1. 3α,19-Dihydroxyl-ent-pimara-8(14),15-diene, a new diterpenoid from the rhizomes of Ricinus communis.
- Author
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Zhang, Sheng-Nan, Zeng, Jin, Ma, Rui-Jing, Zhang, Gui-Jie, Tan, Qin-Gang, Tan, Ya-Nan, and Wang, Heng-Shan
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SPECTRUM analysis , *BIOLOGICAL assay , *COMPARATIVE studies , *CRYSTALLOGRAPHY , *ETHANOL , *HYDROCARBONS , *MEDICINAL plants , *MOLECULAR biology , *POLYENES , *PROTEINS , *RESEARCH funding , *PLANT roots , *TERPENES , *X-rays , *PLANT extracts , *DESCRIPTIVE statistics , *CHEMICAL inhibitors , *EQUIPMENT & supplies - Abstract
A new natural product, 3α,19-dihydroxyl-ent-pimara-8(14),15-diene (1), which possesses an α-orientation hydroxymethyl at C-4 and ∆8,14 groups, as well as eight known compounds, was isolated from the rhizomes of Ricinus communis. The structure of 1 was elucidated by extensive spectroscopic methods and its absolute configurations were confirmed by X-ray crystallographic analysis. The inhibitory rate of 1 against protein tyrosine phosphatase 1B (PTP1B) was 49.49% at the concentration of 6.58 × 10−5 mol/L. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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