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Recently, many studies have shown various beneficial effects of polyphenol resveratrol (Res) on human health. The most important of these effects include cardioprotective, neuroprotective, anti-cancer, anti-inflammatory, osteoinductive, and anti-microbial effects. Resveratrol has cis and trans isoforms, with the trans isoform being more stable and biologically active. Despite the results of in vitro experiments, resveratrol has limited potential for application in vivo due to its poor water solubility, sensitivity to oxygen, light, and heat, rapid metabolism, and therefore low bioavailability. The possible solution to overcome these limitations could be the synthesis of resveratrol in nanoparticle form. Accordingly, in this study, we have developed a simple, green solvent/non-solvent physicochemical method to synthesize stable, uniform, carrier-free resveratrol nanobelt-like particles (ResNPs) for applications in tissue engineering. UV–visible spectroscopy (UV-Vis) was used to identify the trans isoform of ResNPs which remained stable for at least 63 days. The additional qualitative analysis was performed by Fourier transform infrared spectroscopy (FTIR), while X-ray diffraction (XRD) determined the monoclinic structure of resveratrol with a significant difference in the intensity of diffraction peaks between commercial and nano-belt form. The morphology of ResNPs was evaluated by optical microscopy and field-emission scanning electron microscope (FE-SEM) that revealed a uniform nanobelt-like structure with an individual thickness of less than 1 μm. Bioactivity was confirmed using Artemia salina in vivo toxicity assay, while 2,2–diphenyl-1-picrylhydrazylhydrate (DPPH) reduction assay showed the good antioxidative potential of concentrations of 100 μg/ml and lower. Microdilution assay on several reference strains and clinical isolates showed promising antibacterial potential on Staphylococci, with minimal inhibitory concentration (MIC) being 800 μg/ml. Bioactive glass-based scaffolds were coated with ResNPs and characterized to confirm coating potential. All of the above make these particles a promising bioactive, easy-to-handle component in various biomaterial formulations. Graphical Abstract [ABSTRACT FROM AUTHOR]

This study describes the hydrothermal synthesis of cupric oxide nanoparticles (CuO NPs) using Mint extract agent. A mixture of 0.1 M copper nitrate and a mint extract was hydrothermally treated at a temperature of 180 °C for two hours. Meanwhile, the Mint leaf extract had reduced the copper ions of the nanoparticles after five minutes, resulting in dark-green precipitation. The structural and optical properties of the nanoparticles were studied using X-ray diffraction (XRD), field-emission scanning electron microscope (FE-SEM), and UV-Vis spectroscopy. The nanoparticles showed a simple cubic structure with a crystallite size range of 22 nm ‒ 25 nm. According to the UV-Vis spectrum, an absorption peak was observed at 346 nm. The antibacterial activity was checked against Escherichia coli (E-coli) and Bacillus subtilis (B-subtilis) cultures by which the inhibition zones were found to be 35 mm and 38 mm, respectively. It is concluded that the CuO NPs have a good ability to resist microbes. [ABSTRACT FROM AUTHOR]