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Background: Apalutamide is a new drug class, which is approved to treat prostate cancer (PCa). The aim of our study was to assess the safety profiles of apalutamide in real-world through data mining of the United States Food and Drug Administration Adverse Event Reporting System (FAERS). Method: We included adverse event (AE) reports regarding apalutamide submitted to the FAERS from 2018 quarter 1 (2018Q1) to 2022 quarter 1 (2022Q1). Disproportionality analyses, including reporting odds ratio (ROR), were performed to identify the signals of AEs in patients receiving apalutamide. A signal was detected if the lower limit of the 95% confidence interval (CI) of ROR >1 and at least 3 AEs were reported. Results: The FAERS database documented 4,156 reports regarding apalutamide from 1 January 2018, to 31 March 2022. A total of 100 significant disproportionality preferred terms (PTs) were retained. Frequently observed AEs in patients receiving apalutamide included rash, fatigue, diarrhea, hot flush, fall, weight decreased, hypertension. The most significant system organ class (SOC) was "skin and subcutaneous tissue disorders", which mainly consisted of dermatological adverse events (dAEs). The additional AEs observed with the significantly signal contain lichenoid keratosis, increased eosinophil count, bacterial pneumonia, pulmonary tuberculosis, hydronephrosis. Conclusion: Our findings provide valuable evidence for apalutamide safety profile in the real-world, which could help clinicians and pharmacists to enhance their vigilance and improve the safety of apalutamide in clinical practice. [ABSTRACT FROM AUTHOR]

Aim: To identify the learning needs of patients with heart failure (HF) in China and to examine the relationships between learning needs and patients' characteristics. Background: Little information on the learning needs of patients with HF in China is known. Besides, it is important to identify the potential characteristics that may influence patients' perceived learning needs. Methods: This cross-sectional questionnaire survey was conducted in three university affiliated hospitals in Xi'an, Mainland China. A total of 347 HF patients selected by convenience sampling were investigated using the Chinese version of the HF learning needs inventory. Descriptive statistics, independent t-test, Pearson correlation, and one-way analysis of variance were used for data analysis. Results: The mean scores rated by Chinese patients with HF were lower than the corresponding scores rated by patients of Western countries. Information on risk factors, prognosis, general HF information and medications were identified as the most important topics while lifestyle modification and psychological factors were regarded as the least important ones. Age negatively correlated with the learning needs on activity (r = -0.125) and prognosis information (r = -0.141). Educational level was significantly related to the learning needs about risk factors. Conclusion: Patients with HF in China considered most of the topics important for them to learn. Age and educational level were related with the learning needs on only three topics including activity, prognosis information and risk factors. Relevance to clinical practice: The study findings may be used by health professionals to develop tailored educational programme for patients with HF in China. [ABSTRACT FROM AUTHOR]