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The article presents a case study of a 69-year old female who was refereed with eczematous dermatitis affecting the temporal portion of forehead and cheeks. It states that she reported application of honey for cosmetic purpose. It mentions that the reaction to Myroxylon perierae resin was considered to be cross-reaction with propolis.

Drug skin tests can be helpful in determining the cause of a cutaneous adverse drug reaction (CADR). Patch tests and prick tests can be performed with any commercialized form of a drug. Intradermal tests (IDTs) have a greater value, but their techniques have not been standardized. Moreover, IDTs can be done only if an injectable form of the drug is commercialized and are restricted to patients with nonsevere CADR. Prick tests and IDTs are used in investigating immediate hypersensitivity. Patch tests both with IDTs with delayed readings are helpful for maculopapular rash and generalized or localized eczema. Results obtained with drug skin tests in β-lactam sensitization have been extensively published, but fortunately, during the last few years the value of skin tests in CADR due to other drug classes (e.g., synergistins, platinium salts or radiocontrast medias) was also studied. The analysis of recent literature permits to propose which tests to choose for each clinical feature of CADR and to give the list of all drugs, having had patch tests with positive results but, emphasizes the lack of standardization in performing and reading IDTs. This standardization is absolutely necessary to determine the thresholds of specificity of the IDT. Except for IDTs, drug skin tests induce only rarely adverse reactions. False-positive results can occur and should be considered by testing new products. The negative predictive value of drug skin tests is a crucial point that will have to be studied in more detail in the near future. [ABSTRACT FROM AUTHOR]

A group of 36 normal control persons was patch-tested with glass fibers. The tested filaments had a length of about 3 to 5 mm and a diameter of 9 to 13 µm. The glass fibers were obtained from the normal production process. They were coated with cured epoxy resin. A group of 29 normal control persons was tested with the same type of fibers from which the epoxy finish had been burned off. Another group of 36 persons was patch-tested with ultrasmall glass globes with a diameter of 10 to 15 µm. Coated and uncoated glass globules were tested. On every person 5 patch tests with the same material were done. They were removed after 1, 5, 24, 48 and 72 h. On coated fiber, 12 of 36 tested people reacted with either a + or a ++ reaction. On the uncoated fibers a reaction could be noted in 10 out of 29 persons. The patch tests with coated as well as uncoated glass globules were all negative. A total of 60 biopsies was performed In those cases where + or ++ reactions were noted. The histological examination of the biopsies showed no differences between the reactions on coated and uncoated fibers. The skin reactions to glass fiber showed, besides microtraumatic changes, several histological characteristics of an eczematous reaction, like spongiosis and perivascular lymphocytic infiltration. The importance of these findings is discussed. It is emphasized that histological alterations are only one of the six points which must be taken into account when the diagnosis of eczema is considered. [ABSTRACT FROM AUTHOR]

We have studied a group of 104 patients with pompholyx. to investigate the relationship between allergotogical factors and its etiopathogenesis, The following examinations were performed, blood sampling routine tests and IgE levels. allergological tests (patch, prick. intradennal. and oral renovation tests with nickel sulphate), skin biopsy to exclude pemphigus vulgarism or bullous pemphigoid. An accurate history of familial and personal allergic diathesis was enquired for and various possible aggravating factors (season. microclimate, perspiration and emotional stress) were considered. The results were age `and sex-matched with a healthy control group (208 Subjects). We found familial and personal atopic diathesis in 50% of patients versus 11.5% of controls (P < 0.001); 39 positivity on patch testing 20.19% versus 6.25% of the control group (P<0.001) the % of Patients allergic to nicked reached 26% meluding those (6 Patients) reacting to the oral propagation test season 143 patients) and hyperhidrosis (38) were the aggravating factors most commonly claimed. We detected no correlation between age, sex, grading of pompholyx, and the allergological parameters investigated. Though several different allergological findings have previously been reported indydhidroiss their role in its pathogenses has not yet been fully explained. We think that different haptens or antigens can produce the same clinical and histological picture of pompholyx in predisposed subjects [ABSTRACT FROM AUTHOR]

Of 7887 patients with eczema seen in a private dermatological practice over a period of 2 years and 4 month a specific final diagnosis was found in 5376 (68%), while a final diagnosis of non-specific eczema was made in 2511 cases (32%) The most common final diagnoses were seborrhoeic dermatitis (1351) contact dermatitis (1317), atopic dermatitis (1009) and nummular eczema (822). Battery patch testing was the initial diagnostic procedure performed, and 897 of the 3164 patients who were patch tested had one or more positive patch tests. In 545 cases, the reactions were considered of relevance to the current dermatitis. Tests for immediate-type allergy were carried out in 618 patients, and 284 of these had once or more positive tests. In 86 patients,these test results were of diagnostic significance 257 patients with positive patch tests were challenged orally with the relevant substance , and 53 of 156 reacted to metal salts, most commonly nickel, while 25 of 101 reacted to orally ingested balsam of Peru. Among patch-test-negative patients, 66 of 408 had positive reactions to one or more metal salts; 41 of 180 reacted to balsam of Peru, while 15 of 41 reacted to various food additives. [ABSTRACT FROM AUTHOR]

Nickel is the most important sensitizer in Lagos, with an incidence of 12.3% of 453 patients tested. There was no sex difference, as the wearing of necklaces and bracelets was equally fashionable among both sexes. Housewife eczema is not common, probably because of hardening. Dermatitis from additives in the processing of leather and rubber footwear was the next most common. Chromate sensitivity comes usually from leather or cement. Cultural and climatic factors are mainly responsible for differences in the incidence of contact dermatitis found in Lagos from other countries. [ABSTRACT FROM AUTHOR]

Routine patch testing with a series of 6 industrial biocides containing methylene-bis-thiocyanate (Cytox 3522®), benzisothiazolin-3-one (BIT), chlorocresol (Preventol CMR®), 2-n-octyl-4-isothiazolin-3-one (Kathon 893®), polyhydroxymethylene monobenzylether (Preventol D2®) or 1,3,5-tris (hydroxy-ethyl) hexahydrotriazine (Grotan BK®) was carried out in 6 Danish out-patients clinics to evaluate guinea pig allergy test results with the same compounds. A total of 1652 consecutive patients with dermatitis were tested. The usefulness of this patch test battery was limited. There was a few positive reaction to Cytox 3522® , BIT and the 2-formaldehyde releaser, Preventol D2® and Grotan BK®. These reactions could not however, be explained. The MOAHL-index (% of Male patients from the 6 clinics showed equal frequencies of male patients and atopics, but significant differences in the frequencies of occupational cases, hand eczema, and leg ulcer/ stasis dermatitis, indicating possible variations in referral patterns, use of patch tests, and / or environmental factors. [ABSTRACT FROM AUTHOR]

Forty-eight patients with a positive patch test to potassium dichromate 0.5 % were retested after 4-7 years; 38 patients (79 %) still had a positive patch test. Chromate allergy seems to be persistent. In 72 % of the cases a history of occupational exposure to chromates could be proved. [ABSTRACT FROM AUTHOR]

Clinical examinations, patch tests and prick tests were carried out in a group of railwaymen. Only 3 had both eczema and atopy. Prick tests were positive in a high proportion of subjects, including both those with eczema and controls. [ABSTRACT FROM AUTHOR]

Focuses on the diagnosis of an allergic contact dermatitis to naftifine in the abdomen and genitals. Observation of an acute pruritic eczematous eruption developed on the treated areas; Healing of the dermatitis with oral antihistamines, systemic and topical steroids; Assessment of the fungicidal activity of synthetic allylamine derivative against dermatophytes and fungistatic activity toward Candida species.