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We report K α x-ray production with a high energy (110 mJ per pulse at 800 nm before compression/15 mJ at 400 nm after compression), high repetition rate (100 Hz), and high pulse contrast (better than 10−9 at 400 nm) laser system. To develop laser-based x-ray sources for biomedical imaging requires to use high-energy and high-power ultrafast laser system where compression is achieved under vacuum. Using this type of laser system, we demonstrate long-term stability of the x-ray yield, conversion efficiency higher than 1.5×10−5 with a Mo target, and the x-ray spot size close to the optical focal spot. This high-repetition K α x-ray source can be very useful for x-ray phase-contrast imaging. [ABSTRACT FROM AUTHOR]

We demonstrate the feasibility of phase-contrast imaging with an ultrafast laser-based hard x-ray source. Hard x rays are generated during the interaction of a high-intensity femtosecond laser pulse (10 TW, 60 fs, 10 Hz) focused onto solid target in a very small spot (3 μm diam). Such a novel x-ray source has a number of advantages over other sources previously used for phase-contrast imaging: It is very compact and much cheaper than a synchrotron, it has higher power and better x-ray spectrum control than a microfocal x-ray tube, and it has much higher repetition rate than an x-pinch source. The Kα line at 17 keV produced using a solid Mo target, and the in-line imaging geometry have been utilized in this study. Phase-contrast images of test objects and biological samples have been realized. The characteristics of the images are the significant enhancement of interfaces due to an x-ray phase shift that reveal details that were hardly observable, or even undetectable, in absorption images and suppression of optically dense structures well defined in the absorption images. Our study indicates that the absorption and the phase-contrast images obtained with an ultrafast laser-based x-ray source provide complementary information about the imaged objects, thus enriching our arsenal of research tools for laboratory or clinic-based biomedical imaging. [ABSTRACT FROM AUTHOR]