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Your search keyword '"Shah, Raj"' showing total 4 results
4 results on '"Shah, Raj"'

1. Relation of blood pressure to risk of incident Alzheimer's disease and change in global cognitive function in older persons.

Author

Shah RC, Wilson RS, Bienias JL, Arvanitakis Z, Evans DA, and Bennett DA

Subjects
Antihypertensive Agents therapeutic use, Apolipoproteins E genetics, Clergy, Female, Genotype, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Proportional Hazards Models, Risk Assessment, Socioeconomic Factors, United States epidemiology, Aged psychology, Alzheimer Disease epidemiology, Alzheimer Disease psychology, Blood Pressure physiology, Cognition physiology
Abstract

Purpose: To examine the relation of systolic and diastolic blood pressure to incident Alzheimer's disease (AD) and rate of cognitive change., Methods: Longitudinal cohort study with annual clinical evaluations. At baseline, blood pressure was measured, apolipoprotein E (APOE) genotyping was performed, and medications were reviewed., Results: 824 older Catholic clergy members without baseline dementia were recruited from across the United States. During a mean of about 6 years of observation, 151 persons developed AD. In a proportional hazards model adjusted for age, sex and education, neither systolic (relative risk = 0.995; 95% CI: 0.986, 1.004, p = 0.249) nor diastolic (relative risk = 1.000; 95% CI: 0.985, 1.015, p = 0.975) blood pressure was related to AD incidence. In mixed effects models, neither systolic nor diastolic blood pressure was related to level or to annual rate of change on a global measure of cognition. These results did not change in subsequent models that accounted for the use of medications with antihypertensive properties or for the possession of an APOE epsilon4 allele., Conclusions: In a cohort of older persons with a majority taking medications with antihypertensive properties, we did not find a relationship between blood pressure and risk of AD or cognitive decline.

Published
2006
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2. Social isolation, social support, and loneliness and their relationship with cognitive health and dementia.

Author

Joyce, Johanna, Ryan, Joanne, Owen, Alice, Hu, Jessie, McHugh Power, Joanna, Shah, Raj, Woods, Robyn, Storey, Elsdon, Britt, Carlene, Freak‐Poli, Rosanne, Freak-Poli, Rosanne, and ASPREE Investigator Group

Subjects
LONELINESS, SOCIAL isolation, SOCIAL support, DEMENTIA, OLDER people, SOCIAL perception
Abstract

Background: Poor social health is prevalent in older adults and may be associated with worse cognition, and increased dementia risk. The aim of this study was to determine whether social isolation, social support and loneliness are independently associated with cognitive function and incident dementia over 5 years in older adults, and to investigate potential gender differences.Methods: Participants were 11,498 community-dwelling relatively healthy Australians aged 70-94, in the ASPREE Longitudinal Study of Older Persons (ALSOP). Social isolation, social support, loneliness and cognitive function were assessed through self-report. Outcomes examined were cognitive decline (>1.5 SD decline in cognitive performance since baseline) and incident dementia (adjudicated according to DSM-IV criteria).Results: Most participants self-reported good social health (92%) with very few socially isolated (2%), with low social support (2%) or lonely (5%). Among women, social isolation and low social support were consistently associated with lower cognitive function (e.g., social support and cognition β = -1.17, p < 0.001). No consistent longitudinal associations were observed between baseline social health and cognitive decline (over median 3.1 years) or incident dementia (over median 4.4 years; social isolation: HR = 1.00, p = 0.99; low social support: HR = 1.79, p = 0.11; loneliness: HR = 0.72, p = 0.34 among women and men).Conclusion: Our study provides evidence that social isolation and a low social support are associated with worse cognitive function in women, but not men. Social health did not predict incident cognitive decline or dementia, but we lacked power to stratify dementia analyses by gender. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Does posterior cingulate hypometabolism result from disconnection or local pathology across preclinical and clinical stages of Alzheimer's disease?

Author

Teipel, Stefan, Grothe, Michel J, Trojanowki, John Q, Quinn, Joseph, Silbert, Lisa, Lind, Betty, Carter, Raina, Dolen, Sara, Schneider, Lon S, Pawluczyk, Sonia, Becerra, Mauricio, Teodoro, Liberty, Spann, Bryan M, Toga, Arthur W, Brewer, James, Vanderswag, Helen, Fleisher, Adam, Heidebrink, Judith L, Lord, Joanne L, Petersen, Ronald, Mason, Sara S, Albers, Colleen S, Knopman, David, Johnson, Kris, Beckett, Laurel, Doody, Rachelle S, Villanueva-Meyer, Javier, Pavlik, Valory, Shibley, Victoria, Chowdhury, Munir, Rountree, Susan, Dang, Mimi, Stern, Yaakov, Honig, Lawrence S, Bell, Karen L, Green, Robert C, Ances, Beau, Morris, John C, Carroll, Maria, Creech, Mary L, Franklin, Erin, Mintun, Mark A, Schneider, Stacy, Oliver, Angela, Marson, Daniel, Geldmacher, David, Saykin, Andrew J, Love, Marissa Natelson, Griffith, Randall, Clark, David, Brockington, John, Roberson, Erik, Grossman, Hillel, Mitsis, Effie, Shah, Raj C, deToledo-Morrell, Leyla, Duara, Ranjan, Morris, John, Greig-Custo, Maria T, Barker, Warren, Albert, Marilyn, Onyike, Chiadi, D'Agostino, Daniel, Kielb, Stephanie, Sadowski, Martin, Sheikh, Mohammed O, Ulysse, Anaztasia, Gaikwad, Mrunalini, Shaw, Leslie M, Doraiswamy, P Murali, Petrella, Jeffrey R, Borges-Neto, Salvador, Wong, Terence Z, Coleman, Edward, Arnold, Steven E, Karlawish, Jason H, Wolk, David A, Clark, Christopher M, Smith, Charles D, Khachaturian, Zaven, Jicha, Greg, Hardy, Peter, Sinha, Partha, Oates, Elizabeth, Conrad, Gary, Lopez, Oscar L, Oakley, MaryAnn, Simpson, Donna M, Porsteinsson, Anton P, Goldstein, Bonnie S, Sorensen, Greg, Martin, Kim, Makino, Kelly M, Ismail, M Saleem, Brand, Connie, Potkin, Steven G, Preda, Adrian, Nguyen, Dana, Womack, Kyle, Mathews, Dana, Quiceno, Mary, Carrillo, Maria, Levey, Allan I, Lah, James J, Cellar, Janet S, Burns, Jeffrey M, Swerdlow, Russell H, Brooks, William M, Apostolova, Liana, Tingus, Kathleen, Woo, Ellen, Silverman, Daniel H S, Initiative, Alzheimer´s Disease Neuroimaging, Kuller, Lew, Lu, Po H, Bartzokis, George, Graff-Radford, Neill R, Parfitt, Francine, Poki-Walker, Kim, Farlow, Martin R, Hake, Ann Marie, Matthews, Brandy R, Brosch, Jared R, Herring, Scott, Raichle, Marc, van Dyck, Christopher H, Carson, Richard E, MacAvoy, Martha G, Varma, Pradeep, Chertkow, Howard, Bergman, Howard, Hosein, Chris, Black, Sandra, Stefanovic, Bojana, Caldwell, Curtis, Paul, Steven, Hsiung, Ging-Yuek Robin, Feldman, Howard, Mudge, Benita, Assaly, Michele, Finger, Elizabeth, Pasternack, Stephen, Rachisky, Irina, Trost, Dick, Kertesz, Andrew, Bernick, Charles, Davies, Peter, Munic, Donna, Mesulam, Marek-Marsel, Rogalski, Emily, Lipowski, Kristine, Weintraub, Sandra, Bonakdarpour, Borna, Kerwin, Diana, Wu, Chuang-Kuo, Johnson, Nancy, Sadowsky, Carl, Fillit, Howard, Villena, Teresa, Turner, Raymond Scott, Johnson, Kathleen, Reynolds, Brigid, Sperling, Reisa A, Johnson, Keith A, Marshall, Gad, Yesavage, Jerome, Taylor, Joy L, Lane, Barton, Hefti, Franz, Rosen, Allyson, Tinklenberg, Jared, Sabbagh, Marwan N, Belden, Christine M, Jacobson, Sandra A, Sirrel, Sherye A, Kowall, Neil, Killiany, Ronald, Budson, Andrew E, Norbash, Alexander, Holtzman, David, Johnson, Patricia Lynn, Obisesan, Thomas O, Wolday, Saba, Allard, Joanne, Lerner, Alan, Ogrocki, Paula, Tatsuoka, Curtis, Fatica, Parianne, Fletcher, Evan, Maillard, Pauline, Mesulam, M Marcel, Olichney, John, DeCarli, Charles, Carmichael, Owen, Kittur, Smita, Borrie, Michael, Lee, T-Y, Bartha, Rob, Johnson, Sterling, Asthana, Sanjay, Carlsson, Cynthia M, Potter, William, Tariot, Pierre, Burke, Anna, Milliken, Ann Marie, Trncic, Nadira, Reeder, Stephanie, Bates, Vernice, Snyder, Peter, Capote, Horacio, Rainka, Michelle, Scharre, Douglas W, Kataki, Maria, Kelley, Brendan, Zimmerman, Earl A, Celmins, Dzintra, Brown, Alice D, Pearlson, Godfrey D, Blank, Karen, Weiner, Michael W, Schwartz, Adam, Anderson, Karen, Flashman, Laura A, Seltzer, Marc, Hynes, Mary L, Santulli, Robert B, Sink, Kaycee M, Gordineer, Leslie, Williamson, Jeff D, Garg, Pradeep, Watkins, Franklin, Ott, Brian R, Tremont, Geoffrey, Daiello, Lori A, Salloway, Stephen, Malloy, Paul, Correia, Stephen, Rosen, Howard J, Miller, Bruce L, Perry, David, Mintzer, Jacobo, Montine, Tom, Spicer, Kenneth, Bachman, David, Pasternak, Stephen, Rachinsky, Irina, Rogers, John, Drost, Dick, Pomara, Nunzio, Hernando, Raymundo, Sarrael, Antero, Schultz, Susan K, Smith, Karen Ekstam, Koleva, Hristina, Nam, Ki Won, Shim, Hyungsub, Relkin, Norman, Chiang, Gloria, Lin, Michael, Ravdin, Lisa, Aisen, Paul, Smith, Amanda, Raj, Balebail Ashok, Fargher, Kristin, Weiner, Michael, Harvey, Danielle, Thomas, Ronald G, Jack, Clifford R, Jagust, William, Neylan, Thomas, Grafman, Jordan, Donohue, Michael, Gessert, Devon, Sather, Tamie, Davis, Melissa, Morrison, Rosemary, Walter, Sarah, Jiminez, Gus, Hayes, Jacqueline, Finley, Shannon, Bernstein, Matthew, Borowski, Bret, Gunter, Jeff, Senjem, Matt, Kantarci, Kejal, Ward, Chad, Koeppe, Robert A, Foster, Norm, Reiman, Eric M, Chen, Kewei, Landau, Susan, Cairns, Nigel J, Householder, Erin, Lee, Virginia, Korecka, Magdalena, Figurski, Michal, Crawford, Karen, Neu, Scott, Foroud, Tatiana M, Potkin, Steven, Shen, Li, Faber, Kelley, Kim, Sungeun, Nho, Kwangsik, Friedl, Karl, Balasubramanian, Archana B, Fleischman, Debra, Arfanakis, Konstantinos, Mason, Jennifer, Varon, Daniel, Greig, Maria T, James, Olga, Goldstein, Bonnie, Martin, Kimberly S, Sim, Iris, Massoglia, Dino, Brawman-Mintzer, Olga, Martinez, Walter, Rosen, Howard, Behan, Kelly, Johnson, Sterling C, Fruehling, J Jay, Harding, Sandra, Peskind, Elaine R, Petrie, Eric C, Li, Gail, Yesavage, Jerome A, Furst, Ansgar J, Chao, Steven, Fox, Nick, Thompson, Paul, Schuff, Norbert, DeCArli, Charles, Vemuri, Prashanthi, Jones, David, Mathis, Chet, Taylor-Reinwald, Lisa, Thal, Lean, Thal, Leon, Buckholtz, Neil, Snyder, Peter J, Frank, Richard, Hsiao, John, and Kaye, Jeffrey

Subjects
Male, Pathology, Aging, physiopathology [Cognitive Dysfunction], diagnostic imaging [Cognitive Dysfunction], Hippocampus, 030218 nuclear medicine & medical imaging, metabolism [Cognitive Dysfunction], 0302 clinical medicine, Cognition, pathology [Gray Matter], Cortex (anatomy), Image Processing, Computer-Assisted, Gray Matter, diagnostic imaging [Hippocampus], General Medicine, Middle Aged, Magnetic Resonance Imaging, medicine.anatomical_structure, Female, metabolism [Alzheimer Disease], medicine.medical_specialty, Amyloid, Grey matter, Gyrus Cinguli, physiopathology [Alzheimer Disease], Article, 03 medical and health sciences, Atrophy, Neuroimaging, Alzheimer Disease, Fluorodeoxyglucose F18, mental disorders, metabolism [Gyrus Cinguli], medicine, Dementia, Humans, Cognitive Dysfunction, Radiology, Nuclear Medicine and imaging, ddc:610, chemistry [Fluorodeoxyglucose F18], physiopathology [Gyrus Cinguli], Aged, business.industry, diagnostic imaging [Gray Matter], medicine.disease, pathology [Hippocampus], Posterior cingulate, Positron-Emission Tomography, bacteria, business, diagnostic imaging [Alzheimer Disease], 030217 neurology & neurosurgery
Abstract

Posterior cingulate cortex (PCC) hypometabolism as measured by FDG PET is an indicator of Alzheimer’s disease (AD) in prodromal stages, such as in mild cognitive impairment (MCI), and has been found to be closely associated with hippocampus atrophy in AD dementia. We studied the effects of local and remote atrophy and of local amyloid load on the PCC metabolic signal in patients with different preclinical and clinical stages of AD. We determined the volume of the hippocampus and PCC grey matter based on volumetric MRI scans, PCC amyloid load based on AV45 PET, and PCC metabolism based on FDG PET in 667 subjects participating in the Alzheimer’s Disease Neuroimaging Initiative spanning the range from cognitively normal ageing through prodromal AD to AD dementia. In cognitively normal individuals and those with early MCI, PCC hypometabolism was exclusively associated with hippocampus atrophy, whereas in subjects with late MCI it was associated with both local and remote effects of atrophy as well as local amyloid load. In subjects with AD dementia, PCC hypometabolism was exclusively related to local atrophy. Our findings suggest that the effects of remote pathology on PCC hypometabolism decrease and the effects of local pathology increase from preclinical to clinical stages of AD, consistent with a progressive disconnection of the PCC from downstream cortical and subcortical brain regions.

Published
2016

4. Effect of Statin Therapy on Cognitive Decline and Incident Dementia in Older Adults.

Author

Zhou, Zhen, Ryan, Joanne, Ernst, Michael E., Zoungas, Sophia, Tonkin, Andrew M., Woods, Robyn L., McNeil, John J., Reid, Christopher M., Curtis, Andrea J., Wolfe, Rory, Wrigglesworth, Jo, Shah, Raj C., Storey, Elsdon, Murray, Anne, Orchard, Suzanne G., Nelson, Mark R., and ASPREE Investigator Group

Subjects
*OLDER people, *COGNITIVE therapy, *STATINS (Cardiovascular agents), *REMINISCENCE therapy, *COGNITIVE ability, *MILD cognitive impairment, *PHYSICAL & theoretical chemistry, *RESEARCH, *ANTILIPEMIC agents, *RESEARCH methodology, *COGNITION, *MEDICAL cooperation, *EVALUATION research, *COMPARATIVE studies, *DEMENTIA, *RESEARCH funding, *LONGITUDINAL method
Abstract

Background: The neurocognitive effect of statins in older adults remain uncertain.Objectives: The aim of this study was to investigate the associations of statin use with cognitive decline and incident dementia among older adults.Methods: This analysis included 18,846 participants ≥65 years of age in a randomized trial of aspirin, who had no prior cardiovascular events, major physical disability, or dementia initially and were followed for 4.7 years. Outcome measures included incident dementia and its subclassifications (probable Alzheimer's disease, mixed presentations); mild cognitive impairment (MCI) and its subclassifications (MCI consistent with Alzheimer's disease, other MCI); and changes in domain-specific cognition, including global cognition, memory, language and executive function, psychomotor speed, and the composite of these domains. Associations of baseline statin use versus nonuse with dementia and MCI outcomes were examined using Cox proportional hazards models and with cognitive change using linear mixed-effects models, adjusting for potential confounders. The impact of statin lipophilicity on these associations was further examined, and effect modifiers were identified.Results: Statin use versus nonuse was not associated with dementia, MCI, or their subclassifications or with changes in cognitive function scores over time (p > 0.05 for all). No differences were found in any outcomes between hydrophilic and lipophilic statin users. Baseline neurocognitive ability was an effect modifier for the associations of statins with dementia (p for interaction < 0.001) and memory change (p for interaction = 0.02).Conclusions: In adults ≥65 years of age, statin therapy was not associated with incident dementia, MCI, or declines in individual cognition domains. These findings await confirmation from ongoing randomized trials. [ABSTRACT FROM AUTHOR]

Published
2021
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