1. Sleep and COMT polymorphism in ADHD children: preliminary actigraphic data.
- Author
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Gruber, Reut, Grtzenko, Natalie, Schwartz, George, Amor, Leila Ben, Gauthier, Julie, De Guzman, Rosherrie, Joober, Ridha, Grizenko, Natalie, and Ben Amor, Leila
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ATTENTION-deficit hyperactivity disorder , *BEHAVIOR disorders in children , *CLINICAL trials , *PATHOLOGICAL physiology , *SLEEP disorders - Abstract
Objective: To examine whether COMT (catechol-O-methyltransferase) polymorphism modulates aspects of sleep in children diagnosed with attention-deficit/hyperactivity disorder (ADHD).Method: Nightly sleep actigraphic recordings during a double-blind, placebo-controlled, crossover clinical study (1 week of 0.5 mg/kg MPH; 1 week of placebo) were obtained for 34 children, 7.4 to 12 years old, diagnosed with ADHD (DSM-IV). Diagnosis was generated by the Diagnostic Interview Schedule for Children and was confirmed by multidisciplinary consensus.Results: Children who were Val allele carriers had poorer sleep continuity compared with children with the Met-Met genotype while receiving a placebo and while receiving methylphenidate.Conclusions: The findings of the present study support the hypothesis that sleep disturbances in children with ADHD are related to the underlying pathophysiology of the disorder. [ABSTRACT FROM AUTHOR]- Published
- 2006
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