a 100 point-scale. Schoolchildren’s attitude (risk awareness) score significantly increased from 77 to 83 points. Seroprevalence declined from 3.4% to 0.4%. Health centres responded to the community bug reports by insecticide spraying. As key factors, the health centres had potential management capacity and influence over the inhabitants’ behaviours and living environment directly and through community health volunteers. The National Chagas Programme played an essential role in facilitating changes with adequate distribution of responsibilities, participatory modelling, training and, evaluation and advocacy. Conclusions We found that Chagas disease vector surveillance can be integrated into the PHC service. Health centres demonstrated capacity to manage vector surveillance and improve performance, children’s awareness, vector report-response and seroprevalence, once tasks were simplified to be performed by trained non-specialists and distributed among the stakeholders. Health systems integration requires health workers to perform beyond their usual responsibilities and acquire management skills. Integration of vector control is feasible and can contribute to strengthening the preventive capacity of the PHC service.
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55. Remimazolam-based total intravenous anesthesia in a patient with a confirmed diagnosis of malignant hyperthermia: a case report.
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Kondo, Hiroshi, Mukaida, Keiko, Sasai, Kurumi, Nao, Yukiko, Hashimoto, Ken, Miyoshi, Hirotsugu, Kanzaki, Rieko, and Tsutsumi, Yasuo M.
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MALIGNANT hyperthermia ,INTRAVENOUS anesthesia ,CALCIUM channels ,RYANODINE receptors ,DIAGNOSIS ,GENETIC testing - Abstract
Background: Malignant hyperthermia (MH) is a rare, life-threatening disorder of calcium homeostasis in skeletal muscle cells that is triggered by volatile anesthetics and succinylcholine, leading to a hypermetabolic reaction. The pathogenic ryanodine receptor 1 (RYR1) gene variant is critical. Patients susceptible to MH should avoid triggering agents, and total intravenous anesthesia (TIVA) is preferred. Remimazolam is safe in patients with suspected MH. Case presentation: We present the first case of remimazolam treatment in a genetically confirmed patient with MH without MH development. A 72-year-old man with a family history of MH underwent remimazolam-based TIVA. After informed consent was obtained, a muscle biopsy and genetic testing were performed. Intraoperatively and postoperatively, the patient exhibited no signs of MH. An enhanced function of the RYR1 channel into releasing calcium was indicated, and the genetic testing revealed a pathogenic variant of RYR1. Conclusions: Remimazolam-based TIVA is safe in patients confirming the diagnosis of MH. [ABSTRACT FROM AUTHOR]
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- 2024
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56. Comparative analysis of ventricular stiffness across species.
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Usui, Yuu, Hanashima, Akira, Hashimoto, Ken, Kimoto, Misaki, Ohira, Momoko, and Mohri, Satoshi
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CONNECTIN ,SPECIES ,COMPARATIVE studies ,DIASTOLE (Cardiac cycle) ,LABORATORY rats ,CHORDATA - Abstract
Investigating ventricular diastolic properties is crucial for understanding the physiological cardiac functions in organisms and unraveling the pathological mechanisms of cardiovascular disorders. Ventricular stiffness, a fundamental parameter that defines ventricular diastolic functions in chordates, is typically analyzed using the end‐diastolic pressure–volume relationship (EDPVR). However, comparing ventricular stiffness accurately across chambers of varying maximum volume capacities has been a long‐standing challenge. As one of the solutions to this problem, we propose calculating a relative ventricular stiffness index by applying an exponential approximation formula to the EDPVR plot data of the relationship between ventricular pressure and values of normalized ventricular volume by the ventricular weight. This article reviews the potential, utility, and limitations of using normalized EDPVR analysis in recent studies. Herein, we measured and ranked ventricular stiffness in differently sized and shaped chambers using ex vivo ventricular pressure‐volume analysis data from four animals: Wistar rats, red‐eared slider turtles, masu salmon, and cherry salmon. Furthermore, we have discussed the mechanical effects of intracellular and extracellular viscoelastic components, Titin (Connectin) filaments, collagens, physiological sarcomere length, and other factors that govern ventricular stiffness. Our review provides insights into the comparison of ventricular stiffness in different‐sized ventricles between heterologous and homologous species, including non‐model organisms. [ABSTRACT FROM AUTHOR]
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- 2024
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57. Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study.
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Højgaard, Kristoffer, Szöllősi, Bianka, Henningsen, Kim, Minami, Natsumi, Nakanishi, Nobuhiro, Kaadt, Erik, Tamura, Makoto, Morris, Richard G.M., Takeuchi, Tomonori, and Elfving, Betina
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DOPAMINE ,GENE expression ,DOPAMINE receptors ,MEMORY ,GLUTAMATE receptors ,LOCUS coeruleus ,TRANSGENIC organisms - Abstract
Copyright of Molecular Brain is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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58. AUTOIMMUNE EPIDERMAL BLISTERING DISEASES.
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Abreu Velez, Ana Maria, Calle, Juliana, and Howard, Michael S.
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BLISTERS ,SKIN diseases ,AUTOANTIBODIES ,BASAL lamina ,BULLOUS pemphigoid ,DERMATITIS herpetiformis ,ENZYME-linked immunosorbent assay - Abstract
Autoimmune bullous skin diseases (ABDs) are uncommon, potentially fatal diseases of skin and mucous membranes which are associated with deposits of autoantibodies and complement against distinct molecules of the epidermis and dermal/epidermal basement membrane zone (BMZ). These autoantibodies lead to a loss in skin molecular integrity, which manifests clinically as formation of blisters or erosions. In pemphigus vulgaris, loss of adhesion occurs within the epidermis. The pioneering work of Ernst H. Beutner, Ph.D. and Robert E. Jordon, M.D. confirmed the autoimmune nature of these diseases. Walter F. Lever, M.D. contributed significantly to our understanding of the histopathologic features of these diseases. Walter Lever, M.D. and Ken Hashimoto, M.D. contributed electron microscopic studies of these diseases, especially in pemphigus vulgaris and bullous pemphigoid. In bullous pemphigoid (BP), linear IgA bullous dermatosis, epidermolysis bullosa acquisita (EBA) and dermatitis herpetiformis (DH), loss of adhesion takes place within or underneath the BMZ. Classic EBA demonstrates extensive skin fragility; DH is commonly associated with gluten-sensitive enteropathy, and manifests clinically with pruritic papulovesicles on the extensor surfaces of the extremities and the lumbosacral area. The clinical spectrum of bullous pemphigoid includes tense blisters, urticarial plaques, and prurigo-like eczematous lesions. Pemphigoid gestationis mostly occurs during the last trimester of pregnancy, and mucous membrane pemphigoid primarily involves the oral mucosa and conjunctivae and leads to scarring. Linear IgA bullous dermatosis manifests with tense blisters in a cluster of jewels-like pattern in childhood (chronic bullous disease of childhood) and is more clinically heterogeneous in adulthood. Many of the autoantigens in these disorders are known and have been well characterized. ABDs may be influenced by both genetic and exogenous factors. The diagnoses of ABDs is based on histology of lesional skin and direct immunofluorescence (DIF) of perilesional skin, as well as by serologic confirmation of autoantibodies by indirect immunofluorescence (IIF) and recombinant autoantigens. The titers of the autoantibodies may correlate with the disease severity, and can be measured by indirect immunofluorescence and by ELISA testing. Therapeutically, systemic treatment with glucocorticoids is combined with immunosuppressive adjuvants which allow for fast reduction of systemic steroids. A prospective clinical trial in pemphigus showed that adjuvant treatment with azathioprine, mycophenolate mofetil and cyclophosphamide led to a significant reduction of the cumulative dose of systemic steroids until complete clinical remission was achieved. In bullous pemphigoid, topical treatment with clobetasol can help to accomplish a clinical remission without the major side effects seen with systemic steroids. Also, therapeutic depletion of B lymphocytes by rituximab has considerably improved the overall prognosis of pemphigus. Nurses and other paramedical personal caring for patients with these disorders play a critical role in improving the quality of life of the patients and their families. The patients need to be continuously evaluated to avoid secondary infections, especially if they have long term immuosupressive treatment. [ABSTRACT FROM AUTHOR]
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- 2013
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59. Activation of Astrocytes and Microglia in the C3–T4 Dorsal Horn by Lower Trunk Avulsion in a Rat Model of Neuropathic Pain
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Iwasaki, Ryutaro, Matsuura, Yusuke, Ohtori, Seiji, Suzuki, Takane, Kuniyoshi, Kazuki, and Takahashi, Kazuhisa
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- 2013
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60. Spatial control of skyrmion stabilization energy by low-energy Ga+ ion implantation.
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Miki, S., Hashimoto, K., Cho, J., Jung, J., You, C. Y., Ishikawa, R., Tamura, E., Nomura, H., Goto, M., and Suzuki, Y.
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ION implantation ,SECONDARY ion mass spectrometry ,SKYRMIONS ,FOCUSED ion beams ,ATOMIC force microscopy ,MAGNETIC films - Abstract
Magnetic skyrmions are candidates for information carriers in Brownian and stochastic computers. Developing a technique for fabricating a film with a suitable potential landscape, wherein the information carrier may diffuse freely, is essential for these probabilistic computers. In this study, to build the desired local potential into magnetic films, a 1.2 nm-thick Co-Fe-B film with a 5.2 nm-thick cap layer was irradiated by a focused ion beam (FIB) using Ga
+ as the ion source under a low acceleration voltage of 5 keV. The fluences ranged from 0 to 25 × 1012 ions/cm2 . Consequently, the critical temperature at which skyrmions appear or disappear is shifted by several 1–10 K depending on the ion fluence. The origin of this effect is discussed by observing the ion implantation profile and the surface sputtering depth using time-of-flight secondary ion mass spectrometry (TOF-SIMS) and atomic force microscopy (AFM). The results of TOF-SIMS measurements show that most of the Ga atoms exist in the Co–Fe–B layer. If all Ga atoms exist in the Co–Fe–B layer, the Ga concentration is 7 × 10−3 at. % after irradiation of 0.8 × 1012 ions/cm2 . The AFM results show a sputtered pattern with 0.2 nm depth after irradiation of 16 × 1012 ions/cm2 . Finally, the effect of irradiation on the diffusion coefficient was examined. It was determined that small fluences of 1.6 × 1012 and 0.8 × 1012 ions/cm2 can construct a potential barrier controlling skyrmions while maintaining diffusion coefficients as high as 10 μm2 /s. The FIB process can be used to draw a circuit of probabilistic computers with skyrmions as information carriers. [ABSTRACT FROM AUTHOR]- Published
- 2023
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61. Tumor-associated macrophages: Prognostic and therapeutic targets for cancer in humans and dogs.
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Brady, Rachel V. and Thamm, Douglas H.
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MACROPHAGES ,DRUG target ,DOGS ,TUMOR microenvironment ,IMMUNE system - Abstract
Macrophages are ancient, phagocytic immune cells thought to have their origins 500 million years ago in metazoan phylogeny. The understanding of macrophages has evolved to encompass their foundational roles in development, homeostasis, tissue repair, inflammation, and immunity. Notably, macrophages display high plasticity in response to environmental cues, capable of a strikingly wide variety of dynamic gene signatures and phenotypes. Macrophages are also involved in many pathological states including neural disease, asthma, liver disease, heart disease, cancer, and others. In cancer, most tumor-associated immune cells are macrophages, coined tumor-associated macrophages (TAMs). While some TAMs can display anti-tumor properties such as phagocytizing tumor cells and orchestrating an immune response, most macrophages in the tumor microenvironment are immunosuppressive and pro-tumorigenic. Macrophages have been implicated in all stages of cancer. Therefore, interest in manipulating macrophages as a therapeutic strategy against cancer developed as early as the 1970s. Companion dogs are a strong comparative immuno-oncology model for people due to documented similarities in the immune system and spontaneous cancers between the species. Data from clinical trials in humans and dogs can be leveraged to further scientific advancements that benefit both species. This review aims to provide a summary of the current state of knowledge on macrophages in general, and an in-depth review of macrophages as a therapeutic strategy against cancer in humans and companion dogs. [ABSTRACT FROM AUTHOR]
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- 2023
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62. Cardiac hemodynamics and ventricular stiffness of sea-run cherry salmon (Oncorhynchus masou masou) differ critically from those of landlocked masu salmon.
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Usui, Yuu, Kimoto, Misaki, Hanashima, Akira, Hashimoto, Ken, and Mohri, Satoshi
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LAKE trout ,SWEET cherry ,ONCORHYNCHUS ,DOPPLER echocardiography ,ANADROMOUS fishes ,SALMON ,DIASTOLE (Cardiac cycle) - Abstract
Ventricular diastolic mechanical properties are important determinants of cardiac function and are optimized by changes in cardiac structure and physical properties. Oncorhynchus masou masou is an anadromous migratory fish of the Salmonidae family, and several ecological studies on it have been conducted; however, the cardiac functions of the fish are not well known. Therefore, we investigated ventricular diastolic function in landlocked (masu salmon) and sea-run (cherry salmon) types at 29–30 months post fertilization. Pulsed-wave Doppler echocardiography showed that the atrioventricular inflow waveforms of cherry salmon were biphasic with early diastolic filling and atrial contraction, whereas those of masu salmon were monophasic with atrial contraction. In addition, end-diastolic pressure–volume relationship analysis revealed that the dilatability per unit myocardial mass of the ventricle in cherry salmon was significantly suppressed compared to that in masu salmon, suggesting that the ventricle of the cherry salmon was relatively stiffer (relative ventricular stiffness index; p = 0.0263). Contrastingly, the extensibility of cardiomyocytes, characterized by the expression pattern of Connectin isoforms in their ventricles, was similar in both types. Histological analysis showed that the percentage of the collagen accumulation area in the compact layer of cherry salmon increased compared with that of the masu salmon, which may contribute to ventricle stiffness. Although the heart mass of cherry salmon was about 11-fold greater than that of masu salmon, there was no difference in the morphology of the isolated cardiomyocytes, suggesting that the heart of the cherry salmon grows by cardiomyocyte proliferation, but not cell hypertrophy. The cardiac physiological function of the teleosts varies with differences in their developmental processes and life history. Our multidimensional analysis of the O. masou heart may provide a clue to the process by which the heart acquires a biphasic blood-filling pattern, i.e., a ventricular diastolic suction. [ABSTRACT FROM AUTHOR]
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- 2022
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63. The Fate of Epidermal Tight Junctions in the stratum corneum : Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions.
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Haftek, Marek, Oji, Vinzenz, Feldmeyer, Laurence, Hohl, Daniel, Hadj-Rabia, Smaïl, and Abdayem, Rawad
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EXTRACELLULAR enzymes ,HYDROLASES ,CELL fusion ,SALICYLIC acid ,SKIN diseases ,TIGHT junctions - Abstract
We evaluated the presence of tight junction (TJ) remnants in the stratum corneum (SC) of in vitro reconstructed human epidermis and human skin explants subjected or not to an aggressive topical treatment with beta-lipohydroxy salicylic acid (LSA) for 24 h. LSA-treated samples showed an increased presence of TJ remnants in the two lowermost layers of the SC, as quantified with standard electron microscopy. The topical aggression-induced overexpression of TJ-like cell–cell envelope fusions may influence SC functions: (1) directly, through an enhanced cohesion, and (2) indirectly, by impeding accessibility of peripheral corneodesmosomes to extracellular hydrolytic enzymes and, thus, slowing down desquamation. Observations of ichthyotic epidermis in peeling skin disease (PSD; corneodesmosin deficiency; two cases) and ichthyosis hypotrichosis sclerosing cholangitis syndrome (IHSC/NISCH; absence of claudin-1; two cases) also demonstrated increased persistence of TJ-like intercellular fusions in pathological SC and contributed to the interpretation of the diseases' pathological mechanisms. [ABSTRACT FROM AUTHOR]
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- 2022
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64. Effects of intravenous injection of indocyanine green on the oxygen reserve index (ORi[TM])
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Kondo, Hiroshi, Nakamura, Ryuji, Kobatake, Ayako, Nao, Yukiko, Hashimoto, Ken, and Nakatani, Keio
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Medical research -- Analysis -- Usage ,Medicine, Experimental -- Analysis -- Usage ,Nervous system -- Surgery ,Health - Abstract
Purpose The oxygen reserve index (ORi[TM]) is a parameter used for the noninvasive evaluation of arterial partial pressure of oxygen (PaO.sub.2), specifically in the 100-200 mmHg range. We aimed to report on the impact of indocyanine green (ICG) on the ORi[TM]. Methods In this study, we retrospectively examined patients who underwent neurosurgery between April and July 2019 and assessed the impact of ICG on ORi[TM]. We excluded patients who did not use ICG or who were not examined for ORi[TM]. The dose and timing of ICG administration were determined by a neurosurgeon. The changes in ORi[TM] were measured for up to 30 min. Results We analyzed ten patients and found that the ORi[TM] increased to 1.00 in all of them. The median time for ORi [TM] to rise to 1.00 after ICG administration was 2 min (range 1-4). After rising to 1.00, ORi [TM] decreased and took 27 min to return to the pre-dose value. Conclusion It is important to consider the initial rapid increase and subsequent slow decrease in ORi[TM] when using ICG during surgery., Author(s): Hiroshi Kondo [sup.1], Ryuji Nakamura [sup.2], Ayako Kobatake [sup.1], Yukiko Nao [sup.1], Ken Hashimoto [sup.1], Keio Nakatani [sup.1] Author Affiliations: (1) grid.505831.a, 0000 0004 0623 2857, Department of Anesthesiology, [...]
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- 2020
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65. Study Results from Kawasaki Medical School Provide New Insights into Cardiology (Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics).
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NUCLEAR nonproliferation ,HEART diseases ,CONNECTIN ,MEDICAL schools ,CARDIOLOGY - Abstract
A recent study conducted at Kawasaki Medical School has provided new insights into cardiology. The study focused on the role of connectin (also known as titin), a muscle protein that provides elasticity to the sarcomere. The researchers analyzed novex-3 knockout mice and found that the deficiency of novex-3 led to heart dysfunction, compromised cardiomyocyte proliferation, and abnormal nuclear mechanics. These findings suggest that novex-3 plays a vital non-sarcomeric function in cardiac pathophysiology and contributes to cardiomyocyte proliferation. Further research is needed to fully understand the underlying causal relationships. [Extracted from the article]
- Published
- 2024
66. Acral peeling skin syndrome
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Hashimoto, Ken, Hamzavi, Iltefat, Tanaka, Kazuaki, and Shwayder, Tor
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- 2000
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67. Characteristics of aspiration pneumonia patients in acute care hospitals: A multicenter, retrospective survey in Northern Japan.
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Suzuki, Jun, Ikeda, Ryoukichi, Kato, Kengo, Kakuta, Risako, Kobayashi, Yuta, Ohkoshi, Akira, Ishii, Ryo, Hirano-Kawamoto, Ai, Ohta, Jun, Kawata, Rei, Kanbayashi, Tomonori, Hatano, Masaki, Shishido, Tadahisa, Miyakura, Yuya, Ishigaki, Kento, Yamauchi, Yasunari, Nakazumi, Miho, Endo, Takuya, Tozuka, Hiroki, and Kitaya, Shiori
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ASPIRATION pneumonia ,DEGLUTITION ,HOSPITAL care ,PATIENT care ,ACCOUNTS payable ,MEDICAL records ,NEUROMUSCULAR diseases - Abstract
Background: Pneumonia is a common cause of illness and death of the elderly in Japan. Its prevalence is escalating globally with the aging of population. To describe the latest trends in pneumonia hospitalizations, especially aspiration pneumonia (AP) cases, we assessed the clinical records of pneumonia patients admitted to core acute care hospitals in Miyagi prefecture, Japan. Methods: A retrospective multi-institutional joint research was conducted for hospitalized pneumonia patients aged ≥20 years from January 2019 to December 2019. Clinical data of patients were collected from the medical records of eight acute care hospitals. Results: Out of the 1,800 patients included in this study, 79% of the hospitalized pneumonia patients were aged above 70 years. The most common age group was in the 80s. The ratio of AP to total pneumonia cases increased with age, and 692 out of 1,800 patients had AP. In univariate analysis, these patients had significantly older ages, lower body mass index (BMI), a lower ratio of normal diet intake and homestay before hospitalization, along with more AP recurrences and comorbidities. During hospitalization, AP patients had extended fasting periods, more swallowing assessments and interventions, longer hospitalization, and higher in-hospital mortality rate than non-AP patients. A total of 7% and 2% AP patients underwent video endoscopy and video fluorography respectively. In multivariate analysis, lower BMI, lower C-reactive protein, a lower ratio of homestay before hospitalization, a higher complication rate of cerebrovascular disease, dementia, and neuromuscular disease were noted as a characteristic of AP patients. Swallowing interventions were performed for 51% of the AP patients who had been hospitalized for more than two weeks. In univariate analysis, swallowing intervention improved in-hospital mortality. Lower AP recurrence before hospitalization and a lower ratio of homestay before hospitalization were indicated as characteristics of AP patients of the swallowing intervention group from multivariate analysis. Change in dietary pattern from normal to modified diet was observed more frequently in the swallowing intervention group. Conclusion: AP accounts for 38.4% of all pneumonia cases in acute care hospitals in Northern Japan. The use of swallowing evaluations and interventions, which may reduce the risk of dysphagia and may associate with lowering mortality in AP patients, is still not widespread. [ABSTRACT FROM AUTHOR]
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- 2021
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68. Biphasic amyloidosis: link between macular and lichenoid forms.
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Brownstein, Martin H., Hashimoto, Ken, and Grennwald, Gerald
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AMYLOIDOSIS ,PROTEIN metabolism disorders ,LYMPHOPROLIFERATIVE disorders ,ANTI-inflammatory agents ,STEROID drugs ,EPIDERMIS - Abstract
A woman manifested lichen amyloidosus of the right lower limb and macular amyloidosis of her left leg with congenitally impaired cutaneous sensation. Another patient had bilateral lichenoid amyloidosis of her legs. Unilateral triamcinolone injections produced the picture of macular amyloidosis in the treated leg. Light and electron microscopic studies of biopsies from both patients showed similar amyloid deposits in the papillae; the significant difference was epidermal hyperplasia in the lichenoid lesions. We suggest the term biophasic for the existence of both macular and lichenoid amyloidosis in the same patient. The dramatic clinical picture of intensely pruritic keratotic papules in lichenoid amyloidosis contrasts sharply with the subtle pigmentary changes found in the macular variety. Nevertheless, it has recently been suggested (Brownstein & Hashimoto, 1972) that these conditions may represent the same basic disease process, and that the essential differences are due mainly to secondary hyperplastic changes of the epidermis. Our purpose here is to present evidence of an intimate relationship between these disorders by describing two patients with biphasic amyloidosis-lichen amyloidosus of one tower limb and macular amyloidosis of the other. [ABSTRACT FROM AUTHOR]
- Published
- 1973
69. THE ULTRASTRUCTURE OF THE SKIN OF HUMAN EMBRYOS V. THE HAIR GERM AND PERIFOLLICULAR MESENCHYMAL CELLS.
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Hashimoto, Ken
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HUMAN embryos ,CONNECTIVE tissues ,HAIR follicles ,ELECTRON microscopy ,DEVELOPMENTAL biology ,DESMOSOMES - Abstract
Electron microscopic studies on embryonic hair development were performed using the scalp and eyebrow skin of 10 Negro embryos of the menstrual ages of 9 to 15 weeks. New ultramicroscopic findings were: (1) The peripheral cells of the hair germ extended into the mesenchyme pseudopodia, not covered by the basal lamina. (2) Mesenchymal cells crowded beneath the hair germ were connected with desmosome-like junctions. Direct contact of these cells with the basal lamina of the hair germ was seen. (3) A half-desmosome- like structure was found between the mesenchymal cells and mesenchymal fine filaments. [ABSTRACT FROM AUTHOR]
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- 1970
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70. Has the prevalence of Chagas disease increased in Central Latin America?
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Yoshioka, Kota, Hashimoto, Ken, and Monroy, Carlota
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CHAGAS' disease ,DISEASE prevalence - Abstract
In their editorial published in PLOS NTDs, Hotez et al. [[1]] wrote that "the GBD 2017 [Global Burden of Disease Study 2017] tells a sobering story about progress in controlling malaria and NTDs [neglected tropical diseases]" in Central Latin America (CLA). In this article, we show that the GBD 2017 can tell a different story about Chagas disease in CLA. Our article also suggests that progress of disease control should not be assessed by a single indicator and that there is a need to improve GBD estimates about Chagas disease in CLA. [Extracted from the article]
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- 2020
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71. Comparison of long-term changes in size and longevity of bee colonies in mid-west Japan and Maui with and without exposure to pesticide, cold winters, and mites.
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Toshiro Yamada and Kazuko Yamada
- Subjects
BEE colonies ,FENITROTHION ,THIAMETHOXAM ,LONGEVITY ,ACARICIDES ,PESTICIDES ,MITES ,HONEYBEES - Abstract
Four long-term field experiments in mid-west Japan (Shika) made it clear that extinction of colonies exposed to neonicotinoid was much higher than for colonies exposed to organophosphates. The incidence of hive death for of organophosphate-exposed and control (pesticide-free) colonies was similar. We conducted a field experiment in Maui for 271 days using the same pesticides (dinotefuran: 0.2 ppm, clothianidin: 0.08 ppm, fenitrothion: 1 ppm) as used in Shika with the honeybee, Apis mellifera, colonies without mites. Numbers of adult bees, capped brood, mites and other hive parameters were accurately counted on photographs of combs and on the inside of the hives. All six neonicotinoid (dinotefuran & clothianidin)-exposed colonies failed during the experiment. One of three organophosphate (fenitrothion)-exposed colonies and one of the three control colonies also failed. The findings from Maui, where colonies displayed no mites, provides evidence from Shika, with mites, that neonicotinoids are more hazardous to honeybee colonies than organophosphates. The apparent longevity of honeybee colonies on Maui was estimated by numbers of adult bees and capped brood using a mathematical model previously proposed. Seasonal changes in longevity on Maui differ greatly from changes at Shika, the latter showing distinct seasonal variation. Longevity on Maui remains nearly constant throughout the year with wide variations. At Shika, it increases drastically in winter, by six- to ten fold more than the other seasons. Differences seem to depend on the existence of cold winters and the length of flowering seasons. In a perpetually hospitable environment, small changes in conditions can be sensitively reflected in apparent longevity. Examining wide variations in apparent longevity that are seemingly incoherent, we recognized several differences in apparent longevity between neonicotinoidexposed and organophosphate-exposed colonies: The colony that failed in after organophosphate-exposure colony group exhibited the longest apparent longevity and the fewest number of newly capped brood, as also was the case in control colonies. Extended longevity when few brood are newly produced is reasonable to maintain the colony from a physiological point of view. Extension of apparent longevity is not seen in neonicotinoid-exposed colonies when the number of newly capped brood is fewer. This finding suggests that neonicotinoid pesticides may inhibit normal apian physiology. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
72. Moving Towards Universal Health Coverage in Haiti.
- Author
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Hashimoto, Ken, Adrien, Lauré, and Rajkumar, Sunil
- Subjects
NATIONAL health insurance ,FINANCIAL management ,QUALITY of service ,COMMUNITY involvement - Abstract
Haiti announced in 2018 its aim to achieve universal health coverage. In this paper, we discuss what this objective means for the country and what next steps should be taken. To contextualize the notion, we framed Haiti en route to the 2030 goal and analyzed qualitatively the status quo in terms of geographic, financial, and service access. For each dimension, we focused on the context, the government's policies and political agendas, their implementation progress, and key influential factors. Our analysis found little progress and numerous challenges. Geographic access was limited due principally to the insufficient number of facilities, difficulties in reaching health facilities, and local customs. Financial coverage was low because of the government's insufficient budgets, inefficient budget allocation, and ineffective management. Service access also had room for significant improvement for a lack of basic infrastructure and resources, gaps between the essential service package guidelines, health professionals' skills, and the needs, as well as deficiencies in people-centered care. These factors affected not only health service coverage but also its quality. We found that the root causes of these issues were composed of unstable financing mechanisms, opportunistic resource allocation, and ineffective management control systems. We suggest that to overcome these issues and achieve universal health coverage with decent service quality, Haiti's health system needs to be reformed by implementing strategic financing, decentralized management systems, and community engagement in primary health care. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
73. Festschrift: in honor of Walter F. Lever, M. D.
- Author
-
Mcnutt, N. Scutt
- Subjects
CONFERENCES & conventions ,ELECTRON microscopy ,DERMATOLOGY ,DESMOSOMES - Abstract
The article presents information about various papers that were presented in a symposium at the annual meeting of the American Society of Dermatopathology in Washington D.C. on December 2, 1993. They have been updated and are presented here as a continuing tribute to Dr. Walter F. Lever who was a founding member of the Society. The first paper in the Symposium was given by researcher Gundula Schaurnburg-Lever, his wife and collaborator in his famous textbook and an atlas of dermatopathology. Her paper is entitled New Applications of Electron Microscopy Techniques in Dermatopathology. The second paper was given by researcher Ken Hashimoto, entitled Desmosomal Dissolution in Grover's Disease.
- Published
- 1995
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74. Table of Contents.
- Published
- 1993
- Full Text
- View/download PDF
75. Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects.
- Author
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Yamaga, Masayuki, Tani, Hiroko, Yamaki, Ayanori, Tatefuji, Tomoki, and Hashimoto, Ken
- Published
- 2019
- Full Text
- View/download PDF
76. A mathematical model to estimate the seasonal change in apparent longevity of bee colony.
- Author
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Yamada, Yasuhiro, Yamada, Toshiro, and Yamada, Kazuko
- Published
- 2019
- Full Text
- View/download PDF
77. In Memoriam: Judge Deborah A. Batts.
- Subjects
JUDGES ,COURT personnel - Published
- 2021
78. Program of the 23rd Annual Meeting of the Electron Microscopy Society of America.
- Published
- 1965
- Full Text
- View/download PDF
79. Synaptic migration and reorganization after noise exposure suggests regeneration in a mature mammalian cochlea
- Author
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Hickman, Tyler T., Hashimoto, Ken, Liberman, Leslie D., and Liberman, M. Charles
- Published
- 2020
- Full Text
- View/download PDF
80. Autoimmune Dermatoses.
- Author
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Zheng, Jie, Pan, Meng, Gianfaldoni, S., D'Erme, A. M., Lotti, T., Zhang, Xingqi, Zhang, Peng, Yuan, Jin, Lu, Qianjin, Hashimoto, Ken, and Lewis, Fiona
- Published
- 2017
- Full Text
- View/download PDF
81. FrontMatter.
- Published
- 2017
82. On behalf of our readership, we thank the following reviewers for their time and effort.
- Abstract
The article presents a list of reviewers who contributed in reviewing articles in the December 1986 issue of the journal "The Journal of Dermatologic Surgery & Oncology." Some of the reviewers name are Richard Fleming, David F. Fretzin, Marc L. Frost, Andrew A. Gage, Roy Geronemus, John W. Gerwels, Barbara Gilchrest, Richard G. Glogau, John L. Glover, David Goldberg, Leonard Goldberg, Peter M. Goldman, Loren E. Golitz, Daniel E. Gormley, Blake J. Goslen, Hubert T. Greenway, Roy C. Grekin, Donald Groot, Daniel Gross, Ruth Hanno, David R. Harris, Ken Hashimoto, Robert Jeffrey Herten, Antoinette Hood, Ned B. Hornback, William R. Howard, Robert Hurwitz, Leo Indianer, Paul Jacobs, Brian Jegasothy, Roy Knowles, Gerald G Krueger, Emanuel G. Kuflik, Pearon G. Lang, Nikoljas A. Lapins, Paul O. Larson, Leonard Lewis, James J. Leyden, Bobby L. Limmer, Toby Mayer, Amir H. Mehregan, George R. Mikhail, Frederic E. Mohs, Gary D. Monheit, Ricardo Mora, Victor D. Newcomer, Alvin R. Solomon, Neil A. Swanson, James S. Taylor, Robert Tomsick.
- Published
- 1986
83. Royal Jelly Supplementation Improves Menopausal Symptoms Such as Backache, Low Back Pain, and Anxiety in Postmenopausal Japanese Women.
- Author
-
Asama, Takashi, Matsuzaki, Hidenori, Fukushima, Shinobu, Tatefuji, Tomoki, Hashimoto, Ken, and Takeda, Takashi
- Subjects
SYMPTOMS ,DIETARY supplements ,DISEASES ,PLACEBOS ,PROBABILITY theory ,QUESTIONNAIRES ,T-test (Statistics) ,WOMEN ,RANDOMIZED controlled trials ,POSTMENOPAUSE ,DATA analysis software ,DESCRIPTIVE statistics ,PREVENTION - Abstract
Objectives . This study aimed to evaluate the effect of Royal Jelly (RJ) at a dose of 800 mg/day on menopausal symptoms in healthy Japanese postmenopausal women with placebo-controlled design.Material and Methods . A total of 42 healthy Japanese postmenopausal women have been recruited for this study. The subjects were randomized to oral treatment with either 800 mg of protease-digested lyophilized powder of RJ (enzyme-treated RJ) or placebo (800 mg of dextrin) daily for 12 weeks. The level of menopausal symptoms has been evaluated every 4 weeks, using menopausal symptoms questionnaire of Japanese women. Independent t-test was used to evaluate statistical significance of the treatment effects between the two groups.Results and Conclusion . All of the 42 women have completed the trial. There were significant differences related to the anxiety score (P=0.046) and backache and low back pain score (P=0.040) between 800 mg/day enzyme-treated RJ and placebo-treated groups after 12 weeks of administration, and no significant differences were found between the two groups in 4 weeks after intervention. No side effects were observed in either group. This study demonstrates that enzyme-treated RJ supplementation with doses of 800 mg/day is effective in relieving menopausal symptoms such as anxiety, backache, and low back pain in Japanese postmenopausal women. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
84. Boom Times on the Psychic Frontier.
- Subjects
PARAPSYCHOLOGY ,PRECOGNITION ,PSYCHOLOGISTS - Abstract
The article focuses on the psychic phenomena in the U.S. and abroad. It states that the book "The Secret Life of Plants" became a bestseller in the U.S. by offering an astonishing and heretical thesis. It also states that the image of painting is transmitted by extrasensory perception (ESP) at the Maimonides Medical Center in New York City. It adds that in England, 70 percent of the respondents believe in the possibility of extrasensory perception. It also adds that Charles Tart of the University of California reported that his subjects showed a marked increase in extrasensory perception.
- Published
- 1974
85. Findings in the Area of Obesity, Fitness and Wellness Reported from Tohoku University (Effects of Ndufs4 Deletion On Hearing After Various Acoustic Exposures).
- Subjects
OBESITY ,NOISE-induced deafness - Abstract
Keywords: Miyagi; Japan; Asia; Obesity Fitness and Wellness EN Miyagi Japan Asia Obesity Fitness and Wellness 605 605 1 09/11/23 20230915 NES 230915 2023 SEP 15 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators discuss new findings in Obesity, Fitness and Wellness. Keywords for this news article include: Miyagi, Japan, Asia, Obesity, Fitness and Wellness, Tohoku University. [Extracted from the article]
- Published
- 2023
86. AUTOIMMUNE EPIDERMAL BLISTERING DISEASES
- Author
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Ana Maria Abreu Velez, Juliana Calle, and Michael S. Howard
- Subjects
autoimmune blistering skin diseases ,bullous pemphigoid (BP) ,cicatricial pemphigoid (CP) ,basement membrane zone (BMZ) ,pemphigus vulgaris (PV) ,dermatitis herpetiformis (DH) ,Dermatology ,RL1-803 - Abstract
Autoimmune bullous skin diseases (ABDs) are uncommon, potentially fatal diseases of skin and mucous membranes which are associated with deposits of autoantibodies and complement against distinct molecules of the epidermis and dermal/epidermal basement membrane zone (BMZ). These autoantibodies lead to a loss in skin molecular integrity, which manifests clinically as formation of blisters or erosions. In pemphigus vulgaris, loss of adhesion occurs within the epidermis. The pioneering work of Ernst H. Beutner, Ph.D. and Robert E. Jordon, M.D. confirmed the autoimmune nature of these diseases. Walter F. Lever, M.D. contributed significantly to our understanding of the histopathologic features of these diseases. Walter Lever, M.D. and Ken Hashimoto, M.D. contributed electron microscopic studies of these diseases, especially in pemphigus vulgaris and bullous pemphigoid. In bullous pemphigoid (BP), linear IgA bullous dermatosis, epidermolysis bullosa acquisita (EBA) and dermatitis herpetiformis (DH), loss of adhesion takes place within or underneath the BMZ. Classic EBA demonstrates extensive skin fragility; DH is commonly associated with gluten-sensitive enteropathy, and manifests clinically with pruritic papulovesicles on the extensor surfaces of the extremities and the lumbosacral area. The clinical spectrum of bullous pemphigoid includes tense blisters, urticarial plaques, and prurigo-like eczematous lesions. Pemphigoid gestationis mostly occurs during the last trimester of pregnancy, and mucous membrane pemphigoid primarily involves the oral mucosa and conjunctivae and leads to scarring. Linear IgA bullous dermatosis manifests with tense blisters in a „cluster of jewels”-like pattern in childhood (chronic bullous disease of childhood) and is more clinically heterogeneous in adulthood. Many of the autoantigens in these disorders are known and have been well characterized. ABDs may be influenced by both genetic and exogenous factors. The diagnoses of ABDs is based on histology of lesional skin and direct immunofluorescence (DIF) of perilesional skin, as well as by serologic confirmation of autoantibodies by indirect immunofluorescence (IIF) and recombinant autoantigens. The titers of the autoantibodies may correlate with the disease severity, and can be measured by indirect immunofluorescence and by ELISA testing. Therapeutically, systemic treatment with glucocorticoids is combined with immunosuppressive adjuvants which allow for fast reduction of systemic steroids. A prospective clinical trial in pemphigus showed that adjuvant treatment with azathioprine, mycophenolate mofetil and cyclophosphamide led to a significant reduction of the cumulative dose of systemic steroids until complete clinical remission was achieved. In bullous pemphigoid, topical treatment with clobetasol can help to accomplish a clinical remission without the major side effects seen with systemic steroids. Also, therapeutic depletion of B lymphocytes by rituximab has considerably improved the overall prognosis of pemphigus. Nurses and other paramedical personal caring for patients with these disorders play a critical role in improving the quality of life of the patients and their families. The patients need to be continuously evaluated to avoid secondary infections, especially if they have long term immuosupressive treatment.
- Published
- 2013
- Full Text
- View/download PDF
87. Corrigendum: Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction.
- Author
-
Suzuki, Jun, Hashimoto, Ken, Xiao, Ru, Vandenberghe, Luk H., and Liberman, M. Charles
- Abstract
This corrects the article DOI: 10.1038/srep45524 [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
88. Protection from noise-induced cochlear synaptopathy by virally mediated overexpression of NT3
- Author
-
Hashimoto, Ken, Hickman, Tyler T., Suzuki, Jun, Ji, Lingchao, Kohrman, David C., Corfas, Gabriel, and Liberman, M. Charles
- Published
- 2019
- Full Text
- View/download PDF
89. Resveratrol derivative-rich melinjo (<italic>Gnetum gnemon</italic> L.) seed extract improves obesity and survival of C57BL/6 mice fed a high-fat diet.
- Author
-
Ikuta, Tomoki, Saito, Shinichiro, Tani, Hiroko, Tatefuji, Tomoki, and Hashimoto, Ken
- Subjects
GNETUM gnemon ,OBESITY treatment ,PHYSIOLOGICAL effects of resveratrol - Abstract
Melinjo (
Gnetum gnemon L.) seed extracts (MSEs) are rich in resveratrol dimers (gnemonoside A, C, D, gnetin C),trans -resveratrol, and other resveratrol derivatives.trans -Resveratrol is a widely studied caloric restriction mimetic. In mice fed a high-fat diet (HFD),trans -resveratrol protects against obesity, type 2 diabetes, and premature death. Here, treatment of HFD-fed mice with 2.0% MSE significantly reduced body weight gain (p < 0.001), blood insulin (p < 0.01), and HOMA-IR (p < 0.05) after 8 weeks compared with untreated HFD-fed mice. Additionally, 0.2% MSE treatment of HFD-fed mice significantly improved physiological activity (p < 0.05) at 18 months of age and reduced risk of death due to HFD by 25% (hazard ratio = 0.75,p = 0.036). These data show that MSE can improve several aspects of metabolic syndrome and survival in mice and may have health benefits as a dietary supplement. [ABSTRACT FROM AUTHOR]- Published
- 2015
- Full Text
- View/download PDF
90. Accuracy of specimen-specific nonlinear finite element analysis for evaluation of radial diaphysis strength in cadaver material.
- Author
-
Matsuura, Yusuke, Kuniyoshi, Kazuki, Suzuki, Takane, Ogawa, Yasufumi, Sukegawa, Koji, Rokkaku, Tomoyuki, Thoreson, Andrew Ryan, An, Kai-Nan, and Takahashi, Kazuhisa
- Subjects
FOREARM injuries ,BONE plates (Orthopedics) ,FINITE element method ,UNIVERSAL testing machines (Engineering) ,BONE density ,COMPUTED tomography - Abstract
The feasibility of a user-specific finite element model for predicting thein situstrength of the radius after implantation of bone plates for open fracture reduction was established. The effect of metal artifact in CT imaging was characterized. The results were verified against biomechanical test data. Fourteen cadaveric radii were divided into two groups: (1) intact radii for evaluating the accuracy of radial diaphysis strength predictions with finite element analysis and (2) radii with a locking plate affixed for evaluating metal artifact. All bones were imaged with CT. In the plated group, radii were first imaged with the plates affixed (for simulating digital plate removal). They were then subsequently imaged with the locking plates and screws removed (actual plate removal). Fracture strength of the radius diaphysis under axial compression was predicted with a three-dimensional, specimen-specific, nonlinear finite element analysis for both the intact and plated bones (bones with and without the plate captured in the scan). Specimens were then loaded to failure using a universal testing machine to verify the actual fracture load. In the intact group, the physical and predicted fracture loads were strongly correlated. For radii with plates affixed, the physical and predicted (simulated plate removal and actual plate removal) fracture loads were strongly correlated. This study demonstrates that our specimen-specific finite element analysis can accurately predict the strength of the radial diaphysis. The metal artifact from CT imaging was shown to produce an overestimate of strength. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
91. MarketLine Company Profile: Kao Corporation.
- Published
- 2014
92. Music of the Plants.
- Author
-
Vitale, Simone
- Subjects
COMMUNICATION ,HUMAN-plant relationships ,MUSIC - Published
- 2017
93. Japanese Colonizers in the Honam Plain of Colonial Korea.
- Author
-
Takenori MATSUMOTO and Seungjin CHUNG
- Subjects
JAPANESE colonies ,EMIGRATION & immigration - Abstract
Japan, as a latecomer to imperial expansion, began to seek a food supply for its empire in its neighbor Korea's southern rice basket--the Honam Plain. With the outbreak of the Russo-Japanese War (1904-1905), a massive wave of Japanese immigration brought many settlers to the Honam Plain, where they initiated their own development (takushoku) and production (shokusan) activities centered around their farms, ahead of officials and merchants. Emerging in time as local "elites or notables" (K. yuji, J. yūshi), these settler farm owners extended their activities to the arena of public and community projects by organizing and supporting a host of public and semi-official organizations. Economically based on agricultural farms tilled by Korean tenants, they succeeded in turning themselves into colonial masters in their localities by dominating the colonial public sphere that was largely closed to Koreans and local politics. During the period of the well-known Campaign to Increase Rice Production (1920-1933), they served as symbiotic local partners of the Government-General of Korea in implementing assimilation (doka) through local development. Their activities also allowed the authorities to present their rule in a positive light, in spite of worsening conditions for the Korean rural population. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
94. Modulation of transepithelial electric resistance ( TEER) in reconstructed human epidermis by excipients known to permeate intestinal tight junctions.
- Author
-
Abdayem, Rawad, Callejon, Sylvie, Portes, Pascal, Kirilov, Plamen, Demarne, Frédéric, Pirot, Fabrice, Jannin, Vincent, and Haftek, Marek
- Subjects
ELECTRIC resistance ,EPIDERMIS ,DECANOIC acid ,TIGHT junctions ,CYTOPLASM - Abstract
Several excipients are commonly used to enhance the drug absorption through simple epithelia of the digestive tract. They permeate the paracellular barrier constituted by tight junctions ( TJs). We compared the effects of two excipients, sodium caprate (C10) and a self-emulsifying excipient Labrasol composed of a mixture of caprylocaproyl polyoxyl-8 glycerides, both applied to emerged reconstructed human epidermis either 'systemically', that is by addition to the culture medium, or topically. During the 'systemic' application, which produced cytoplasmic translocation of occludin and leakage of the biotin marker into the lower stratum corneum, the decrease in the trans-epithelial electrical resistance ( TEER) was less abrupt with Labrasol when compared with C10, even though both excipients produced comparable final effects over time. With topical Labrasol, a significant TEER decrease was obtained with 5 times the 'systemic' concentrations. Topical application of C10 also resulted in the loss of the barrier function measured with TEER but had dramatic deleterious effects on the tissue morphology observed with light and electron microscopy. Our study demonstrates the potential value of Labrasol as an enhancer of bioavailability of molecules applied through the transcutaneous route. Our results suggest modulation of the epidermal TJs by both compounds. Even though the C10 action was at least partly due to overall cell damage and despite the fact that the decrease in TEER after topical application was apparently related to the permeabilization of the primary barrier of the stratum corneum in the first place. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
95. Urinary retention occurring one week after spinal anesthesia: a case of Elsberg syndrome.
- Author
-
Fujii, Kiyoshi, Moriwaki, Katsuyuki, Torii, Tsuyoshi, Hashimoto, Ken, Shiroyama, Kazuhisa, Tajima, Minoru, Sanuki, Mikako, and Kurita, Shigeaki
- Abstract
Copyright of Canadian Journal of Anaesthesia / Journal Canadien d'Anesthésie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2015
- Full Text
- View/download PDF
96. Clear Cell Carcinoma of the Base of the Tongue: Case Report and Literature Review.
- Author
-
Watanabe, Kenichi, Okumura, Yuri, Hashimoto, Ken, and Suzuki, Takashi
- Subjects
HISTOLOGY methodology ,TONGUE ,DIFFERENTIAL diagnosis ,SYMPTOMS ,TONGUE tumors ,DIAGNOSIS ,ANATOMY - Abstract
Objective: Clear cell carcinoma (CCC) is a rare, low-grade malignant neoplasm of minor salivary glands. Clear cell carcinoma is composed of monomorphic clear cells that contain glycogen within a hyalinized stroma. The microscopic diagnosis can be challenging, and the treatment strategy has not been established. Methods: We report a case of a 56-year-old woman with CCC in the base of the tongue. A literature review, including 22 published cases and our case, was performed to clarify the clinical characteristics of CCC in the base of the tongue. Results: The exophytic tumor showed no infiltration to the neighboring tissues. She underwent a local excision en bloc transorally and is free of the disease 15 months after surgery. In our review of 23 cases of CCC in the base of the tongue, 21 cases received surgical excision for the purpose of the primary treatment modality. The fact that the distinctive features of restricted site-related symptoms and the rare presentation of pain emerged was similar to previously reported cases of CCC. A relatively good prognosis was still indicated. Conclusion: We reveal the features of the unusual occurrence of CCC in the base of the tongue and consider the appropriate surgical approach for primary treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
97. Collapse of mixed monolayers with saturated and unsaturated phospholipids.
- Author
-
Hibino, Masahiro and Hashimoto, Ken
- Subjects
MONOMOLECULAR films ,PHOSPHOLIPIDS ,MIXTURES ,CHEMICAL models ,SURFACE active agents ,MOLECULAR self-assembly ,FLUORESCENCE microscopy - Abstract
We have studied the microscopic behavior in the collapse of lipid monolayers of a 7:3 mixture of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-rac-glycerol)(POPG), a model system of a pulmonary surfactant assembly, using Langmuir isotherms and fluorescence microscopy. The monolayers appear to be phase separated under compression, and retain the continuous liquid-expanded phasenetwork surrounding islands of the condensed phase. When the two-dimensional (2D) monolayers are compressedbeyond the equilibrium surface pressure, three-dimensional structures are formed in the 2D monolayers through collapse. Collapse events involve the folding of the monolayer on a micrometer scale, and each event produces a sudden, macroscopic, coherent translation of the layer. Folds are formed perpendicularly to the compression direction, and growgradually wider with the formation of multiple folds. Folded regions that remain attached to the monolayer arereversibly reincorporated into the monolayer upon expansion. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
98. REPLY.
- Author
-
Hanau, Daniel, Fabre, Michel, and Grosshans, Edouard
- Subjects
- *
LANGERHANS cells , *LETTERS to the editor - Abstract
Presents a response from the author to a letter to the editor, regarding analysis of his article on langerhans cells by authors Davide lacobelli and Ken Hashimoto, published in the August 1986 issue of the "Journal of Investigative Dermatology."
- Published
- 1986
- Full Text
- View/download PDF
99. Table of Contents.
- Published
- 1974
100. Ultrastructural studies of perichromatin granules with special references to Merkel cell carcinoma.
- Author
-
Narisawa, Yutaka, Koba, Shinichi, Nagase, Kotaro, Inoue, Takuya, Misago, Noriyuki, and Hashimoto, Ken
- Subjects
MERKEL cell carcinoma ,POLYOMAVIRUSES ,ELECTRON microscopy ,ULTRASTRUCTURE (Biology) ,CYTOPLASMIC granules ,VIRUS-like particles ,DIAGNOSTIC specimens - Abstract
Since it has been convincingly demonstrated that Merkel cell polyomavirus (MCPyV), a new type of virus, isolated in 2008, induces some of Merkel cell carcinoma (MCC), we searched MCPyV in specimens taken from MCC patients by electron microscopy. The purpose of this communication is to report the presence of perichromatin granules (PCGs), which can be misinterpreted as virus-like particles (VLP). Tissues from several cutaneous tumors including MCC were examined by electron microscopy (EM). EM revealed intranuclear and spherical electron-dense particles with halo, approximately 55 nm in diameter suggesting possible VLP. However, granular structures were detected in MCPyV DNA positive and also negative MCC. Moreover, the same structures were detected in the tumor cells of SCC associated with MCC, those of malignant melanoma (MM), schwannoma, and also in the lesional melanocyte, fibroblast, apoptotic cell and mitotic cell. Since MCPyV DNA could not be detected in collision MCC with SCC, MM and schwannoma, this observation could mean that the granular structures we dealt with in this report represent PCGs, but not VLP and show an absence of viral particles in MCC. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
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