1. Cytotoxic iridal-type triterpenoids from Iris tectorum.
- Author
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Zhang, Chun-Lei, Wang, Yan, Liu, Yan-Fei, Liang, Dong, Hao, Zhi-You, Luo, Huan, Zhang, Qing-Jian, Shi, Guo-Ru, Chen, Ruo-Yun, Cao, Zheng-Yu, and Yu, De-Quan
- Subjects
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ANTINEOPLASTIC agents , *TRITERPENOIDS , *EPIMERIZATION , *CHIRALITY , *CANCER cells , *CELL lines - Abstract
Seven new iridals ( 1 – 7 ), designated as iritectols C–F, 22-epiiritectol D, 22-epiiritectol E, 22-epiiritectol F together with three known analogues were isolated from the rhizomes of Iris tectorum . Among them, compounds 2 and 3 , 4 and 5 , and 6 and 7 were found to be three pairs of C-22 epimers, some of which were separated by chiral column chromatography. This is the first report on the occurrence of epimers of monocyclic iridals. Their structures were elucidated on the basis of extensive spectroscopic analysis. The isolates were evaluated for their cytotoxic activities against five human tumor cell lines. Compound 1 but not others exhibited moderate cytotoxic activities, with IC 50 values ranging from 4.1 to 9.8 μM. The structure–activity relationship of the tested compounds was briefly discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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