1. TNFα and IL-8 vitreous concentrations variations with two antidiabetic therapies in patients with proliferative diabetic retinopathy: an observational study
- Author
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Oscar Morales-Lopez, Octavio Rodríguez-Cortés, Pedro López-Sánchez, Héctor Javier Pérez-Cano, Omar García-Liévanos, Virgilio Lima-Gómez, and Selma Alin Somilleda-Ventura
- Subjects
Antidiabetic therapy ,Diabetic retinopathy ,Inflammatory response ,Insulin ,Interleukins ,Metformin ,Ophthalmology ,RE1-994 - Abstract
Abstract Background Antidiabetic therapies are effective, but could indirectly modify the inflammatory response in the ocular microenvironment; therefore, a study was developed to evaluate the inflammatory cytokine profile in the vitreous humor of diabetic patients with retinopathy under treatment with antidiabetic drugs. Methods Observational, comparative, retrospective, cross-sectional study. Interleukins 1β, 6, 8, 10, and tumor necrosis factor-alpha (TNFα) were evaluated in the vitreous humor obtained from patients with type 2 diabetes mellitus, proliferative diabetic retinopathy, and concomitant retinal detachment or vitreous hemorrhage, and who were already on antidiabetic treatment with insulin or metformin + glibenclamide. The quantification analysis of each cytokine was performed by the cytometric bead array (CBA) technique; medians and interquartile ranges were obtained, and the results were compared between groups using the Mann-Whitney U test, where a p-value
- Published
- 2024
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