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Amomum villosum Lour. (A. villosum), a comestible medicinal plant, has been traditionally used in China to treat diarrhea, stomach fullness, and abdominal distension. Polysaccharide, the main chemical component of A. villosum, has been shown to possess potential antioxidant and glycosidase inhibitory activities; however, whether it has anticolitis activity is unknown. The aim of this research was to evaluate the anticolitis effects of A. villosum polysaccharide (AVLP) in BALB/c mice. The results showed that AVLP administration significantly reversed body weight loss, colon shortening and colon weight gain and decreased the levels of proinflammatory cytokines and chemokines in colitis mice (p < 0.05). AVLP administration also maintained intestinal barrier function by the upregulation of ZO-1 protein expression (p < 0.05). In addition, high-throughput sequencing analysis showed that AVLP possessed a great regulatory effect on the growth of Adlercreutzia, Clostridium, Streptococcus, Parabacteroides, Helicobacter, Odoribacter, and Alistipes (p < 0.05, LDA score > 2). The correlation analysis revealed that the protective effects against colitis of AVLP were highly correlated with intestinal bacterium regulation. These results suggest that AVLP intake could serve as a prospective nutritional strategy for inflammatory bowel diseases. [ABSTRACT FROM AUTHOR]

Seven different tree-ring parameters (tree-ring width, earlywood width, latewood width, maximum density, minimum density, mean earlywood density, and mean latewood density) were obtained from Qinghai spruce ( Picea crassifolia) at one chronology site in the Hexi Corridor, China. The chronologies were analyzed individually and then compared with each other. Growth-climate response analyses showed that the tree-ring width and maximum latewood density (MXD) are mainly influenced by warm season temperature variability. Based on the relationships derived from the climate response analysis, the MXD chronology was used to reconstruct the May-August maximum temperature for the period 1775-2008 A.D., and it explained the 38.1% of the total temperature variance. It shows cooling in the late 1700s to early 1800s and warming in the twentieth century. Spatial climate correlation analyses with gridded land surface data revealed that our warm season temperature reconstruction contains a strong large-scale temperature signal for north China. Comparison with regional and Northern Hemisphere reconstructions revealed similar low-frequency change to longer-term variability. Several cold years coincide with major volcanic eruptions. [ABSTRACT FROM AUTHOR]

Abstract: We have reconstructed the spring (March–June) temperature from 1701 to 2008 for the Changling Mountains, the southern edge of the Gobi Desert, using mean earlywood density data of Pinus tabulaeformis. The reconstruction explains 41.7% of the actual temperature variance during the common period 1959–2008. The temperature reconstruction is representative of temperature conditions over a large area of Central and East Asia, especially in the Gobi Desert. Significant spectral peaks are identified at 2.0–2.8 and 26.9years. Our temperature reconstruction successfully captured most recent warming and agreed in general with other temperature reconstructions from nearby regions, eastern China and Northern Hemisphere on a decadal timescale. Our reconstructed temperature is significantly correlated with sea surface temperature in the western tropical and northern Pacific Ocean. Preliminary analysis of links between large-scale climatic variation and the temperature reconstruction shows that there is a relationship between extremes in spring temperature and the Asian summer monsoon circulations. [Copyright &y& Elsevier]

Abstract: September–March mean temperature has been reconstructed to A.D. 1680 for the Kaiduhe River watershed on the southern slope of the Tien Shan Mountains, China, using the Picea schrenkiana tree-ring width. The reconstruction explains the variance of 47% in the observed mean temperature from 1953 to 2011. Power spectral and wavelet analyses demonstrated the existence of significant 50-year and 2- to 7-year cycles of variability. The results of the spatial correlations suggest that our reconstruction contains climatic signals for Central Asia. Warm periods occurred during 1696–1708, 1730–1748, 1784–1804, 1832–1855, 1892–1903, 1924–1928, 1937–1943, and 1987–2006; while the periods of 1685–1695, 1709–1729, 1749–1783, 1805–1831, 1856–1891, 1904–1923, 1929–1936, and 1944–1986 were relatively cold. The significant correlation coefficient between the reconstruction and the temperature reconstruction for the Urumqi River source reveals that the temperature variations in the annual cold period for the southern and the northern slope of the central Tien Shan Mountains are roughly synchronous over the last nearly 300 years. A comparison between the reconstruction and three winter North Atlantic Oscillation indexes revealed similar long-term trends. [Copyright &y& Elsevier]

Abstract: July–June precipitation has been reconstructed back to A.D. 1464 for the Baluntai region on the southern slope of the central Tien Shan Mountains, China, using the Picea schrenkiana tree-ring width. The reconstruction explains the variance of 51% in the observed precipitation from 1959 to 2005. By employing a 21-year moving average to the reconstruction, nine periods with above average reconstructed precipitation comprised ∼1474–1503, 1550–1577, 1588–1619, 1658–1713, 1790–1812, 1833–1867, 1890–1907, 1923–1944, and 1988–1995∼; eight periods with below average reconstruction consisted of 1504–1549, 1578–1587, 1620–1657, 1714–1789, 1813–1832, 1868–1889, 1908–1922 and 1945–1987. The wet/dry periods of the reconstructed precipitation correspond well with other reconstructions. Some droughts in the historical documents are also precisely captured in the reconstruction. Precipitation variations for the southern slope of the central Tien Shan Mountains are roughly synchronous with that of the northern slope in the recent ∼300 year. Power spectral and wavelet analysis demonstrated the existence of significant ∼100-y, ∼60-y, ∼50-y, ∼16-y, ∼10-y and ∼2-y cycles of variability. [Copyright &y& Elsevier]

Abstract: Drought is a recurring phenomenon in north-central China. Long-term information about the history of drought is still limited because the instrumental records for many areas in north-central China go back only a few decades at best. This paper presents an earlywood width (EWW) chronology of Chinese pine (Pinus tabulaeformis) in the Shimen Mountains, Tianshui, eastern Gansu, north-central China. The climate-response analysis shows that April–July precipitation is the main factor limiting the earlywood growth of Chinese pines in the Shimen Mountains, Tianshui. Based on the EWW chronology, an April–July precipitation reconstruction for the period A.D. 1629–2008 was developed for Tianshui. The climate/tree-growth model accounts for 41.6% of the observed precipitation variance during the period 1953–2008. Spatial analysis shows that the precipitation reconstruction contains a strong common drought signal for north-central China. Reconstructed drought events are compared to a precipitation reconstruction of Huashan and historical archives for north-central China. The results reveal common climatic extremes over much of north-central China. Moreover, some dry periods coincided with solar minima or volcanic eruptions over the past several hundred years. Multi-taper spectral analysis reveals the existence of significant 3.8-year (90%), 3.1-year (95%), 2.7-year (99%), 2.4-year (99%) and 2.0-year (99%) periods of variability. The linkages to the Asian-Pacific Oscillation Index suggest regional precipitation variations may be linked to the East Asian summer monsoon circulations. [Copyright &y& Elsevier]

Background: To explore the relationship between enteroviruses and hospitalized children with hand, foot and mouth disease (HFMD) complicated with nervous system disease. 234 hospitalized HFMD patients treated in Shengjing Hospital, Liaoning Province were analyzed retrospectively. Based on the presence and severity of nervous system disease, the patients were grouped as follows: general patients, severely ill patients, critically ill patients and fatal patients. Based on the detected pathogen, the patients were grouped as follows: Enterovirus 71 (EV71) infection, coxsackie A16 (CA16) infection and other enterovirus (OE) infection., Results: Of the 423 hospitalized patients, most were admitted in July 2010(129/423, 30.5%). Enteroviruses were detected in 177(41.8%). 272/423 patients were male (64.3%), and fatal patients had the greatest proportion of male patients (p < 0.05). EV71 infection was found in 89/423 patients (21%). CA16 infection was detected in 8/423 patients (16.1%). Compared to group CA16, patients in group EV71 were hospitalized earlier, and the duration of hospitalization was longer (p < 0.05). Of the 92 patients with nervous system damage, 65 were infected with EV71 and 19 were infected with CA16. Among these CA16 infected patients, 2 had brainstem encephalitis and 1 had AFP. There were more patients with nervous system dysfunction in group EV71 than in groups CA16 or OE (p < 0.05). The 5 fatalities all occurred in group EV71 patients (p < 0.05). Infection with EV71 was most likely to cause neurogenic pulmonary edema (p < 0.05). Patients in group EV71 had a higher rate of suffering from coma and limb movement disorder than patients in groups CA16 or OE (p < 0.05)., Conclusion: The disease progresses faster in EV71-infected HFMD patients. These patients are more likely to suffer nervous system damage, neurogenic pulmonary edema, severe sequelae or death. CA16 and other enteroviruses can also cause HFMD with severe nervous system complications.