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To explore the endoscopic features and risk factors of early gastric cancer (EGC) after eradication of Helicobacter pylori (H. pylori). A total of 1961 patients who underwent esophago-gastro-duodenoscopy (EGD) with a history of successful H. pylori eradication were enrolled in this multicenter research. Among them, 162 EGC lesions of 132 patients were detected. The endoscopic features and risk factors of post-eradication EGC were explored. Severe atrophy (75.3% vs. 16.7%, p value <.01), intestinal metaplasia (96.3% vs. 77.1%, p value <.01), map-like redness (89.5% vs. 65.4%, p value <.01), distinct intermediate zone (IZ) (68.5% vs. 23.4%, p value <.01) and xanthoma (58.0% vs. 17.9%, p value <.01) were significantly more frequent in the CA group (patients with newly detected EGC after eradication of H. pylori) than in the NC group (patients without gastric cancer after eradication of H. pylori). In multivariate analysis, severe atrophy (odds ratio (OR) = 8.08; 95% confidence interval (CI), 3.43–20.0; p value<.01), map-like redness (OR = 1.75; 95% CI, 0.11–5.25; p value =.04), distinct IZ (OR = 2.87; 95% CI, 1.20–6.93; p value =.02) and xanthoma (OR = 2.84; 95% CI, 1.20–7.03; p value=.02) were proved to be risk factors for detection of EGC after eradication of H. pylori. Severe atrophy and map-like redness and distinct IZ and xanthoma are risk factors of EGC after eradication of H. pylori. [ABSTRACT FROM AUTHOR]

Aim: To introduce the method of stripping of early gastric signet ring cell carcinioma by two ESD procedures.Methods: A lesion of early gastric signet ring cell carcinoma in an elderly was removed by two consecutive ESD procedures. The pathology was analyzed and the patient was followed-up.Results: The lesion removed by first ESD procedure, which was 10 cm in diameter, has tumor tissue on its edge, and the second lesion which was 5 cm in diameter had an edge without tumor. There was no metastasis or recurrence during 24-month follow-up.Conclusion: We first described the method using two consecutive ESD procedures in man with gastric signet ring cell carcinoma, and the procedure was proved to be safe and efficient. [ABSTRACT FROM AUTHOR]