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Disaggregation of regional-scale (103 m) flux estimates to micrometeorological scales (101–102 m) facilitates direct comparison between land surface models and ground-based observations. Inversely, it also provides a means for upscaling flux-tower information into a regional context. The utility of the Atmosphere–Land Exchange Inverse (ALEXI) model and associated disaggregation technique (DisALEXI) in effecting regional to local downscaling is demonstrated in an application to thermal imagery collected with the Geostationary Operational Environmental Satellite (GOES) (5-km resolution) and Landsat (60-m resolution) over the state of Oklahoma on 4 days during 2000–01. A related algorithm (DisTrad) sharpens thermal imagery to resolutions associated with visible–near-infrared bands (30 m on Landsat), extending the range in scales achievable through disaggregation. The accuracy and utility of this combined multiscale modeling system is evaluated quantitatively in comparison with measurements made with flux towers in the Oklahoma Mesonet and qualitatively in terms of enhanced information content that emerges at high resolution where flux patterns can be identified with recognizable surface phenomena. Disaggregated flux fields at 30-m resolution were reaggregated over an area approximating the tower flux footprint and agreed with observed fluxes to within 10%. In contrast, 5-km flux predictions from ALEXI showed a higher relative error of 17% because of the gross mismatch in scale between model and measurement, highlighting the efficacy of disaggregation as a means for validating regional-scale flux predictions over heterogeneous landscapes. Sharpening the thermal inputs to DisALEXI with DisTrad did not improve agreement with observations in comparison with a simple bilinear interpolation technique because the sharpening interval associated with Landsat (60–30 m) was much smaller than the dominant scale of heterogeneity (200–500 m) in the scenes studied. Greater benefit is expected in application to Moderate Resolution Imaging Spectroradiometer (MODIS) data, where the potential sharpening interval (1 km to 250 m) brackets the typical agricultural field scale. Thermal sharpening did, however, significantly improve output in terms of visual information content and model convergence rate. [ABSTRACT FROM AUTHOR]