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In the early stages of the COVID-19 pandemic, physiotherapists (PTs) across the globe were required to rapidly adapt clinical practice to provide safe and effective care for people with HIV/AIDS and cancer and those in hospice and palliative care. These rapid decisions included developing criteria for in-person versus remote care and developing equitable platforms for telehealth and telerehabilitation. Most decisions were made with limited guidelines or evidence for practice related to the pandemic. The purpose of this perspective was to provide a synopsis of the experiences of 25 PTs from 16 countries regarding their clinical decisions for (1) rapid adaptation of patient care delivery, (2) evaluation criteria to treat in-person or remotely, (3) utilization decisions for telerehabilitation, (4) determinations for future practice and research needs, and (5) promotion of health equity in an environment rapidly transformed by a highly infectious and deadly disease.

To fully understand the role of diet diversity on allergy outcomes and to set standards for conducting research in this field, the European Academy of Allergy and Clinical Immunology Task Force on Diet and Immunomodulation has systematically explored the association between diet diversity and allergy outcomes. In addition, a detailed narrative review of information on diet quality and diet patterns as they pertain to allergic outcomes is presented. Overall, we recommend that infants of any risk category for allergic disease should have a diverse diet, given no evidence of harm and some potential association of benefit in the prevention of particular allergic outcomes. In order to harmonize methods for future data collection and reporting, the task force members propose relevant definitions and important factors for consideration, when measuring diet diversity in the context of allergy. Consensus was achieved on practice points through the Delphi method. It is hoped that the definitions and considerations described herein will also enable better comparison of future studies and improve mechanistic studies and pathway analysis to understand how diet diversity modulates allergic outcomes.

The review analyzes the collected materials from the 13th International Scientific Conference “The Current Problems of Parliamentarism: History and Modernity” (Tauride Readings 2019). Most of the papers in the collection cover various aspects of the activities of the parliament of the Russian Empire. Some of the materials touch on the issues of the current situation in the people’s representation in the Russian Federation and the CIS countries as well as important aspects of the history of foreign parliamentarism. The review considers the key articles of the collection and notes the role of the published proceedings of the conference discussion platforms. It is concluded that the collection under review is of great relevance for studying history, theory, and practice of Russian and foreign parliamentarism.

Aim:The aim of this position paper is to assist primary health care (PHC) providers, policymakers, and researchers by discussing the current context in which palliative health care functions within PHC in Europe. The position paper gives examples for improvements to palliative care models from studies and international discussions at European Forum for Primary Care (EFPC) workshops and conferences.Background:Palliative care is a holistic approach that improves the quality of life of patients and their families facing problems associated with terminal illness, through the prevention and relief of suffering by means of early identification and diligent assessment and treatment of pain and other problems, whether physical, psychosocial, or spiritual. Unfortunately, some Europeans, unless they have cancer, still do not have access to generalist or specialist palliative care.Methods:A draft of this position paper was distributed electronically through the EFPC network in 2015, 2016, and 2017. Active collaboration with the representatives of the International Primary Palliative Care Network was established from the very beginning and more recently with the EAPC Primary Care Reference Group. Barriers, opportunities, and examples of good and bad practices were discussed at workshops focusing on palliative care at the international conferences of Southeastern European countries in Ljubljana (2015) and Budva (2017), at regular conferences in Amsterdam (2015) and Riga (2016), at the WONCA Europe conferences in Istanbul (2015), Copenhagen (2016), and Prague (2017), and at the EAPC conference in Madrid (2017).Findings:There is great diversity in the extent and type of palliative care provided in primary care by European countries. Primary care teams (PCTs) are well placed to encourage timely palliative care. We collected examples from different countries. We found numerous barriers influencing PCTs in preparing care plans with patients. We identified many facilitators to improve the organization of palliative care.

With new technology, writing became a skill that is being developed year after year. The present study questions whether there is a difference between paper-based and computer-based writing in terms of errors and lexico-grammar. It aims at exploring sentence-level errors and lexico-grammatical competence in two writing genres in a collaborative writing environment within paper-based and computer-based writing. A sample of 73 female intermediate level learners participated in the study at the University of Business and Technology (UBT), in Saudi Arabia. This mixed-methods research is significant in the literature of second language writing since it highlights genre awareness, lexico-grammatical competence, analyzing errors, and collaboration in two styles of writing. The reading-based writing tasks acted as a reflection of the learners' lexico-grammatical competence on paper and via Web 2.0 tool (Padlet). Statistically, the Mann-Whitney U-tests showed that there was no significant difference between paper-based and computer-based groups in the sentence-level errors in narrative genre, whereas there was a significant difference between the two different tools of writing groups in the sentence-level errors in opinion genre. However, there was no significant difference between paper-based and computer-based groups in the clauses (lexico-grammar) of the two groups. Immediate semi-structured interviews were conducted and analyzed through NVIVO to get more insights from the learners to explain the comparison between the paper-based and the computer-based writing. In light of the significant findings, implications are sought to create an equillibrium between paper-based and computer-based writing, along with enhancing collaboration in second language writing.

The investigation of both paper-based and virtual pedagogical environments allows us to reflect upon the diverse range of material available to the language learning community today. In this paper, the significance of the cultural component in language learning will be discussed firstly, highlighting its crucial role with regard to the promotion of tolerance and understanding between diverse cultures. Secondly, a number of FLE (Français Langue Erangère) manuals will be analysed in terms of the transmission of cultural data. The study will then conclude with an examination of examples of online environments which reflect an alternative medium for the acquisition of information on the target language and culture.

This introduction provides the rationale for a fresh look at an apparently obvious phenomenon – the production and life of state documents. Whilst ethnographies of statehood have multiplied in recent years, we focus on an underexplored avenue of inquiry: the role played by pieces of paper in constituting modern bureaucratic states. To date, attempts to map out this area of study have focused predominantly on the discourse and semiotics of state documentation. Our work goes further, discussing not just what is on such paper but also its shifting materiality, meaning and social significance throughout its production, circulation and preservation or destruction. These discussions deepen our understanding of statehood, sovereignty and power across Africa, with our part special issue drawing particularly on research in Nigeria, Sierra Leone, South Africa, and Zimbabwe.

We use the data leak of the Panama Papers on April 3, 2016 to study whether and how the use of secret offshore vehicles affects firm value around the world. The data provide insights into the operations of more than 214,000 shell companies incorporated in tax havens by Panama-based law firm Mossack Fonseca. Using event study techniques, we find that the data leak erases US$135 billion in market capitalization among 397 public firms with direct exposure to the revelations of the Panama Papers, reflecting 0.7 percent of their market value. Tax aggressive firms and firms with exposure to perceptively corrupt countries are more adversely affected. This is consistent with the leak (i) reducing firms’ ability to avoid taxes and finance corruption, or (ii) increasing regulatory fines for past tax evasion and violations of anti-corruption regulations. Taken together, secret offshore vehicles are used for value-enhancing but potentially illegal activities that go beyond tax avoidance. Offshore intermediaries facilitate such activities.

Citation prediction of scholarly papers is of great significance in guiding funding allocations, recruitment decisions, and rewards. However, little is known about how citation patterns evolve over time. By exploring the inherent involution property in scholarly paper citation, we introduce the Paper Potential Index (PPI) model based on four factors: inherent quality of scholarly paper, scholarly paper impact decaying over time, early citations, and early citers' impact. In addition, by analyzing factors that drive citation growth, we propose a multi-feature model for impact prediction. Experimental results demonstrate that the two models improve the accuracy in predicting scholarly paper citations. Compared to the multi-feature model, the PPI model yields superior predictive performance in terms of range-normalized RMSE. The PPI model better interprets the changes in citation, without the need to adjust parameters. Compared to the PPI model, the multi-feature model performs better prediction in terms of Mean Absolute Percentage Error and Accuracy; however, their predictive performance is more dependent on the parameter adjustment Refereed/Peer-reviewed

This good clinical practice paper provides an overview of the current evidence around second stage care, highlighting the challenges and the importance of maintaining high‐quality, safe, and respectful care in all settings. It includes a series of recommendations based on best available evidence regarding length of second stage, judicious use of episiotomy, and the importance of competent attendants and adequate resource to facilitate all aspects of second stage management, from physiological birth to assisted vaginal delivery and cesarean at full dilatation. The second stage of labor is potentially the most dangerous time for the baby and can have significant consequences for the mother, including death or severe perineal trauma or fistula, especially where there are failures to recognize and repair. This paper sets out principles of care, including the vital role of skilled birth attendants and birth companions, and the importance of obstetricians and midwives working together effectively and speaking with one voice, whether to women or to policy makers. The optimization of high‐quality, safe, and personalized care in the second stage of labor for all women globally can only be achieved by appropriate attention to the training of birth attendants, midwives, and obstetricians. FIGO is committed to this aim alongside the WHO, ICM, and all FIGO’s 132 member societies., This paper provides an overview of the current evidence in best practice for second stage care, highlighting the challenges of maintaining high‐quality, safe, and respectful care in all settings.

This inter(re)view is a conversation with book historian and Professor Lisa Kuitert on the occasion of the publication of her book The Book and the Bathwater. Why Paper Books Matter (Het boek en het badwater. De betekenis van papieren boeken) by Amsterdam University Press. The dialogue starts with a central question: what is the future of the paper book? Kuitert responds by discussing, from a historical perspective, the unique qualities and meaning of paper books (in contradistinction to the immateriality of digital books), as well as the consequences and positive effects that its existence has had for the reader through different epochs. In that journey, she also enriches the definition of the book while contextualizing it amidst the technological developments that influence book production and consumption at all times.

The purpose of this study was to investigate the effects of paper and e-dictionaries on Iranian intermediate learners' reading comprehension. To this end, 90 female English Foreign language learners were randomly selected and assigned into 2 experimental groups (e-dictionaries and paper dictionaries groups) and 1 control group. All the groups took a pretest using no dictionaries. After 2 weeks of treatment design for the experimental groups, all the 3 groups took part in the posttest. The experimental groups did their task with their relevant dictionaries, whereas the control group did their task without using any kind of dictionary. Data were analyzed through analysis of covariance (ANCOVA) and paired samples t test. Results showed that the participants’ reading comprehension improved from the pretest to the posttest in both experimental groups. Results also indicated that the learners in the e-dictionaries group outperformed those in the paper dictionaries group. The outcome of study reveals that e-dictionaries could improve students’ reading comprehension by motivating them, shortening the time of searching words and reading a text, and increasing the number of look ups.

This paper contends that sociotherapy, a sociologically informed approach to therapy, is a viable alternative to the diagnostic model recognized by the College of Registered Psychotherapists in Ontario (CRPO). The Psychotherapy Act (2007) along with the Regulated Health Professions Act (1991) gives the CRPO authorization to regulate the practice of psychotherapy and to control titles affiliated with the act of psychotherapy. I offer a discussion of sociotherapy and socioanalysis as clinical alternatives to the conservative and normalizing approaches endorsed by the College. I situate sociotherapy and socioanalysis in the discipline of sociology and in relation to Freudian psychoanalysis. I offer my own sociotherapeutic practice as an illustration of how the societal and the psychological, the social, and the psychic must be engaged in concert. I underscore the importance of dialogue, as opposed to diagnostics, interpretation as opposed to assessments and psychosocial contemplation as opposed to cognitive-behavioral treatment in clinical practice.

New Ukrainian and world realities set new tasks for the higher educational establishments, which are related to the search for new, modern methods that allow to increase the effectiveness of training. Currently, topical are the issues of not only professional but also the personal development of the student forming the priority in the implementation of educational activities in universities, preparation for future professional activities, as well as for successful interaction in society. The concept of «individual social competence» is an important factor in creating a system of educational process which takes into account aspects of professional development, and at the same time the peculiarities of the formation of the student personality. The author analyses the concept of «competence», considers the key competences for lifelong learning, identified by the European Parliament and the Council of the European Union, including social competence, studies the scientific achievements of Ukrainian and foreign scientists, including G. Gedviliene, H. S. Han, K. M. Kemple, U.P. Kanning, M. Horenburg, G.W. Ladd, H. K. Ma, K. Monahan, M. Monnier, O.V. Varetska, N.I. Hlebova, D.V. Hubareva, O.I. Hura, M.O. Doktorovych, I.B. Zarubinska, O.O. Subina, V.M. Shakhrai. They explored different aspects of social competence of different age categories. The author concludes that, despite different interpretations, all scientists agree that social competence is an acquired skill, it can be formed and developed throughout life. It was also determined that the developed social competence determines the status of the individual in society, it affects the success in professional activities. The high level of social competence allows a person not only to be realized in professional activities, but also to influence the processes in society, which in turn determines its stability. The author’s definition of the concept of «individual social competence» is given in the paper; the author concludes that social competence is an integrated ability that contains other competencies: spiritual, civic, communicative, linguistic; the concept of social competence is closely related to professional competence, without the successful interaction of the individual with society it is impossible to acquire the skills and abilities inherent in a qualified specialist. Thus, an important task for modern higher education is the formation and development of social competence of students, which is the key to successful implementation of the future specialist in professional activities. The educational process should be aimed at forming a system of knowledge about interaction in society, understanding the system of social values, ability to cooperate in society, the ability to communicate constructively, because only a socially competent person can.

Accurate and quantitative profiling of air particulate matter (PM) compositions is essential for assessing local pollution information. The method combining mobile aerial sampling using unmanned aerial vehicles (UAVs) and prompt analysis excels in this regard as it allows spatiotemporal mapping of air pollution, especially in the vertical direction. However, applications of the method are still scarce as it is limited by a lack of sampling reliability due to insufficient aerial sampling time and a lack of accurate, portable quantification techniques. In this work, by integrating mobile aerial sampling with in-flight tethered charging and smartphone-based colorimetric analysis in a cost-effective paper microfluidic device, we present a method for quantitative, reliable profiling of spatiotemporal variation in air PM compositions. The method extends aerial sampling time to 12–15 flight hours per deployment, thereby significantly improving sampling reliability while maintaining the maneuverability of the UAVs. Also, smartphone-based colorimetric analysis combined with paper-based microfluidics enables portable, economically efficient analysis and is well-suited for using in low-resource settings. We demonstrated the utility of the method by carrying out a spatiotemporal variation study of air PM trace metal components (Fe, Ni, and Mn) at 4 geographical locations in Fuzhou, China, for a period of 21 days, and the results were in good agreement with results obtained from using a commercial instrument. Beside air PM composition study, this method is universally applicable and holds great potential to be extended to multipollutant analysis, such as prompt detection of airborne viruses, bacteria, and others.

Background Service providers throughout Europe have identified the need to define how high-quality community-based mental health care looks to organize their own services and to inform governments, commissioners and funders. In 2016, representatives of mental health care service providers, networks, umbrella organizations and knowledge institutes in Europe came together to establish the European Community Mental Health Services Provider (EUCOMS) Network. This network developed a shared vision on the principles and key elements of community mental health care in different contexts. The result is a comprehensive consensus paper, of which this position paper is an outline. With this paper the network wants to contribute to the discussion on how to improve structures in mental healthcare, and to narrow the gap between evidence, policy and practice in Europe. Main text The development of the consensus paper started with an expert workshop in April 2016. An assigned writing group representing the workshop participants built upon the outcomes of this meeting and developed the consensus paper with the input from 100 European counterparts through two additional work groups, and two structured feedback rounds via email. High quality community-based mental health care: 1) protects human rights; 2) has a public health focus; 3) supports service users in their recovery journey; 4) makes use of effective interventions based on evidence and client goals; 5) promotes a wide network of support in the community and; 6) makes use of peer expertise in service design and delivery. Each principle is illustrated with good practices from European service providers that are members of the EUCOMS Network. Conclusions Discussion among EUCOMS network members resulted in a blueprint for a regional model of integrated mental health care based upon six principles.

The UK's recent Improving Lives Green Paper, and the new joint Work and Health Unit that penned it, offers a genuine window of opportunity for much-needed transformative change in service user experiences and system performance around health-related unemployment. Its analysis of the current system problems and its articulation of the UK's need for a better integrated future work-health system are well-considered. Its proposed reforms to bridge the gap are, however, inadequate. Focusing on this conversion gap, the article highlights the central but neglected role of three Cs (capacity, conditionality, connectivity) urgently needed to come to the aid of the Green Paper vision if it is to realise its potential.

International audience; How can the title of a paper affect its subsequent number of citations? We compared the citation rate of 5941 papers published in the journal Biological Conservation from 1968 to 2012 in relation to: paper length; title length; number of authors; paper age; presence of punctuation (colons, commas or question marks); geographic and taxonomic breadth; the word ‘method’; and the type of manuscript (article, review). The total number of citations increased in more recently published papers and thus we corrected citation rate (average number of citations per year since publication) by publication age. As expected, review papers had, on average, twice the number of citations compared to other types of articles. Papers with the greatest geographic or taxonomic breadth were cited up to twice as frequently as narrowly focused papers. Titles phrased as questions, shorter titles, and papers with more authors had slightly higher numbers of citations. However, overall, we found that the included parameters explained only 12% of the variability in citation rate. This suggests that finding a good title is necessary, but that other factors are more important to construct a well-cited paper. We suggest that to become highly cited, a primary requirement is that papers need to advance the science significantly and be useful to readers.

Purpose This article provides an overview of five papers appearing together on the topic of “Advances in Specific Language Impairment Research and Intervention,” which was the 2019 program in an ongoing series of research symposia presented at the Annual Convention of the American Speech-Language-Hearing Association. Method The article provides a historical context for the set of papers, then a short summation of each paper's content, followed by the identification of overarching themes and working conclusions. Results Each paper provides summations of empirical results, and some papers provide new empirical evidence. Conclusion The papers collectively highlight six points: (a) Children with specific language impairment (SLI) are likely to be unidentified among their age peers. (b) There is great need for better identification of children with SLI across developmental levels. (c) Progress is evident toward a better understanding of causal pathways, as examined across different research designs involving comparison of children with typical language acquisition to children with SLI and other possibly co-occurring atypical conditions. (d) Measuring multiple dimensions of language brings enhanced informativeness, with differing outcomes for differing dimensions. (e) Replicated research findings require precision of methods in order to reduce unexplained error variance especially when defining groups. (f) Accurate identification of children with SLI is the first step toward a sound treatment plan for SLI and reading disorders as well. Presentation Video https://doi.org/10.23641/asha.13063721

Objective: The objective of the study was to clarify how the Grading of Recommendations Assessment, Development and Evaluation (GRADE) concept of certainty of evidence applies to certainty ratings of test accuracy. Study Design and Setting: After initial brainstorming with GRADE Working Group members, we iteratively refined and clarified the approaches for defining ranges when assessing the certainty of evidence for test accuracy within a systematic review, health technology assessment, or guideline. Results: Ranges can be defined both for single test accuracy and for comparative accuracy of multiple tests. For systematic reviews and health technology assessments, approaches for defining ranges include some that do not require value judgments regarding downstream health outcomes. Key challenges arise in the context of a guideline that requires ranges for sensitivity and specificity that are set considering possible effects on all critical outcomes. We illustrate possible approaches and provide an example from a systematic review of a direct comparison between two test strategies. Conclusions: This GRADE concept paper provides a framework for assessing, presenting, and making decisions based on the certainty of evidence for test accuracy. More empirical research is needed to support future GRADE guidance on how to best operationalize the candidate approaches.

This study was concerned on the way the author explores the hidden meaning and message in semiotics signification of President Jokowi cartoons in Jakarta Post e-paper. The writer focused on five cartoons of President Jokowi published by Jakarta Post e-paper and wanted to know about the hidden meaning and message that tried to convey by the Jakarta Post e-paper. Furthermore, this research covered an interdisciplinary study that scopes semiotics and Critical Discourse Analysis (CDA, in which the researcher tried to unhook the messages and explain the linguistic means of that construct the hidden message and ideology of the cartoons. In conducting the research, the researcher used Peirce's semiotic and Van Dijk's ideological square model. The researcher used purposive sampling in taking data. The total of the data analyzed was five cartoons. From the analysis, the message conveyed in the first cartoon criticizes to President Jokowi’s decision which is rated as indifference. The second cartoon also criticizes President Jokowi rated as pretend to against china's exploration. Furthermore, the third cartoon criticizes President Jokowi controlled by some political parties. Meanwhile, the fourth cartoon criticizes President Jokowi as a President uneasily defeated in a political term, but ignoring the humanity, and the last cartoon criticizes about President Jokowi and Prabowo similarities with previous President in terms of attitudes. The researcher also got the linguistic as means of used to convey the message such as the choice of a figure of speech.

Supplemental Digital Content is available in the text, Objective: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) was released as a standard of reporting systematic reviewers (SRs). However, not all SRs adhere completely to this standard. This study aimed to evaluate the reporting quality of SRs published in the Cochrane Library and paper-based journals. Methods: The SRs which evaluate the effectiveness of nursing interventions in 2016 were identified via PubMed. The reporting quality of selected articles was evaluated using the PRISMA checklist. For comparison, we divided these articles into Cochrane review (CR) and non-Cochrane review (NCR). Based on the satisfaction of the applicable criteria, each article is assigned an accumulated score and a total percentage score. Results: Overall, 41.7% articles were concentrated in 19.0 to 22.5 points which represent the moderate quality, 22% articles were high quality. There were still 36.5% articles with low quality. The mean PRISMA score was 20.54 ± 2.367 for CRs, and 18.81 ± 2.536 for NCRs. Although no significant difference was exit between overall CR and NCR scores, there were differences between items 1, 5, 8, 16, 23. Analysis indicated that CR was significantly associated with the overall PRISMA score. Conclusion: Compliance of CR and NCR with PRISMA checklist exhibited different strengths and weaknesses. Our study underscores that nursing researchers should pay more attention to comprehensive reporting of SRs in nursing to follow the PRISMA statement. Implications for nursing and/or health policy: Nursing researchers who participate in SRs should follow the latest Cochrane Handbook to prepare such study. Meanwhile, the PRISMA statement should be followed strictly to report SRs, so as to improve the quality of SRs.

In several highly eusocial insect species with morphologically distinct castes, queen-characteristic cuticular hydrocarbons (CHCs) have been shown to act as queen signals that suppress the reproduction of nestmate workers. However, it is not known whether such queen pheromones might also play a role in regulating reproductive division of labour in primitively eusocial insects that lack morphologically defined castes. Here, we experimentally tested whether a blend of CHCs which occurred in higher concentrations in the dominant breeding female act as a queen pheromone, and inhibit reproduction by subordinate females in the primitively eusocial paper wasp Polistes satan. In contrast to earlier findings with highly eusocial species, our results show that although specific compounds were enhanced in dominant, reproductively active females, a blend of five of these compounds did not inhibit development of the ovaries of female nestmates. Instead, the dominant female had to be physically present to prevent subordinate females from reproducing. Our results are in line with earlier evidence suggesting that fertility-linked compounds in primitively eusocial wasps act only as cues and help to regulate reproduction when used in conjunction with aggressive dominance behaviour, meaning the physical presence of the dominant female. Alternatively, our results support the hypothesis that queen pheromones in highly eusocial insects were co-opted from fertility cues that were already present in primitively eusocial ancestors, even when initially, such compounds were merely produced as by-products of ovarian activation, without actually serving to signal reproductive status.

Drug hypersensitivity reactions (DHRs) are common, and the skin is by far the most frequently involved organ with a broad spectrum of reaction types. The diagnosis of cutaneous DHRs (CDHR) may be difficult because of multiple differential diagnoses. A correct classification is important for the correct diagnosis and management. With these guidelines, we aim to give precise definitions and provide the background needed for doctors to correctly classify CDHR.

The main objective of the Journal of Theoretical and Applied Electronic Commerce Research (JTAER) is to publish the results of high quality original and innovative research concerning electronic commerce and related fields, both theoretical and applied. The field of electronic commerce is understood as an inherently interdisciplinary area of research and practice, having an investigative and analytic purpose. Electronic commerce objectives include the study of the phenomena related to practices and processes enabled by communications, Web and mobile technologies in private and public organizations, as well as, social, legal, educational and cultural issues, and information privacy and security, among many other relevant topics of interest in this rapidly changing field. Therefore, electronic commerce includes components of different fields, such as, computer science, psychology, economics, organizational theory, management, sociology, and the natural sciences, among others. However, the main topic of a paper should always be fully related to the electronic commerce field in order to be within the scope of JTAER.

Adverse reactions to insects occur in both human and veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in all species. In this position paper, we summarize the current knowledge on insect allergy induced via stings, bites, inhalation or ingestion, and compare reactions in companion animals to those in people. With few exceptions, the situation in human insect allergy is better documented than in animals. We focus on a review of recent literature and give overviews of the epidemiology and clinical signs. We discuss allergen sources and allergenic molecules to the extent described, and aspects of diagnosis, prophylaxis, management and therapy. © 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Early warning systems detect new psychoactive substances (NPS), while dedicated monitoring programs and routine drug and toxicology testing identify fluctuations in prevalence. We report the increasing prevalence of the synthetic cannabinoid receptor agonist (SCRA) ADB-BUTINACA (N-[1-amino-3,3-dimethyl-1-oxobutan-2-yl]-1-butyl-1H-indazole-3-carbox-amide). ADB-BUTINACA was first detected in a seizure in Sweden in 2019, and we report its detection in 13 routine Swedish forensic toxicology cases soon after. In January 2021, ADB-BUTINACA was detected in SCRA-infused papers seized in Scottish prisons and has rapidly increased in prevalence, being detected in 60.4% of the SCRA-infused papers tested between January and July 2021. In this work, ADB-BUTINACA was incubated with human hepatocytes (HHeps), and 21 metabolites were identified in vitro, 14 being detected in authentic case samples. The parent drug and metabolites B9 (mono-hydroxylation on the n-butyl tail) and B16 (mono-hydroxylation on the indazole ring) are recommended biomarkers in blood, while metabolites B4 (dihydrodiol formation on the indazole core), B9, and B16 are suitable biomarkers in urine. ADB-4en-PINACA (N-[1-amino-3,3-dimethyl-1-oxobutan-2-yl]-1-[pent-4-en-1-yl]-1H-indazole-3-carboxamide) was detected in Scottish prisons in December 2020, but, unlike ADB-BUTINACA, prevalence has remained low. ADB-4en-PINACA was incubated with HHeps, and 11 metabolites were identified. Metabolites E3 (dihydrodiol formed in the tail moiety) and E7 (hydroxylation on the linked/head group) are the most abundant metabolites in vitro and are suggested as urinary biomarkers. The in vitro potencies of ADB-BUTINACA (EC50, 11.5 nM and ADB-4en-PINACA (EC50, 11.6 nM) are similar to that of MDMB-4en-PINACA (EC50, 4.3 nM). A third tert-leucinamide SCRA, ADB-HEXINACA was also detected in prison samples and warrants further investigation. Funding Agencies|Linkopings Universitet; Dubai Police Force [2427681]; Leverhulme TrustLeverhulme Trust [RC-2015-01]; Scottish Prison Service [01865]; Linkoping University; VINNOVAVinnova [2019-03566]; European CommissionEuropean CommissionEuropean Commission Joint Research Centre [E! 113377]

Misuse of statistics in medical and sports science research is common and may lead to detrimental consequences to healthcare. Many authors, editors and peer reviewers of medical papers will not have expert knowledge of statistics or may be unconvinced about the importance of applying correct statistics in medical research. Although there are guidelines on reporting statistics in medical papers, a checklist on the more general and commonly seen aspects of statistics to assess when peer-reviewing an article is needed. In this article, we propose a CHecklist for statistical Assessment of Medical Papers (CHAMP) comprising 30 items related to the design and conduct, data analysis, reporting and presentation, and interpretation of a research paper. While CHAMP is primarily aimed at editors and peer reviewers during the statistical assessment of a medical paper, we believe it will serve as a useful reference to improve authors’ and readers’ practice in their use of statistics in medical research. We strongly encourage editors and peer reviewers to consult CHAMP when assessing manuscripts for potential publication. Authors also may apply CHAMP to ensure the validity of their statistical approach and reporting of medical research, and readers may consider using CHAMP to enhance their statistical assessment of a paper.

Complex phenomena such as play, creativity or innovation are familiar, yet difficult to describe in a systematic manner. In this short article I propose six necessary conditions for any comprehensive description of play. Against this background I discuss my systems-theoretic, constructivist and practice-informed approach to play.

In the name of women’s protection, Dutch immigration authorities police cross-border marriages differentiating between acceptable and non-acceptable forms of marriage (e.g. ‘forced’, ‘sham’, ‘arranged’). The categorisation of marriages between ‘sham’ and ‘genuine’ derives from the assumption that interest and love are and should be unconnected. Nevertheless, love and interest are closely entwined and their consideration as separate is not only misleading but affects the exchanges that take place within marriage and, therefore, has particular implications for spouses, especially for women. The ethnographic analysis of marriages between unauthorised African male migrants and (non-Dutch) EU female citizens, often suspected by immigration authorities of being ‘sham’, demonstrate the complex articulation of love and interest and the consequences of neglecting this entanglement – both for the spouses and scholars. The cases show that romantic love is not a panacea for unequal gender relations and may place women in a disadvantaged position – all the more so because the norms of love are gendered and construe self-sacrifice as more fundamental in women’s manifestations of love than that of men’s.

Chronic airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), together with their comorbidities, bear a significant burden on public health. Increased appreciation of molecular networks underlying inflammatory airway disease needs to be translated into new therapies for distinct phenotypes not controlled by current treatment regimens. On the other hand, development of new safe and effective therapies for such respiratory diseases is an arduous and expensive process. Antibody-based (biological) therapies are successful in treating certain respiratory conditions not controlled by standard therapies such as severe allergic and refractory eosinophilic severe asthma, while in other inflammatory respiratory diseases, such as COPD, biologicals are having a more limited impact. Small molecule drug (SMD)-based therapies represent an active field in pharmaceutical research and development. SMDs expand biologicals' therapeutic targets by reaching the intracellular compartment by delivery as either an oral or topically based formulation, offering both convenience and lower costs. Aim of this review was to compare and contrast the distinct pharmacological properties and clinical applications of SMDs- and antibody-based treatment strategies, their limitations and challenges, in order to highlight how they should be integrated for their optimal utilization and to fill the critical gaps in current treatment for these chronic inflammatory respiratory diseases.

The skill of reading undergoes dramatic changes due to the change of reading interface readers are exposed to. Readers who want to be active participants of knowledge society need to perceive it as more than just a receptive skill. The study aims to assess the condition of homo legens, diagnose what kind of reading interface preferences characterize 21st-century readers, how they respond to texts considering reading both digitally and in print, accepting or viewing critically the underlying ideology of the text. The analysis of the collected data attempts to determine if the reported preferences are conducive to the development of critical thinking skills for 21st-century literacy, which include understanding complex ideas, evaluating evidence, weighing alternative perspectives and constructing justifiable arguments.

International audience; The increasing number of frail elderly people in our aging society is becoming problematic: about 11% of community-dwelling older persons are frail and another 42% are pre-frail. Consequently, a major challenge in the coming years will be to test people over the age of 60 years to detect pre-frailty at the earliest stage and to return them to robustness using the targeted interventions that are becoming increasingly available. This challenge requires individual longitudinal monitoring (ILM) or follow-up of community-dwelling older persons using quantitative approaches. This paper briefly describes an effort to tackle this challenge. Extending the detection of the pre-frail stages to other population groups is also suggested. Appropriate algorithms have been used to begin the tracing of faint physiological signals in order to detect transitions from robustness to pre-frailty states and from pre-frailty to frailty states. It is hoped that these studies will allow older adults to receive preventive treatment at the correct institutions and by the appropriate professionals as early as possible, which will prevent loss of autonomy. Altogether, ILM is conceived as an emerging property of databases ("digital twins") and not the reverse. Furthermore, ILM should facilitate a coordinated set of actions by the caregivers, which is a complex challenge in itself. This approach should be gradually extended to all ages, because frailty has no age, as is testified by overwork, burnout, and post-traumatic syndrome.

Computer-assisted collaborative writing has been gradually employed in L2 and FL contexts due to the introduction of Web 2.0 applications and tools (i.e., Google Docs and wikis) and its benefits in developing learners’ writing skills. Accordingly, extensive literature that dealt with computer-assisted collaborative learning and learners’ perceptions towards this activity has been condensed on shelves by time passing. Thus, a review of former studies over the recent decade is called forth aiming to ameliorate the difficulties of reaching this literature and to awaken broadened knowledge in this promising area. This paper reviewed and discussed about 40 relevant articles published from 2011 to 2019 that dealt with computer-assisted collaborative writing using Web 2.0 tools, precisely Google Docs and wikis, and learners’ perceptions towards this activity (computer-assisted collaborative writing) and tools. All the articles were selected according to specific criteria, where only a true collaborative writing peer-reviewed articles were selected. After that, two main themes were synthesized: (a) collaborative writing outcomes and (b) students’ perceptions, and specific research components in relation to each theme were further reviewed and summarized using illustrative tables. Drawing on the review of this literature, the researchers discuss pedagogical implications in terms of technology integration and writing development and address future research directions including systematically reviewing this topic with teachers’ perceptions of computer-assisted collaborative writing.

Intriguing unforced regularities in human behaviors have been reported in varied research domains, including scientometrics. In this study we examine the manuscript submission behavior of researchers, with a focus on its monthly pattern. With a large and reliable dataset which records the submission history of articles published on 10 multidisciplinary journals and 10 management journals over a five-year period (2013-2017), we observe a prominent turn-of-the-month submission effect for accepted papers in management journals but not multidisciplinary journals. This effect gets more pronounced in submissions to top-tier journals and when the first day of a month happens to be a Saturday or Sunday. Sense of ceremony is proposed as a likely explanation of this effect, since the first day of a month is a fundamental temporal landmark which has a 'fresh start effect' on researchers. To conclude, an original and interesting day-of-the-month effect in the academia is reported in this study, which calls for more research attention.

This paper analyzes the southeastern Connecticut Eastern Pequot Tribal Nation’s battle with cultural erasure and resistance through education. Indigenous education programs are gradual yet the most effective method of resisting Western cultural erasure from the United States government, because they peacefully invite both Natives and non-Natives to learn about Native American history outside of European colonizer textbooks. The Tribe battles the erasure that can result from external parties’ ability to grant state or federal titles recognizing tribal authority (known as recognition titles) to determine who receives the powerful stamp of Indigeneity and the right to self- govern. My case study focuses on the Eastern Pequots Archaeology Field School project in collaboration with University of Massachusetts, Boston. I evaluate how the Eastern Pequots use a collaborative archaeology education program with their Tribal members and non-Native individuals to resist erasure by decolonizing Western pedagogy. The Field School has gathered over 99,000 artifacts over 15 seasons that dismantle common misconceptions of how Native Americans lived during the beginning of the United States’ history and redefine modern beliefs about how Natives survived European colonization. The Field School contributes to expanding brief descriptions of Native history into a more complicated and dynamic story that elaborates on Native struggle, survival and resistance.

Paper and ink have been continually evolving since their invention. Conventional printing quality and cost is constantly improving, yet only few examples of commercial embedded electronics on paper exist. This is due to the fact that inks with optical and electronic properties do not suit conventional paper and are still challenging to print reliably. In this project, we aim to develop a new generic mass media "next generation" paper. We present the challenges and progress on book augmentation, using printing technologies such as screen printing and roll-to-roll fabrication. This first step aims to create an augmented book prototype via hybrid integration of optical sensors in its pages and by embedding energyefficient control and communication electronics in the cover. The system senses user interaction and, through wireless connectivity, presents the user with relevant, updated digital content on an adjunct device. The proposed fabrication sequence has been developed with close attention to the requirements of industrial scale-up.

The use of disposable recyclable, eco-friendly, sustainable and low-cost devices with multiple functions is becoming a demand in the emerging area of the Internet of Things as a way to decrease the degree of complexity of the electronic circuits required to serve a plethora of applications. Moreover, for low-cost disposable applications, it is relevant the systems to be recyclable. The idea beyond the present study concerns to exploit our imagination with simple questions such as: What happens if it is possible to have a simple and universal device architecture, easy to implement on paper substrates, but capable to provide different multiple functionalities? It would be possible to have a common template for electronic systems on paper that would be then easily customized depending on the final application? The present study answers to these demands by reporting the physics and electronics behavior of a multigate paper transistor where paper is simultaneously the substrate and the dielectric, while a metal-oxide-semiconductor (IGZO) is used as the active channel. Moreover, the same device is able to present logic functionalities simply by varying the amplitude and frequency of the input gate signals. These transistors operate at drain voltages of 1 V with low power, exhibiting ION/IOFF > 104 and a mobility ≈2 cm2 V−1 s−1, serving the specifications for a broad range of smart disposable low power electronics. To sustain all this, an analytical compact model was developed able to precisely reproduce the response of paper-based dual-gate FETs and provide full understanding of their unique and innovative operational characteristics. publishersversion published

Objectives To overcome challenges in the implementation of electronic dental record systems in a low-resource setting, it is crucial to know the level of users’ satisfaction with the existing system of paper-based dental records and their perceptions of electronic dental records. Methods A cross-sectional paper-based questionnaire survey was conducted among Myanmar dental professionals who worked in one of two teaching hospitals or in private dental clinics. Descriptive data were analyzed and regression analysis was carried out to identify factors influencing perceptions of electronic dental records. Results Most dental professionals (>60%) were satisfied with just three out of six aspects of paper-based dental records (familiarity, flexibility, and portability). In addition, generalized positive perceptions were found among decision makers towards electronic dental records, and 86% of dentists indicated that they were willing to use them. Financial concerns were identified as the most important barrier to the implementation of electronic dental records among dentists who were not willing to use the proposed system. Conclusions The first step towards implementing electronic dental records in Myanmar should be improvement of the content and structure of paper-based dental records, especially in private dental clinics. Utilization of appropriate open-source electronic dental record software in private dental clinics is recommended to address perceived issues around financial barriers. For the long term, we recommend providing further education and training in health informatics to healthcare professionals to facilitate the efficient use of electronic dental record software in Myanmar in the future.

International audience; To reduce pollution emissions and achieve a cleaner production in paper industry, it is essential to understand the inner links between concentrations of gaseous pollutants, types of final products and production techniques. In this study, the concentrations of four potential gaseous pollutants, total volatile organic compounds (TVOC), formaldehyde (HCHO), hydrogen sulfide (H 2 S), and hydrocarbon compounds (C x H y), in the ambient air on thirty sampling points of five pulp and paper mills were detected and analyzed. The results were summarized with respect to the following aspects: (1) Levels of four gaseous pollutants on all the sampling points in five mills. It was obvious that the situation of gaseous pollution from pulp mill was much more serious than those from paper mills. (2) Gaseous pollutant distinctions due to different production processes. The levels of gaseous pollutants from five mills were greatly influenced by the utilized raw materials and the applied paper chemical agents (flavor, coating materials and additives) in mills. (3) Gaseous pollution comparisons at common points. At the two common points in five mills, i.e. the wet end of paper machine and the wastewater treatment process, TVOC and HCHO, C x H y and H 2 S were the main gaseous pollutants, respectively. In addition, some feasible measures to realize a cleaner production in pulping and papermaking process were also put forward in the article.

Misuse of statistics in medical and sports science research is common and may lead to detrimental consequences to healthcare. Many authors, editors and peer reviewers of medical papers will not have expert knowledge of statistics or may be unconvinced about the importance of applying correct statistics in medical research. Although there are guidelines on reporting statistics in medical papers, a checklist on the more general and commonly seen aspects of statistics to assess when peer-reviewing an article is needed. In this article, we propose a CHecklist for statistical Assessment of Medical Papers (CHAMP) comprising 30 items related to the design and conduct, data analysis, reporting and presentation, and interpretation of a research paper. While CHAMP is primarily aimed at editors and peer reviewers during the statistical assessment of a medical paper, we believe it will serve as a useful reference to improve authors’ and readers’ practice in their use of statistics in medical research. We strongly encourage editors and peer reviewers to consult CHAMP when assessing manuscripts for potential publication. Authors also may apply CHAMP to ensure the validity of their statistical approach and reporting of medical research, and readers may consider using CHAMP to enhance their statistical assessment of a paper.

INTRODUCTION The successful implementation of Evidence Based Practice (EBP) depends significantly on practitioners’ access to relevant research articles. It has been argued that the time consuming nature of EBP is a major detriment to its acceptance and widespread use,1 and the logistical difficulties, like having to retrieve research publications of interest from the local university library, are likely to exacerbate this issue. In recognizing the associated adverse effects that this problem could present for knowledge generation and dissemination, the idea to make all research findings publicly available online led to the conception of the world wide web in the early 1990s.2 However, many scientific journals that are slow to abandon their subscription-based business models hide their online content behind paywalls, charging article fees that are usually in the range between $20 and $40. Acknowledging the barriers to EBP that these fees can impose, we have previously compared different strategies for prosthetists and orthotists to maximize their free online access to relevant research literature. The respective data collection in the Spring of 2017 resulted in the finding that approximately 40% of search results in Google Scholar linked to freely available full papers, whereas the remaining 60% links offered only the abstract, but not the full paper, free-of-charge.3 In light of the ever progressing efforts to improve public availability of research, such as the open-access publishing movement or the respective requirements mandated by research funding agencies, we hypothesized that the ratio of freely available online articles is increasing over time, and we repeated our data collection one year after the initial study. Abstract PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32010/24429 How to cite: Burke J, Fiedler G. ONLINE ACCESS TO RESEARCH PAPERS – CHANGES OVER TIME. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018, ABSTRACT, POSTER PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee. http://www.aopanet.org/

In the last 20 years, with the liberalization of the economy, and the trend of industrial globalization, people have gradually paid more attention to environmental protection. With the tremendous advances in information technology, enterprises facing such a severe impact on the business operations, business administrative models must be innovative and adaptable in order to survive and flourish. The paper industry is not only a highly polluting industry, but in the case of long-term overcapacity, the price of paper products is often suppressed, which lowers profitability. The purpose of this study, which is based on the production data of a paper company, is to pose a mathematical programming decision model which integrates green manufacturing technologies, activity-based costing (ABC), and the theory of constraint (TOC), this model should assist in preparing the best production plans, and achieve the optimal profitable product mix. In addition, this study also proposes that the most popular related technologies developed by Industry 4.0 be applied to production control in recent years in order to enhance production efficiency and quality. The findings of this study should contribute to the improvement of the competitiveness of the paper industry, and provide insights into the value of an integrated mathematical programming model applied for product-mix decision. At the same time, we have also applied the related technologies developed by Industry 4.0 to machine maintenance and quality control in manufacturing workshops. With its tremendous benefits, we can actively arouse the industry&rsquo, s understanding of, and attention to, Industry 4.0, thereby increasing the interest in industrial 4.0-related technology investments.

The nutritional status of every patient with cancer may be negatively affected by the cancer itself (ie, mechanical obstruction) or indirectly through tumour-induced metabolic changes (often referred to as cancer-induced malnutrition or cachexia).1 Most of the antineoplastic treatments are likely to cause bothersome side effects (eg, xerostomy, nausea, diarrhoea, taste alterations) that alter appetite and reduce food intake. Some of these side effects may persist for long after treatment has stopped and in some cases, patients do not ever recover (ie, taste alterations due to radiotherapy for head and neck cancer). This may provoke a loss in food enjoyment, which can lead patients to withdraw from social situations that may involve food,2 thus, suggesting that nutrition in patients with cancer is a complex issue that requires a multidisciplinary approach by involving oncologists, nutrition specialists, psychologists, nurses and other allied healthcare professionals. According to several studies, medical oncologists and other healthcare professionals treating patients with cancer seem to neglect nutritional issues, both considering screening and information or intervention.3 4 This has lead the European Cancer Patient Coalition to publish a Cancer Patient’s Nutritional Bill of Rights, which was presented in the European Parliament in Brussels in November 2017.5 The Bill of Rights is also based on the recently updated European Society of Parenteral and Enteral Nutrition guidelines on nutrition in patients with cancer patients.6 Nutrition is a major issue for most patients with cancer and their families, and its impact will often lead to highly emotionalised discussions in our daily practice. Many patients will be worried when they witness loss of appetite and weight. Family members will pronounce even more often concerns, even when patients try to belittle them: weight loss is for many scarily synonymous with late, fatal stage cancer. For all participants, there often is …

Proceedings of the 10th International Conference on computer supported education (CSEDU): Funchal, Madeira, Portugal: March 15, 2018, This paper examines the preferences of students regarding computer-based versus paper-based assessment, in an introductory computer programming course. Two groups of students were surveyed about their preference between paper-based and computer-based tests and respective rationale. All students had already been assessed: one group using two paper-based tests and the other group using two computer-based tests. Both groups expressed an overwhelming preference for computer-based tests independently of their previous programming experience. We conclude that, from the students’ point of view, computer-based tests should be the used over paper-based ones for introductory programming courses. This adds to existing literature about computer-based testing of programming skills.

Made available in DSpace on 2018-11-12T17:26:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2018. Added 1 bitstream(s) on 2018-11-12T17:34:24Z : No. of bitstreams: 1 S0103-65132018000100203.pdf: 741128 bytes, checksum: f2ed68cd9016977a8d8f0a5c580ce1d6 (MD5) AbstractPaper aims The purpose of the paper is to offer guidance regarding how to write a Literature Review for empirical papers, that provides adequate background and convincing support. The literature review plays the fundamental role of unveiling the theory, or theories, that underpin the paper argument, sets its limits, and defines and clarifies the main concepts that will be used in the empirical sections of the text.Originality Most papers and books focus on literature review as full articles (systematic reviews, meta analyses and critical analyses) or dissertation, chapters, this paper is focused on literature review for an empirical article.Research method It is a theoretical essay.Main findings The paper summarizes the main steps for performing a literature review and guides how to organize the analyzed literature.Implications for theory and practice Well-crafted literature reviews are the cornerstone of good papers, and this paper offers some guidance on how to write good reviews for empirical papers, and, as a consequence, to produce better quality texts. Universidade de São Paulo Universidade Estadual Paulista Universidade Estadual Paulista

The declining cost of sea transport has been a necessary condition for the growth of the global pulp and paper industry, especially in regions remote from economic centres. Thus, pulp and paper industries and international shipping have coevolved, especially since the 1960s, enabling producers to tap global markets and develop global production chains. The paper products trade flows, however, have changed a number of times over the last 400 years. This chapter describes and explains these developments and shows how the technological solutions in global shipping and strategic choices among the pulp and paper companies have been interdependent, especially since the 1960s. peerReviewed

It is notable to note here that self-efficacy needs to be ingrained strongly within graduate students to show a higher enthusiasm, efforts, and persistence in accomplishing various demanding academic writing projects. Tangibly, there are still many graduate students who lack motivation and confidence when doing academic writings. As a result, their attitudes toward writing turn into negative actions crippling their self-efficacy. This study aimed to investigate graduate students’ perceived self-efficacy in academic writings. One research problem was formulated in this study namely, how do English Education Master Students maintain their self-efficacy to accomplish their academic writings? This study employed a mixed-method harnessing classroom survey and interview questions to gather data from English Education Master Students engaging in academic writings, Sanata Dharma University, Yogyakarta. Findings from this study revealed that graduate students are able to produce more qualified academic writing products when they are motivated continuously by their lecturer. Keywords: self-efficacy, perceptions, academic writings, graduate students, mixed method

Carprofen (CAR) is a non-steroidal anti-inflammatory drug commonly used to treat various musculoskeletal diseases and infections in food animals. While CAR residues in food animal tissues caused by veterinary medicine abuse are a potential danger to human health. In this study, a high-affinity monoclonal antibody (mAb) against CAR was prepared, and then an immunochromatographic strip for rapidly screening CAR in bovine muscle was developed to help enforce regulatory compliance. The visual detection limit (cut-off value) by the naked eye of the fabricated test strip was 12.5 ng g−1. Scanning by the strip reader, the IC50 of the test strip was calculated as 1.743 ng g−1, and the limit of detection (LOD, IC10) was 0.283 ng g−1. The proposed method provided an efficient tool for monitoring CAR in bovine muscle. Meantime, our work suggested great potential for the analysis of CAR residues in other food matrixes.