21 results on '"Murty, Upadhyayula Suryanarayana"'
Search Results
2. Selection of appropriate dapsone and poly(1-vinylpyrrolidone-co-vinyl acetate) ratios for the preparation of amorphous solid dispersions
- Author
-
Choudhury, Dinesh, Murty, Upadhyayula Suryanarayana, and Banerjee, Subham
- Published
- 2023
- Full Text
- View/download PDF
3. In-line treatments and clinical initiatives to fight against COVID-19 outbreak
- Author
-
Agrawal, Mukta, Saraf, Shailendra, Saraf, Swarnlata, Murty, Upadhyayula Suryanarayana, Kurundkar, Sucheta Banerjee, Roy, Debjani, Joshi, Pankaj, Sable, Dhananjay, Choudhary, Yogendra Kumar, Kesharwani, Prashant, and Alexander, Amit
- Published
- 2022
- Full Text
- View/download PDF
4. Biochanin A Ameliorates Nephropathy in High-Fat Diet/Streptozotocin-Induced Diabetic Rats: Effects on NF-kB/NLRP3 Axis, Pyroptosis, and Fibrosis.
- Author
-
Ram, Chetan, Gairola, Shobhit, Verma, Shobhit, Mugale, Madhav Nilakanth, Bonam, Srinivasa Reddy, Murty, Upadhyayula Suryanarayana, and Sahu, Bidya Dhar
- Subjects
NF-kappa B ,PYROPTOSIS ,KIDNEY diseases ,TRANSFORMING growth factors ,SPRAGUE Dawley rats ,HYPERGLYCEMIA ,FIBRONECTINS - Abstract
Nephropathy is the most prevalent microvascular disorder in diabetes mellitus. Oxidative stress and inflammatory cascade provoked by the persistent hyperglycemic milieu play integral roles in the aggravation of renal injury and fibrosis. We explored the impact of biochanin A (BCA), an isoflavonoid, on the inflammatory response, nod-like receptor protein 3 (NLRP3) inflammasome activation, oxidative stress, and fibrosis in diabetic kidneys. A high-fat-diet/streptozotocin (HFD/STZ)-induced experimental model of diabetic nephropathy (DN) was established in Sprague Dawley rats, and in vitro studies were performed in high-glucose-induced renal tubular epithelial (NRK-52E) cells. Persistent hyperglycemia in diabetic rats was manifested by perturbation of renal function, marked histological alterations, and oxidative and inflammatory renal damage. Therapeutic intervention of BCA mitigated histological changes, improved renal function and antioxidant capacity, and suppressed phosphorylation of nuclear factor-kappa B (NF-κB) and nuclear factor-kappa B inhibitor alpha (IκBα) proteins. Our in vitro data reveal excessive superoxide generation, apoptosis, and altered mitochondrial membrane potential in NRK-52E cells that were cultured in a high-glucose (HG) environment were subsided by BCA intervention. Meanwhile, the upregulated expressions of NLRP3 and its associated proteins, the pyroptosis-indicative protein gasdermin-D (GSDMD) in the kidneys, and HG-stimulated NRK-52E cells were significantly ameliorated by BCA treatment. Additionally, BCA blunted transforming growth factor (TGF)-β/Smad signaling and production of collagen I, collagen III, fibronectin, and alfa-smooth muscle actin (α-SMA) in diabetic kidneys. Our results indicate the plausible role of BCA in attenuating DN, presumably through modulation of the apoptotic cascade in renal tubular epithelial cells and the NF-κB/NLRP3 axis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Analysis of NSAIDs in Rat Plasma Using 3D-Printed Sorbents by LC-MS/MS: An Approach to Pre-Clinical Pharmacokinetic Studies.
- Author
-
Adye, Daya Raju, Jorvekar, Sachin B., Murty, Upadhyayula Suryanarayana, Banerjee, Subham, and Borkar, Roshan M.
- Subjects
LIQUID chromatography-mass spectrometry ,SORBENTS ,ORAL drug administration ,NONSTEROIDAL anti-inflammatory agents ,PHARMACOKINETICS ,RATS ,PLASTIC extrusion - Abstract
Analytical sample preparation techniques are essential for assessing chemicals in various biological matrices. The development of extraction techniques is a modern trend in the bioanalytical sciences. We fabricated customized filaments using hot-melt extrusion techniques followed by fused filament fabrication-mediated 3D printing technology to rapidly prototype sorbents that extract non-steroidal anti-inflammatory drugs from rat plasma for determining pharmacokinetic profiles. The filament was prototyped as a 3D-printed sorbent for extracting small molecules using Affinisol
TM , polyvinyl alcohol, and triethyl citrate. The optimized extraction procedure and parameters influencing the sorbent extraction were systematically investigated by the validated LC-MS/MS method. Furthermore, a bioanalytical method was successfully implemented after oral administration to determine the pharmacokinetic profiles of indomethacin and acetaminophen in rat plasma. The Cmax was found to be 0.33 ± 0.04 µg/mL and 27.27 ± 9.9 µg/mL for indomethacin and acetaminophen, respectively, at the maximum time (Tmax ) (h) of 0.5–1 h. The mean area under the curve (AUC0–t ) for indomethacin was 0.93 ± 0.17 µg h/mL, and for acetaminophen was 32.33± 10.8 µg h/mL. Owing to their newly customizable size and shape, 3D-printed sorbents have opened new opportunities for extracting small molecules from biological matrices in preclinical studies. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
6. 3D Printed Housing Devices for Segregated Compartmental Delivery of Oral Fixed-Dose Anti-Tubercular Drugs Adopting Print and Fill Strategy.
- Author
-
Malakar, Tushar Kanti, Chaudhari, Vishal Sharad, Dwivedy, Santosha Kumar, Murty, Upadhyayula Suryanarayana, and Banerjee, Subham
- Published
- 2022
- Full Text
- View/download PDF
7. Mechanisms of Electron Transfer Rate Modulations in Cytochrome P450 BM3.
- Author
-
Dixit, Vaibhav A., Murty, Upadhyayula Suryanarayana, Bajaj, Priyanka, Blumberger, Jochen, and de Visser, Sam P.
- Published
- 2022
- Full Text
- View/download PDF
8. Classification and clustering analysis of pyruvate dehydrogenase enzyme based on their physicochemical properties
- Author
-
Banerjee, Amit Kumar, M, Sunita, M, Naveen, and Murty, Upadhyayula Suryanarayana
- Subjects
chemistry.chemical_classification ,Self-organizing map ,Radial basis function network ,KNIME ,Self Organizing Maps (SOM) ,General Medicine ,Biology ,Hypothesis ,computer.software_genre ,Pyruvate dehydrogenase complex ,Clustering ,Enzyme ,chemistry ,α helices ,Multilayer perceptron ,Sequential minimal optimization ,Data Mining ,Data mining ,Pyruvate Dehydrogenase ,Cluster analysis ,Biological system ,computer - Abstract
Biological systems are highly organized and enormously coordinated maintaining greater complexity. The increment of secondary data generation and progress of modern mining techniques provided us an opportunity to discover hidden intra and inter relations among these non linear dataset. This will help in understanding the complex biological phenomenon with greater efficiency. In this paper we report comparative classification of Pyruvate Dehydrogenase protein sequences from bacterial sources based on 28 different physicochemical parameters (such as bulkiness, hydrophobicity, total positively and negatively charged residues, α helices, β strand etc.) and 20 type amino acid compositions. Logistic, MLP (Multi Layer Perceptron), SMO (Sequential Minimal Optimization), RBFN (Radial Basis Function Network) and SL (simple logistic) methods were compared in this study. MLP was found to be the best method with maximum average accuracy of 88.20%. Same dataset was subjected for clustering using 2*2 grid of a two dimensional SOM (Self Organizing Maps). Clustering analysis revealed the proximity of the unannotated sequences with the Mycobacterium and Synechococcus genus.
- Published
- 2010
9. Insulin receptor knockdown blocks filarial parasite development and alters egg production in the southern house mosquito, Culex quinquefasciatus.
- Author
-
Nuss, Andrew Bradley, Brown, Mark R., Murty, Upadhyayula Suryanarayana, and Gulia-Nuss, Monika
- Subjects
INSULIN receptors ,CULEX quinquefasciatus ,FILARIASIS ,ALBENDAZOLE ,PLASMODIUM - Abstract
Lymphatic filariasis, commonly known as elephantiasis, is a painful and profoundly disfiguring disease. Wuchreria bancrofti (Wb) is responsible for >90% of infections and the remainder are caused by Brugia spp. Mosquitoes of the genera Culex (in urban and semi-urban areas), Anopheles (in rural areas of Africa and elsewhere), and Aedes (in Pacific islands) are the major vectors of W. bancrofti. A preventive chemotherapy called mass drug administration (MDA), including albendazole with ivermectin or diethylcarbamazine citrate (DEC) is used in endemic areas. Vector control strategies such as residual insecticide spraying and long-lasting insecticidal nets are supplemental to the core strategy of MDA to enhance elimination efforts. However, increasing insecticide resistance in mosquitoes and drug resistance in parasite limit the effectiveness of existing interventions, and new measures are needed for mosquito population control and disruption of mosquito-parasite interactions to reduce transmission. Mosquito insulin signaling regulates nutrient metabolism and has been implicated in reduced prevalence and intensity of malaria parasite, Plasmodium falciparum, infection in mosquitoes. Currently no data are available to assess how insulin signaling in mosquitoes affects the development of multi-cellular parasites, such as filarial nematodes. Here, we show that insulin receptor knockdown in blood fed C. quinquefasciatus, the major vector of Wb in India, completely blocks the development of filarial nematode parasite to the infective L3 stage, and results in decreased ecdysteroid production and trypsin activity leading to fewer mosquito eggs. These data indicate that a functional mosquito insulin receptor (IR) is necessary for filarial parasite development and mosquito reproduction. Therefore, insulin signaling may represent a new target for the development of vector control or parasite blocking strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
10. Towards seasonal forecasting of malaria in India.
- Author
-
Lauderdale, Jonathan M., Caminade, Cyril, Heath, Andrew E., Jones, Anne E., MacLeod, David A., Gouda, Krushna C., Murty, Upadhyayula Suryanarayana, Goswami, Prashant, Mutheneni, Srinivasa R., and Morse, Andrew P.
- Abstract
Background: Malaria presents public health challenge despite extensive intervention campaigns. A 30-year hindcast of the climatic suitability for malaria transmission in India is presented, using meteorological variables from a state of the art seasonal forecast model to drive a process-based, dynamic disease model. Methods: The spatial distribution and seasonal cycles of temperature and precipitation from the forecast model are compared to three observationally-based meteorological datasets. These time series are then used to drive the disease model, producing a simulated forecast of malaria and three synthetic malaria time series that are qualitatively compared to contemporary and pre-intervention malaria estimates. The area under the Relative Operator Characteristic (ROC) curve is calculated as a quantitative metric of forecast skill, comparing the forecast to the meteorologically-driven synthetic malaria time series. Results and discussion: The forecast shows probabilistic skill in predicting the spatial distribution of Plasmodium falciparum incidence when compared to the simulated meteorologically-driven malaria time series, particularly where modelled incidence shows high seasonal and interannual variability such as in Orissa, West Bengal, and Jharkhand (North-east India), and Gujarat, Rajastan, Madhya Pradesh and Maharashtra (North-west India). Focusing on these two regions, the malaria forecast is able to distinguish between years of “high”, “above average” and “low” malaria incidence in the peak malaria transmission seasons, with more than 70% sensitivity and a statistically significant area under the ROC curve. These results are encouraging given that the three month forecast lead time used is well in excess of the target for early warning systems adopted by the World Health Organization. This approach could form the basis of an operational system to identify the probability of regional malaria epidemics, allowing advanced and targeted allocation of resources for combatting malaria in India. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
11. Histone Lysine Demethylase JMJD2D/KDM4D and Family Members Mediate Effects of Chronic Social Defeat Stress on Mouse Hippocampal Neurogenesis and Mood Disorders.
- Author
-
Maitra, Swati, Khandelwal, Nitin, Kootar, Scherazad, Sant, Pooja, Pathak, Salil S., Reddy, Sujatha, K., Annapoorna P., Murty, Upadhyayula Suryanarayana, Chakravarty, Sumana, and Kumar, Arvind
- Subjects
HISTONE demethylases ,AFFECTIVE disorders ,HIPPOCAMPUS (Brain) ,DEVELOPMENTAL neurobiology ,DENTATE gyrus ,IMMOBILIZATION stress ,SYNAPTOPHYSIN - Abstract
Depression, anxiety and related mood disorders are major psychiatric illnesses worldwide, and chronic stress appears to be one of the primary underlying causes. Therapeutics to treat these debilitating disorders without a relapse are limited due to the incomplete molecular understanding of their etiopathology. In addition to the well-studied genetic component, research in the past two decades has implicated diverse epigenetic mechanisms in mediating the negative effects of chronic stressful events on neural circuits. This includes the cognitive circuitry, where the dynamic hippocampal dentate gyrus (DG) neurogenesis gets affected in depression and related affective disorders. Most of these epigenetic studies have focused on the impact of acetylation/deacetylation and methylation of several histone lysine residues on neural gene expression. However, there is a dearth of investigation into the role of demethylation of these lysine residues in chronic stress-induced changes in neurogenesis that results in altered behaviour. Here, using the chronic social defeat stress (CSDS) paradigm to induce depression and anxiety in C57BL/6 mice and ex vivo DG neural stem/progenitor cell (NSCs/NPCs) culture we show the role of the members of the JMJD2/KDM4 family of histone lysine demethylases (KDMs) in mediating stress-induced changes in DG neurogenesis and mood disorders. The study suggests a critical role of JMJD2D in DG neurogenesis. Altered enrichment of JMJD2D on the promoters of Id2 (inhibitor of differentiation 2) and Sox2 (SRY-Box Transcription Factor 2) was observed during proliferation and differentiation of NSCs/NPCs obtained from the DG. This would affect the demethylation of repressive epigenetic mark H3K9, thus activating or repressing these and possibly other genes involved in regulating proliferation and differentiation of DG NSCs/NPCs. Treatment of the NSCs/NPCs culture with Dimethyloxallyl Glycine (DMOG), an inhibitor of JMJDs, led to attenuation in their proliferation capacity. Additionally, systemic administration of DMOG in mice for 10 days induced depression-like and anxiety-like phenotype without any stress exposure. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
12. Towards seasonal forecasting of malaria in India
- Author
-
Caminade, Cyril, Heath, Andrew E., Jones, Anne E., MacLeod, David A., Gouda, Krushna C., Murty, Upadhyayula Suryanarayana, Goswami, Prashant, Mutheneni, Srinivasa R., Morse, Andrew P., Lauderdale, Jonathan, Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences, and Lauderdale, Jonathan
- Subjects
Veterinary medicine ,Forecast skill ,India ,Models, Biological ,Operational system ,Seasonal forecasting ,Statistics ,parasitic diseases ,medicine ,Hindcast ,Humans ,Weather ,Models, Statistical ,Warning system ,biology ,business.industry ,Incidence (epidemiology) ,Research ,Plasmodium falciparum ,medicine.disease ,biology.organism_classification ,3. Good health ,Malaria ,Infectious Diseases ,ROC Curve ,Disease modelling ,Relative operating characteristic ,Parasitology ,Seasons ,business ,Lead time - Abstract
Background: Malaria presents public health challenge despite extensive intervention campaigns. A 30-year hindcast of the climatic suitability for malaria transmission in India is presented, using meteorological variables from a state of the art seasonal forecast model to drive a process-based, dynamic disease model. Methods: The spatial distribution and seasonal cycles of temperature and precipitation from the forecast model are compared to three observationally-based meteorological datasets. These time series are then used to drive the disease model, producing a simulated forecast of malaria and three synthetic malaria time series that are qualitatively compared to contemporary and pre-intervention malaria estimates. The area under the Relative Operator Characteristic (ROC) curve is calculated as a quantitative metric of forecast skill, comparing the forecast to the meteorologically-driven synthetic malaria time series. Results and discussion: The forecast shows probabilistic skill in predicting the spatial distribution of Plasmodium falciparum incidence when compared to the simulated meteorologically-driven malaria time series, particularly where modelled incidence shows high seasonal and interannual variability such as in Orissa, West Bengal, and Jharkhand (North-east India), and Gujarat, Rajastan, Madhya Pradesh and Maharashtra (North-west India). Focusing on these two regions, the malaria forecast is able to distinguish between years of "high", "above average" and "low" malaria incidence in the peak malaria transmission seasons, with more than 70% sensitivity and a statistically significant area under the ROC curve. These results are encouraging given that the three month forecast lead time used is well in excess of the target for early warning systems adopted by the World Health Organization. This approach could form the basis of an operational system to identify the probability of regional malaria epidemics, allowing advanced and targeted allocation of resources for combatting malaria in India.
- Full Text
- View/download PDF
13. Immune peptides modelling of Culex pipiens sp by in silico methods.
- Author
-
Harikrishna N, Rao MS, and Murty US
- Subjects
- Animals, Cecropins chemistry, Cecropins pharmacology, Computer Simulation, Defensins chemistry, Defensins pharmacology, Insect Proteins chemistry, Insect Proteins pharmacology, Models, Molecular, Protein Conformation, Sequence Homology, Amino Acid, Antimicrobial Cationic Peptides chemistry, Antimicrobial Cationic Peptides pharmacology, Bacteria drug effects, Culex chemistry, Fungi drug effects, Parasites drug effects
- Abstract
Background: In the past 60 years, antibiotics have been critical in the fight against infectious diseases caused by bacteria and other microbes. Development of resistance to the antibiotics is emerging as a major public health issue which has resulted in the search for new antibiotics in order to maintain a pool of effective drugs at all times. Currently, there is a great interest in cationic peptides as antibiotics. These are reported to destroy the host cell membrane rather interacting with the other cell components, which may not face emergence of resistance. In mosquitoes, peptides like cecropin, defensin and gambicin reported to have inhibitory effect on bacteria, fungi and parasites. These peptides are well-characterized at both the biochemical and molecular level from Anopheles and Culex species, yet their 3D structures were not reported., Methods: Defensin, cecropin and gambicin immune peptides of Culex pipiens was characterised to have antiparasitic, antibacterial and antifungal activities. Since the crystal structure of defensin, cecropin and gambicin are not yet available their 3D structures were determined using homology modeling and Rosetta fragment insertion methods and were validated., Results: Stereo chemical evaluation indicated that defensin and gambicin showed that 100% residues of constructed model lie in the most favoured and allowed regions. Cecropin iso-forms A and B showed 100% while C showed 97.6% residues that lie in most favoured and allowed regions, which indicated quality models., Conclusion: Predicted model provide insight into their structure and aid in the development of novel antibiotic peptides.
- Published
- 2012
14. Assessing the relationship among physicochemical properties of proteins with respect to hydrophobicity: a case study on AGC kinase superfamily.
- Author
-
Banerjee AK, Manasa BP, and Murty US
- Subjects
- Chemical Phenomena, Computer Simulation, Data Mining, Hydrophobic and Hydrophilic Interactions, Protein Folding, Protein Kinases classification, Stochastic Processes, Protein Kinases chemistry
- Abstract
Understanding the protein structures is crucial, as it is involved in every cellular activity. Several experimental techniques, such as X-Ray crystallography, nuclear magnetic resonance and electron microscopy are available to gain insight about the structure and function of a protein molecule. Gigantic data on protein structural and sequential information is deposited in various repositories regularly which provide us the scope for more theoretical studies. Hydrophobicity always plays a vital role in tertiary structure formation and behavior of a protein molecule. This study focuses on elucidating influence of several physicochemical properties on hydrophobicity of AGC kinase proteins. AGC kinase superfamily is selected due to its tremendous structural and functional variability and sequence data availability. A combined data mining and stochastic approach confirmed that out of 47 parameters, transmembrane tendency influences the target variable most, followed by percent buried residues, GRAVY (Grand Average Hydropathicity) and aliphatic index. Calculating the influence of different physicochemical parameters and their interrelation will aid tremendously in the future of protein science.
- Published
- 2010
15. Comparative characterization of commercially important xylanase enzymes.
- Author
-
Arora N, Banerjee AK, Mutyala S, and Murty US
- Abstract
Xylanase is an industrially important enzyme having wide range of applications especially in paper industry. It is crucial to gain an understanding about the structure and functional aspects of various xylanases produced from diverse sources. In this study, a bioinformatics and molecular modeling approach was adopted to explore properties and structure of xylanases. Physico-chemical properties were predicted and prediction of motifs, disulfide bridges and secondary structure was performed for functional characterization. Apart from these analyses, three dimensional structures were constructed and stereo-chemical quality was evaluated by different structure validation tools. Comparative catalytic site analysis and assessment was performed to extract information about the important residues. Asn72 was found to be the common residue in the active sites of the proteins P35809 and Q12603.
- Published
- 2009
- Full Text
- View/download PDF
16. A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culexspecies from diverse geographical locations.
- Author
-
Bhargavi R, Vishwakarma S, and Murty US
- Abstract
In the present study, sequence and structural analysis of ITS2 region (the spacer segment between 5.8S and 28S rRNA of mature rRNA sequences) of 7 Culex species belonging to 5 different geographical locations was carried out. Alignment of the ITS2 sequence from the 7 species revealed 8 homologous domains. Four species namely C. vishnui, C. annulus, C. pipiens, C. quiquefasciatusshowed high sequence (98-100%) and RNA secondary structure similarity. The ITS2 similarity among different species is high despite their varying geographical locations. Several common features of secondary structure are shared among these species, with some of them supported by compensatory changes, suggesting the significant role by ITS2 as an RNA domain during ribosome biogenesis.
- Published
- 2005
- Full Text
- View/download PDF
17. Rapid identification of female Culexmosquito species using Expert System in the South East Asian region.
- Author
-
Murty US, Kumar DV, Rao MS, Reuben R, Tewari SC, Hiriyan J, Akiyama J, and Akavaram D
- Abstract
Unlabelled: Rapid identification of mosquito (vector) species is critical for vector control and disease management. Pictorial keys of mosquito species are currently used for the identification of new mosquito species. However, this approach is not very effective. Here, we describe the use of an ID3 algorithm (part of artificial intelligence) for the rapid identification of the South East Asian female Culex mosquito species., Availability: http://www.envisiict.org/
- Published
- 2005
- Full Text
- View/download PDF
18. Modeling analysis of GST (glutathione-S-transferases) from Wuchereria bancrofti and Brugia malayi.
- Author
-
Bhargavi R, Vishwakarma S, and Murty US
- Abstract
GST (glutathione S-transferases) are a family of detoxification enzymes that catalyze the conjugation of reduced GSH (glutathione) to xenobiotic (endogenous electrophilic) compounds. GST from Wb (Wuchereria bancrofti) and Bm (Brugia malayi) are significantly different from human GST in sequence and structure. Thus, Wb-GST and Bm-GST are potential chemotherapeutic targets for anti-filarial treatment. Comparison of modeled Wb and Bm GST with human GST show structural difference between them. Analysis of the active site residues for the binding of electrophilic co-substrates provides insight towards the design of parasite specific GST inhibitors.
- Published
- 2005
- Full Text
- View/download PDF
19. A web based relational database management system for filariasis control.
- Author
-
Murty US, Kumar DV, Sriram K, Rao KM, Bhattacharyulu CH, Praveen B, and Krishna AR
- Abstract
Unlabelled: The present study describes a RDBMS (relational database management system) for the effective management of Filariasis, a vector borne disease. Filariasis infects 120 million people from 83 countries. The possible re-emergence of the disease and the complexity of existing control programs warrant the development of new strategies. A database containing comprehensive data associated with filariasis finds utility in disease control. We have developed a database containing information on the socio-economic status of patients, mosquito collection procedures, mosquito dissection data, filariasis survey report and mass blood data. The database can be searched using a user friendly web interface., Availability: http://www.webfil.org (login and password can be obtained from the authors).
- Published
- 2005
- Full Text
- View/download PDF
20. A rapid identification system for metallothionein proteins using expert system.
- Author
-
Praveen B, Vincent S, Murty US, Krishna AR, and Jamil K
- Abstract
Metallothioneins (MT) are low molecular weight proteins mostly rich in cysteine residues with high metal content. Generally, MT proteins are responsible for regulating the intracellular supply of biologically essential metal ions and they protect cells from the deleterious effects of non-essential polarizable transition and post-transition metal ions. Due to their biological importance, proper characterization of MT is necessary. Here we describe a computer program (ID3 algorithm, a part of Artificial Intelligence) developed using available data for the rapid identification of MT. Tissue samples contains several low molecular weight proteins with different physical, chemical and biological characteristics. The described software solution proposes to categorize MT proteins without aromatic amino acids and high metal content. The proposed solution can be expanded to other types of proteins with specific known characteristics.
- Published
- 2005
- Full Text
- View/download PDF
21. Management of filariasis using prediction rules derived from data mining.
- Author
-
Satya Kumar DV, Sriram K, Rao KM, and Murty US
- Abstract
The present paper demonstrates the application of CART (classification and regression trees) to control a mosquito vector (Culex quinquefasciatus) for bancroftian filariasis in India. The database on filariasis and a commercially available software CART (Salford systems Inc. USA) were used in this study. Baseline entomological data related to bancroftian filariasis was utilized for deriving prediction rules. The data was categorized into three different aspects, namely (1) mosquito abundance, (2) meteorological and (3) socio-economic details. This data was taken from a database developed for a project entitled "Database management system for the control of bancroftian filariasis" sponsored by Ministry of Communication and Information Technology (MC&IT), Government of India, New Delhi. Predictor variables (maximum temperature, minimum temperature, rain fall, relative humidity, wind speed, house type) were ranked by CART according to their influence on the target variable (month). The approach is useful for forecasting vector (mosquito) densities in forthcoming seasons.
- Published
- 2005
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.