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Objectives. Ankylosing spondylitis (AS) is a chronic disease that decreases mobility, function, and quality of life. This study introduced the "Smart-phone SpondyloArthritis Management System" (SpAMS), an interactive mobile health (mHealth) tool designed for AS/spondyloarthritis (SpA) disease management and used SpAMS data to evaluate clinical characteristics of Chinese patients with AS. Methods. SpAMS integrates patient's and physician's portals in a smart phone application. The Chinese Ankylosing Spondylitis Prospective Imaging Cohort was launched using SpAMS in April 2016. Patient self-assessments were completed online at baseline and at every subsequent clinic visit. Physician-reported assessments and treatments were recorded by rheumatologists during each visit. Results. In total, 1201 patients with AS [mean (SD) age, 30.6 (8.7) years; male, 82.6%] were recruited. Mean (SD) disease duration was 8.4 (6.1) years. Past or current symptoms of acute anterior uveitis (AAU), psoriasis, and inflammatory bowel disease (IBD) were observed in 21.0%, 3.7%, and 9.4% of patients, respectively. AAU and IBD occurred significantly more in patients with symptom duration > 10 years. The most commonly used medications at baseline were nonsteroidal anti-inflammatory drugs (98.2%). Patients using tumour necrosis factor inhibitors accounted for 20.8%, and 66.4% of patients used conventional synthetic disease-modifying antirheumatic drugs. At baseline, 57.2% of patients had inactive disease (ID)/low disease activity (LDA); this rate significantly improved to 79.2% after a mean follow-up of 13.3 (5.9) months. Compared with relapsed patients, new achievers of ID/LDA underwent more online patient assessments (P < .001). Problems solved in SpAMS caused 29.1% of clinic visits to a tertiary hospital unnecessary. SpAMS saved an average of 5.3 hours and 327.4 RMB per person on traffic expenses; these expenses equalled 16% of the Chinese monthly disposable personal income. Conclusions. SpAMS is a time- and cost-saving disease management tool that can help patients with AS perform self-management and provide valuable data to clinicians. [ABSTRACT FROM AUTHOR]

Since 2013, severe haze events frequently have occurred in Beijing between October and March, which have created a significant public health threat. Although variations in the chemical composition of these haze events have been studied widely, information pertaining to airborne bacteria in such haze events remains limited. In this study, we characterized the concentration, community structure, and composition of the airborne bacteria in response to nine haze events that occurred between October 1, 2015, and January 5, 2016. We also analyzed the correlations of airborne bacteria (concentration, community structure, and composition) with pollution levels and meteorological factors. The results indicated that airborne bacterial concentration showed a positive cyclical correlation with the haze events, but the bacterial concentration plateaued at the yellow pollution level. In addition, we found particulate matter (PM10) and relative humidity to be key factors that significantly affected the airborne bacterial concentration and community structure. Moreover, Halomonas and Shewanella were enriched on haze days for all nine of the haze events. Finally, the correlations between haze pollution and airborne bacteria in midwinter were weaker than those in fall and early winter, indicating an obvious staged distinction among the effects of haze on airborne bacteria. Our study illuminated the dynamic variation of bioaerosols corresponding to the cyclical haze events and revealed the interactions among air pollution, climate factors (mainly relative humidity), and airborne bacteria. These results imply that different strategies should be applied to deal with the potential threat of airborne bacteria during haze events in different seasons. [ABSTRACT FROM AUTHOR]

The geomorphologic and environmental evolution of the Loess Plateau is greatly affected by the strong fault activity, leading to the frequent occurrence of geological hazards, particularly the loess-mudstone landslide (LML). Thus, it is crucial to investigate the formation mechanism of such landslides in active fault zones. In this study, a field survey was conducted in the Weibei tableland of Baoji where the active fault zone is developed. To study the creep behavior of LML sliding zone soil, the triaxial creep tests of multi-stage loading under different water content, confining pressure, dry density, loess-mudstone binary structure (LMBS) contact surface angle, and thickness were carried out using the sliding zone soil samples (loess, mudstone, and LMBS samples) obtained from Wolongsi landslide in the study area as an example. Experimental results revealed that: (1) Water content has a significant weakening effect on the strength of LML sliding zone soil. The strength of the LMBS sample is extremely water-sensitive. The weakening effect of water on the long-term strength of LML sliding zone soil mainly manifested in promoting the elastoplastic deformation of loess and the viscoplastic deformation of mudstone. (2) The long-term strength of the LML slip zone soil increases linearly with the increase in confining pressure and increases exponentially with the dry density. (3) The degrading effect of the stratigraphic interface dip angle on the long-term slope strength is mainly reflected in the change in the weakening degree of water on the strength of the LML sliding zone. In addition, according to the test results, the traditional Nishihara model is improved by introducing nonlinear parameters, and a new constitutive equation describing LML sliding zone soil is established. The new constitutive model can accurately describe the creep curve's whole process especially sensitively identifying the accelerated creep stage. Finally, after conducting a field investigation and laboratory tests, the main hazard factors affecting the occurrence of the LML were analyzed in the presence of fault activity on the Weibei Plateau of Baoji, China, and its formation mechanism was revealed as well. [ABSTRACT FROM AUTHOR]

As the third pole of the world and Asia's water tower, the Tibetan Plateau experiences daily release of pharmaceutical and personal care products (PPCPs) due to increasing human activity. This study aimed to explore the potential relationship between the concentration and composition of PPCPs and human activity, by assessing the occurrence of PPCPs in areas of typical human activity on the Qinghai-Tibet Plateau and evaluating their ecological risk. The results indicate that 28 out of 30 substances were detected in concentrations ranging from less than 1 ng/L to hundreds of ng/L, with the average concentration of most PPCPs in the Tibet Autonomous Region being higher than that in Qinghai Province. Among the detected substances, CAF, NOR, CTC, CIP, TCN, OTC, AZN, and DOX accounted for over 90% of the total concentration. The emission sources of PPCPs were identified by analyzing the correlation coefficients of soil and water samples, with excess PPCPs used by livestock breeding discharged directly into soil and then into surface water through leaching or runoff. By comparing the concentration and composition of PPCPs with those in other regions, this study found that CIP, ENR, LOM, NOR, CTC, DOX, OTC, and TCN were the most commonly used PPCPs in the Qinghai-Tibet Plateau. To assess the ecological risk of PPCPs, organisms at different trophic levels, including algae, crustaceans, fish, and insects, were selected. The prediction of the no effect concentration of each PPCP showed that NOR, CTC, TCN, CAF, and CBZ may have deleterious effects on water biota. This study can assist in identifying the emission characteristics of PPCPs from different types and intensities of human activities, as well as their occurrence and fate during the natural decay of aquatic systems., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

A dwarf mutant, designated LB4D, was obtained among the progeny of backcrosses to a wild rice introgression line. Genetic analysis of LB4D indicated that the dwarf phenotype was controlled by a single semidominant dwarfing gene, which was named LB4D. The mutants were categorized as dn-type dwarf mutants according to the pattern of internode reduction. In addition, gibberellin (GA) response tests showed that LB4D plants were neither deficient nor insensitive to GA. This study found that tiller formation by LB4D plants was decreased by 40% compared with the wild type, in contrast to other dominant dwarf mutants that have been identified, indicating that a different dwarfing mechanism might be involved in the LB4D dominant mutant. The reduction of plant height in F(1) plants ranged from 27.9% to 38.1% in different genetic backgrounds, showing that LB4D exerted a stronger dominant dwarfing effect. Using large F(2) and F(3) populations derived from a cross between heterozygous LB4D and the japonica cultivar Nipponbare, the LB4D gene was localized to a 46 kb region between the markers Indel 4 and Indel G on the short arm of chromosome 11, and four predicted genes were identified as candidates in the target region., (© 2011 Institute of Botany, Chinese Academy of Sciences.)