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To investigate the timing of deposition and provenance of early Mesozoic strata in the northeastern North China Craton (NCC) and to understand the early Mesozoic paleotectonic evolution of the region, we combine stratigraphy, U–Pb zircon geochronology, and Hf isotopic analyses. Early Mesozoic strata include the Early Triassic Heisonggou, Late Triassic Changbai and Xiaoyingzi, and Early Jurassic Yihe formations. Detrital zircons in the Heisonggou Formation yield ∼58 % Neoarchean to Paleoproterozoic ages and ∼42 % Phanerozoic ages and were sourced from areas to the south and north of the basins within the NCC, respectively. This indicates that Early Triassic deposition was controlled primarily by the southward subduction of the Paleo-Asian oceanic plate beneath the NCC and collision between the NCC and the Yangtze Craton (YC). Approximately 88 % of the sediments within the Late Triassic Xiaoyingzi Formation were sourced from the NCC to the south, with the remaining ∼12 % from the Xing'an–Mongolia Orogenic Belt (XMOB) to the north. This implies that Late Triassic deposition was related to the final closure of the Paleo-Asian Ocean during the Middle Triassic and the rapid exhumation of the Su–Lu Orogenic Belt between the NCC and YC. In contrast, ∼88 % of sediments within the Early Jurassic Yihe Formation were sourced from the XMOB to the north, with the remaining ∼12 % from the NCC to the south. We therefore infer that rapid uplift of the XMOB and the onset of the subduction of the Paleo-Pacific Plate beneath Eurasia occurred in the Early Jurassic. [ABSTRACT FROM AUTHOR]

Metal-organic frameworks (MOFs) are crystalline porous hybrid materials with periodic network structure and abundant active sites, which are promising adsorbents for organic pollutants. Herein, a novel Co(II)-based organic framework (Co-MOF) [Co 2 (L 1) 2 (L 2)] (L 1 = 3-(3-carboxylphenyl) isonicotinic acid, L 2 = 4, 4′-Azopyridin) was developed for selective dyes adsorption. Experiments suggest that the Co-MOF exhibits high stability, good photoelectricity and high selectivity for dyes adsorption. For dyes adsorption, the Co-MOF shows a strong adsorption to methyl orange achieving a high capacity up to 440.5 mg g−1, but shows a weak adsorption to methylene blue or rhodamine, indicating its better selectivity for anionic dyes. An insight into the selective removal of the methyl orange is being accounted for by acid-base attraction, anion-π and π–π stacking interactions, involving the Co ion, phenyl rings, and ocarboxylate of L, and the phenyl rings, and osulfonate of MO. The current work contributes to the development of future multifunctional MOF materials with the application in environment protection. [ABSTRACT FROM AUTHOR]

A layer of Mesoproterozoic tsunami deposits from the North China Craton was recently discovered and investigated in the Xingcheng area, Liaoning Province, China. They occur at the bottom of the Dahongyu Formation of the Changcheng Group (1.8-1.6 Ga). The tsunami deposits are identified based on the analysis of the sedimentary facies. They are markedly different from the normal deposits of shore-shallow sea siliciclastics, and are characterized by rip-up clasts, poorly sorted gravels, fining-upward sequences, redeposited underlying materials, complex sources of underlying strata and erosional bases at the bottom of beds. They are compelling features of tsunamiites when they occur together. During the Mesoproterozoic, the Xingcheng area was in an active tectonic belt, the Yanshan Taphrogenic Trough. The origin of the tsunami was probably triggered by the earthquake, which resulted from the the activities of the Luanxian-Jianchang Fault in early Mesoproterozoic times. The deposition of tsunamiites occurred in a coastal environment and involved several stages, from the origin, propagation, inundation, and deposition to the backwash flow. The geodynamic backgrounds of the tsunami event in the North China Craton are consistent with the breakup event of the Columbia supercontinent in the Mesoproterozoic. Some events, such as tsunamis and volcanism, are all controlled by extensional rift systems and should be recognized as effects of the breakup of the Columbia supercontinent in the North China Craton. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Background: There were few studies on real-world data about autologous hematopoietic stem cell transplantation (auto-HSCT) or allogeneic HSCT (allo-HSCT) in peripheral T-cell lymphoma (PTCL). This study aimed to investigate the clinical outcomes of patients who received auto-HSCT or allo-HSCT in China., Methods: From July 2007 to June 2017, a total of 128 patients who received auto-HSCT (n  = 72) or allo-HSCT (n  = 56) at eight medical centers across China were included in this study. We retrospectively collected their demographic and clinical data and compared the clinical outcomes between groups., Results: Patients receiving allo-HSCT were more likely to be diagnosed with stage III or IV disease (95% vs. 82%, P = 0.027), bone marrow involvement (42% vs. 15%, P = 0.001), chemotherapy-resistant disease (41% vs. 8%, P = 0.001), and progression disease (32% vs. 4%, P < 0.001) at transplantation than those receiving auto-HSCT. With a median follow-up of 30 (2-143) months, 3-year overall survival (OS) and progression-free survival (PFS) in the auto-HSCT group were 70%(48/63) and 59%(42/63), respectively. Three-year OS and PFS for allo-HSCT recipients were 46%(27/54) and 44%(29/54), respectively. There was no difference in relapse rate (34%[17/63] in auto-HSCT vs. 29%[15/54] in allo-HSCT, P = 0.840). Three-year non-relapse mortality rate in auto-HSCT recipients was 6%(4/63) compared with 27%(14/54) for allo-HSCT recipients (P = 0.004). Subanalyses showed that patients with lower prognostic index scores for PTCL (PIT) who received auto-HSCT in an upfront setting had a better outcome than patients with higher PIT scores (3-year OS: 85% vs. 40%, P = 0.003). Patients with complete remission (CR) undergoing auto-HSCT had better survival (3-year OS: 88% vs. 48% in allo-HSCT, P = 0.008). For patients beyond CR, the outcome of patients who received allo-HSCT was similar to that in the atuo-HSCT group (3-year OS: 51% vs. 46%, P = 0.300)., Conclusions: Our study provided real-world data about auto-HSCT and allo-HSCT in China. Auto-HSCT seemed to be associated with better survival for patients in good condition (lower PIT score and/or better disease control). For patients possessing unfavorable characteristics, the survival of patients receiving allo-HSCT group was similar to that in the auto-HSCT group., (Copyright © 2021 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.)

Background: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome. Central nervous system (CNS) involvement is a severe complication, which can lead to rapid disease development and higher morality. However, this has not been given enough attention in adult HLH. Therefore, we carried out this study to analyze the clinical features, laboratory findings, treatment outcomes, and other characteristics of adult HLH with CNS involvement., Methods: A retrospective analysis of 96 adult patients with HLH combined with CNS involvement between June 2003 and December 2016 was conducted. Clinical features, cerebrospinal fluid (CSF) features, image changes, and therapeutic outcomes were analyzed., Results: Among the 96 patients, 86 had various CNS symptoms and 33 (38.4%) had already presented symptoms before the HLH diagnosis was confirmed. A total of 59 patients received CSF examinations and showed abnormalities in 23 patients (39.0%). Seventy patients received imaging examinations and the results showed fifty patients with imaging changes (71.4%). Fifty-seven patients received multiple rounds of repeated intrathecal injection therapy and 35 patients improved (61.4%). As for the multiple analyses of effective factors on survival time, the results showed that the effects of combined Epstein-Barr virus (EBV) infection (P = 0.026, Exp(B) = 2.309, 95% confidence interval [CI] [1.108, 4.823) and intrathecal injection therapy (P = 0.013, Exp(B) = 0.422, 95% CI [0.214, 0.831]) on the survival time of the CNS-HLH patients were significant., Conclusions: Complication with EBV infection is a risk factor, and intrathecal injection is a protective factor. CNS involvement in HLH is not rare, which can result in a poor prognosis. Multiple rounds of repeated intrathecal injection therapy can improve the prognosis of CNS-HLH patients., Competing Interests: There are no conflicts of interest