1. Influence of Maternal Obesity on Insulin Sensitivity and Secretion in Offspring.
- Author
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Mingrone, Geltrude, Manco, Melania, Mora, Maria Elena Valera, Guidone, Caterina, Iaconelli, Amerigo, Gniuli, Donatella, Leccesi, Laura, Chiellini, Chiara, and Ghirlanda, Giovanni
- Subjects
OBESITY ,INSULIN ,GLUCOSE ,C-peptide ,LEPTIN ,BIRTH weight ,SEX differences (Biology) ,MATHEMATICAL models - Abstract
OBJECTIVE -- The purpose of this study was to clarify the effects of maternal obesity on insulin sensitivity and secretion in offspring. RESEARCH DESIGN AND METHODS-- Fifty-one offspring of both sexes of obese (Ob group) and 15 offspring of normal-weight (control group) mothers were studied. Plasma glucose, insulin, and C-peptide were measured during an oral glucose tolerance test (OGTT). Insulin sensitivity was calculated using the oral glucose insulin sensitivity index, and insulin secretion and β-cell glucose sensitivity were computed by a mathematical model. Fasting leptin and adiponectin were also measured. Body composition was assessed by dual-X-ray absorptiometry. RESULTS -- No birth weight statistical difference was observed in the two groups. Of the Ob group, 69% were obese and 19% were overweight. The Ob group were more insulin resistant than the control group (398.58 ± 79.32 vs. 513.81 ± 70.70 ml[sup -1] ⋅ min[sup -1] ⋅ m[sup -2] in women, P < 0.0001; 416.42 ± 76.17 vs. 484.242 ± 45.76 m1[sup -1] ⋅ min[sup -1] ⋅ m[sup -2] in men, P < 0.05). Insulin secretion after OGTT was higher in Ob group than in control group men (63.94 ± 21.20 vs. 35.71 ± 10.02 nmol ⋅ m[sup -2], P < 0.01) but did not differ significantly in women. β-Cell glucose sensitivity was not statistically different between groups. A multivariate analysis of variance showed that maternal obesity and offspring sex concurred together with BMI and β-cell glucose sensitivity to determine the differences in insulin sensitivity and secretion observed in offspring. CONCLUSIONS-- Obese mothers can give birth to normal birth weight babies who later develop obesity and insulin resistance. The maternal genetic/epigenetic transmission shows a clear sexual dimorphism, with male offspring having a higher value of insulin sensitivity (although not statistically significant) associated with significantly higher insulin secretion than female offspring. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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