1. Identification of canine parvovirus with the Q370R point mutation in the VP2 gene from a giant panda (Ailuropoda melanoleuca).
- Author
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Ling Guo, Shao-lin Yang, Shi-jie Chen, Zhihe Zhang, Chengdong Wang, Rong Hou, Yupeng Ren, Xintian wen, Sanjie Cao, Wanzhu Guo, Zhongxiang Hao, Zifang Quan, Manli Zhang, and Qi-gui Yan
- Subjects
GIANT panda ,CANINE parvovirus ,CAPSIDS ,NUCLEOTIDE sequence ,MOLECULAR epidemiology ,LABORATORY dogs - Abstract
Background: In this study, we sequenced and phylogenetic analyses of the VP2 genes from twelve canine parvovirus (CPV) strains obtained from eleven domestic dogs and a giant panda (Ailuropoda melanoleuca) in China. A novel canine parvovirus (CPV) was detected from the giant panda in China. Results: Nucleotide and phylogenetic analysis of the capsid protein VP2 gene classified the CPV as a new CPV-2a type. Substitution of Gln for Arg at the conserved 370 residue in CPV presents an unusual variation in the new CPV-2a amino acid sequence of the giant panda and is further evidence for the continuing evolution of the virus. Conclusions: These findings extend the knowledge on CPV molecular epidemiology of particular relevance to wild carnivores. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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