Search

Your search keyword '"Zhang, Guilong"' showing total 192 results
Start Over Author "Zhang, Guilong" Search Limiters Full Text Language english
192 results on '"Zhang, Guilong"'

24. Can microplastics mediate soil properties, plant growth and carbon/nitrogen turnover in the terrestrial ecosystem?

Author

Yao Yao, Wang Lili, Pan Shufen, Li Gang, Liu Hongmei, Xiu Weiming, Gong Lingxuan, Zhao Jianning, Zhang Guilong, and Yang Dianlin

Subjects
MPs, terrestrial ecosystems, carbon and nitrogen turnover, greenhouse gases, microorganisms, Ecology, QH540-549.5
Abstract

Microplastic (MP) pollution, a global environmental problem, has been recently studied in marine and freshwater environments. However, our understanding of MP effect on terrestrial ecosystems, especially carbon (C) and nitrogen (N) turnover remains poor. This review summarizes the sources and distribution characteristics of MPs in terrestrial ecosystems and explores their effects on soil properties, plant growth, C and N turnover. Once entering the terrestrial ecosystem, MPs could involve in sequestrating carbon and nitrogen by changing soil properties (e.g., pH, soil aggregate stability, and soil porosity). MPs could exert direct influences on plants or on soil physical environment and microbial metabolic environment to indirectly affect plant growth, thus altering the quantity and quality of soil C and N inputs by shifts in plant litter and roots. The changes of the dominant bacteria phyla, related functional genes, and enzymes caused by MP pollution could affect C and N cycles. Additionally, the MP effect varies with its properties (e.g., types, shapes, elemental composition, functional groups, released additives). Future researches should unify the standard system of MP separation, detection, and reveal the ecological effects of MPs, especially their impacts on terrestrial carbon and nitrogen cycles in the context of climate changes.

Published
2022
Full Text
View/download PDF

34. Glucagon Enhances Chemotherapy Efficacy By Inhibition of Tumor Vessels in Colorectal Cancer.

Author

Xu, Yuxue, Ni, Feixue, Sun, Daxi, Peng, Yue, Zhao, Yaxuan, Wu, Xiaojun, Li, Shasha, Qi, Xiangyu, He, Xinkang, Li, Min, Zhou, Yizi, Zhang, Chao, Yan, Miao, Yao, Cuifang, Zhu, Shuaishuai, Yang, Yang, An, Baijiao, Yang, Chunhua, Zhang, Guilong, and Jiang, Wenguo

Subjects
NEOVASCULARIZATION, GLUCAGON, COLORECTAL cancer, COLON tumors, VASCULOGENIC mimicry, LIPOSOMES, CANCER chemotherapy
Abstract

Chemotherapy is widely used to treat colorectal cancer (CRC). Despite its substantial benefits, the development of drug resistance and adverse effects remain challenging. This study aimed to elucidate a novel role of glucagon in anti‐cancer therapy. In a series of in vitro experiments, glucagon inhibited cell migration and tube formation in both endothelial and tumor cells. In vivo studies demonstrated decreased tumor blood vessels and fewer pseudo‐vessels in mice treated with glucagon. The combination of glucagon and chemotherapy exhibited enhanced tumor inhibition. Mechanistic studies demonstrated that glucagon increased the permeability of blood vessels, leading to a pronounced disruption of vessel morphology. Signaling pathway analysis identified a VEGF/VEGFR‐dependent mechanism whereby glucagon attenuated angiogenesis through its receptor. Clinical data analysis revealed a positive correlation between elevated glucagon expression and chemotherapy response. This is the first study to reveal a role for glucagon in inhibiting angiogenesis and vascular mimicry. Additionally, the delivery of glucagon‐encapsulated PEGylated liposomes to tumor‐bearing mice amplified the inhibition of angiogenesis and vascular mimicry, consequently reinforcing chemotherapy efficacy. Collectively, the findings demonstrate the role of glucagon in inhibiting tumor vessel network and suggest the potential utility of glucagon as a promising predictive marker for patients with CRC receiving chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

46. The effects of different biochars on Caenorhabditis elegans and the underlying transcriptomic mechanisms.

Author

Chen, Yixuan, Wang, Xinrui, Li, Jie, Wang, Zhiwen, Song, Tingting, Lai, Xin, Zhang, Guilong, and Ruan, Weibin

Subjects
SOIL nematodes, ANIMAL clutches, CAENORHABDITIS, AGRICULTURE, CAENORHABDITIS elegans, TRANSCRIPTOMES, VOLATILE organic compounds
Abstract

Different biochars have diverse properties, with ambiguous effects on soil nematodes. This study investigated how aspen sawdust (ABC), bamboo powder (BBC), maize straw (MBC) and peanut-shell biochars (PBC) affected Caenorhabditis elegans via culture assays and RNA-seq analysis. The results showed that biochars derived from different agricultural materials varied significantly in physicochemical properties, and PBC produced more volatile organic compounds (VOCs) to attract C. elegans than ABC, BBC and MBC. Moreover, worms in ABC experienced the worst outcomes, while worms in PBC experienced milder impacts. Nematode body length decreased to 724.6 μm, 784.0 μm and 799.7 μm on average in ABC, BBC and MBC, respectively, compared to the control (1052 μm) and PBC treatments (960 μm). The brood size in ABC, MBC, BBC and PBC decreased 41.1%, 39.4%, 39.2% and 19.1% compared to the control, respectively. Furthermore, the molecular mechanisms of biochar-induced developmental effects on C. elegans were explored. Although several differentially expressed genes (DEGs) were different among the four biochars, worm phenotypic changes were mainly related to col genes (col-129; col-140; col-40; col-184), bli-6, sqt-3, perm-2/4, cdk-8, daf-16 and sod-1/2/5, which are associated with cuticle collagen synthesis, eggshell formation in postembryonic growth and rhythmic processes. Our study suggests that different properties of biochars could be crucial to soil nematodes, as well as the worms' biochemical changes are important for the health in agriculture soil. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

50. PDGFB-targeted functional MRI nanoswitch for activatable T1–T2 dual-modal ultra-sensitive diagnosis of cancer.

Author

Zhang, Ya'nan, Liu, Lu, Li, Wenling, Zhang, Caiyun, Song, Tianwei, Wang, Peng, Sun, Daxi, Huang, Xiaodan, Qin, Xia, Ran, Lang, Tian, Geng, Qian, Junchao, and Zhang, Guilong

Subjects
FUNCTIONAL magnetic resonance imaging, CANCER diagnosis, MAGNETIC resonance imaging, TUMOR diagnosis, EARLY diagnosis, ENDORECTAL ultrasonography
Abstract

As one of the most significant imaging modalities currently available, magnetic resonance imaging (MRI) has been extensively utilized for clinically accurate cancer diagnosis. However, low signal-to-noise ratio (SNR) and low specificity for tumors continue to pose significant challenges. Inspired by the distance-dependent magnetic resonance tuning (MRET) phenomenon, the tumor microenvironment (TME)-activated off–on T1–T2 dual-mode MRI nanoswitch is presented in the current study to realize the sensitive early diagnosis of tumors. The tumor-specific nanoswitch is designed and manufactured on the basis of PDGFB-conjugating ferroferric oxide coated by Mn-doped silica (PDGFB-FMS), which can be degraded under the high-concentration GSH and low pH in TME to activate the T1–T2 dual-mode MRI signals. The tumor-specific off–on dual-mode MRI nanoswitch can significantly improve the SNR and is used successfully for the accurate diagnosis of early-stage tumors, particularly for orthotopic prostate cancer. In addition, the systemic delivery of the nanoswitch did not cause blood or tissue damage, and it can be excreted out of the body in a timely manner, demonstrating excellent biosafety. Overall, the strategy is a significant step in the direction of designing off–on dual-mode MRI nanoprobes to improve imaging accuracy, which opens up new avenues for the development of new MRI probes. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results