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12 results on '"Laforgia, Nicola"'

2. Complementary feeding in preterm infants: a position paper by Italian neonatal, paediatric and paediatric gastroenterology joint societies

Author

Baldassarre, Maria Elisabetta, Panza, Raffaella, Cresi, Francesco, Salvatori, Guglielmo, Corvaglia, Luigi, Aceti, Arianna, Giannì, Maria Lorella, Liotto, Nadia, Ilardi, Laura, Laforgia, Nicola, Maggio, Luca, Lionetti, Paolo, Agostoni, Carlo, Orfeo, Luigi, Di Mauro, Antonio, Staiano, Annamaria, Mosca, Fabio, Baldassarre, Maria Elisabetta, Panza, Raffaella, Cresi, Francesco, Salvatori, Guglielmo, Corvaglia, Luigi, Aceti, Arianna, Giannì, Maria Lorella, Liotto, Nadia, Ilardi, Laura, Laforgia, Nicola, Maggio, Luca, Lionetti, Paolo, Agostoni, Carlo, Orfeo, Luigi, Di Mauro, Antonio, Staiano, Annamaria, and Mosca, Fabio

Subjects
Weaning [Mesh], Fortification, Gestational Age, Complementary feeding, Premature [Mesh], Births [Mesh], Preterm, Humans, Preterm, Births [Mesh], Infant Nutritional Physiological Phenomena, Child, Premature, Infant, Premature [Mesh], Nutrition, Settore MED/38 - Pediatria Generale e Specialistica, Milk, Human, Infant, Newborn, Gastroenterology, Infant, General Medicine, Breast milk [Mesh], Breastfeeding [Mesh], Newborn, Breast Feeding, Milk, Female, Infant, Premature, Human
Abstract

Nutrition in the first 1000 days of life is essential to ensure appropriate growth rates, prevent adverse short- and long-term outcomes, and allow physiologic neurocognitive development. Appropriate management of early nutritional needs is particularly crucial for preterm infants. Although the impact of early nutrition on health outcomes in preterm infants is well established, evidence-based recommendations on complementary feeding for preterm neonates and especially extremely low birth weight and extremely low gestational age neonates are still lacking. In the present position paper we performed a narrative review to summarize current evidence regarding complementary feeding in preterm neonates and draw recommendation shared by joint societies (SIP, SIN and SIGENP) for paediatricians, healthcare providers and families with the final aim to reduce the variability of attitude and timing among professionals.

Published
2022

3. How Much Is an Abortion Worth? Was a Human "Not Formed"? An Italian Proposal.

Author

Marrone, Maricla, De Luca, Benedetta Pia, Pititto, Fortunato, Grattagliano, Ignazio, Laforgia, Nicola, Vimercati, Antonella, and Dell'Erba, Alessandro

Subjects
PARENT attitudes, MISCARRIAGE, GESTATIONAL age, LEGAL liability, FAMILIES, ABORTION laws, PARENT-infant relationships, INTERPERSONAL relations, COURTS, DAMAGES (Law), LEGISLATION, LAW
Abstract

Introduction: "Human capital" is defined as an integration of innate skills and knowledge acquired by investing in the formation of an individual; it is a real "capital" that pays off in the long term. In the Italian legal system, a human being is recognised as a "person" from the moment of birth. This determines the acquisition of the personal rights of an individual. Necessarily, therefore, by law, a fetus does not own such rights; nevertheless, it has an innate "potential" to acquire such rights after birth. Objective: In Italian jurisprudence, in general, the damage from a loss of a parental relationship is justified by the condition of existential emptiness caused in the family by the loss of a child. Compensation for this damage in the event of abortion due to third-party responsibility presents a non-uniform recognition in the judgements of the Italian courts, but in any case, it is almost always recognised with limitations since the emotional relationship with the lost individual is defined only in terms of "potential". Consequently, in this matter, at least two questions can be raised: (i) Is the economic estimate of abortion based on objective and standardised criteria, or is it heavily influenced by subjective evaluation? (ii) Is it possible to find standard criteria that may act as guidelines to quantify the loss of that human capital "in progress"? Methodology: The authors try to answer these questions by analysing the different approaches to this issue adopted at an international level. Conclusions: In conclusion, the authors propose homogeneous criteria to quantify the damage caused by abortion. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Use of Sotrovimab in a cohort of pregnant women with a high risk of COVID 19 progression: a single-center experience.

Author

Frallonardo, Luisa, Vimercati, Antonella, Novara, Roberta, Lepera, Cherola, Ferrante, Ilaria, Chiarello, Giulia, Cicinelli, Rossana, Mongelli, Michele, Brindicci, Gaetano, Segala, Francesco Vladimiro, Santoro, Carmen Rita, Bavaro, Davide Fiore, Laforgia, Nicola, Cicinelli, Ettore, Saracino, Annalisa, and Di Gennaro, Francesco

Subjects
COVID-19, PREGNANT women, MONOCLONAL antibodies, DRUG efficacy, IMMUNOGLOBULINS, GESTATIONAL age, DISEASE progression
Abstract

Neutralizing monoclonal antibodies (mAbs) have been shown to reduce disease progression in patients with underlying predisposing conditions. Unfortunately, there is no evidence on the use of Sotrovimab in pregnant women. Herein we present a case series of pregnant women who received mAbs with Sotrovimab following the Italian Drug Agency (AIFA) indications. Since February 1, 2022 all pregnant women – regardless of gestational age – admitted to Obstetrics & Gynaecology of Policlinico University of Bari, with positive nasopharyngeal NAAT for SARS-CoV-2 were screened according to the AIFA indications for Sotrovimab and, if eligible, were proposed for treatment. Data on COVID-19, pregnancy, delivery, newborn outcomes, and adverse events were collected. From February 1 to May 15, 2022, 58 pregnant women were screened. Fifty (86%) patients were eligible, 19 of them (32.7%) denied their consent, in 18 cases (31%), the drug was temporarily unavailable, and the remaining 13 (22%) were treated with Sotrovimab. Out of these 13 patients, 6 (46%) were in the 3rd and 7 (54%) in the 2nd trimester of pregnancy. None of the 13 patients experienced adverse reactions due to Sotrovimab and all had a good clinical outcome. Furthermore, evaluating pre- and post-infusion clinical status and hematochemical profile, a reduction in D-dimers and an increase in SARS-CoV-2 antibodies (p < 0.01) during the 72 h following the infusion were observed. Our data, the first on the use of Sotrovimab in pregnant women, showed the safety and efficacy drug profile and its potential crucial role in preventing COVID-19 disease progression. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Enteral Nutrition Tolerance and REspiratory Support (ENTARES) Study in preterm infants: Study protocol for a randomized controlled trial

Author

Cresi, Francesco, Maggiora, Elena, Borgione, Silvia Maria, Spada, Elena, Coscia, Alessandra, Bertino, Enrico, Meneghin, Fabio, Corvaglia, Luigi Tommaso, Ventura, Maria Luisa, Lista, Gianluca, Mosca, Fabio, Orsi, Anna, Mercadante, Domenica, Martinelli, Stefano, Ilardi, Laura, Proto, Alice, Gatto, Sara, Aceti, Arianna, Sandri, Fabrizio, Chakrokh, Roksana, Laforgia, Nicola, Di Mauro, Antonio, Baldassarre, Maria E., Del Vecchio, Antonio, Petrillo, Flavia, Spalierno, Maria P., Raimondi, Francesco, Capasso, Letizia, PALMA, MARTA, Farina, Daniele, Campagnoli, Maria F., Boetti, Tatiana, Logrippo, Federica, Agosti, Massimo, Morlacchi, Laura, Perniciaro, Simona, Dani, Carlo, Elia, Serena, Vento, Giovanni, Maggio, Luca, Stronati, Mauro, Civardi, Elisa, Lidia, Grappone, Angela, Borrelli, Cresi, Francesco, Maggiora, Elena, Borgione, Silvia Maria, Spada, Elena, Coscia, Alessandra, Bertino, Enrico, Meneghin, Fabio, Corvaglia, Luigi Tommaso, Ventura, Maria Luisa, Lista, Gianluca, Mosca, Fabio, Orsi, Anna, Mercadante, Domenica, Martinelli, Stefano, Ilardi, Laura, Proto, Alice, Gatto, Sara, Aceti, Arianna, Sandri, Fabrizio, Chakrokh, Roksana, Laforgia, Nicola, Di Mauro, Antonio, Baldassarre, Maria E., Del Vecchio, Antonio, Petrillo, Flavia, Spalierno, Maria P., Raimondi, Francesco, Capasso, Letizia, Palma, Marta, Farina, Daniele, Campagnoli, Maria F., Boetti, Tatiana, Logrippo, Federica, Agosti, Massimo, Morlacchi, Laura, Perniciaro, Simona, Dani, Carlo, Elia, Serena, Vento, Giovanni, Maggio, Luca, Stronati, Mauro, Civardi, Elisa, Lidia, Grappone, Borrelli, ANGELA CARLA, and ENTARES Study Research Group

Subjects
Male, Pediatrics, Time Factors, medicine.medical_treatment, Enteral nutrition, Feeding intolerance, HFNC, NCPAP, NEC, Non-invasive ventilation, Preterm, RDS, Very low birth weight infant, Medicine (miscellaneous), Pharmacology (medical), Enteral administration, Study Protocol, 0302 clinical medicine, Multicenter Studies as Topic, Single-Blind Method, 030212 general & internal medicine, Continuous positive airway pressure, Infant Nutritional Physiological Phenomena, Lung, Randomized Controlled Trials as Topic, lcsh:R5-920, Respiratory Distress Syndrome, Respiratory distress, Continuous Positive Airway Pressure, Nutritional Support, Respiration, Enteral Nutrition, Female, Gestational Age, Humans, Infant, Newborn, Italy, Respiratory Distress Syndrome, Newborn, Treatment Outcome, Infant, Extremely Premature, Premature Birth, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, lcsh:Medicine (General), medicine.medical_specialty, Extremely Premature, Lung injury, 03 medical and health sciences, Intensive care, medicine, Mechanical ventilation, business.industry, Infant, medicine.disease, Newborn, Parenteral nutrition, Bronchopulmonary dysplasia, business, 030217 neurology & neurosurgery
Abstract

Background Respiratory distress syndrome (RDS) and feeding intolerance are common conditions in preterm infants and among the major causes of neonatal mortality and morbidity. For many years, preterm infants with RDS have been treated with mechanical ventilation, increasing risks of acute lung injury and bronchopulmonary dysplasia. In recent years non-invasive ventilation techniques have been developed. Showing similar efficacy and risk of bronchopulmonary dysplasia, nasal continuous positive airway pressure (NCPAP) and heated humidified high-flow nasal cannula (HHHFNC) have become the most widespread techniques in neonatal intensive care units. However, their impact on nutrition, particularly on feeding tolerance and risk of complications, is still unknown in preterm infants. The aim of the study is to evaluate the impact of NCPAP vs HHHFNC on enteral feeding and to identify the most suitable technique for preterm infants with RDS. Methods A multicenter randomized single-blind controlled trial was designed. All preterm infants with a gestational age of 25–29 weeks treated with NCPAP or HHHFNC for RDS and demonstrating stability for at least 48 h along with the compliance with inclusion criteria (age less than 7 days, need for non-invasive respiratory support, suitability to start enteral feeding) will be enrolled in the study and randomized to the NCPAP or HHHFNC arm. All patients will be monitored until discharge, and data will be analyzed according to an intention-to-treat model. The primary outcome is the time to reach full enteral feeding, while parameters of respiratory support, feeding tolerance, and overall health status will be evaluated as secondary outcomes. The sample size was calculated at 141 patients per arm. Discussion The identification of the most suitable technique (NCPAP vs HHHFNC) for preterm infants with feeding intolerance could reduce gastrointestinal complications, improve growth, and reduce hospital length of stay, thus improving clinical outcomes and reducing health costs. The evaluation of the timing of oral feeding could be useful in understanding the influence that these techniques could have on the development of sucking-swallow coordination. Moreover, the evaluation of the response to NCPAP and HHHFNC could clarify their efficacy as a treatment for RDS in extremely preterm infants. Trial registration ClinicalTrials.gov, NCT03548324. Registered on 7 June 2018. Electronic supplementary material The online version of this article (10.1186/s13063-018-3119-0) contains supplementary material, which is available to authorized users.

Published
2019

6. In-hospital and web-based intervention to counteract vaccine hesitancy in very preterm infants' families: a NICU experience.

Author

Di Mauro, Antonio, Di Mauro, Federica, Greco, Chiara, Giannico, Orazio Valerio, Grosso, Francesca Maria, Baldassarre, Maria Elisabetta, Capozza, Manuela, Schettini, Federico, Stefanizzi, Pasquale, and Laforgia, Nicola

Subjects
VACCINATION, STATISTICS, PARENT attitudes, NEONATAL intensive care, IMMUNIZATION, CONFIDENCE, CONFIDENCE intervals, ATTITUDE (Psychology), INTERNET, AGE distribution, FAMILIES, NEONATAL intensive care units, HOSPITAL health promotion programs, GESTATIONAL age, MEDICAL protocols, BIRTH weight, DESCRIPTIVE statistics, AT-risk people, DATA analysis, MMR vaccines, ODDS ratio, LONGITUDINAL method
Abstract

Background: Vaccine hesitancy is a global problem, carrying significant health risks for extremely vulnerable population as that of preterm infants. Social media are emerging as significant tools for public health promotion. Our aim was to evaluate both the coverage and the timeliness of routine immunizations in a cohort of preterm infants (< 33 weeks of gestational age) at 24 months of age whose families have been subjected to in-hospital and web-based interventions to counteract vaccine hesitancy. Methods: For a period of 2 years parents of preterm infants were instructed during their follow up visits by a member of the NICU team to get correct informations about vaccines from a social network page. Vaccination rates of preterm infants were assessed at 24 months of chronological age with an electronic database and compared to both general population and historical cohort. Results: Coverage and timeliness of vaccinations at 24 months of age of 170 preterm infants were analyzed in December 2019. Gestational age and birth weight median (IQR) were, respectively, 31.0 (5.0) weeks and 1475.0 (843.8) g. Coverage rates were similar to those of the regional population (p > 0.05), while timeliness of administration was significantly delayed compared to the recommended schedule (p < 0.001). Age of administration was not correlated with either body weight and gestational age at birth (Spearman rank, p > 0.05). DTaP-IPV-HBV-Hib 2nd and 3rd doses, MMR and Varicella vaccines coverage data were higher compared to historical cohort (p < 0.05). Conclusion: Increasing vaccine confidence through web-based interventions could have a positive impact on vaccination acceptance of parents of preterm infants, although timeliness results still delayed. There is a strong need to develop different and effective vaccination strategies to protect this very vulnerable population. [ABSTRACT FROM AUTHOR]

Published
2021
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7. Birth Weight and the Development of Functional Gastrointestinal Disorders in Infants.

Author

Baldassarre, Maria Elisabetta, Di Mauro, Antonio, Salvatore, Silvia, Tafuri, Silvio, Bianchi, Francesco Paolo, Dattoli, Enzo, Morando, Lucia, Pensabene, Licia, Meneghin, Fabio, Dilillo, Dario, Mancini, Valentina, Talarico, Valentina, Tandoi, Francesco, Zuccotti, Gianvincenzo, Agosti, Massimo, and Laforgia, Nicola

Subjects
BIRTH weight, INFANTS, LOW birth weight, INFANTILE colic, GESTATIONAL age
Abstract

Purpose: To assess the association between birth weight and the development of functional gastrointestinal disorders (FGIDs) in the first year of life. Methods: This is a secondary analysis of a prospective cohort multicenter study including neonates, consecutively enrolled at birth, and followed up for one year. At birth all infants were classified by birth weight as extremely low (ELBW), very low, or low when <1,000, <1,500, and <2,500 g, respectively, and by birth weight for gestational age as appropriate (AGA, weight in the 10-90th percentile), small (SGA, weight <10th percentile), and large (LGA, weight >90th percentile) for gestational age. FGIDs were classified according to the Rome III criteria and assessed at 1, 3, 6, and 12 months of life. Results: Among 1,152 newborns enrolled, 934 (81.1%) completed the study: 302 (32.3%) were preterm, 35 (3.7%) were ELBW, 104 (11.1%) were SGA, 782 (83.7%) were AGA, and 48 (5.1%) were LGA infants. Overall, throughout the first year of life, 718 (76.9%) reported at least one FGID. The proportion of infants presenting with at least one FGID was significantly higher in ELBW (97%) compared to LBW (74%) ( p=0.01) and in LGA (85.4%) and SGA (85.6%) compared to AGA (75.2%) ( p=0.0001). On multivariate analysis, SGA was significantly associated with infantile colic. Conclusion: We observed an increased risk of FGIDs in ELBW, SGA, and LGA neonates. Our results suggest that prenatal factors determining birth weight may influence the development of FGIDs in infants. Understanding the role of all potential risk factors may provide new insights and targeted approaches for FGIDs. [ABSTRACT FROM AUTHOR]

Published
2020
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8. Association of maternal hypertension and chorioamnionitis with preterm outcomes

Author

Gagliardi, Luigi, Rusconi, Franca, Bellù, Roberto, Zanini, Rinaldo, Mirri, Gianpaolo, Condò, Manuela, Turoli, Daniela, Vanzati, Mara, Mosca, Fabio, De Nisi, Giuseppe, Polacco, Paola, Villa, Elena, Barbarini, Mario, Fasolato, Valeria, Franco, Caterina, Contiero, Raffaella, Ellero, Serena, Cattarossi, Luigi, Abbiati, Laura, Borroni, Cesarina, Prandi, Giovanna, Fabris, Claudio, Vielmi, Francesca, Borgione, Silvia, Agosti, Massimo, Tandoi, Francesco, Guidali, Rosanna, De Curtis, Mario, Tozzi, Claudio, Lucchini, Renato, Battaglioli, Marina, Lista, Gian Luca, Introvini, Paola, Ferrari, Fabrizio, Gallo, Claudio, Bellante, Elvira, Bottura, Chiara, Zeringyte, Aurelija, Pasquali, Francesca, Boccacci, Simona, Latini, Giuseppe, Giannuzzi, Raffaella, Martinelli, Stefano, Brunelli, Alberto, Di Nunzio, Maria Lucia, Vendemmiati, Antonio, Carli, Giovanna, Bordigato, Michela Alfiero, Filippone, Marco, Meneghesso, Davide, Romeo, Nicola, Mammoliti, Palma, Mastretta, Emanuele, Barberis, Laura, Farina, Daniele, Gancia, Gianpaolo, Dalmazzo, Cristina, Napolitano, Marcello, Messina, Francesco, Villa Betania, Napoli, Magaldi, Rosario, Rinaldi, Matteo, Litta, Rosangela, Lago, Paola, Zanardo, Vincenzo, Chiandetti, Lino, Visentin, Stefano, Presta, Giuseppe, Cella, Davide, Poggiani, Carlo, Ferrari, Daniela, Parati, Sara, Lombardo, Francesco, Grigorio, Rosetta, Barera, Graziano, Bove, Maddalena, Poloniato, Antonella, Burgio, Giampiero, Sala, Elena, Barberi, Ignazio, Tiralongo, Venera, Arco, Alessandro, Mazzeo, Danila, Dani, Carlo, Pratesi, Simone, Mignatti, Valeria, Ancora, Gina, Faldella, Giacomo, Grandi, Sara, Locatelli, Chiara, Stronati, Mauro, Perotti, Gianfranco, Chirico, Gaetano, Migliori, Claudio, De Marini, Sergio, Forleo, Vincenzo, Paludetto, Roberto, Capasso, Letizia, Mansi, Giuseppina, Raimondi, Francesco, Bona, Gianni, Stucchi, Ilaria, Savastio, Silvia, Ferrero, Federica, Parola, Andrea, Padovani, Ezio Maria, Viviani, Elena, Pecoraro, Laura, Agostino, Rocco, Gizzi, Camilla, Massenzi, Luca, Messner, Hubert, Staffler, Alex, Salvia, Gennaro, Esposito, Luigi, Forziati, Vincenzo, Latorre, Giuseppe, Sandri, Fabrizio, Alati, Stefania, Demarca, Fabrizio, Lombardi, Oreste, Costabile, Carmine Deni, Scarpelli, Gianfranco, Cavalli, Claudio, Volante, Enrico, Moretti, Sabrina, Ganguzza, Olga, Spinella, Bartolomeo, Haass, Cristina, Scapillati, Eleonora, Consigli, Chiara, Gatta, Alberto, Quitadamo, Pasqua, Boldrini, Antonio, Vuerich, Marco, Sigali, Emilio, Fiorini, Patrizio, Petrucci, Letizia, Moroni, Marco, Meyer, Firenze, Bragetti, Patrizia, Casucci, Paola, Minelli, Liliana, Mezzetti, Daniele, Orfeo, Luigi, De Luca, Maria Gabriella, Laforgia, Nicola, Grassi, Alessandro, Dotta, Andrea, Savignoni, Ferdinando, Bagnoli, Franco, De Felice, Claudio, Badii, Silvia, Biasini, Augusto, Belluzzi, Antonio, Stella, Marcello, Romagnoli, Costantino, Zecca, Enrico, Barone, Giovanni, Colleselli, Paolo, Vecchiato, Luca, Nicolussi, Silvia, Giliberti, Paolo, Chello, Giovanni, Rojo, Silvana, De Vivo, Massimiliano, Giovanettoni, Chiara, Colnaghi, Clelia A., Manfredini, Valeria, Verucci, Elena, Placidi, Giulia, Belloni, Cesare, Carrera, Giuseppe, Zambetti, Chiara, Biban, Paolo, Serra, Alessandra, Sacco, Francesco, Vetrano, Gennaro, Furcolo, Giuseppe, Pasquariello, Brigida, Falco, Luigi, Ausanio, Gaetano, Bernardo, Italo, Capasso, Antonella, Marchesano, Giuseppe, Nosari, Norberto, Sarnelli, Paola, Ciraci, Giovanni, Merazzi, Daniele, Gazzolo, Diego, Temperini, Francesca, Sabatini, Miriam, Colivicchi, Micaela, Del Vecchio, Antonio, Tarantino, Marzia, Gargano, Giancarlo, Pedori, Simona, Bellettato, Massimo, Pesavento, Roberta, Cesaro, Alessandra, Scollo, Massimo, Mondello, Isabella, Pugliese, Aniello, Iervolino, Claudio, Corsello, Giovanni, Giuffré, Mario, Betta, Pasqua, Romeo, Mario Giuseppe, Saporito, Alessandro, Leone, Maria Grazia, Rodonò, Alessandro, Franceschi, Alessia, Risso, Francesco M., Carpentieri, Mauro, Vecchiano, Teresa, Cigliano, Maria Pia, Paolillo, Piermichele, Picone, Simonetta, Marra, Antonio, Rossetti, Gessica, Testa, Tiziana, Del Cuore, Fernando, Crescenzi, Francesco, Poloni, Gianna, Russo, Maria Chiara, Nigro, Francesco, Tina, Gabriella Lucia, Brindisino, Patrizia, Gurrado, Raffaele, Felice, Maurizio, Formica, Isabella, Gagliardi, L, Rusconi, F, Bellu, R, Zanini, R, Corsello, G, Giuffre, M, Italian Neonatal Network, Luigi Gagliardi, Franca Rusconi, Roberto Bellù, Rinaldo Zanini, the Italian Neonatal Network [.., Gina Ancora, Giacomo Faldella, Sara Grandi, Chiara Locatelli, ]., Gagliardi, Luigi, Rusconi, Franca, Bellù, Roberto, Zanini, Rinaldo, Mirri, Gianpaolo, Condò, Manuela, Turoli, Daniela, Vanzati, Mara, Mosca, Fabio, De Nisi, Giuseppe, Polacco, Paola, Villa, Elena, Barbarini, Mario, Fasolato, Valeria, Franco, Caterina, Contiero, Raffaella, Ellero, Serena, Cattarossi, Luigi, Abbiati, Laura, Borroni, Cesarina, Prandi, Giovanna, Fabris, Claudio, Vielmi, Francesca, Borgione, Silvia, Agosti, Massimo, Tandoi, Francesco, Guidali, Rosanna, De Curtis, Mario, Tozzi, Claudio, Lucchini, Renato, Battaglioli, Marina, Lista, Gian Luca, Introvini, Paola, Ferrari, Fabrizio, Gallo, Claudio, Bellante, Elvira, Bottura, Chiara, Zeringyte, Aurelija, Pasquali, Francesca, Boccacci, Simona, Latini, Giuseppe, Giannuzzi, Raffaella, Martinelli, Stefano, Brunelli, Alberto, Di Nunzio, Maria Lucia, Vendemmiati, Antonio, Carli, Giovanna, Bordigato, Michela Alfiero, Filippone, Marco, Meneghesso, Davide, Romeo, Nicola, Mammoliti, Palma, Mastretta, Emanuele, Barberis, Laura, Farina, Daniele, Gancia, Gianpaolo, Dalmazzo, Cristina, Napolitano, Marcello, Messina, Francesco, Villa Betania, Napoli, Magaldi, Rosario, Rinaldi, Matteo, Litta, Rosangela, Lago, Paola, Zanardo, Vincenzo, Chiandetti, Lino, Visentin, Stefano, Presta, Giuseppe, Cella, Davide, Poggiani, Carlo, Ferrari, Daniela, Parati, Sara, Lombardo, Francesco, Grigorio, Rosetta, Barera, Graziano, Bove, Maddalena, Poloniato, Antonella, Burgio, Giampiero, Sala, Elena, Barberi, Ignazio, Tiralongo, Venera, Arco, Alessandro, Mazzeo, Danila, Dani, Carlo, Pratesi, Simone, Mignatti, Valeria, Ancora, Gina, Faldella, Giacomo, Grandi, Sara, Locatelli, Chiara, Stronati, Mauro, Perotti, Gianfranco, Chirico, Gaetano, Migliori, Claudio, De Marini, Sergio, Forleo, Vincenzo, Paludetto, Roberto, Capasso, Letizia, Mansi, Giuseppina, Raimondi, Francesco, Bona, Gianni, Stucchi, Ilaria, Savastio, Silvia, Ferrero, Federica, Parola, Andrea, Padovani, Ezio Maria, Viviani, Elena, Pecoraro, Laura, Agostino, Rocco, Gizzi, Camilla, Massenzi, Luca, Messner, Hubert, Staffler, Alex, Salvia, Gennaro, Esposito, Luigi, Forziati, Vincenzo, Latorre, Giuseppe, Sandri, Fabrizio, Alati, Stefania, Demarca, Fabrizio, Lombardi, Oreste, Costabile, Carmine Deni, Scarpelli, Gianfranco, Cavalli, Claudio, Volante, Enrico, Moretti, Sabrina, Ganguzza, Olga, Spinella, Bartolomeo, Haass, Cristina, Scapillati, Eleonora, Consigli, Chiara, Gatta, Alberto, Quitadamo, Pasqua, Boldrini, Antonio, Vuerich, Marco, Sigali, Emilio, Fiorini, Patrizio, Petrucci, Letizia, Moroni, Marco, Meyer, Firenze, Bragetti, Patrizia, Casucci, Paola, Minelli, Liliana, Mezzetti, Daniele, Orfeo, Luigi, De Luca, Maria Gabriella, Laforgia, Nicola, Grassi, Alessandro, Dotta, Andrea, Savignoni, Ferdinando, Bagnoli, Franco, De Felice, Claudio, Badii, Silvia, Biasini, Augusto, Belluzzi, Antonio, Stella, Marcello, Romagnoli, Costantino, Zecca, Enrico, Barone, Giovanni, Colleselli, Paolo, Vecchiato, Luca, Nicolussi, Silvia, Giliberti, Paolo, Chello, Giovanni, Rojo, Silvana, De Vivo, Massimiliano, Giovanettoni, Chiara, Colnaghi, Clelia A., Manfredini, Valeria, Verucci, Elena, Placidi, Giulia, Belloni, Cesare, Carrera, Giuseppe, Zambetti, Chiara, Biban, Paolo, Serra, Alessandra, Sacco, Francesco, Vetrano, Gennaro, Furcolo, Giuseppe, Pasquariello, Brigida, Falco, Luigi, Ausanio, Gaetano, Bernardo, Italo, Capasso, Antonella, Marchesano, Giuseppe, Nosari, Norberto, Sarnelli, Paola, Ciraci, Giovanni, Merazzi, Daniele, Gazzolo, Diego, Temperini, Francesca, Sabatini, Miriam, Colivicchi, Micaela, Del Vecchio, Antonio, Tarantino, Marzia, Gargano, Giancarlo, Pedori, Simona, Bellettato, Massimo, Pesavento, Roberta, Cesaro, Alessandra, Scollo, Massimo, Mondello, Isabella, Pugliese, Aniello, Iervolino, Claudio, Corsello, Giovanni, Giuffré, Mario, Betta, Pasqua, Romeo, Mario Giuseppe, Saporito, Alessandro, Leone, Maria Grazia, Rodonò, Alessandro, Franceschi, Alessia, Risso, Francesco M., Carpentieri, Mauro, Vecchiano, Teresa, Cigliano, Maria Pia, Paolillo, Piermichele, Picone, Simonetta, Marra, Antonio, Rossetti, Gessica, Testa, Tiziana, Del Cuore, Fernando, Crescenzi, Francesco, Poloni, Gianna, Russo, Maria Chiara, Nigro, Francesco, Tina, Gabriella Lucia, Brindisino, Patrizia, Gurrado, Raffaele, Felice, Maurizio, and Formica, Isabella

Subjects
Male, Pediatrics, Logistic models, Mortality, Outcomes, Pregnancy complications, Preterm infants, Risks, Female, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Diseases, Pregnancy, Pregnancy Outcome, Prospective Studies, Chorioamnionitis, Hypertension, Pregnancy-Induced, Pediatrics, Perinatology and Child Health, Medicine (all), Arts and Humanities (miscellaneous), Diseases, outcomes, Maternal hypertension, risk, Obstetrics, pregnancy complications, Gestational age, Retinopathy of prematurity, Perinatology and Child Health, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Logistic models, Mortality, Outcomes, Pregnancy complications, Preterm infants, Risks, Necrotizing enterocolitis, Hypertension, outcome, Human, medicine.medical_specialty, Pregnancy-Induced, preterm infant, Pregnancy complication, medicine, preterm infants, Premature, logistic model, Chorioamnioniti, business.industry, Infant, Infant, Premature, Disease, Odds ratio, medicine.disease, Newborn, mortality, Prospective Studie, Bronchopulmonary dysplasia, business, logistic models, risks
Abstract

OBJECTIVES: We compared the relative effect of hypertensive disorders of pregnancy and chorioamnionitis on adverse neonatal outcomes in very preterm neonates, and studied whether gestational age (GA) modulates these effects. METHODS: A cohort of neonates 23 to 30 weeks' GA, born in 2008 to 2011 in 82 hospitals adhering to the Italian Neonatal Network, was analyzed. Infants born from mothers who had hypertensive disorders (N = 2096) were compared with those born after chorioamnionitis (N = 1510). Statistical analysis employed logistic models, adjusting for GA, hospital, and potential confounders. RESULTS: Overall mortality was higher after hypertension than after chorioamnionitis (odds ratio [OR], 1.39; 95% confidence interval [CI], 1.08–1.80), but this relationship changed across GA weeks; the OR for hypertension was highest at low GA, whereas from 28 weeks' GA onward, mortality was higher for chorioamnionitis. For other outcomes, the relative risks were constant across GA; infants born after hypertension had an increased risk for bronchopulmonary dysplasia (OR, 2.20; 95% CI, 1.68–2.88) and severe retinopathy of prematurity (OR, 1.48; 95% CI, 1.02–2.15), whereas there was a lower risk for early-onset sepsis (OR, 0.25; 95% CI, 0.19–0.34), severe intraventricular hemorrhage (OR, 0.65; 95% CI, 0.48–0.88), periventricular leukomalacia (OR, 0.70; 95% CI, 0.48–1.01), and surgical necrotizing enterocolitis or gastrointestinal perforation (OR, 0.47; 95% CI, 0.31–0.72). CONCLUSIONS: Mortality and other adverse outcomes in very preterm infants depend on antecedents of preterm birth. Hypertension and chorioamnionitis are associated with different patterns of outcomes; for mortality, the effect changes across GA weeks.

Published
2014

9. Candidemia in the Neonatal Intensive Care Unit: A Retrospective, Observational Survey and Analysis of Literature Data.

Author

Caggiano, Giuseppina, Lovero, Grazia, De Giglio, Osvalda, Barbuti, Giovanna, Montagna, Osvaldo, Laforgia, Nicola, and Montagna, Maria Teresa

Subjects
INFECTION, ACADEMIC medical centers, ANTIFUNGAL agents, BIRTH weight, LOW birth weight, BLOOD testing, BLOODBORNE infections, CANDIDA albicans, CELL culture, CHI-squared test, DATABASES, ETHICS, FISHER exact test, GESTATIONAL age, HOSPITAL care, LENGTH of stay in hospitals, INFORMED consent (Medical law), MEDLINE, NEONATAL intensive care, PATHOGENIC microorganisms, POLYMERASE chain reaction, SURVEYS, LITERATURE reviews, NEONATAL intensive care units, HUMAN research subjects, RETROSPECTIVE studies, DATA analysis software, DESCRIPTIVE statistics, CANDIDEMIA, MANN Whitney U Test, DIAGNOSIS
Abstract

We evaluated the epidemiology of Candida bloodstream infections in the neonatal intensive care unit (NICU) of an Italian university hospital during a 9-year period as a means of quantifying the burden of infection and identifying emerging trends. Clinical data were searched for in the microbiological laboratory database. For comparative purposes, we performed a review of NICU candidemia. Forty-one candidemia cases were reviewed (overall incidence, 3.0 per 100 admissions). Candida parapsilosis sensu stricto (58.5%) and C. albicans (34.1%) were the most common species recovered. A variable drift through years was observed; in 2015, 75% of the cases were caused by non-albicans species. The duration of NICU hospitalization of patients with non-albicans was significantly longer than in those with C. albicans (median days, 10 versus 12). Patients with non-albicans species were more likely to have parenteral nutrition than those with C. albicans (96.3% versus 71.4%). Candida albicans was the dominant species in Europe and America (median, 55% and 60%; resp.); non-albicans species predominate in Asia (75%). Significant geographic variation is evident among cases of candidemia in different parts of the world, recognizing the importance of epidemiological data to facilitate the treatment. [ABSTRACT FROM AUTHOR]

Published
2017
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10. Usefulness of tissue transglutaminase type 2 antibodies in early pregnancy.

Author

Baldassarre, Maria Elisabetta, Laneve, Annamaria, Fontana, Antonietta, Manca, Fabio, Salvia, Gennaro, Barcaglioni, Patrizia, Cella, Adolfo, Giannuzzo, Silvia, Esposito, Luigi, Capursi, Teresa, Mastrorilli, Carla, Padovano, Alexander, and Laforgia, Nicola

Subjects
TRANSGLUTAMINASES, IMMUNOGLOBULINS, PREGNANCY complications, CELIAC disease, GESTATIONAL age, GLUTEN content of food, REPRODUCTIVE health, FETAL growth disorders
Abstract

Celiac disease (CD), an autoimmune disease triggered by dietary gluten, is a multi-systemic disorder that primarily results in mucosal damage of the small intestine. Reproductive disorders and pregnancy complications have been associated with CD. Conflicting results have been published concerning CD and the risk of impaired fetal growth with reduced birthweight. The aim of our multicentric, perspective, case-control study was to determine the prevalence of undiagnosed CD in mothers of small for gestational age (SGA) newborns in two regions of Italy. The study included 480 mothers: group A consisted of 284 SGA newborns' mothers and group B consisted of 196 appropriate for gestational age (AGA) newborns' mothers. Tissue transglutaminase type 2 antibodies (TG2) IgA and IgG were measured in blood samples. We diagnosed two new cases of CD in asymptomatic mothers. It may be appropriate to include the TG2 to the panel of prenatal blood test. [ABSTRACT FROM AUTHOR]

Published
2012
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11. Effect of hyperbilirubinemia on intestinal permeability in healthy term newborns.

Author

Indrio, Flavia, Raimondi, Francesco, Laforgia, Nicola, Riezzo, Gieuseppe, Polimeno, Lorenzo, and Francavilla, Ruggiero

Subjects
HYPERBILIRUBINEMIA, PERMEABILITY, INTESTINES, NEWBORN infants, SERUM, BILIRUBIN, BIRTH weight, GESTATIONAL age, PHOTOTHERAPY
Abstract

We investigated the effect of serum bilirubin (SB) on intestinal permeability (IP) of healthy, term, birth weight appropriate for gestational age neonates before phototherapy. IP was measured by the dual probe (lactulose/mannitol) sugar absorption test (SAT) performed on the third day of life in 12 healthy jaundiced newborns (total bilirubin 249 ± 39.75 µmol/L) and compared to that of 12 non-jaundiced newborns (total bilirubin 83.79 + 37.62 µmol/L) matched for sex, gestational age, birth weight and Apgar score. Jaundiced newborns have a significantly higher La/Ma ratio than non-jaundiced (0.31 ± 0.28 vs. 0.053 ± 0.043; p < 0.0004). A significant correlation was found between serum bilirubin level and La/Ma ratio (r = 0.56 p < 0.006). Conclusion: Our study demonstrates a direct effect of UCB on gut epithelial barrier of at-term newborns in whom UCB appears to be responsible for an alteration of IP that theoretically may lead to a passage of macromolecules through the intestinal epithelium increasing the risk of sensitization. [ABSTRACT FROM AUTHOR]

Published
2007
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12. Exposure to Gastric Acid Inhibitors Increases the Risk of Infection in Preterm Very Low Birth Weight Infants but Concomitant Administration of Lactoferrin Counteracts This Effect

Author

Paolo Manzoni, Ruben García Sánchez, Michael Meyer, Ilaria Stolfi, Lorenza Pugni, Hubert Messner, Silvia Cattani, Pasqua Maria Betta, Luigi Memo, Lidia Decembrino, Lina Bollani, Matteo Rinaldi, Maria Fioretti, Michele Quercia, Milena Maule, Elena Tavella, Alessandro Mussa, Chryssoula Tzialla, Nicola Laforgia, Fabio Mosca, Rosario Magaldi, Michael Mostert, Daniele Farina, Amelia Di Comite, Alessandro Borghesi, Giovanni Agriesti, Riccardo Arisio, Caterina Franco, Roberta Guardione, Elena Boano, Alessia Catarinella, Cristina Romano, Cesare Monetti, Ugo Sala, Caterina Carbonara, Emmanuele Mastretta, Paola Del Sordo, Claudio Priolo, Paolo Galletto, Francesca Campagnoli, Mauro Vivalda, Giuseppina Bonfante, Giovanna Gomirato, Davide Montin, Roberta Camilla, Alessandro Messina, Marta Pieretto, Domenico Cipolla, Mario Giuffrè, Giovanni Corsello, Fabio Natale, Gennaro Vetrano, Elisabetta Tridapalli, Giacomo Faldella, Maria Grazia Capretti, PierMichele Paolillo, Simonetta Picone, Serafina Lacerenza, Giancarlo Gargano, Cristiana Magnani, Onofrio Sergio Saia, Elena Della Casa, Manzoni, Paolo, García Sánchez, Ruben, Meyer, Michael, Stolfi, Ilaria, Pugni, Lorenza, Messner, Hubert, Cattani, Silvia, Betta, Pasqua Maria, Memo, Luigi, Decembrino, Lidia, Bollani, Lina, Rinaldi, Matteo, Fioretti, Maria, Quercia, Michele, Maule, Milena, Tavella, Elena, Mussa, Alessandro, Tzialla, Chryssoula, Laforgia, Nicola, Mosca, Fabio, Magaldi, Rosario, Mostert, Michael, Farina, Daniele, Giuffrè, Mario, Corsello, Giovanni, Manzoni P, García Sánchez R, Meyer M, Stolfi I, Pugni L, Messner H, Cattani S, Betta PM, Memo L, Decembrino L, Bollani L, Rinaldi M, Fioretti M, Quercia M, Maule M, Tavella E, Mussa A, Tzialla C, Laforgia N, Mosca F, Magaldi R, Mostert M, Farina D, and Di Comite A, Borghesi A, Agriesti G, Arisio R, Franco C, Guardione R, Boano E, Catarinella A, Romano C, Monetti C, Sala U, Carbonara C, Mastretta E, Del Sordo P, Priolo C, Galletto P, Campagnoli F, Vivalda M, Bonfante G, Gomirato G, Montin D, Camilla R, Messina A, Pieretto M, Cipolla D, Giuffrè M, Corsello G, Natale F, Vetrano G, Tridapalli E, Faldella G, Capretti MG, Paolillo P, Picone S, Lacerenza S, Gargano G, Magnani C, Sergio Saia O, Della Casa E

Subjects
Colonization, Proton Pump Inhibitor, Neonatal intensive care unit, Administration, Oral, Histamine H2 Antagonist, Probiotic, Gastroenterology, Pediatrics, H2 blocker, 0302 clinical medicine, Risk Factors, Infant, Very Low Birth Weight, 030212 general & internal medicine, Candida, VLBW neonate, Lacticaseibacillus rhamnosus, Gestational age, Perinatology and Child Health, Histamine H2 Antagonists, Italy, Necrotizing enterocolitis, medicine.symptom, Infection, Infant, Premature, Human, medicine.medical_specialty, Birth weight, Gastric Acid, Sepsis, 03 medical and health sciences, Enterocolitis, Necrotizing, Intensive Care Units, Neonatal, 030225 pediatrics, Internal medicine, medicine, H2 blockers, Humans, Dietary Supplement, business.industry, Risk Factor, Probiotics, Infant, Newborn, Proton Pump Inhibitors, medicine.disease, Low birth weight, Lactoferrin, Concomitant, Dietary Supplements, Pediatrics, Perinatology and Child Health, VLBW neonates, Gastric acid, Lactobacillus rhamnosu, business, New Zealand
Abstract

Objective: To investigate whether exposure to inhibitors of gastric acidity, such as H2 blockers or proton pump inhibitors, can independently increase the risk of infections in very low birth weight (VLBW) preterm infants in the neonatal intensive care unit. Study design: This is a secondary analysis of prospectively collected data from a multicenter, randomized controlled trial of bovine lactoferrin (BLF) supplementation (with or without the probiotic Lactobacillus rhamnosus GG) vs placebo in prevention of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) in preterm infants. Inhibitors of gastric acidity were used at the recommended dosages/schedules based on the clinical judgment of attending physicians. The distribution of days of inhibitors of gastric acidity exposure between infants with and without LOS/NEC was assessed. The mutually adjusted effects of birth weight, gestational age, duration of inhibitors of gastric acidity treatment, and exposure to BLF were controlled through multivariable logistic regression. Interaction between inhibitors of gastric acidity and BLF was tested; the effects of any day of inhibitors of gastric acidity exposure were then computed for BLF-treated vs -untreated infants. Results: Two hundred thirty-five of 743 infants underwent treatment with inhibitors of gastric acidity, and 86 LOS episodes occurred. After multivariate analysis, exposure to inhibitors of gastric acidity remained significantly and independently associated with LOS (OR, 1.03; 95% CI, 1.008-1.067; P = .01); each day of inhibitors of gastric acidity exposure conferred an additional 3.7% odds of developing LOS. Risk was significant for Gram-negative (P < .001) and fungal (P = .001) pathogens, but not for Gram-positive pathogens (P = .97). On the test for interaction, 1 additional day of exposure to inhibitors of gastric acidity conferred an additional 7.7% risk for LOS (P = .003) in BLF-untreated infants, compared with 1.2% (P = .58) in BLF-treated infants. Conclusion: Exposure to inhibitors of gastric acidity is significantly associated with the occurrence of LOS in preterm VLBW infants. Concomitant administration of BLF counteracts this selective disadvantage. Trial registration: isrctn.org: ISRCTN53107700.

Published
2018

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