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The past decade has seen the rapid emergence of research on Big Data and its implications in our society, yet research on its impact on organizations' sustainability challenges is still at an early stage. Based on the organizational learning theory, we develop a framework to investigate the effects of Big Data capability (BDC) and further intellectual capital on a firm's sustainability‐oriented innovation performance (SIP). Using a multi‐source data collected from 358 Chinese firms, we tested our proposed hypotheses using the partial least squares‐structural equation modeling (PLS‐SEM) and the fuzzy‐set qualitative comparative analysis (fsQCA). The results show that BDC is positively related to SIP and economic innovation performance (EIP), mediated by intellectual capital. The fsQCA results further reveal that three configurative combinations, that is, "external capability‐internal resource promotion," "external capability and relationship building help," and "external relationship collaboration compensation," can lead to high SIP. This study provides new insights for firms to develop sustainability‐oriented innovation and to coordinate sustainability innovation and economic innovation practices in order to create balanced outcomes. [ABSTRACT FROM AUTHOR]

Humanity is in more danger from escalating greenhouse gas (G.H.G.) emissions, making the world warmer. The study examined the relationship between China's environmental technologies, ecological innovation, and carbon emissions using time-series data from 1975 to 2020. The N.A.R.D.L. approach is used to examine the cointegration of variables in the short and long run. In the short run, environmental technologies, industrialisation (I.N.D.), positive shocks to natural resource depletion (N.R.D.), negative shocks to renewable energy (R.E.) use, and technical advancements affect carbon emissions. On the other hand, positive shocks to environmental technologies and financial development (F.D.), negative shocks to N.R.D., R.E. consumption (E.C.), and technical innovation all have a long-term effect on carbon emissions. Granger causality was used to examine the causal link between variables. According to the findings, environmental technologies, F.D., technical innovation, N.R.D., and economic growth (E.G.) cause carbon emissions. The impulse response function revealed an inverse link between asymmetric environmental technology and carbon emissions. In contrast, F.D. and N.R.D. directly affect environmental degradation over time. The outcome of the variance decomposition revealed that negative shocks of F.D. would likely exert greater pressure on achieving sustainable environmental agenda. Investment in environmental technology, F.D., technological innovation and R.E. should be encouraged by the Chinese government to achieve sustainable prosperity. [ABSTRACT FROM AUTHOR]

Livestream shopping has attracted great attention in an increasingly digitalized society. This study is to explore the mechanism through which social presence and physical presence affect consumer purchase intentions in livestream shopping as an emerging e-commerce model. Based on the flow theory, this study proposes an integrated model to explain the mechanism through which the feeling of presence affects consumers' purchase intentions in livestream shopping. Empirical data on livestream shopping were collected in China to test the proposed model for an exploratory study. The results show that the feeling of physical presence influences consumers' purchase intentions through concentration and perceived control, and the feeling of social presence influences consumers' purchase intentions through concentration and enjoyment, and, thus, both social presence and physical presence are important elements in livestream shopping. This study provides a better understanding on the mechanism of how the feeling of presence helps improve purchase intentions in livestream shopping. This study shows both physical presence and social presence are positively related to consumers' purchase intention, but with different paths, and, thus, sheds new lights on the feeling of presence and its impact on consumer behaviors in e-commerce. [ABSTRACT FROM AUTHOR]

The past decade has seen impressive developments in financial technology (FinTech) in China. As a new technology and innovative method that competes with, and also supplements, traditional financial methods, fintech has had a significant impact on traditional financial businesses and has thus challenged the role of commercial banks as credit intermediaries in the financial sector. This paper examines the potential risks that fintech brings to commercial banks in China, and collects data from 19 systemically important banks from 2011–2020 to analyze the effect of fintech development on commercial banks' financial risks in order to achieve sustainable development in the financial sector. Using the Z value and non-performing loan ratio as the criterion variables, this study shows that the impact of fintech on the financial risks of systemically important banks demonstrates an inverted U-shaped pattern, with the financial risk increasing first and then decreasing alongside the further development of fintech. The results also show that commercial banks' responses to fintech development has been comparatively slow. Managerial suggestions are then discussed on risk supervision for commercial banks and the financial sector in China and other emerging markets. [ABSTRACT FROM AUTHOR]

Platform enterprises have emerged as one of the most popular business models in the era of knowledge economy. The success of platform enterprises relies on continuous value creation by constructing an efficient platform and attracting more users to participate in order to create more value for the users and by the users. This study is to explore the key factors that drive value creation in platform enterprises' ecosystem to help better understand the management of platform enterprises as the knowledge-based entrepreneurial ventures in emerging markets. This study employs a newly emerged method—a fuzzy-set qualitative comparative analysis to empirically analyze the antecedent configurations of value creation for Chinese platform enterprises. This method extends qualitative comparative analysis by integrating fuzzy-sets and fuzzy-logic principles with qualitative comparative analysis principles, which offers a more realistic approach. This paper identifies different configurations for high and non-high levels of value creation in platform enterprises. The results show that continuous user commitment is crucial to creating positive value for Chinese platform enterprises, and active user participation and knowledge sharing as well as platform construction/improvement are the key elements that determine the platform enterprises' value creation process. The results also demonstrate a hybrid value creation logic with efficiency and innovation in platform enterprises. This study further identifies an asymmetric causality in the Chinese platform enterprises' value creation process that is crucial for knowledge sharing and effective management of platform enterprises. The findings can shed light on the strategic management of platform enterprises for emerging markets. [ABSTRACT FROM AUTHOR]

There is accumulating evidence showing that apoptosis induced by endoplasmic reticulum (ER) stress plays a key role in pancreatic β cell dysfunction and insulin resistance. 3β-Hydroxysteroid-Δ24 Reductase (DHCR24) is a multifunctional enzyme located in the endoplasmic reticulum (ER), which has been previously shown to protect neuronal cells from ER stress-induced apoptosis. However, the role of DHCR24 in type 2 diabetes is only incompletely understood so far. In the present study, we induced ER stress by tunicamycin (TM) treatment and showed that infection of MIN6 cells with Ad-DHCR24-myc rendered these cells resistant to caspase-3-mediated apoptosis induced by TM, while cells transfected with siRNAs targeting DHCR24 were more sensitive to TM. Western blot analysis showed that TM treatment induced upregulation of Bip protein levels in both cells infected with Ad-LacZ (the control group) and Ad-DHCR24-myc, indicating substantial ER stress. Cells infected with Ad-LacZ exhibited a rapid and strong activation of ATF6 and p38, peaking at 3 h after TM exposure. Conversely, cells infected with Ad-DHCR24-myc showed a higher and more sustained activation of ATF6 and Bip than control cells. DHCR24 overexpression also inhibited the generation of intracellular reactive oxygen species (ROS) induced by ER stress and protected cells from apoptosis caused by treatment with both cholesterol and hydrogen peroxide. In summary, these data demonstrate, for the first time, that DHCR24 protects pancreatic β cells from apoptosis induced by ER stress. [ABSTRACT FROM AUTHOR]

Knowledge sharing plays an important role in promoting innovation and helping improve R&D team performance in the digital age. Based on the evolutionary game theory, this study develops an evolutionary game model of knowledge sharing in R&D teams in order to explore its system evolution path, the evolutionary stability strategy, and the influencing mechanism in knowledge sharing. Then using a simulation model, this study examines the dynamic evolution process of knowledge sharing within R&D teams. The results show that the effectiveness of knowledge sharing in the R&D teams can be promoted by R&D team members' cognitive ability, knowledge absorption ability, knowledge transformation ability, knowledge innovation ability, and the degree of knowledge complementarity within teams. The simulation results further show that reducing the environmental risk can also effectively improve R&D teams' innovation performance. The findings of this study thus provide evidence for knowledge sharing as an important route to sustainable development. [ABSTRACT FROM AUTHOR]

While ethical tourism is becoming more important in the tourist industry, relatively little is known about ethical tourism in China and what motivates Chinese tourists to undertake ethical tourism. This study examines this issue by adopting the planned behavior theory to explore the impact of Chinese tourists' personal factors, positive social influence, image of destination and quality of services on their behavioral intentions in order to better understand what motivate Chinese tourists to participate ethical tourism. The results show that knowledge of ethical tourism, attitude toward ethical tourism, influences from family and friends, and local environment of the destinations are the key factors that drive Chinese tourists to undertake ethical tourism. In addition, service customization, service support and past experiences with ethical tourism are also important determinants of tourists' satisfaction with ethical tourism, which further affects Chinese tourists' intention to visit. Implications for ethical tourism marketing and management are then discussed with reference to how to promote more ethical tourism. [ABSTRACT FROM AUTHOR]

In today's highly uncertain environment, the value of creativity and innovation are increasingly critical. How individuals could improve their creativity and innovation performance has become the focus of attention. Future work self as an intrinsic motivation factor plays an important role in creativity and innovation. Based on the self-consistency theory, this study integrated proactive personality and informal field-based learning (IFBL) to explore the relationship between future work self and employee creativity to increase innovation performance. It used data from 201 R&D department employees in China's high-tech companies. The results show that future work self has a positive effect on employee creativity and that IFBL mediates the relationship between future work self and employee creativity. This process is then positively moderated by a proactive personality. This study's results help clarify the formation mechanism of creativity from the perspective of intrinsic motivation and indicate that future work self can drive individuals' creativity and innovation efforts, especially under the consistency of self-concept, motivation and personality. This research also emphasizes the importance of IFBL in improving individual creativity and further organizational innovation performance. Implications for theory and management to help improve creativity and innovation performance are then discussed in detail. [ABSTRACT FROM AUTHOR]

Knowledge management has become increasingly important in the era of knowledge economy. This study explores what is an optimal knowledge network for more efficient knowledge diffusion among strategic partners in order to provide insights on sustainable enterprises and a more knowledge-efficient innovation ecosystem. Based on simulated analyses of the efficiency of knowledge network models, including regular network, random network, and small world network, this study shows that a random knowledge network is more efficient for knowledge diffusion when a mixture knowledge trade rule is used. This study thus helps identify which knowledge networks facilitate knowledge exchange among collaborative partners for sustainable knowledge management. Management practitioners and policymakers can use the findings to design more appropriate knowledge exchange networks to improve the efficiency of knowledge diffusion in an innovation ecosystem. [ABSTRACT FROM AUTHOR]

Globalization has created an urgent need to understand management practices in different cultures. This study examines Confucianism-based work values of nurse practitioners in Taiwan and explores their impact on conflict management approaches in order to help health practitioners maintain sustainable work relationships and improve organizational effectiveness in an increasingly stressful workplace. Based on the data from 259 nurse practitioners in Taiwan, this study shows that nurse practitioners in Taiwan consider holistic rewards, self-fulfillment and personal growth, challenge and responsibility, autonomy, and meaningfulness as important work values. Hierarchical regression results further indicate that nurse practitioners with strong group-centered needs, such as needs for holistic rewards, preferred collaborative methods to manage conflicts in the workplace, and individuals with strong self-centered needs, such as needs for personal growth and self-fulfillment and needs for autonomy, preferred competitive methods to manage conflicts. Interestingly, this study also finds that self-centered needs such as needs for self-fulfillment and personal growth, and needs for challenge and responsibility are also related to collaborative approaches. Managerial implications are then discussed for conflict management training for nurse practitioners under stressful work conditions. [ABSTRACT FROM AUTHOR]

While it is well-known knowledge management is crucial for an organization's competitive advantage, relatively little research has explored the process whereby knowledge management affects firm performance in a collectivistic culture such as China. This study is to explore the mechanism through which knowledge management helps improve firm performance and then to examine the mediating role of decision quality in the Chinese context. Using a self-administered questionnaire to collect data from Chinese entrepreneurs and with structural equation modeling, this study shows that knowledge accumulation, internal sharing, and external knowledge sharing all have a positive impact on firm performance, and decision quality partially mediates the impact of knowledge management on firm performance. This study adds value to the knowledge management literature by introducing decision quality as a mediating variable to examine the impact of knowledge sharing on firm performance in China. The findings of this study can help enrich the literature on knowledge management and firm performance and highlight the important impact of decision quality on knowledge management and firm performance. Management practitioners can also benefit from the findings. [ABSTRACT FROM AUTHOR]

This study explores personality effects on the endorsement of ethically questionable negotiation strategies in Canada and China. With a sample of over 400 business professionals, this study examines the relationship between the Big Five personality traits and the perceived appropriateness of five categories of negotiation strategies in the two cultures. The results show that the Big Five personality traits strongly affect the endorsement of ethically questionable negotiation strategies (EQNS) both in Canada and in China, but in different ways. For Canadian negotiators, individuals high in conscientiousness, extraversion, and openness are more prone to use EQNS, and individuals high in emotional stability and agreeableness are less likely to use them. For negotiators from Mainland China, only agreeableness and emotional stability are negatively associated with the endorsement of the EQNS. Implications for research on business ethics and for negotiation practitioners and policymakers are then discussed. [ABSTRACT FROM AUTHOR]

There is accumulating evidence showing that apoptosis induced by endoplasmic reticulum (ER) stress plays a key role in pancreatic β cell dysfunction and insulin resistance. 3 β -Hydroxysteroid- Δ 24 Reductase (DHCR24) is a multifunctional enzyme located in the endoplasmic reticulum (ER), which has been previously shown to protect neuronal cells from ER stress-induced apoptosis. However, the role of DHCR24 in type 2 diabetes is only incompletely understood so far. In the present study, we induced ER stress by tunicamycin (TM) treatment and showed that infection of MIN6 cells with Ad-DHCR24-myc rendered these cells resistant to caspase-3-mediated apoptosis induced by TM, while cells transfected with siRNAs targeting DHCR24 were more sensitive to TM. Western blot analysis showed that TM treatment induced upregulation of Bip protein levels in both cells infected with Ad-LacZ (the control group) and Ad-DHCR24-myc, indicating substantial ER stress. Cells infected with Ad-LacZ exhibited a rapid and strong activation of ATF6 and p38, peaking at 3 h after TM exposure. Conversely, cells infected with Ad-DHCR24-myc showed a higher and more sustained activation of ATF6 and Bip than control cells. DHCR24 overexpression also inhibited the generation of intracellular reactive oxygen species (ROS) induced by ER stress and protected cells from apoptosis caused by treatment with both cholesterol and hydrogen peroxide. In summary, these data demonstrate, for the first time, that DHCR24 protects pancreatic β cells from apoptosis induced by ER stress., Competing Interests: The authors declare no conflict of interest regarding the publication of this paper., (Copyright © 2020 Yang Li et al.)

Adult neurogenesis persists in the rodent dentate gyrus and is stimulated by chronic treatment with conventional antidepressants through BDNF/TrkB signaling. Ketamine in low doses produces both rapid and sustained antidepressant effects in patients. Previous studies have shed light on post-transcriptional synaptic NMDAR mediated mechanisms underlying the acute effect, but how ketamine acts at the cellular level to sustain this anti-depressive function for prolonged periods remains unclear. Here we report that ketamine accelerates differentiation of doublecortin-positive adult hippocampal neural progenitors into functionally mature neurons. This process requires TrkB-dependent ERK pathway activation. Genetic ablation of TrkB in neural stem/progenitor cells, or pharmacologic disruption of ERK signaling, or inhibition of adult neurogenesis, each blocks the ketamine-induced behavioral responses. Conversely, enhanced ERK activity via Nf1 gene deletion extends the response and rescues both neurogenic and behavioral deficits in mice lacking TrkB. Thus, TrkB-dependent neuronal differentiation is involved in the sustained antidepressant effects of ketamine.

The mechanisms that activate some genes while silencing others are critical to ensure precision in lineage specification as multipotent progenitors become restricted in cell fate. During neurodevelopment, these mechanisms are required to generate the diversity of neuronal subtypes found in the nervous system. Here we report interactions between basic helix-loop-helix (bHLH) transcriptional activators and the transcriptional repressor PRDM13 that are critical for specifying dorsal spinal cord neurons. PRDM13 inhibits gene expression programs for excitatory neuronal lineages in the dorsal neural tube. Strikingly, PRDM13 also ensures a battery of ventral neural tube specification genes such as Olig1 , Olig2 and Prdm12 are excluded dorsally. PRDM13 does this via recruitment to chromatin by multiple neural bHLH factors to restrict gene expression in specific neuronal lineages. Together these findings highlight the function of PRDM13 in repressing the activity of bHLH transcriptional activators that together are required to achieve precise neuronal specification during mouse development.

Studies on large double-stranded DNA (dsDNA) viruses such as poxviruses have been helpful in identifying a number of viral and cellular growth factors that contribute to our broad understanding of virus-host interaction. Orthopoxviruses and leporipoxviruses are among the most studied viruses in this aspect. However, tanapoxvirus (TPV), a member of the genus Yatapoxvirus, still remains largely unexplored, as the only known hosts for this virus are humans and monkeys. Here, we describe the initial characterization of an epidermal growth factor (EGF)-like growth factor mimicking human neuregulin from TPV, expressed by the TPV-15L gene. Assays using a baculovirus-expressed and tagged TPV-15L protein demonstrated the ability to phosphorylate neuregulin receptors. Neuregulins represent a large family of EGF-like growth factors that play important roles in embryonic endocardium development, Schwann and oligodendrocyte survival and differentiation, localized acetylcholine receptor expression at the neuromuscular junction, and epithelial morphogenesis. Interestingly, certain neuregulin molecules are able to target specific tissues through interactions with heparin sulfate proteoglycans via an immunoglobulin (Ig)-like domain. Analyses of TPV-15L revealed no Ig-like domain, but it retains the ability to bind heparin and phosphorylate neuregulin receptors, providing compelling evidence that TPV-15L is a functional mimetic of neuregulin. TPV-15L knockout virus experiments demonstrate that the virus replicates in human umbilical vein endothelial cells less efficiently than wild-type TPV-Kenya, indicating that this is a nonessential protein for virus viability but can serve a stimulatory role for replication in some cultured cells. However, the precise role of this protein in host-virus interaction still remains to be deduced.

During peripheral nervous system development, successful communication between axons and Schwann cells is required for proper function of both myelinated and nonmyelinated nerve fibers. Alternatively spliced proteins belonging to the neuregulin1 (NRG1) gene family of growth and differentiation factors are essential for Schwann cell survival and peripheral nerve development. Although recent studies have strongly implicated membrane-bound NRG1 forms (type III) in the myelination at late stages, little is known about the role of soluble, heparin-binding forms of NRG1 (type I/II) in regulating early Schwann cell development in vivo. These forms are rapidly released from axons in vitro by Schwann-cell-secreted neurotrophic factors and, unlike membrane-bound forms, have a unique ability to diffuse and adhere to heparan sulfate-rich cell surfaces. Here, we show that axon-derived soluble NRG1 translocates from axonal to Schwann cell surfaces in the embryonic chick between days 5 and 7, corresponding to the critical period of Schwann cell survival. Downregulating endogenous type I/II NRG1 signaling either with a targeted NRG1 antagonist or by shRNA blocks their differentiation from precursors into immature Schwann cells and increases programmed cell death, whereas upregulating NRG1 rescues Schwann cells. Exogenous BDNF also promotes Schwann cell survival through promoting the local release of axonal NRG1. Consistently, increased Schwann cell death occurs both in trkB knock-out mice and after knocking down axonal trkB in chick embryos, which can then be rescued with soluble NRG1. These findings suggest a localized, axoglial feedback loop through soluble NRG1 and BDNF critical for early Schwann cell survival and differentiation.

A key component in the response of the nervous system to injury is the proliferation and switch to a "proinflammatory" phenotype by microglia (microgliosis). In situations where the blood-brain barrier is intact, microglial numbers increase via the proliferation and chemotaxis of resident microglia; however, there is limited knowledge regarding the factors mediating this response. After peripheral nerve injury, a dorsal horn microgliosis develops, which directly contributes to the development of neuropathic pain. Neuregulin-1 (NRG-1) is a growth and differentiation factor with a well characterized role in neural and cardiac development. Microglia express the NRG1 receptors erbB2, 3, and 4, and NRG1 signaling via the erbB2 receptor stimulated microglial proliferation, chemotaxis, and survival, as well as interleukin-1beta release in vitro. Intrathecal treatment with NRG1 resulted in microglial proliferation within the dorsal horn, and these cells developed an activated morphology. This microglial response was associated with the development of both mechanical and cold pain-related hypersensitivity. Primary afferents express NRG1, and after spinal nerve ligation (SNL) we observed both an increase in NRG1 within the dorsal horn as well as activation of erbB2 specifically within microglia. Blockade of the erbB2 receptor or sequestration of endogenous NRG after SNL reduced the proliferation, the number of microglia with an activated morphology, and the expression of phospho-P38 by microglia. Furthermore, consequent to such changes, the mechanical pain-related hypersensitivity and cold allodynia were reduced. NRG1-erbB signaling therefore represents a novel pathway regulating the injury response of microglia.

A major limitation in biopharmaceutical development is selectively targeting drugs to diseased tissues. Growth factors and viruses have solved this problem by targeting tissue-specific cell-surface heparan sulfates. Neuregulin (NRG), a growth factor important in both nervous system development and cancer, has a unique heparin-binding domain (HBD) that targets to cell surfaces expressing its HER2/3/4 receptors (Esper, R. M., Pankonin, M. S., and Loeb, J. A. (2006) Brain Res. Rev. 51, 161-175). We have harnessed this natural targeting ability of NRG by fusing the HBD of NRG to soluble HER4. This fusion protein retains high affinity heparin binding to heparin and to cells that express heparan sulfates resulting in a more potent NRG antagonist. In vivo, it is targeted to peripheral nerve segments where it blocks the activity of NRG as a Schwann cell survival factor. The fusion protein also efficiently blocks autocrine and paracrine signaling and reduces the proliferation of MCF10CA1 breast cancer cells. These findings demonstrate the utility of the HBD of NRG in biopharmaceutical targeting and provide a new way to block HER signaling in cancer cells.