1. Frequency of Transmitted Drug Resistance Mutations Among Treatment-Naïve HIV-1-Infected Individuals at a Tertiary Care Centre in South India.
- Author
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Kannangai, Rajesh, David, Shoba, Sundaresan, Vijayanand, Sachithanandham, Jaiprasath, Mani, Monika, Abraham, Ooriapadickal, Pulimood, Susanne, Rupali, Priscilla, and Sridharan, Gopalan
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DRUG resistance , *HIV infections , *THERAPEUTICS , *ANTIRETROVIRAL agents , *TERTIARY care , *GENETIC mutation , *DEATH rate , *DISEASE prevalence - Abstract
Introduction: Morbidity and mortality among HIV-1-infected individuals has been dramatically reduced by the implementation of combinational antiretroviral therapy (ART). However, the efficiency of these therapies is compromised due to HIV-1 transmitted drug resistance mutations (TDRMs). Methods: We collected a total of 127 samples from ART-naïve HIV-infected individuals and sequenced the pol gene and analysed for drug resistance mutations using the Calibrated Population Resistance (CPR) tool in the Stanford database. Results: All the 127 clinical samples (100 %) were identified as HIV-1 subtype C. Based on the CPR tool, three strains (2.4 %) had TDRMs, and these were K101E, Y181C and G190A. Our findings correlated well with the WHO surveys conducted in Asia, including India, which consistently reported <5 % TDRM among the specific populations assessed. Conclusion: In countries like India, regular monitoring of TDRMs will provide better information for clinical practice improvement and policy making. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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