Abstract: While the Ensenadan Stage/Age (ca. 2.1 to 0.5Ma) was characterized by certain mammal associations in the Pampean plains, the Andean ranges of Patagonia and Tierra del Fuego, their piedmont areas and, in some cases, the adjacent lowlands were undergoing a well-defined alternating sequence of glacial and interglacial stages driven by the regional climate of Southernmost South America and Antarctica. This paper reviews the available geographical, geological and chronological evidence of glaciation during the Ensenadan stage/age, with perhaps more than 15 distinct glacial events, including the Great Patagonian Glaciation (GPG) and other cold episodes that took place before and after it. Finally, a tentative correlation of Patagonian glacial episodes and the Pampean biostratigraphic stages, based on radiometric dating and paleomagnetic studies, is herein presented. [Copyright &y& Elsevier]