1. Renin-angiotensin system modulation through enalapril and/or exercise training improves visceral adiposity in obese mice.
- Author
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Alexandre-Santos B, Magliano DC, Giori IG, Medeiros GRO, Vieira CP, Conte-Junior CA, Nobrega ACLD, and Frantz EDC
- Subjects
- Adipose Tissue, White metabolism, Adiposity drug effects, Adiposity physiology, Animals, Diet, High-Fat, Enalapril metabolism, Insulin metabolism, Insulin Resistance physiology, Intra-Abdominal Fat drug effects, Intra-Abdominal Fat physiology, Male, Mice, Mice, Inbred C57BL, Obesity drug therapy, Obesity metabolism, Obesity, Abdominal metabolism, Receptors, Bradykinin metabolism, Renin-Angiotensin System drug effects, Enalapril pharmacology, Physical Conditioning, Animal physiology, Renin-Angiotensin System physiology
- Abstract
Introduction: Obesity-related metabolic diseases occur as a result of disruptions in white adipose tissue (WAT) plasticity, especially through visceral fat accumulation and adipocyte hypertrophy. This study aimed to evaluate the impact of renin-angiotensin system (RAS) and bradykinin receptors modulation by enalapril treatment and/or exercise training on WAT morphology and related deleterious outcomes., Methods: Male C57BL/6 mice were fed either a standard chow or a high-fat (HF) diet for 16 weeks. At the 8th week, HF-fed animals were divided into sedentary (HF), enalapril treatment (HF-E), exercise training (HF-T), and enalapril treatment plus exercise training (HF-ET) groups. Following the experimental protocol, body mass gain, adiposity index, insulin resistance, visceral WAT morphometry, renin-angiotensin system, and bradykinin receptors were evaluated., Results: The HF group displayed increased adiposity, larger visceral fat mass, and adipocyte hypertrophy, which was accompanied by insulin resistance, overactivation of Ang II/AT1R arm, and favoring of B1R in bradykinin receptors profile. All interventions ameliorated visceral adiposity and related outcomes by favoring the Ang 1-7/MasR arm and the B2R expression in B1R/B2R ratio. However, combined therapy additively reduced Ang II/Ang 1-7 ratio., Conclusion: Our results suggest that Ang 1-7/MasR arm and B2R activation might be relevant targets in the treatment of visceral obesity., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2022
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